Hideki Shirakawa

Hideki Shirakawa is a Japanese Chemist and Nobel Prize Laureate in Chemistry 2000. He shared the prize with Alan MacDiarmid and Alan Heeger. Shirakawa was awarded the prize for his work on conductive polymers. He developed polyacetylene which has a metallic appearance. MacDiarmid and Shirakawa discovered that doping polyacetylene with iodine enhances conductivity of the polymer.
Shirakawa received the SPSJ Award 1982, SPSJ Award for Distinguished Service 1999, Japanese Order of Culture 2000 and CSJ Special Award 2001.

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Hideki Shirakawa
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1983 The Award of the Society of Polymer Science, Japan (FY 1982): Research on polyacetylene

2000 SPSJ Award for Outstanding Achievement in Polymer Science and Technology (FY 1982): Discovery and development of conductive polymer

2000 Nobel Prize in Chemistry: Discovery and development of conductive polymer

2000 Order of Culture and selected as Person of Cultural Merit

2001 Special Award of the Chemical Society of Japan

  1. Shirakawa Hideki; Ito Masahiko; Sato Moritoshi; Umezawa Yoshio; Miyazaki Shunichi. Measurement of intracellular IP3 during Ca2+ oscillations in mouse eggs with GFP-based FRET probe. Biochemical and biophysical research communications 2006;345(2):781-8.
  2. Kouchi Zen; Shikano Tomohide; Nakamura Yoshikazu; Shirakawa Hideki; Fukami Kiyoko; Miyazaki Shunichi. The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta. The Journal of biological chemistry 2005;280(22):21015-21.
  3. Sone Yoshie; Ito Masahiko; Shirakawa Hideki; Shikano Tomohide; Takeuchi Hiroyuki; Kinoshita Katsuyuki; Miyazaki Shunichi. Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic development. Biochemical and biophysical research communications 2005;330(3):690-4.
  4. Asada Yasuki; Suzuki Shoichi; Yamada Masahiro; Sakurai Kumi; Susa Hiromi; Maeda Shigenobu; Ito Miyuki; Takeuchi Yoshihito; Shirakawa Hideki. [Effect of breast composition on patient exposure in mammography]. Nippon Hoshasen Gijutsu Gakkai zasshi 2004;60(12):1675-81.
  5. Yoda Ayako; Oda Shoji; Shikano Tomohide; Kouchi Zen; Awaji Takeo; Shirakawa Hideki; Kinoshita Katsuyuki; Miyazaki Shunichi. Ca2+ oscillation-inducing phospholipase C zeta expressed in mouse eggs is accumulated to the pronucleus during egg activation. Developmental biology 2004;268(2):245-57.
  6. Shirakawa Hideki; Miyazaki Shunichi. Blind spectral decomposition of single-cell fluorescence by parallel factor analysis. Biophysical journal 2004;86(3):1739-52.
  7. Shirakawa Hideki. [Fluorescence spectral component analysis by employing multivariate analysis and its application to experiments on cell physiology]. Nippon seirigaku zasshi. Journal of the Physiological Society of Japan 2004;66(12):381-90.
  8. Awaji T; Hirasawa A; Shirakawa H; Tsujimoto G; Miyazaki S. Novel green fluorescent protein-based ratiometric indicators for monitoring pH in defined intracellular microdomains. Biochemical and biophysical research communications 2001;289(2):457-62.
  9. Kanoh S; Kondo M; Tamaoki J; Shirakawa H; Aoshiba K; Miyazaki S; Kobayashi H; Nagata N; Nagai A. Effect of FK506 on ATP-induced intracellular calcium oscillations in cow tracheal epithelium. The American journal of physiology 1999;276(6 Pt 1):L891-9.
  10. Shirakawa H; Miyazaki S. Spatiotemporal characterization of intracellular Ca2+ rise during the acrosome reaction of mammalian spermatozoa induced by zona pellucida. Developmental biology 1999;208(1):70-8.
  11. Kondo M; Kanoh S; Tamaoki J; Shirakawa H; Miyazaki S; Nagai A. Erythromycin inhibits ATP-induced intracellular calcium responses in bovine tracheal epithelial cells. American journal of respiratory cell and molecular biology 1998;19(5):799-804.
  12. Nakano Y; Shirakawa H; Mitsuhashi N; Kuwabara Y; Miyazaki S. Spatiotemporal dynamics of intracellular calcium in the mouse egg injected with a spermatozoon. Molecular human reproduction 1997;3(12):1087-93.
  13. Shirakawa H; Miyazaki S. Spatiotemporal analysis of calcium dynamics in the nucleus of hamster oocytes. The Journal of physiology 1996;494 ( Pt 1)():29-40.
  14. Shiraishi K; Okada A; Shirakawa H; Nakanishi S; Mikoshiba K; Miyazaki S. Developmental changes in the distribution of the endoplasmic reticulum and inositol 1,4,5-trisphosphate receptors and the spatial pattern of Ca2+ release during maturation of hamster oocytes. Developmental biology 1995;170(2):594-606.
  15. Shirakawa H; Miyazaki S. Evidence for inositol tetrakisphosphate-activated Ca2+ influx pathway refilling inositol trisphosphate-sensitive Ca2+ stores in hamster eggs. Cell calcium 1995;17(1):1-13.
  16. Mohri H; Hamaguchi Y; Hamaguchi M S; Sano K; Shirakawa H; Nakada K; Miyazaki S. Sperm-egg fusion in the sea urchin is blocked in Mg(2+)-free seawater. Zygote (Cambridge, England) 1994;2(2):149-57.
  17. Miyazaki S; Shirakawa H; Nakada K; Honda Y. Essential role of the inositol 1,4,5-trisphosphate receptor/Ca2+ release channel in Ca2+ waves and Ca2+ oscillations at fertilization of mammalian eggs. Developmental biology 1993;158(1):62-78.
  18. Fujiwara T; Nakada K; Shirakawa H; Miyazaki S. Development of inositol trisphosphate-induced calcium release mechanism during maturation of hamster oocytes. Developmental biology 1993;156(1):69-79.
  19. Miyazaki S; Shirakawa H; Nakada K; Honda Y; Yuzaki M; Nakade S; Mikoshiba K. Antibody to the inositol trisphosphate receptor blocks thimerosal-enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs. FEBS letters 1992;309(2):180-4.
  20. Miyazaki S; Yuzaki M; Nakada K; Shirakawa H; Nakanishi S; Nakade S; Mikoshiba K. Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. Science (New York, N.Y.) 1992;257(5067):251-5.

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    Retired Professor
    University of Tsukuba Institute of Materials Science