Avram Hershko

Recent Findings From Avram Hershko

No record yet.

1987, Weizmann Prize for Sciences (Israel)

1994, Israel Prize in biochemistry

1999, Gairdner International Award Canada (with A. Varshavsky)

2000, Albert Lasker Award for Basic Medical Research (with A. Ciechanover and A. Varshavsky)

2001, Louisa Gross Horwitz Prize from Columbia University

2001, Wolf Prize in Medicine (Israel), jointly with Alexander Varshavsky, for ’the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation.”

2003, Foreign Associate, National Academy of Sciences, USA

2004, Nobel Prize in Chemistry for his discovery with Aaron Ciechanover and Irwin Rose, of ubiquitin,mediated protein degradation.

1. Avram Hershko, MD, PhD. Teichner A, Eytan E, Sitry-Shevah D, Miniowitz-Shemtov S, Dumin E, Gromis J, Hershko A. p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3187-92, 2011

2. Avram Hershko, MD, PhD. Hershko A. J. Some lessons from my work on the biochemistry of the ubiquitin system. Biol Chem. 2009 Apr 17;284(16):10291-5, 2009

3. Avram Hershko, MD, PhD. Eytan E, Braunstein I, Ganoth D, Teichner A, Hittle JC, Yen TJ, Hershko A. Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9181-5. Epub 2008 Jun 30.

4. Avram Hershko, MD, PhD. Braunstein I, Miniowitz S, Moshe Y. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4870-5, 2007

5. Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint.

6. Avram Hershko, MD, PhD. Braunstein I, Miniowitz S, Moshe Y. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4870-5, 2007

7. Avram Hershko, MD, PhD. Bornstein G, Ganoth D, Hershko A. Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

8. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20, 2006

9. Avram Hershko, MD, PhD. Eytan E, Moshe Y, Braunstein I, Hershko A. Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding.

10. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2081-6. Epub 2006 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5242. PMID: 16455800 [PubMed - indexed for MEDLINE]

11. Avram Hershko, MD, PhD. Hershko A. The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle. Cell Death Differ. 2005 Sep;12(9):1191-7. Review. PMID: 16094395 [PubMed - indexed for MEDLINE]

12. Avram Hershko, MD, PhD. Hershko A. Early work on the ubiquitin proteasome system, an interview with Avram Hershko. Interview by CDD. Cell Death Differ. 2005 Sep;12(9):1158-61. No abstract available.

13. Avram Hershko, MD, PhD. Hershko A. Angew. The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture). Chem Int Ed Engl. 2005 Sep 19;44(37):5932-43.

14. Avram Hershko, MD, PhD. Hershko A. Affinity purification of mitotic anaphase-promoting complex/cyclosome on p13Suc1. Methods Enzymol. 2005;398:170-5. 2005

15. The cellcycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27.

16. Avram Hershko, MD, PhD. Ganoth D, Bornstein G, To KK, Larsen B, Tyers M, Pagano M, Hershko A. Nat Cell Biol;3:321-324, 2001

17. Avram Hershko, MD, PhD. Carrano AC, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitinmediated degradation of the CDK inhibitor p27. Nat Cell Biol ;1:193-199. 1999

18. Avram Hershko, MD, PhD. Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC, Ruderman JV, Hershko A. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell ;6:185-197. 1995

�