Aaron Ciechanover

Aaron Ciechanover is the 2004 Nobel Prize Laureate in Chemistry. He is an Israeli Physician and Biochemist in Medical Sciences at Israel Institute of Technology in Haifa.

Ciechanover was a postdoctoral fellow at the Department of Biology, MIT, where he studied lasialoglycoprotein and transferrin receptors in the laboratory of Harvey Lodish, and also collaborated with Varsharsky and his student Finley in their studies of ts85 mouse cells.



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Aaron Ciechanover
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2000, Albert Lasker Award for Basic Medical Research

2003, Israel Prize, for biology

2004, Nobel Prize in Chemistry

1.    A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100-1105. Ciechanover, A., Hod, Y., and Hershko, A. (1978)
2.    Proposed role of ATP in protein breakdown: conjugation of proteins with multiple chains of the polypeptide of ATP – dependent proteolysis. Proc. Natl. Acad. Sci. USA 77, 1783-1786. Hershko, A., Ciechanover, A., Heller, H., Haas, A. L., and Rose, I. A. 1980
3.    Covalent affinity purification of I ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542. Ciechanover, A., Elias, S., Heller, H. and Hershko, A. 1982
4.    Components of ubiquitin-protein ligase system: resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 258, 8206-8214. Hershko, A., Heller, H., Elias, S. and Ciechanover, A. 1983
5.    Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell 37, 43-55. Finley, D., Ciechanover, A. and Varshavsky, A. 1984
6.    Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell 37, 57-66. Ciechanover, A., Finley, D. and Varshavsky, A. 1984
7.    Role of Arginine-tRNA in Protein Degradation by the Ubiquitin Pathway. Nature 326,808-811.  Ferber, S. and Ciechanover, A. 1987
8.    Ciechanover, A., Ferber, S., Ganoth, D., Elias, S., Hershko, A. and Arfin, S. (1988) Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes: its involvement in modification and ubiquitin-dependent degradation of proteins bearing acidic N-termini. J. Biol. Chem. 263, 11155-11167.
9.    The ubiquitin system: pathogenesis of human diseases and drug targeting. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, In Press, Corrected Proof, Available online 10 November 2004 Aaron Ciechanover and Alan L. Schwartz
10.    Corrigendum to: ”The ubiquitin–proteasome system in cardiovascular diseases—a hypothesis extended” [Cardiovasc. Res. 61 (2004) 11–21]. Cardiovascular Research, Volume 63, Issue 4, 1 September 2004, Page 756. Joerg Herrmann, Aaron Ciechanover, Lilach O. Lerman and Amir Lerman
11.    Caspase Activation Inhibits Proteasome Function during Apoptosis. Molecular Cell, Volume 14, Issue 1, 9 April 2004, Pages 81-93. Xiao-Ming Sun , Michael Butterworth , Marion MacFarlane , Wolfgang Dubiel , Aaron Ciechanover and Gerald M. Cohen
12.    N-terminal ubiquitination: more protein substrates join in. Trends in Cell Biology, Volume 14, Issue 3, March 2004, Pages 103-106. Aaron Ciechanover and Ronen Ben-Saadon
13.    Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination. Biochemical and Biophysical Research Communications, Volume 314, Issue 2, 6 February 2004, Pages 505-51. Ifat Fajerman, Alan L. Schwartz and Aaron Ciechanover

14.    The ubiquitin–proteasome system in cardiovascular diseases—a hypothesis extended. Cardiovascular Research, Volume 61, Issue 1, 1 January 2004, Pages 11-21. Joerg Herrmann, Aaron Ciechanover, Lilach O. Lerman and Amir Lerman
15.    The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg. Neuron, Volume 40, Issue 2, 9 October 2003, Pages 427-446. Aaron Ciechanover and Patrik Brundin
16.    A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1 Biochemical and Biophysical Research Communications, Volume 303, Issue 1, 28 March 2003, Pages 91-97. Eran Nadav, Ayelet Shmueli, Haim Barr, Hedva Gonen, Aaron Ciechanover and Yuval Reiss
17.    P1645 The coronary ubiquitin proteasome system is functionally active in the early stage of atherogenesis. European Heart Journal, Volume 24, Issue 5, Supplement 1, March 2003, Page 307. J. Herrmann, L. O. Lerman, M. Rodriguez-Porcel, C. Napoli, A. Ciechanover and A. Lerman
18.    Introduction and overview. Seminars in Cancer Biology, Volume 13, Issue 1, February 2003, Pages 1-4. A. Ciechanover
19.    Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes. Journal of the American College of Cardiology, Volume 40, Issue 11, 4 December 2002, Pages 1919-1927. Joerg Herrmann, William D. Edwards, David R. Holmes, Jr , Kris L. Shogren, Lilach O. Lerman, Aaron Ciechanover and Amir Lerman
20.    Ubiquitin-mediated degradation of cellular proteins in health and disease. Hepatology, Volume 35, Issue 1, January 2002, Pages 3-6. Aaron Ciechanover and Alan L. Schwartz
21.    Mechanisms of ubiquitin-mediated, limited processingof the NF- B1 precursor protein p105. Biochimie, Volume 83, Issues 3-4, March-April 2001, Pages 341-349. Aaron Ciechanover, Hedva Gonen, Beatrice Bercovich, Shai Cohen, Ifat Fajerman, Alain Israël, Frank Mercurio, Chaim Kahana, Alan L. Schwartz, Kazuhiro Iwai and Amir Orian
22.    Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice. Neuron, Volume 24, Issue 4, December 1999, Pages 879-892. Christopher J. Cummings, Eyal Reinstein, Yaling Sun, Barbara Antalffy, Yong-hui Jiang, Aaron Ciechanover, Harry T. Orr, Arthur L. Beaudet and Huda Y. Zoghbi
23.    Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1. Molecular Cell, Volume 4, Issue 6, December 1999, Pages 1029-1040. Gil Levkowitz, Hadassa Waterman, Seth A. Ettenberg, Menachem Katz, Alexander Y. Tsygankov, Iris Alroy, Sara Lavi, Kazuhiro Iwai, Yuval Reiss, Aaron Ciechanover et al.
24.    Inhibition of ubiquitin-proteasome dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus (EBV) nuclear antigen (EBNA)-1. Immunology Letters, Volume 56, Part 2, May 1997, Page 438. Jelena Levitskaya, Anatoly Sharipo, Aaron Ciechanover and Maria G. Masucci
25.    On the involvement of calpains in the degradation of the tumor suppressor protein p53  
FEBS Letters, Volume 406, Issues 1-2, 7 April 1997, Pages 17-22. Hedva Gonen, Dganit Shkedy, Sivia Barnoy, Nechama S. Kosower and Aaron Ciechanover
26.    Degradation of tyrosine aminotransferase (TAT) via the ubiquitin–proteasome pathway  
FEBS Letters, Volume 405, Issue 2, 24 March 1997, Pages 175-180. Shlomit Gross-Mesilaty, James L. Hargrove and Aaron Ciechanover
27.    Characterization of ubiquitin genes and -transcripts and demonstration of a ubiquitin-conjugating system in Entamoeba histolytica. Molecular and Biochemical Parasitology, Volume 82, Issue 1, 12 November 1996, Pages 81-90. Claudia Wöstmann, Dimitris Liakopoulos, Aaron Ciechanover and Tilly Bakker-Grunwald
28.    The 26S proteasome of the yeast Saccharomyces cerevisiae. FEBS Letters, Volume 355, Issue 1, 21 November 1994, Pages 69-75. Michael Fischer, Wolfgang Hilt, Birgit Richter-Ruoff, Hedva Gonen, Aaron Ciechanover and Dieter H. Wolf
29.    The ubiquitin-proteasome proteolytic pathway. Cell, Volume 79, Issue 1, 7 October 1994, Pages 13-21. Aaron Ciechanover
30.    Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system 
FEBS Letters, Volume 348, Issue 2, 11 July 1994, Pages 126-130. Dganit Shkedy, Hedva Gonen, Beatrice Bercovich and Aaron Ciechanover
31.    A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes  Biochemical and Biophysical Research Communications, Volume 81, Issue 4, 28 April 1978, Pages 1100-1105. Aharon Ciechanover, Yaacov Hod and Avram Hershko

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    Biochemist in Medical Sciences at Israel Institute of Technology in Haifa