Sydney Brenner

Sydney Brenner is a South African biologist and a Nobel Laureate in Physiology or Medicine 2002. He shared the Nobel Prize with H. Robert Horvitz and Sir John Sulston. Sydney Brenner made prominent contributions in the field of molecular biology and genetic code.

While working with the Nobel Laureate Francis Crick, Brenner discovered the “start” and “stop” signals in the genetic code. He showed that the genetic information flows from deoxyribonucleic acid (DNA) to ribonucleic acid (RNA) to protein. The information never flows in the opposite direction. This phenomenon is commonly known as the “central dogma of molecular biology”. He also established the roundworm Caenorhabditiselegans as a model for the investigation of developmental biology.

Sydney Brenner received the Lasker Award 1971 &2000, Royal Medal 1974, Kyoto Prize 1990 and Dan David Prize 2002.

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1965 Fellow of the Royal Society (FRS)

1971 Albert Lasker Medical Research Award

1974 Royal Medal, Royal Society of London

1976 Honorary DSc, University of Chicago

1978 Gairdner Foundation International Award, Canada

1980 Krebs Medal, Federation of European Biochemical Societies

1981 Ciba Medal, Biochemical Society

1985 Foreign Member of Real Academia de Ciencias, Spain

1986 Rosenstiel Award, Brandeis University, USA

1987 Prix Louis Jeantet de Medecine, Switzerland

1987 Harvey Prize, Technion – Israel Institute of Technology

1988 Waterford Bio-Medical Science Award, The Research Institute of Scripps Clinic

1988 External Scientific Member of the Max-Planck Society

1989 Honorary Fellow of the Indian Academy of Sciences

1989 Honorary Member of the Chinese Society of Genetics, Taiwan

1990 Kyoto Prize

1991 Gairdner Foundation International Award, Canada

1992 King Faisal International Prize for Science, King Faisal Foundation

1992 Associe Etranger, Académie des Sciences, Paris, France

2000 Albert Lasker Award for Special Achievement in Medical Science

2001 Novartis Drew Award In Biomedical Research

2002 Nobel Prize for medicine

Ravi, V; Lam, K; Tay, BH; Tay, A; Brenner, S; Venkatesh, B Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes. Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16327-32.

Larsson, TA; Tay, BH; Sundström, G; Fredriksson, R; Brenner, S; Larhammar, D; Venkatesh, B Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics 2009;93(3):254-60.

Nathanson, JL; Jappelli, R; Scheeff, ED; Manning, G; Obata, K; Brenner, S; Callaway, EM Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types. Frontiers in neural circuits 2009;3():19.

Gwee, PC; Tay, BH; Brenner, S; Venkatesh, B Characterization of the neurohypophysial hormone gene loci in elephant shark and the Japanese lamprey: origin of the vertebrate neurohypophysial hormone genes. BMC evolutionary biology 2009;9():47.

Yu, WP; Rajasegaran, V; Yew, K; Loh, WL; Tay, BH; Amemiya, CT; Brenner, S; Venkatesh, B Elephant shark sequence reveals unique insights into the evolutionary history of vertebrate genes: A comparative analysis of the protocadherin cluster. Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3819-24.

Loh, YH; Brenner, S; Venkatesh, B Investigation of loss and gain of introns in the compact genomes of pufferfishes (Fugu and Tetraodon). Molecular biology and evolution 2008;25(3):526-35.

Sundström, G; Larsson, TA; Brenner, S; Venkatesh, B; Larhammar, D Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. General and comparative endocrinology 2008;155(3):705-16.

Anderson, D; Brenner, S Obituary: Seymour Benzer (1921-2007). Nature 2008;451(7175):139.

Larsson, TA; Olsson, F; Sundstrom, G; Lundin, LG; Brenner, S; Venkatesh, B; Larhammar, D Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions. BMC evolutionary biology 2008;8():184.

Gwee, PC; Amemiya, CT; Brenner, S; Venkatesh, B Sequence and organization of coelacanth neurohypophysial hormone genes: evolutionary history of the vertebrate neurohypophysial hormone gene locus. BMC evolutionary biology 2008;8():93.

Brenner, S An interview with… Sydney Brenner. Interview by Errol C. Friedberg. Nature reviews. Molecular cell biology 2008;9(1):8-9.

Chandrasekaran, A; Toh, KY; Low, SH; Tay, SK; Brenner, S; Goh, DL Identification and characterization of novel mouse PDE4D isoforms: molecular cloning, subcellular distribution and detection of isoform-specific intracellular localization signals. Cellular signalling 2008;20(1):139-53.

Ruhe, JE; Streit, S; Hart, S; Wong, CH; Specht, K; Knyazev, P; Knyazeva, T; Tay, LS; Loo, HL; Foo, P; Wong, W; Pok, S; Lim, SJ; Ong, H; Luo, M; Ho, HK; Peng, K; Lee, TC; Bezler, M; Mann, C; Gaertner, S; Hoefler, H; Iacobelli, S; Peter, S; Tay, A; Brenner, S; Venkatesh, B; Ullrich, A Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. Cancer research 2007;67(23):11368-76.

Brenner, S; Roberts, RJ Save your notes, drafts and printouts: today’s work is tomorrow’s history. Nature 2007;446(7137):725.

Venkatesh, B; Kirkness, EF; Loh, YH; Halpern, AL; Lee, AP; Johnson, J; Dandona, N; Viswanathan, LD; Tay, A; Venter, JC; Strausberg, RL; Brenner, S Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome. PLoS biology 2007;5(4):e101.

McLachlan, CS; Chen, ML; Lynex, CN; Goh, DL; Brenner, S; Tay, SK Changes in PDE4D isoforms in the hippocampus of a patient with advanced Alzheimer disease. Archives of neurology 2007;64(3):456-7.

Lee, AP; Yang, Y; Brenner, S; Venkatesh, B TFCONES: a database of vertebrate transcription factor-encoding genes and their associated conserved noncoding elements. BMC genomics 2007;8():441.

Venkatesh, B; Kirkness, EF; Loh, YH; Halpern, AL; Lee, AP; Johnson, J; Dandona, N; Viswanathan, LD; Tay, A; Venter, JC; Strausberg, RL; Brenner, S Ancient noncoding elements conserved in the human genome. Science (New York, N.Y.) 2006;314(5807):1892.

Brenner, S; Milstein, C Pillars Article: Origin of antibody variation. Nature 1966. 211: 242-243. Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4237-8.

Bromée, T; Venkatesh, B; Brenner, S; Postlethwait, JH; Yan, YL; Larhammar, D Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages. Gene 2006;373():100-8.

Lee, AP; Koh, EG; Tay, A; Brenner, S; Venkatesh, B Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters. Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6994-9.

Varki, A; Holmes, E; Yamada, T; Agre, P; Brenner, S Physician-scientists are needed now more than ever. Nature 2006;440(7085):740.

Christoffels, A; Brenner, S; Venkatesh, B Tetraodon genome analysis provides further evidence for whole-genome duplication in the ray-finned fish lineage. Comparative biochemistry and physiology. Part D, Genomics & proteomics 2006;1(1):13-9.

Venkatesh, B; Dandona, N; Brenner, S Fugu genome does not contain mitochondrial pseudogenes. Genomics 2006;87(2):307-10.

Venkatesh, B; Lu, SQ; Dandona, N; See, SL; Brenner, S; Soong, TW Genetic basis of tetrodotoxin resistance in pufferfishes. Current biology : CB 2005;15(22):2069-72.

Yap, WH; Yeoh, E; Tay, A; Brenner, S; Venkatesh, B STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells. FEBS letters 2005;579(20):4470-8.

Yap, WH; Yeoh, E; Brenner, S; Venkatesh, B Cloning and expression of the reverse transcriptase component of pufferfish (Fugu rubripes) telomerase. Gene 2005;353(2):207-17.

Sundström, G; Larsson, TA; Brenner, S; Venkatesh, B; Larhammar, D Ray-fin fish tetraploidization gave rise to pufferfish duplicates of NPY and PYY, but zebrafish NPY duplicate was lost. Annals of the New York Academy of Sciences 2005;1040():476-8.

Larsson, TA; Olsson, F; Sundström, G; Brenner, S; Venkatesh, B; Larhammar, D Pufferfish and zebrafish have five distinct NPY receptor subtypes, but have lost appetite receptors Y1 and Y5. Annals of the New York Academy of Sciences 2005;1040():375-7.

Venkatesh, B; Tay, A; Dandona, N; Patil, JG; Brenner, S A compact cartilaginous fish model genome. Current biology : CB 2005;15(3):R82-3.

Chou, CF; Tohari, S; Brenner, S; Venkatesh, B Erythropoietin gene from a teleost fish, Fugu rubripes. Blood 2004;104(5):1498-503.

Loh, YH; Christoffels, A; Brenner, S; Hunziker, W; Venkatesh, B Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripes. Genome research 2004;14(7):1248-57.

Christoffels, A; Koh, EG; Chia, JM; Brenner, S; Aparicio, S; Venkatesh, B Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes. Molecular biology and evolution 2004;21(6):1146-51.

Brinkmann, H; Venkatesh, B; Brenner, S; Meyer, A Nuclear protein-coding genes support lungfish and not the coelacanth as the closest living relatives of land vertebrates. Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):4900-5.

Koopman, P; Schepers, G; Brenner, S; Venkatesh, B Origin and diversity of the SOX transcription factor gene family: genome-wide analysis in Fugu rubripes. Gene 2004;328():177-86.

Brenner, S Replicating and reshaping DNA: a celebration of the jubilee of the double helix. Perspectives. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1441):153-4.

Stapleton, T; Luchman, A; Johnston, J; Browder, L; Brenner, S; Venkatesh, B; Jirik, FR Compact intergenic regions of the pufferfish genome facilitate isolation of gene promoters: characterization of Fugu 3’-phosphoadenosine 5’-phosphosulfate synthase 2 (fPapss2) gene promoter function in transgenic Xenopus. FEBS letters 2004;556(1-3):59-63.

Gilligan, P; Brenner, S; Venkatesh, B Neurone-specific expression and regulation of the pufferfish isotocin and vasotocin genes in transgenic mice. Journal of neuroendocrinology 2003;15(11):1027-36.

Brenner, S Humanity as the model system. Science (New York, N.Y.) 2003;302(5645):533.

Brenner, S Nobel lecture. Nature’s gift to science. Bioscience reports 2003;23(5-6):225-37.

Zhang, T; Tan, YH; Fu, J; Lui, D; Ning, Y; Jirik, FR; Brenner, S; Venkatesh, B The regulation of retina specific expression of rhodopsin gene in vertebrates. Gene 2003;313():189-200.

Brenner, S Nature’s gift to science (Nobel lecture). Chembiochem : a European journal of chemical biology 2003;4(8):683-7.

Yu, WP; Brenner, S; Venkatesh, B Duplication, degeneration and subfunctionalization of the nested synapsin-Timp genes in Fugu. Trends in genetics : TIG 2003;19(4):180-3.

Brenner, S Worms and science. An interview with Sydney Brenner, distinguished research professor at The Salk Institute, La Jolla, USA, and one of the winners of 2002 Nobel Prize for Physiology and Medicine. EMBO reports 2003;4(3):224-6.

Koh, EG; Lam, K; Christoffels, A; Erdmann, MV; Brenner, S; Venkatesh, B Hox gene clusters in the Indonesian coelacanth, Latimeria menadoensis. Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1084-8.

Yap, WH; Tay, A; Brenner, S; Venkatesh, B Molecular cloning of the pufferfish (Takifugu rubripes) Mx gene and functional characterization of its promoter. Immunogenetics 2003;54(10):705-13.

Lim, SP; Soo, HM; Tan, YH; Brenner, S; Horstmann, H; MacKenzie, JM; Ng, ML; Lim, SG; Hong, W Inducible system in human hepatoma cell lines for hepatitis C virus production. Virology 2002;303(1):79-99.

Brenner, S The worm’s turn. Current biology : CB 2002;12(21):R713.

Williams, H; Brenner, S; Venkatesh, B Characterization of the platelet-derived growth factor receptor alpha and c-kit genes in the pufferfish Fugu rubripes. DNA sequence : the journal of DNA sequencing and mapping 2002;13(5):263-70.

Aparicio, S; Chapman, J; Stupka, E; Putnam, N; Chia, JM; Dehal, P; Christoffels, A; Rash, S; Hoon, S; Smit, A; Gelpke, MD; Roach, J; Oh, T; Ho, IY; Wong, M; Detter, C; Verhoef, F; Predki, P; Tay, A; Lucas, S; Richardson, P; Smith, SF; Clark, MS; Edwards, YJ; Doggett, N; Zharkikh, A; Tavtigian, SV; Pruss, D; Barnstead, M; Evans, C; Baden, H; Powell, J; Glusman, G; Rowen, L; Hood, L; Tan, YH; Elgar, G; Hawkins, T; Venkatesh, B; Rokhsar, D; Brenner, S Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science (New York, N.Y.) 2002;297(5585):1301-10.

Williams, H; Brenner, S; Venkatesh, B Identification and analysis of additional copies of the platelet-derived growth factor receptor and colony stimulating factor 1 receptor genes in fugu. Gene 2002;295(2):255-64.

Gilligan, P; Brenner, S; Venkatesh, B Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. Gene 2002;294(1-2):35-44.

Abrahams, BS; Mak, GM; Berry, ML; Palmquist, DL; Saionz, JR; Tay, A; Tan, YH; Brenner, S; Simpson, EM; Venkatesh, B Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci. Genomics 2002;80(1):45-53.

Brenner, S; Venkatesh, B; Yap, WH; Chou, CF; Tay, A; Ponniah, S; Wang, Y; Tan, YH Conserved regulation of the lymphocyte-specific expression of lck in the Fugu and mammals. Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2936-41.

Reinartz, J; Bruyns, E; Lin, JZ; Burcham, T; Brenner, S; Bowen, B; Kramer, M; Woychik, R Massively parallel signature sequencing (MPSS) as a tool for in-depth quantitative gene expression profiling in all organisms. Briefings in functional genomics & proteomics 2002;1(1):95-104.

Brenner, S Life sentences: elementary zenetics–do or dai. Genome biology 2002;3(5):comment1008.

Brenner, S Life sentences: Ontology recapitulates philology. Genome biology 2002;3(4):COMMENT1006.

Venkatesh, B; Erdmann, MV; Brenner, S Molecular synapomorphies resolve evolutionary relationships of extant jawed vertebrates. Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11382-7.

Yu, WP; Pallen, CJ; Tay, A; Jirik, FR; Brenner, S; Tan, YH; Venkatesh, B Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function. Oncogene 2001;20(39):5554-61.

Richardson, MP; Tay, BH; Goh, BY; Venkatesh, B; Brenner, S Molecular cloning and genomic structure of a gene encoding interferon regulatory factor in the pufferfish (Fugu rubripes). Marine biotechnology (New York, N.Y.) 2001;3(2):145-51.

Brenner, S After the (draft) sequence. Genome biology 2001;2(5):COMMENT1006.

Khu, YL; Koh, E; Lim, SP; Tan, YH; Brenner, S; Lim, SG; Hong, WJ; Goh, PY Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase. Journal of virology 2001;75(1):205-14.

Brenner, S Biochemistry strikes back. Trends in biochemical sciences 2000;25(12):584.

Brenner, S Special Achievement in Medical Science Award. From cell physiology to cell physiology. Nature medicine 2000;6(10):1087-8.

Brenner, S Inverse genetics. Current biology : CB 2000;10(18):R649.

Venkatesh, B; Gilligan, P; Brenner, S Fugu: a compact vertebrate reference genome. FEBS letters 2000;476(1-2):3-7.

Brenner, S; Johnson, M; Bridgham, J; Golda, G; Lloyd, DH; Johnson, D; Luo, S; McCurdy, S; Foy, M; Ewan, M; Roth, R; George, D; Eletr, S; Albrecht, G; Vermaas, E; Williams, SR; Moon, K; Burcham, T; Pallas, M; DuBridge, RB; Kirchner, J; Fearon, K; Mao, J; Corcoran, K Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nature biotechnology 2000;18(6):630-4.

Peixoto, BR; Brenner, S Characterization of approximately 50 kb of the immunoglobulin VH locus of the Japanese pufferfish, Fugu rubripes. Immunogenetics 2000;51(6):443-51.

Ryder, OA; McLaren, A; Brenner, S; Zhang, YP; Benirschke, K DNA banks for endangered animal species. Science (New York, N.Y.) 2000;288(5464):275-7.

Peixoto, BR; Mikawa, Y; Brenner, S Characterization of the recombinase activating gene-1 and 2 locus in the Japanese pufferfish, Fugu rubripes. Gene 2000;246(1-2):275-83.

Brenner, S Genomics. The end of the beginning. Science (New York, N.Y.) 2000;287(5461):2173-4.

Brenner, S What lies ahead? Current biology : CB 2000;10(6):R211.

Riboldi Tunnicliffe, G; Gloeckner, G; Elgar, GS; Brenner, S; Rosenthal, A Comparative analysis of the PCOLCE region in Fugu rubripes using a new automated annotation tool. Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(3):213-9.

Brenner, S; Williams, SR; Vermaas, EH; Storck, T; Moon, K; McCollum, C; Mao, JI; Luo, S; Kirchner, JJ; Eletr, S; DuBridge, RB; Burcham, T; Albrecht, G In vitro cloning of complex mixtures of DNA on microbeads: physical separation of differentially expressed cDNAs. Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1665-70.

Brenner, S Theoretical biology in the third millennium. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1392):1963-5.

Brenner, S False starts. The book of man. Current biology : CB 1999;9(24):R905.

Jappelli, R; Brenner, S A genetic screen to identify sequences that mediate protein oligomerization in Escherichia coli. Biochemical and biophysical research communications 1999;266(1):243-7.

Brenner, S Remembrance of things past…rumination. Current biology : CB 1999;9(22):R831.

Brenner, S Moron peer review. Current biology : CB 1999;9(20):R755.

Elgar, G; Clark, MS; Meek, S; Smith, S; Warner, S; Edwards, YJ; Bouchireb, N; Cottage, A; Yeo, GS; Umrania, Y; Williams, G; Brenner, S Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning. Genome research 1999;9(10):960-71.

Yamaguchi, F; Yamaguchi, K; Tokuda, M; Brenner, S Molecular cloning of EDG-3 and N-Shc genes from the puffer fish, Fugu rubripes, and conservation of synteny with the human genome. FEBS letters 1999;459(1):105-10.

Brenner, S Sillycon valley fever. Current biology : CB 1999;9(18):R671.

Venkatesh, B; Ning, Y; Brenner, S Late changes in spliceosomal introns define clades in vertebrate evolution. Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10267-71.

Brenner, S Remembrance of things past…writing. Current biology : CB 1999;9(16):R579.

Wentworth, JM; Schoenfeld, V; Meek, S; Elgar, G; Brenner, S; Chatterjee, VK Isolation and characterisation of the retinoic acid receptor-alpha gene in the Japanese pufferfish, F. rubripes. Gene 1999;236(2):315-23.

Brenner, S The march of thyme. Current biology : CB 1999;9(8):R267.

Lim, EH; Brenner, S Short-range linkage relationships, genomic organisation and sequence comparisons of a cluster of five HSP70 genes in Fugu rubripes. Cellular and molecular life sciences : CMLS 1999;55(4):668-78.

Gellner, K; Brenner, S Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu rubripes. Genome research 1999;9(3):251-8.

Brenner, S Remembrance of things past…reading. Current biology : CB 1999;9(4):R115.

Brenner, S Prescience. Current biology : CB 1998;8(25):R899.

Rowitch, DH; Echelard, Y; Danielian, PS; Gellner, K; Brenner, S; McMahon, AP Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate. Development (Cambridge, England) 1998;125(14):2735-46.

Venkatesh, B; Brenner, S Genomic structure and sequence of the pufferfish (Fugu rubripes) gene encoding an actin-related protein. Gene 1998;211(1):169-75.

Naito, T; Saito, Y; Yamamoto, J; Nozaki, Y; Tomura, K; Hazama, M; Nakanishi, S; Brenner, S Putative pheromone receptors related to the Ca2+-sensing receptor in Fugu. Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5178-81.

Jappelli, R; Brenner, S Changes in the periplasmic linker and in the expression level affect the activity of ToxR and lambda-ToxR fusion proteins in Escherichia coli. FEBS letters 1998;423(3):371-5.

Coutelle, O; Nyakatura, G; Taudien, S; Elgar, G; Brenner, S; Platzer, M; Drescher, B; Jouet, M; Kenwrick, S; Rosenthal, A The neural cell adhesion molecule L1: genomic organisation and differential splicing is conserved between man and the pufferfish Fugu. Gene 1998;208(1):7-15.

Brenner, S Biological computation. Novartis Foundation symposium 1998;213():106-11; discussion 111-6.

Venkatesh, B; Si-Hoe, SL; Murphy, D; Brenner, S Transgenic rats reveal functional conservation of regulatory controls between the Fugu isotocin and rat oxytocin genes. Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12462-6.

Yeo, GS; Elgar, G; Sandford, R; Brenner, S Cloning and sequencing of complement component C9 and its linkage to DOC-2 in the pufferfish Fugu rubripes. Gene 1997;200(1-2):203-11.

Koh, CG; Oon, SH; Brenner, S Serine/threonine phosphatases of the pufferfish, Fugu rubripes. Gene 1997;198(1-2):223-8.

Schofield, JP; Elgar, G; Greystrong, J; Lye, G; Deadman, R; Micklem, G; King, A; Brenner, S; Vaudin, M Regions of human chromosome 2 (2q32-q35) and mouse chromosome 1 show synteny with the pufferfish genome (Fugu rubripes). Genomics 1997;45(1):158-67.

Sandford, R; Sgotto, B; Aparicio, S; Brenner, S; Vaudin, M; Wilson, RK; Chissoe, S; Pepin, K; Bateman, A; Chothia, C; Hughes, J; Harris, P Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. Human molecular genetics 1997;6(9):1483-9.

Yamaguchi, F; Brenner, S Molecular cloning of 5-hydroxytryptamine (5-HT) type 1 receptor genes from the Japanese puffer fish, Fugu rubripes. Gene 1997;191(2):219-23.

Aparicio, S; Brenner, S How good a model is the Fugu genome? Nature 1997;387(6629):140.

Aparicio, S; Hawker, K; Cottage, A; Mikawa, Y; Zuo, L; Venkatesh, B; Chen, E; Krumlauf, R; Brenner, S Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes. Nature genetics 1997;16(1):79-83.

Venkatesh, B; Brenner, S Genomic structure and sequence of the pufferfish (Fugu rubripes) growth hormone-encoding gene: a comparative analysis of teleost growth hormone genes. Gene 1997;187(2):211-5.

Cairns, MT; Green, AJ; White, PM; Johnston, PG; Brenner, S A novel bacterial vector system for monitoring protein-protein interactions in the cAMP-dependent protein kinase complex. Gene 1997;185(1):5-9.

Lim, EH; Corrochano, LM; Elgar, G; Brenner, S Genomic structure and sequence analysis of the valyl-tRNA synthetase gene of the Japanese pufferfish, Fugu rubripes. DNA sequence : the journal of DNA sequencing and mapping 1997;7(3-4):141-51.

Lim, EH; Brenner, S Short-range linkage relationships of the valyl-tRNA synthetase gene in Fugu rubripes. Immunogenetics 1997;46(4):332-6.

Brenner, S Interview with Sydney Brenner. the world of genome projects. BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(12):1039-42.

Crosio, C; Cecconi, F; Mariottini, P; Cesareni, G; Brenner, S; Amaldi, F Fugu intron oversize reveals the presence of U15 snoRNA coding sequences in some introns of the ribosomal protein S3 gene. Genome research 1996;6(12):1227-31.

Sarwal, MM; Sontag, JM; Hoang, L; Brenner, S; Wilkie, TM G protein alpha subunit multigene family in the Japanese puffer fish Fugu rubripes: PCR from a compact vertebrate genome. Genome research 1996;6(12):1207-15.

How, GF; Venkatesh, B; Brenner, S Conserved linkage between the puffer fish (Fugu rubripes) and human genes for platelet-derived growth factor receptor and macrophage colony-stimulating factor receptor. Genome research 1996;6(12):1185-91.

Sandford, R; Sgotto, B; Burn, T; Brenner, S The tuberin (TSC2), autosomal dominant polycystic kidney disease (PKD1), and somatostatin type V receptor (SSTR5) genes form a synteny group in the Fugu genome. Genomics 1996;38(1):84-6.

Yamaguchi, F; Tokuda, M; Hatase, O; Brenner, S Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. Biochemical and biophysical research communications 1996;227(2):608-14.

Avalos, J; Corrochano, LM; Brenner, S Genomic organization of the fungus Phycomyces. Gene 1996;174(1):43-50.

Mikawa, YG; Maruyama, IN; Brenner, S Surface display of proteins on bacteriophage lambda heads. Journal of molecular biology 1996;262(1):21-30.

Nonchev, S; Maconochie, M; Vesque, C; Aparicio, S; Ariza-McNaughton, L; Manzanares, M; Maruthainar, K; Kuroiwa, A; Brenner, S; Charnay, P; Krumlauf, R The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation. Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9339-45.

Cecconi, F; Crosio, C; Mariottini, P; Cesareni, G; Giorgi, M; Brenner, S; Amaldi, F A functional role for some Fugu introns larger than the typical short ones: the example of the gene coding for ribosomal protein S7 and snoRNA U17. Nucleic acids research 1996;24(16):3167-72.

Brenner, S; Corrochano, LM Translocation events in the evolution of aminoacyl-tRNA synthetases. Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8485-9.

Yamaguchi, F; Macrae, AD; Brenner, S Molecular cloning of two cannabinoid type 1-like receptor genes from the puffer fish Fugu rubripes. Genomics 1996;35(3):603-5.

Brenner, S Molecular biology by numbers… Current biology : CB 1996;6(8):1040.

Venkatesh, B; Tay, BH; Elgar, G; Brenner, S Isolation, characterization and evolution of nine pufferfish (Fugu rubripes) actin genes. Journal of molecular biology 1996;259(4):655-65.

Jappelli, R; Brenner, S Interaction between cAMP-dependent protein kinase catalytic subunit and peptide inhibitors analyzed with lambda repressor fusions. Journal of molecular biology 1996;259(4):575-8.

Yan, H; Yang, J; Marasco, J; Yamaguchi, K; Brenner, S; Collins, F; Karbon, W Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4661-5.

Elgar, G; Sandford, R; Aparicio, S; Macrae, A; Venkatesh, B; Brenner, S Small is beautiful: comparative genomics with the pufferfish (Fugu rubripes). Trends in genetics : TIG 1996;12(4):145-50.

Trower, MK; Orton, SM; Purvis, IJ; Sanseau, P; Riley, J; Christodoulou, C; Burt, D; See, CG; Elgar, G; Sherrington, R; Rogaev, EI; St George-Hyslop, P; Brenner, S; Dykes, CW Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus) Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1366-9.

Brenner, S Loose ends. Molecular biology by numbers ….. one. Current biology : CB 1995;5(8):964.

Han, H; Wolfe, MM; Brenner, S; Janda, KD Liquid-phase combinatorial synthesis. Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6419-23.

Pöpperl, H; Bienz, M; Studer, M; Chan, SK; Aparicio, S; Brenner, S; Mann, RS; Krumlauf, R Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell 1995;81(7):1031-42.

Elgar, G; Rattray, F; Greystrong, J; Brenner, S Genomic structure and nucleotide sequence of the p55 gene of the puffer fish Fugu rubripes. Genomics 1995;27(3):442-6.

Baxendale, S; Abdulla, S; Elgar, G; Buck, D; Berks, M; Micklem, G; Durbin, R; Bates, G; Brenner, S; Beck, S Comparative sequence analysis of the human and pufferfish Huntington’s disease genes. Nature genetics 1995;10(1):67-76.

Mason, PJ; Stevens, DJ; Luzzatto, L; Brenner, S; Aparicio, S Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD). Genomics 1995;26(3):587-91.

Brenner, S Loose ends. Current biology : CB 1995;5(3):332.

Aparicio, S; Morrison, A; Gould, A; Gilthorpe, J; Chaudhuri, C; Rigby, P; Krumlauf, R; Brenner, S Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes. Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1684-8.

Macrae, AD; Brenner, S Analysis of the dopamine receptor family in the compact genome of the puffer fish Fugu rubripes. Genomics 1995;25(2):436-46.

Venkatesh, B; Brenner, S Structure and organization of the isotocin and vasotocin genes from teleosts. Advances in experimental medicine and biology 1995;395():629-38.

Lim, EH; Brenner, S Sequence analysis of Mhc class II beta-like fragments in the pufferfish Fugu rubripes. Immunogenetics 1995;42(5):432-3.

Erb, E; Janda, KD; Brenner, S Recursive deconvolution of combinatorial chemical libraries. Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11422-6.

Macrae, AD; Brenner, S One armed PCR (OA-PCR): amplification of genomic DNA from a single primer domain. Genomics 1994;24(1):176-8.

Maruyama, IN; Maruyama, HI; Brenner, S Lambda foo: a lambda phage vector for the expression of foreign proteins. Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8273-7.

Perret, X; Fellay, R; Bjourson, AJ; Cooper, JE; Brenner, S; Broughton, WJ Subtraction hybridisation and shot-gun sequencing: a new approach to identify symbiotic loci. Nucleic acids research 1994;22(8):1335-41.

Brenner, S; Elgar, G; Sandford, R; Macrae, A; Venkatesh, B; Aparicio, S Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome. Nature 1993;366(6452):265-8.

Koh, CG; Barnett, L; Brenner, S Vectors lambda 200g and lambda 200c: two useful derivatives of lambda 2001. Gene 1993;130(1):117-9.

Brenner, S Thoughts on genetics at the fin de siècle. Trends in genetics : TIG 1993;9(4):104.

Ahmed, S; Maruyama, IN; Kozma, R; Lee, J; Brenner, S; Lim, L The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor. The Biochemical journal 1992;287 ( Pt 3)():995-9.

Maruyama, IN; Brenner, S A selective lambda phage cloning vector with automatic excision of the insert in a plasmid. Gene 1992;120(2):135-41.

Parsons, JD; Brenner, S; Bishop, MJ Clustering cDNA sequences. Computer applications in the biosciences : CABIOS 1992;8(5):461-6.

Elgar, GS; Brenner, S A novel method for isolation of large insert DNA from recombinant lambda DNA. Nucleic acids research 1992;20(17):4667.

Brenner, S That lonesome grail: The Code of Codes: Scientific and Social Issues in the Human Genome Project. Nature 1992;358(6381):27-8.

Brenner, S; Lerner, RA Encoded combinatorial chemistry. Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5381-3.

Brenner, S Dicing with darwin. Current biology : CB 1992;2(4):167-8.

Thanabalu, T; Hindley, J; Brenner, S; Oei, C; Berry, C Expression of the mosquitocidal toxins of Bacillus sphaericus and Bacillus thuringiensis subsp. israelensis by recombinant Caulobacter crescentus, a vehicle for biological control of aquatic insect larvae. Applied and environmental microbiology 1992;58(3):905-10.

Avalos, J; Corrochano, LM; Brenner, S Cysteinyl-tRNA synthetase is a direct descendant of the first aminoacyl-tRNA synthetase. FEBS letters 1991;286(1-2):176-80.

Maruyama, IN; Brenner, S A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5729-33.

Brenner, S The human genome: the nature of the enterprise. Ciba Foundation symposium 1990;149():6-12; discussion 12-7.

Brenner, S; Livak, KJ DNA fingerprinting by sampled sequencing. Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8902-6.

Maruyama, IN; Miller, DM; Brenner, S Myosin heavy chain gene amplification as a suppressor mutation in Caenorhabditis elegans. Molecular & general genetics : MGG 1989;219(1-2):113-8.

Bernstein, HD; Poritz, MA; Strub, K; Hoben, PJ; Brenner, S; Walter, P Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature 1989;340(6233):482-6.

Kagawa, H; Gengyo, K; McLachlan, AD; Brenner, S; Karn, J Paramyosin gene (unc-15) of Caenorhabditis elegans. Molecular cloning, nucleotide sequence and models for thick filament structure. Journal of molecular biology 1989;207(2):311-33.

Brenner, S The molecular evolution of genes and proteins: a tale of two serines. Nature 1988;334(6182):528-30.

Coulson, A; Sulston, J; Brenner, S; Karn, J Toward a physical map of the genome of the nematode Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 1986;83(20):7821-5.

Salvato, M; Sulston, J; Albertson, D; Brenner, S A novel calmodulin-like gene from the nematode Caenorhabditis elegans. Journal of molecular biology 1986;190(3):281-9.

Wilson, IA; Haft, DH; Getzoff, ED; Tainer, JA; Lerner, RA; Brenner, S Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proceedings of the National Academy of Sciences of the United States of America 1985;82(16):5255-9.

Voordouw, G; Brenner, S Nucleotide sequence of the gene encoding the hydrogenase from Desulfovibrio vulgaris (Hildenborough). European journal of biochemistry / FEBS 1985;148(3):515-20.

Voordouw, G; Walker, JE; Brenner, S Cloning of the gene encoding the hydrogenase from Desulfovibrio vulgaris (Hildenborough) and determination of the NH2-terminal sequence. European journal of biochemistry / FEBS 1985;148(3):509-14.

Chalfie, M; Sulston, JE; White, JG; Southgate, E; Thomson, JN; Brenner, S The neural circuit for touch sensitivity in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(4):956-64.

Roberts, AN; Hudson, GS; Brenner, S An erythromycin-resistance gene from an erythromycin-producing strain of Arthrobacter sp. Gene 1985;35(3):259-70.

Karn, J; Matthes, HW; Gait, MJ; Brenner, S A new selective phage cloning vector, lambda 2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI. Gene 1984;32(1-2):217-24.

Anderson, P; Brenner, S A selection for myosin heavy chain mutants in the nematode Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4470-4.

Karn, J; Brenner, S; Barnett, L Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns. Proceedings of the National Academy of Sciences of the United States of America 1983;80(14):4253-7.

White, JG; Southgate, E; Thomson, JN; Brenner, S Factors that determine connectivity in the nervous system of Caenorhabditis elegans. Cold Spring Harbor symposia on quantitative biology 1983;48 Pt 2():633-40.

Karn, J; Brenner, S; Barnett, L New bacteriophage lambda vectors with positive selection for cloned inserts. Methods in enzymology 1983;101():3-19.

Cesareni, G; Castagnoli, L; Brenner, S The plasmid as a tool for plasmid genetics. II. Isolation of point mutations that affect replication of a ColE1-related plasmid. Genetical research 1982;40(3):233-47.

Lichtenstein, C; Brenner, S Unique insertion site of Tn7 in the E. coli chromosome. Nature 1982;297(5867):601-3.

Mihara, K; Omura, T; Harano, T; Brenner, S; Fleischer, S; Rajagopalan, KV; Blobel, G Rat liver L-glutamate dehydrogenase, malate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, and sulfite oxidase are each synthesized as larger precursors by cytoplasmic free polysomes. The Journal of biological chemistry 1982;257(7):3355-8.

Brenner, S; Cesareni, G; Karn, J Phasmids: hybrids between ColE1 plasmids and E. coli bacteriophage lambda. Gene 1982;17(1):27-44.

Babu, P; Brenner, S Spectrum of 32P-induced mutants of Caenorhabditis elegans. Mutation research 1981;82(2):269-73.

MacLeod, AR; Karn, J; Brenner, S Molecular analysis of the unc-54 myosin heavy-chain gene of Caenorhabditis elegans. Nature 1981;291(5814):386-90.

Lichtenstein, C; Brenner, S Site-specific properties of Tn7 transposition into the E. coli chromosome. Molecular & general genetics : MGG 1981;183(2):380-7.

Karn, J; Brenner, S; Barnett, L; Cesareni, G Novel bacteriophage lambda cloning vector. Proceedings of the National Academy of Sciences of the United States of America 1980;77(9):5172-6.

Waterston, RH; Thomson, JN; Brenner, S Mutants with altered muscle structure of Caenorhabditis elegans. Developmental biology 1980;77(2):271-302.

Horvitz, HR; Brenner, S; Hodgkin, J; Herman, RK A uniform genetic nomenclature for the nematode Caenorhabditis elegans. Molecular & general genetics : MGG 1979;175(2):129-33.

Waterston, RH; Brenner, S A suppressor mutation in the nematode acting on specific alleles of many genes. Nature 1978;275(5682):715-9.

Riddle, DL; Brenner, S Indirect suppression in Caenorhabditis elegans. Genetics 1978;89(2):299-314.

Waterston, RH; Fishpool, RM; Brenner, S Mutants affecting paramyosin in Caenorhabditis elegans. Journal of molecular biology 1977;117(3):679-97.

MacLeod, AR; Waterston, RH; Brenner, S An internal deletion mutant of a myosin heavy chain in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 1977;74(12):5336-40.

MacLeod, AR; Waterston, RH; Fishpool, RM; Brenner, S Identification of the structural gene for a myosin heavy-chain in Caenorhabditis elegans. Journal of molecular biology 1977;114(1):133-40.

Hodgkin, JA; Brenner, S Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans. Genetics 1977;86(2 Pt. 1):275-87.

Crick, FH; Brenner, S; Klug, A; Pieczenik, G A speculation on the origin of protein synthesis. Origins of life 1976;7(4):389-97.

Sheldon, R; Brenner, S Regulatory mutants of dihydrofolate reductase in Escherichia coli K12. Molecular & general genetics : MGG 1976;147(1):91-7.

White, JG; Southgate, E; Thomson, JN; Brenner, S The structure of the ventral nerve cord of Caenorhabditis elegans. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1976;275(938):327-48.

Herman, RK; Albertson, DG; Brenner, S Chromosome rearrangements in Caenorhabditis elegans. Genetics 1976;83(1):91-105.

Katz, ER; Brenner, S Genetic map of the beginning of the rIIB cistron of bacteriophage T4. Molecular & general genetics : MGG 1975;143(1):101-4.

Sulston, J; Dew, M; Brenner, S Dopaminergic neurons in the nematode Caenorhabditis elegans. The Journal of comparative neurology 1975;163(2):215-26.

Berg, P; Baltimore, D; Brenner, S; Roblin, RO; Singer, MF Summary statement of the Asilomar conference on recombinant DNA molecules. Proceedings of the National Academy of Sciences of the United States of America 1975;72(6):1981-4.

Ward, S; Thomson, N; White, JG; Brenner, S Electron microscopical reconstruction of the anterior sensory anatomy of the nematode Caenorhabditis elegans.?2UU. The Journal of comparative neurology 1975;160(3):313-37.

Epstein, HF; Waterston, RH; Brenner, S A mutant affecting the heavy chain of myosin in Caenorhabditis elegans. Journal of molecular biology 1974;90(2):291-300.

Waterston, RH; Epstein, HF; Brenner, S Paramyosin of Caenorhabditis elegans. Journal of molecular biology 1974;90(2):285-90.

Sulston, JE; Brenner, S The DNA of Caenorhabditis elegans. Genetics 1974;77(1):95-104.

Brenner, S The genetics of Caenorhabditis elegans. Genetics 1974;77(1):71-94.

Freedman, R; Brenner, S Hybrid T4 r II B cistrons created by genetic duplications. Journal of molecular biology 1972;69(3):409-19.

Freedman, R; Brenner, S Anomalously revertible r II mutants of phage T 4 . Genetical research 1972;19(2):165-71.

Brenner, S Nonsense mutants and the genetic code. A small piece of molecular genetics. JAMA : the journal of the American Medical Association 1971;218(7):1023-6.

Altman, S; Brenner, S; Smith, JD Identification of an ochre-suppressing anticodon. Journal of molecular biology 1971;56(1):195-7.

Smith, JD; Barnett, L; Brenner, S; Russell, RL More mutant tyrosine transfer ribonucleic acids. Journal of molecular biology 1970;54(1):1-14.

Russell, RL; Abelson, JN; Landy, A; Gefter, ML; Brenner, S; Smith, JD Duplicate genes for tyrosine transfer RNA in Escherichia coli. Journal of molecular biology 1970;47(1):1-13.

Goodman, HM; Abelson, J; Landy, A; Brenner, S; Smith, JD Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA. Nature 1968;217(5133):1019-24.

Sarabhai, A; Brenner, S A mutant which reinitiates the polypeptide chain after chain termination. Journal of molecular biology 1967;27(1):145-62.

Crick, FH; Brenner, S The absolute sign of certain phase-shift mutants in bacteriophage T4. Journal of molecular biology 1967;26(2):361-3.

Sarabhai, A; Brenner, S Further evidence that UGA does not code for tryptophan. Journal of molecular biology 1967;26(1):141-2.

Stretton, AO; Brenner, S Spontaneous revertants of amber mutants. Journal of molecular biology 1967;26(1):137-9.

Sambrook, JF; Fan, DP; Brenner, S A strong suppressor specific for UGA. Nature 1967;214(5087):452-3.

Brenner, S; Barnett, L; Katz, ER; Crick, FH UGA: a third nonsense triplet in the genetic code. Nature 1967;213(5075):449-50.

Brenner, S; Kaplan, S; Stretton, AO Identity of N2 ochre nonsense mutants. Journal of molecular biology 1966;19(2):574-5.

Brenner, S; Milstein, C Origin of antibody variation. Nature 1966;211(5046):242-3.

Stretton, AO; Kaplan, S; Brenner, S Nonsense codons. Cold Spring Harbor symposia on quantitative biology 1966;31():173-9.

Smith, JD; Abelson, JN; Clark, BF; Goodman, HM; Brenner, S Studies on amber suppressor tRNA. Cold Spring Harbor symposia on quantitative biology 1966;31():479-85.

Kaplan, S; Stretton, AO; Brenner, S Amber suppressors: efficiency of chain propagation and suppressor specific amino acids. Journal of molecular biology 1965;14(2):528-33.

Newton, WA; Beckwith, JR; Zipser, D; Brenner, S Nonsense mutants and polarity in the lac operon of Escherichia coli. Journal of molecular biology 1965;14(1):290-6.

Signer, ER; Beckwith, JR; Brenner, S Mapping of suppressor loci in Escherichia coli. Journal of molecular biology 1965;14(1):153-66.

Brenner, S; Stretton, AO; Kaplan, S Genetic code: the ’nonsense’ triplets for chain termination and their suppression. Nature 1965;206(988):994-8.

STRETTON, AO; BRENNER, S MOLECULAR CONSEQUENCES OF THE AMBER MUTATION AND ITS SUPPRESSION. Journal of molecular biology 1965;12():456-65.

BRENNER, S; STRETTON, AO THE AMBER MUTATION. Journal of cellular physiology 1964;64():SUPPL 1:43-9.

MESELSON, M; NOMURA, M; BRENNER, S; DAVERN, C; SCHLESSINGER, D CONSERVATION OF RIBOSOMES DURING BACTERIAL GROWTH. Journal of molecular biology 1964;9():696-711.

SARABHAI, AS; STRETTON, AO; BRENNER, S; BOLLE, A CO-LINEARITY OF THE GENE WITH THE POLYPEPTIDE CHAIN. Nature 1964;201():13-7.

KOHIYAMA, M; LANFROM, H; BRENNER, S; JACOB, F [MODIFICATIONS OF INDISPENSABLE FUNCTIONS IN THERMOSENSITIVE ESCHCERICHIA COLI MUTANTS. ON A MUTATION PREVENTING REPLICATION OF THE BACTERIAL CHROMOSOME]. Comptes rendus hebdomadaires des séances de l’Académie des sciences 1963;257():1979-81.

SHEDLOVSKY, A; BRENNER, S A CHEMICAL BASIS FOR THE HOST-INDUCED MODIFICATION OF T-EVEN BACTERIOPHAGES. Proceedings of the National Academy of Sciences of the United States of America 1963;50():300-5.

JACOB, F; BRENNER, S [On the regulation of DNA synthesis in bacteria: the hypothesis of the replicon]. Comptes rendus hebdomadaires des séances de l’Académie des sciences 1963;256():298-300.

CRICK, FH; BARNETT, L; BRENNER, S; WATTS-TOBIN, RJ General nature of the genetic code for proteins. Nature 1961;192():1227-32.

STENT, GS; BRENNER, S A genetic locus for the regulation of ribonucleic acid synthesis. Proceedings of the National Academy of Sciences of the United States of America 1961;47():2005-14.

ORGEL, A; BRENNER, S Mutagenesis of bacteriophage T4 by acridines. Journal of molecular biology 1961;3():762-8.

BRENNER, S; SMITH, JD Induction of mutations in the deoxyribonucleic acid of phage T2 synthesized in the presence of chloramphenicol. Virology 1959;8(1):124-5.

BRENNER, S; BENZER, S; BARNETT, L Distribution of proflavin-induced mutations in the genetic fine structure. Nature 1958;182(4641):983-5.

Brenner, S ON THE IMPOSSIBILITY OF ALL OVERLAPPING TRIPLET CODES IN INFORMATION TRANSFER FROM NUCLEIC ACID TO PROTEINS. Proceedings of the National Academy of Sciences of the United States of America 1957;43(8):687-94.



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    Professor
    Salk Institute for Biological Studies in La Jolla, USA