Craig C. Mello

Professor Craig Mello is a biology professor who together with biologist Andrew Fire discovered RNA interference and jointly won the 2006 Nobel Prize for Physiology or Medicine.  The Nobel committee stated that “This year’s Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information.”
Mello is a Professor of Molecular Biology at at the University of Massachusetts Medical School, USA and is also an investigator at the Howard Hughes Medical Institute.

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Biologist BIOLOGIST (Molecular Biologist)
Craig C Mello
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1.    Co-recipient (with Andrew Fire) of National Academy of Sciences Award in Molecular Biology in 2003.
2.    Co-recipient (with Andrew Fire, Thomas Tuschl and David Baulcombe) of the Wiley Prize in the Biomedical Sciences from Rockefeller University in 2003.
3.    Elected member National Academy of Sciences in 2005.
4.    Co-recipient (with Victor Ambros, Andrew Fire and Gary Ruvkun) of Brandeis University’s Lewis S. Rosenstiel Award for Distinguished Work in Medical Research in 2005.
5.    Co-recipient (with Andrew Fire) of the Gairdner Foundation International Award in 2005.
6.    Co-recipient (with Andrew Fire and David Baulcombe) of Massry Prize in 2005.
7.    Co-recipient (with Andrew Fire) of the Paul Ehrlich and Ludwig Darmstaedter Prize in 2006.
8.    Inaugural recipient of The Dr. Paul Janssen Award for Biomedical Research by Johnson & Johnson in 2006.
9.    Co-recipient (with Andrew Fire) of the Nobel Prize in Physiology or Medicine in 2006.
10.    Recipient of an honorary doctorate by Brown University in 2007. He gave the keynote Baccalaureate Address at Commencement ceremonies.
11.    Recipient of an honorary doctorate by Simmons College in 2008.

1.    Batista, P.J., Ruby, J.G., Claycomb, J.M., Chiang, R., Fahlgren, N., Kasschau, K.D., Chaves, D.A., Gu, W. Vasale, J.J., Duan, S., Conte, D. Jr., Luo, S., Schroth, G.P., Carrington, J.C., Bartel, D.P., Mello, C.C. (2008) PRG-1 and 21U-RNAs interact to Form the piRNA Complex Required for Fertility in C. elegans. Molecular Cell 2008 Jul 11;31(1):67-78. PMC2570341

2.    Claycomb, J. M., Batista, P.J., Pang, K-M., Gu, W., Vasale, J.J., vanWolfswinkel, J.C., Chaves, D.A., Shirayama, M., Mitani, S., Ketting, R.F., Conte Jr., D., Mello, C.C. (2009) The Argonaute CSR-1 and Its 22G-RNA Cofactors are Required for Holocentric Chromosome Segregation.  Cell 139, October 2, 123-134. PMC2766185

3.    Gu, W., Shirayama, M., Conte Jr., D., Vasale, J., Batista, P. Claycomb, J., Moresco, J.J., Youngman, E.M., Keys, J., Stoltz, M.J., Chen, C-C G., Chaves, D.A., Duan, S., Kasschau, K.D., Fahlgren, N., Yates III, J.R., Mitani, S., Carrington, Mello, C.C. (2009)  Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline.  Molecular Cell 36, October 23, 231-244. PMC2776052

4.    Conine C.C., Batista P.J., Gu W., Claycomb, J.M., Chavez, D.A., Shirayama M., Mello C.C. (2010) The Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans.  PNAS 107:3588-3593. PMC2840486

5.    Vasale, J.J., Gu, W., Thivierge, C., Batista, P.J., Claycomb, J.M., Youngman, E.M., Duchaine, T.F., Mello, C.C., Conte Jr., D. (2010).Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. PNAS 107(8): 3582-3587. PMC2840456

6.    Conte Jr., D., Mello C.C. (2010) Primal RNAs:  The End of the Beginning.  Cell 140. Preview

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    Professor of Molecular Medicine at the University of Massachusetts Medical School