Ryoji Noyori

Japanese born chemist Ryoji Noyori is the recipient of the Nobel Prize in Chemistry 2001 for his work on the study of chirally catalyzed hydrogenations. He shared half of the prize with William Knowles. The other half of the prize was given to K. Barry Sharpless. Noyori is famous for asymmetric hydrogenations using rhodium and ruthenium catalyst complexes particularly those based on BINAP ligand.

Noyori completed his BS in chemistry (1961) and MS (1963) from Kyoto University. He completed his doctorate in 1967. Noyori served as a teacher at Kyoto University and as an associate professor at Nagoya University. He completed his post doctoral research from Harvard University (1969-70). He is still based at Nagoya and is the President of RIKEN (a research centre). Noyori also served as the president of Chemical Society of Japan (2001-2).

Noyori’s Honors include the Japan Academy Prize (1995), Japan Order of Culture (2000), Wolf Prize in Chemistry (2001) and Roger Adams Medal (2001).

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Ryoji Noyori
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1972 CSJ Award for Young Chemists 1972

1978 Matsunaga Prize 1978

1982 Chunichi Cultural Prize 1982

1985 Chemical Society of Japan Award 1985

1990 Toray Science & Technology Prize 1990

1991 ACS John Gamble Kirkwood Medal 1991

1993 Tetrahedron Prize for Creativity in Organic Chemistry 1993 (with K. Barry Sharpless)

1994 Keimei Life Science Prize 1994

1995 Japan Academy Prize 1995

1997 ACS Arthur C. Cope Award 1997

1997 SCI Chirality Medal 1997

1.    Sandoval Christian A; Bie Fusheng; Matsuoka Aki; Yamaguchi Yoshiki; Naka Hiroshi; Li Yuehui; Kato Koichi; Utsumi Noriyuki; Tsutsumi Kunihiko; Ohkuma Takeshi; Murata Kunihiko; Noyori Ryoji: Chiral eta(6)-arene/N-tosylethylenediamine-ruthenium(II) complexes: solution behavior and catalytic activity for asymmetric hydrogenation. Chemistry, an Asian journal 2010;5(4):806-16.
2.    Sandoval Christian A; Shi Qixun; Liu Shasha; Noyori Ryoji: NH/pi attraction: a role in asymmetric hydrogenation of aromatic ketones with binap/1,2-diamine-ruthenium(II) complexes. Chemistry, an Asian journal 2009;4(8):1221-4.
3.    Noyori Ryoji: Synthesizing our future. Nature chemistry 2009;1(1):5-6.
4.    Sandoval Christian A; Li Yuehui; Ding Kuiling; Noyori Ryoji: The hydrogenation/transfer hydrogenation network in asymmetric reduction of ketones catalyzed by [RuCl2(binap)(pica)] complexes. Chemistry, an Asian journal 2008;3(10):1801-10.
5.    Knowles William S; Noyori Ryoji: Pioneering perspectives on asymmetric hydrogenation. Accounts of chemical research 2007;40(12):1238-9.
6.    Sahnoun Riadh; Fujimura Yuichi; Kabuto Kuninobu; Takeuchi Yoshio; Noyori Ryoji: Ab initio molecular orbitals study of the conformational preference in alpha-cyano-alpha-fluorophenylacetic acid ester. The Journal of organic chemistry 2007;72(21):7923-9.
7.    Nambo Masakazu; Noyori Ryoji; Itami Kenichiro: Rh-catalyzed arylation and alkenylation of C(60) using organoboron compounds. Journal of the American Chemical Society 2007;129(26):8080-1.
8.    Ohkuma Takeshi; Tsutsumi Kunihiko; Utsumi Noriyuki; Arai Noriyoshi; Noyori Ryoji; Murata Kunihiko: Asymmetric hydrogenation of alpha-chloro aromatic ketones catalyzed by eta6-arene/TsDPEN-ruthenium(II) complexes. Organic letters 2007;9(2):255-7.
9.    Cui Yilong; Takamatsu Hiroyuki; Kakiuchi Takeharu; Ohba Hiroyuki; Kataoka Yosky; Yokoyama Chihiro; Onoe Hirotaka; Watanabe Yumiko; Hosoya Takamitsu; Suzuki Masaaki; Noyori Ryoji; Tsukada Hideo; Watanabe Yasuyoshi: Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study. Stroke; a journal of cerebral circulation 2006;37(11):2830-6.
10.    Yanagisawa Shuichi; Sudo Tomoko; Noyori Ryoji; Itami Kenichiro: Direct C-H arylation of (hetero)arenes with aryl iodides via rhodium catalysis. Journal of the American Chemical Society 2006;128(36):11748-9.
11.    Sandoval Christian A; Ohkuma Takeshi; Utsumi Noriyuki; Tsutsumi Kunihiko; Murata Kunihiko; Noyori Ryoji: Mechanism of asymmetric hydrogenation of acetophenone catalyzed by chiral eta(6)-arene-N-tosylethylenediamine-ruthenium(II) complexes. Chemistry, an Asian journal 2006;1(1-2):102-10.
12.    Ohkuma Takeshi; Utsumi Noriyuki; Tsutsumi Kunihiko; Murata Kunihiko; Sandoval Christian; Noyori Ryoji: The hydrogenation/transfer hydrogenation network: asymmetric hydrogenation of ketones with chiral eta6-arene/N-Tosylethylenediamine-ruthenium(II) catalysts. Journal of the American Chemical Society 2006;128(27):8724-5.
13.    Ikariya Takao; Murata Kunihiko; Noyori Ryoji: Bifunctional transition metal-based molecular catalysts for asymmetric syntheses. Organic & biomolecular chemistry 2006;4(3):393-406.
14.    Sandoval Christian A; Yamaguchi Yoshiki; Ohkuma Takeshi; Kato Koichi; Noyori Ryoji: Solution structures and behavior of trans-RuH(eta(1)-BH(4)) (binap)(1,2-diamine) complexes. Magnetic resonance in chemistry : MRC 2006;44(1):66-75.
15.    Furuta Hiroki; Hase Mariko; Noyori Ryoji; Mori Yuji: Synthesis of the ABCD ring of gambierol. Organic letters 2005;7(18):4061-4.
16.    Ohkuma Takeshi; Sandoval Christian A; Srinivasan Rajagopal; Lin Quinghong; Wei Yinmao; Muñiz Kilian; Noyori Ryoji: Asymmetric hydrogenation of tert-alkyl ketones. Journal of the American Chemical Society 2005;127(23):8288-9.
17.    Noyori Ryoji; Sandoval Christian A; Muñiz Kilian; Ohkuma Takeshi: Metal-ligand bifunctional catalysis for asymmetric hydrogenation. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2005;363(1829):901-12; discussion 1035-40.
18.    Noyori Ryoji: Pursuing practical elegance in chemical synthesis. Chemical communications (Cambridge, England) 2005;(14):1807-11.
19.    Takeuchi Yoshio; Fujisawa Hidehito; Noyori Ryoji: A very reliable method for determination of absolute configuration of chiral secondary alcohols by 1H NMR spectroscopy. Organic letters 2004;6(24):4607-10.
20.    Doi Hisashi; Barletta Julien; Suzuki Masaaki; Noyori Ryoji; Watanabe Yasuyushi; Langstrom Bengt Synthesis of 11C-labelled N,N’-diphenylurea and ethyl phenylcarbamate by a rhodium-promoted carbonylation via [11C]isocyanatobenzene using phenyl azide and [11C]carbon monoxide. Organic & biomolecular chemistry 2004;2(21):3063-6.
21.    Ohkuma Takeshi; Hattori Tomonori; Ooka Hirohito; Inoue Tsutomu; Noyori Ryoji: BINAP/1,4-diamine-ruthenium(II) complexes for efficient asymmetric hydrogenation of 1-tetralones and analogues. Organic letters 2004;6(16):2681-3.
22.    Noyori Ryoji; Kitamura Masato; Ohkuma Takeshi: Toward efficient asymmetric hydrogenation: architectural and functional engineering of chiral molecular catalysts. Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5356-62.
23.    Mori Yuji; Nogami Kouichi; Hayashi Hiasafumi; Noyori Ryoji: Sulfonyl-stabilized oxiranyllithium-based approach to polycyclic ethers. Convergent synthesis of the ABCDEF-ring system of yessotoxin and adriatoxin. The Journal of organic chemistry 2003;68(23):9050-60.
24.    Sandoval Christian A; Ohkuma Takeshi; Muñiz Kilian; Noyori Ryoji: Mechanism of asymmetric hydrogenation of ketones catalyzed by BINAP/1,2-diamine-rutheniumII complexes. Journal of the American Chemical Society 2003;125(44):13490-503.
25.    Noyori Ryoji; Aoki Masao; Sato Kazuhiko: Green oxidation with aqueous hydrogen peroxide. Chemical communications (Cambridge, England) 2003;(16):1977-86.
26.    Hamada Takayuki; Torii Takayoshi; Izawa Kunisuke; Noyori Ryoji; Ikariya Takao: Practical synthesis of optically active styrene oxides via reductive transformation of 2-chloroacetophenones with chiral rhodium catalysts. Organic letters 2002;4(24):4373-6.
27.    Noyori Ryoji: Asymmetric catalysis: science and opportunities (Nobel lecture). Angewandte Chemie (International ed. in English) 2002;41(12):2008-22.
28.    Kitamura Masato; Tsukamoto Masaki; Bessho Yuhki; Yoshimura Masahiro; Kobs Uwe; Widhalm Michael; Noyori Ryoji: Mechanism of asymmetric hydrogenation of alpha-(acylamino)acrylic esters catalyzed by BINAP-ruthenium(II) diacetate. Journal of the American Chemical Society 2002;124(23):6649-67.
29.    Ohkuma Takeshi; Koizumi Masatoshi; Muñiz Kilian; Hilt Gerhard; Kabuto Chizuko; Noyori Ryoji: trans-RuH(eta1-BH4)(binap)(1,2-diamine): a catalyst for asymmetric hydrogenation of simple ketones under base-free conditions. Journal of the American Chemical Society 2002;124(23):6508-9.
30.    Noyori R; Yamakawa M; Hashiguchi S: Metal-ligand bifunctional catalysis: a nonclassical mechanism for asymmetric hydrogen transfer between alcohols and carbonyl compounds. The Journal of organic chemistry 2001;66(24):7931-44.
31.    Kitamura M; Nakano K; Miki T; Okada M; Noyori R: Stereochemistry of aldols: configuration and conformation of aldols derived from cycloalkanones and aldehydes. Journal of the American Chemical Society 2001;123(37):8939-50.
32.    Hayakawa Y; Kawai R; Hirata A; Sugimoto J I; Kataoka M; Sakakura A; Hirose M; Noyori R: Acid/azole complexes as highly effective promoters in the synthesis of DNA and RNA oligomers via the phosphoramidite method. Journal of the American Chemical Society 2001;123(34):8165-76.
33.    Fukushima S; Takeuchi Y; Kishimoto S; Yamashita S; Uetsuki K; Shirakawa S; Suzuki M; Furuta K; Noyori R; Sasaki H; Kikuchi Y; Kita T; Yamori T; Sawada J; Kojima M; Hazato A; Kurozumi S; Fukushima M: Antitumor activity, optimum administration method and pharmacokinetics of 13,14-dihydro-15-deoxy-deoxy-Delta7 -prostaglandin A1 methyl ester (TEI-9826) integrated in lipid microspheres (Lipo TEI-9826). Anti-cancer drugs 2001;12(3):221-34.
34.    Noyori R; Suga S; Oka H; Kitamura M: Self and nonself recognition of chiral catalysts: the origin of nonlinear effects in the amino-alcohol catalyzed asymmetric addition of diorganozincs to aldehydes. Chemical record (New York, N.Y.) 2001;1(2):85-100.
35.    Satoh T; Ishikawa Y; Kataoka Y; Cui Y; Yanase H; Kato K; Watanabe Y; Nakadate K; Matsumura K; Hatanaka H; Kataoka K; Noyori R; Suzuki M; Watanabe Y: CNS-specific prostacyclin ligands as neuronal survival-promoting factors in the brain. The European journal of neuroscience 1999;11(9):3115-24.
36.    Watanabe Y; Matsumura K; Takechi H; Kato K; Morii H; Björkman M; Långström B; Noyori R; Suzuki M; Watanabe Y: A novel subtype of prostacyclin receptor in the central nervous system. Journal of neurochemistry 1999;72(6):2583-92.
37.    Ishikawa T; Akimaru K; Nakanishi M; Tomokiyo K; Furuta K; Suzuki M; Noyori R: Anti-cancer-prostaglandin-induced cell-cycle arrest and its modulation by an inhibitor of the ATP-dependent glutathione S-conjugate export pump (GS-X pump). The Biochemical journal 1998;336 ( Pt 3)():569-76.
38.    Suzuki M; Kiho T; Tomokiyo K; Furuta K; Fukushima S; Takeuchi Y; Nakanishi M; Noyori R: Rational design of antitumor prostaglandins with high biological stability. Journal of medicinal chemistry 1998;41(16):3084-90.
39.    Tanikawa M; Yamada K; Tominaga K; Morisaki H; Kaneko Y; Ikeda K; Suzuki M; Kiho T; Tomokiyo K; Furuta K; Noyori R; Nakanishi M: Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. The Journal of biological chemistry 1998;273(29):18522-7.
40.    Björkman M; Andersson Y; Doi H; Kato K; Suzuki M; Noyori R; Watanabe Y; Långström B: Synthesis of 11C/13C-labelled prostacyclins. Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1998;52(5):635-40.
41.    Fukushima S; Kishimoto S; Takeuchi Y; Fukushima M; Suzuki M; Furuta K; Noyori R; Sasaki H; Kikuchi Y; Nakano M; Kurozumi S: [Pharmaceutical and pharmacological development of antitumor prostaglandins]. Nippon rinsho. Japanese journal of clinical medicine 1998;56(3):663-9.
42.    Akimaru K; Nakanishi M; Suzuki M; Furuta K; Noyori R; Ishikawa T: Cell growth inhibition by antitumor prostaglandin and its modulation by MRP/GS-X pump. Advances in experimental medicine and biology 1997;407():387-91.
43.    Takechi H; Matsumura K; Watanabe Y; Kato K; Noyori R; Suzuki M; Watanabe Y: A novel subtype of the prostacyclin receptor expressed in the central nervous system. The Journal of biological chemistry 1996;271(10):5901-6.
44.    Akimaru K; Kuo M T; Furuta K; Suzuki M; Noyori R; Ishikawa T: Induction of MRP/GS-X pump and cellular resistance to anticancer prostaglandins. Cytotechnology 1996;19(3):221-7.
45.    Noyori R; Suzuki M: Organic synthesis of prostaglandins: advancing biology. Science (New York, N.Y.) 1993;259(5091):44-5.
46.    Hirose M; Noyori R; Hayakawa Y: Synthesis of phenylphosphonodiester-modified oligodeoxyribonucleotides via the allyl protection. Nucleic acids symposium series 1993;(29):7-8.
47.    Ito S; Hashimoto H; Negishi M; Suzuki M; Koyano H; Noyori R; Ichikawa A: Identification of the prostacyclin receptor by use of [15-3H1]19-(3-azidophenyl)-20-norisocarbacyclin, an irreversible specific photoaffinity probe. The Journal of biological chemistry 1992;267(28):20326-30.
48.    Hayakawa Y; Hayakawa M; Hirose M; Noyori R: Partial methyl phosphotriester-modification of oligodeoxyribonucleotides. Nucleic acids symposium series 1992;(27):103-4.
49.    Hayakawa Y; Harada H; Hirose M; Noyori R; Wakabayashi S; Miyazaki K; Kawase Y; Kato I: Direct synthesis of solid-anchored DNA oligomers. Nucleic acids symposium series 1991;(25):63-4.
50.    Tominaga A; Saito S; Kohno S; Sakurai K; Hayakawa Y; Noyori R: Antiviral effects of 2’,5’oligoadenylates (2-5As), and related compounds. Microbiology and immunology 1990;34(9):737-47.
51.    Hayakawa Y; Hirose M; Noyori R: Allyl protection of O6 position of 2’-deoxyguanosine. Nucleic acids symposium series 1990;(22):1-2.
52.    Hayakawa Y; Hirose M; Noyori R: General, regiocontrolled synthesis of unsymmetrically linked dinucleoside adenosine 2’,3’-bis(phosphate)s. Nucleic acids symposium series 1989;(21):103-4.
53.    Noyori R; Yanagisawa A; Koyano H; Suzuki M: Natural and unnatural prostaglandins via the three-component coupling synthesis. Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():631-4.
54.    Mitsuhira Y; Tahara S; Goto K; Hayakawa Y; Noyori R: Application of allyloxycarbonyl group as a protecting group to oligodeoxyribonucleotide synthesis. Nucleic acids symposium series 1988;(19):25-8.
55.    Sobue M; Habuchi H; Ito K; Yonekura H; Oguri K; Sakurai K; Kamohara S; Ueno Y; Noyori R; Suzuki S: beta-D-xylosides and their analogues as artificial initiators of glycosaminoglycan chain synthesis. Aglycone-related variation in their effectiveness in vitro and in ovo. The Biochemical journal 1987;241(2):591-601.
56.    Kato T; Fukushima M; Kurozumi S; Noyori R: Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo. Cancer research 1986;46(7):3538-42.
57.    Hayakawa Y; Kato H; Nobori T; Noyori R; Imai J: Allyl and allyloxycarbonyl groups as versatile protecting groups in nucleotide synthesis. Nucleic acids symposium series 1986;(17):97-100.
58.    Sugiura S; Hazato A; Tanaka T; Okamura N; Bannai K; Manabe K; Kurozumi S; Suzuki M; Noyori R: Synthesis of new antineoplastic alkylidenecyclopentenones. Chemical & pharmaceutical bulletin 1985;33(9):4120-3.
59.    Hayakawa Y; Uchiyama M; Noyori R: A convenient method for the oxidation of nucleoside phosphites to phosphates. Nucleic acids symposium series 1985;(16):145-7.
60.    Hayakawa Y; Nobori T; Noyori R: Synthesis of 2’-end-modified 2’-5’-oligoadenylates. Nucleic acids symposium series 1985;(16):129-32.
61.    Kurozumi S; Tanaka T; Okamura N; Bannai K; Hazato A; Sugiura S; Manabe K; Noyori R: Three-component coupling process to synthesize prostaglandin analogues of pharmacological interest. Advances in prostaglandin, thromboxane, and leukotriene research 1985;15():299-301.
62.    Noyori R; Suzuki M: Convergent synthesis of prostaglandins. Advances in prostaglandin, thromboxane, and leukotriene research 1985;15():295-7.
63.    Sugiura S; Toru T; Tanaka T; Hazato A; Okamura N; Bannai K; Manabe K; Kurozumi S; Noyori R: Synthesis of new antineoplastic prostaglandins. Chemical & pharmaceutical bulletin 1984;32(11):4658-61.
64.    Hayakawa Y; Uchiyama M; Nobori T; Noyori R: A convenient synthesis of adenylyl-(2’—-5’)-adenylyl-(2’—-5’)-adenosine (2-5A core). Nucleic acids symposium series 1984;(15):85-8.
65.    Hayakawa Y; Aso Y; Uchiyama M; Noyori R: Chemoselective phosphorylation of N-unblocked nucleosides. Nucleic acids symposium series 1983;(12):47-50.
66.    Hayakawa Y; Aso Y; Uchiyama M; Noyori R: A new phosphorylation method for the nucleotide synthesis. Nucleic acids symposium series 1982;(11):65-8.
67.    Sato T; Noyori R: The stereocontrolled synthesis of homo-C-nucleosides. Nucleic acids symposium series 1979;(6):s19-22.
68.    Noyori R; Kumagai Y; Umeda I; Takaya H: Localization of tyrosine at the binding site of neurophysin II by negative nuclear Overhauser effects. Journal of the American Chemical Society 1972;94(11):4017-20.
69.    Corey E J; Noyori R: A total synthesis of prostaglandin F2-alpha (dl) from 2-oxabicyclo[3.3.0]oct-6-en-3-one. Tetrahedron letters 1970;(4):311-3.



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  • Postings

    University Professor
    Nagoya University

    President of RIKEN
    Institute of Physical and Chemical Research