Tim Hunt

Sir Richard Timothy Hunt is an English biochemist. He is also known as Tim Hunt, and he is a Nobel Laureate in Physiology or Medicine 2001. He received the award with Paul Nurse and Leland H. Hartwell for the discovery of regulators of the cell cycle. Hunt found the cyclin molecules (which regulate the cell cycle) in sea urchins. Cyclins bind and activate the cyclin-dependent kinases. He also found the cyclin molecule in vertebrae cells. He found that activation of cyclin dependent kinases regulates the cell cycle.

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Biologist BIOLOGIST (Protein Synthesis, Cell Cycle)
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1991 Fellow of the Royal Society

1991 Foreign Associate of the US National Academy of Sciences

1993 Abraham White Scientific Achievement Award of the George Washington University

2001  Nobel Prize in Physiology or Medicine

Mochida, S; Maslen, SL; Skehel, M; Hunt, T Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science (New York, N.Y.) 2010;330(6011):1670-3.

Errico, A; Deshmukh, K; Tanaka, Y; Pozniakovsky, A; Hunt, T Identification of substrates for cyclin dependent kinases. Advances in enzyme regulation 2010;50(1):375-99.

Errico, A; Cosentino, C; Rivera, T; Losada, A; Schwob, E; Hunt, T; Costanzo, V Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion. The EMBO journal 2009;28(23):3681-92.

Malumbres, M; Harlow, E; Hunt, T; Hunter, T; Lahti, JM; Manning, G; Morgan, DO; Tsai, LH; Wolgemuth, DJ Cyclin-dependent kinases: a family portrait. Nature cell biology 2009;11(11):1275-6.

Mochida, S; Ikeo, S; Gannon, J; Hunt, T Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. The EMBO journal 2009;28(18):2777-85.

Hunt, T You never know: Cdk inhibitors as anti-cancer drugs. Cell cycle (Georgetown, Tex.) 2008;7(24):3789-90.

Hochegger, H; Takeda, S; Hunt, T Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nature reviews. Molecular cell biology 2008;9(11):910-6.

Ruiz, EJ; Hunt, T; Nebreda, AR Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation. Molecular cell 2008;32(2):210-20.

Fang, TC; Otto, WR; Jeffery, R; Hunt, T; Alison, MR; Cook, HT; Wright, NA; Poulsom, R Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen. Cell proliferation 2008;41(4):592-606.

Fang, TC; Otto, WR; Rao, J; Jeffery, R; Hunt, T; Alison, MR; Cook, HT; Wright, NA; Poulsom, R Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2 -induced acute tubular injury. Cell proliferation 2008;41(4):575-91.

Hunt, T European young investigators. Science (New York, N.Y.) 2007;317(5846):1833.

Mochida, S; Hunt, T Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature 2007;449(7160):336-40.

Errico, A; Costanzo, V; Hunt, T Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):14929-34.

Hochegger, H; Dejsuphong, D; Sonoda, E; Saberi, A; Rajendra, E; Kirk, J; Hunt, T; Takeda, S An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. The Journal of cell biology 2007;178(2):257-68.

Petri, ET; Errico, A; Escobedo, L; Hunt, T; Basavappa, R The crystal structure of human cyclin B. Cell cycle (Georgetown, Tex.) 2007;6(11):1342-9.

Hunt, T; Sassone-Corsi, P Riding tandem: circadian clocks and the cell cycle. Cell 2007;129(3):461-4.

Hunt, T Treating pain in the older person. Journal of pain & palliative care pharmacotherapy 2006;20(4):55-7.

Casaletto, JB; Nutt, LK; Wu, Q; Moore, JD; Etkin, LD; Jackson, PK; Hunt, T; Kornbluth, S Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. The Journal of cell biology 2005;169(1):61-71.

Esashi, F; Christ, N; Gannon, J; Liu, Y; Hunt, T; Jasin, M; West, SC CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005;434(7033):598-604.

Dinarina, A; Perez, LH; Davila, A; Schwab, M; Hunt, T; Nebreda, AR Characterization of a new family of cyclin-dependent kinase activators. The Biochemical journal 2005;386(Pt 2):349-55.

Yamano, H; Kominami, K; Harrison, C; Kitamura, K; Katayama, S; Dhut, S; Hunt, T; Toda, T Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2. The Journal of biological chemistry 2004;279(18):18974-80.

Prigent, C; Hunt, T Oocyte maturation and cell cycle control: a farewell symposium for Pr Marcel Dorée. Biology of the cell / under the auspices of the European Cell Biology Organization 2004;96(3):181-5.

Hunt, T The discovery of cyclin (I). Cell 2004;116(2 Suppl):S63-4, 1 p following S65.

Yamano, H; Gannon, J; Mahbubani, H; Hunt, T Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts. Molecular cell 2004;13(1):137-47.

Timmerman, P; Van Dijk, E; Puijk, W; Schaaper, W; Slootstra, J; Carlisle, SJ; Coley, J; Eida, S; Gani, M; Hunt, T; Perry, P; Piron, G; Meloen, RH Mapping of a discontinuous and highly conformational binding site on follicle stimulating hormone subunit-beta (FSH-beta) using domain Scan and Matrix Scan technology. Molecular diversity 2004;8(2):61-77.

Moore, JD; Kirk, JA; Hunt, T Unmasking the S-phase-promoting potential of cyclin B1. Science (New York, N.Y.) 2003;300(5621):987-90.

Moore, JD; Kornbluth, S; Hunt, T Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. Molecular biology of the cell 2002;13(12):4388-400.

Hunt, T Nobel Lecture. Protein synthesis, proteolysis, and cell cycle transitions. Bioscience reports 2002;22(5-6):465-86.

Graeser, R; Gannon, J; Poon, RY; Dubois, T; Aitken, A; Hunt, T Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. Journal of cell science 2002;115(Pt 17):3479-90.

Dorée, M; Hunt, T From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner? Journal of cell science 2002;115(Pt 12):2461-4.

Hochegger, H; Klotzbücher, A; Kirk, J; Howell, M; le Guellec, K; Fletcher, K; Duncan, T; Sohail, M; Hunt, T New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation. Development (Cambridge, England) 2001;128(19):3795-807.

Ellenrieder, C; Bartosch, B; Lee, GY; Murphy, M; Sweeney, C; Hergersberg, M; Carrington, M; Jaussi, R; Hunt, T The long form of CDK2 arises via alternative splicing and forms an active protein kinase with cyclins A and E. DNA and cell biology 2001;20(7):413-23.

Sohail, M; Hochegger, H; Klotzbücher, A; Guellec, RL; Hunt, T; Southern, EM Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo. Nucleic acids research 2001;29(10):2041-51.

Geley, S; Kramer, E; Gieffers, C; Gannon, J; Peters, JM; Hunt, T Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. The Journal of cell biology 2001;153(1):137-48.

Yamano, H; Kitamura, K; Kominami, K; Lehmann, A; Katayama, S; Hunt, T; Toda, T The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases. Molecular cell 2000;6(6):1377-87.

Funakoshi, M; Geley, S; Hunt, T; Nishimoto, T; Kobayashi, H Identification of XDRP1; a Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation. The EMBO journal 1999;18(18):5009-18.

Tugal, T; Zou-Yang, XH; Gavin, K; Pappin, D; Canas, B; Kobayashi, R; Hunt, T; Stillman, B The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. The Journal of biological chemistry 1998;273(49):32421-9.

Yamano, H; Tsurumi, C; Gannon, J; Hunt, T The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: defining the D-box receptor. The EMBO journal 1998;17(19):5670-8.

Hunt, T Endnote 3.0. Trends in biochemical sciences 1998;23(7):268.

Brandeis, M; Rosewell, I; Carrington, M; Crompton, T; Jacobs, MA; Kirk, J; Gannon, J; Hunt, T Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4344-9.

Gannon, JV; Nebreda, A; Goodger, NM; Morgan, PR; Hunt, T A measure of the mitotic index: studies of the abundance and half-life of p34cdc2 in cultured cells and normal and neoplastic tissues. Genes to cells : devoted to molecular & cellular mechanisms 1998;3(1):17-27.

Hunt, T; Nasmyth, K Cell multiplication. Current opinion in cell biology 1997;9(6):765-7.

Funabiki, H; Yamano, H; Nagao, K; Tanaka, H; Yasuda, H; Hunt, T; Yanagida, M Fission yeast Cut2 required for anaphase has two destruction boxes. The EMBO journal 1997;16(19):5977-87.

Funakoshi, M; Sikder, H; Ebihara, H; Irie, K; Sugimoto, K; Matsumoto, K; Hunt, T; Nishimoto, T; Kobayashi, H Xenopus cyclin A1 can associate with Cdc28 in budding yeast, causing cell-cycle arrest with an abnormal distribution of nuclear DNA. Genes to cells : devoted to molecular & cellular mechanisms 1997;2(5):329-43.

Goodger, NM; Gannon, J; Hunt, T; Morgan, PR Cell cycle regulatory proteins–an overview with relevance to oral cancer. Oral oncology 1997;33(2):61-73.

Brandeis, M; Hunt, T The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. The EMBO journal 1996;15(19):5280-9.

Yamano, H; Gannon, J; Hunt, T The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. The EMBO journal 1996;15(19):5268-79.

Klotzbücher, A; Stewart, E; Harrison, D; Hunt, T The ’destruction box’ of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed. The EMBO journal 1996;15(12):3053-64.

Strausfeld, UP; Howell, M; Descombes, P; Chevalier, S; Rempel, RE; Adamczewski, J; Maller, JL; Hunt, T; Blow, JJ Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. Journal of cell science 1996;109 ( Pt 6)():1555-63.

Funabiki, H; Yamano, H; Kumada, K; Nagao, K; Hunt, T; Yanagida, M Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Nature 1996;381(6581):438-41.

Doonan, J; Hunt, T Cell cycle. Why don’t plants get cancer? Nature 1996;380(6574):481-2.

Goodger, NM; Gannon, J; Hunt, T; Morgan, PR The localization of p34cdc2 in the cells of normal, hyperplastic, and malignant epithelial and lymphoid tissues of the oral cavity. The Journal of pathology 1996;178(4):422-8.

Hunt, T From molecules to slides: EPStoPICTTM and epsConverterTM for the Macintosh. Trends in biochemical sciences 1996;21(2):74.

Baptist, M; Lamy, F; Gannon, J; Hunt, T; Dumont, JE; Roger, PP Expression and subcellular localization of CDK2 and cdc2 kinases and their common partner cyclin A in thyroid epithelial cells: comparison of cyclic AMP-dependent and -independent cell cycles. Journal of cellular physiology 1996;166(2):256-73.

Brown, NR; Noble, ME; Endicott, JA; Garman, EF; Wakatsuki, S; Mitchell, E; Rasmussen, B; Hunt, T; Johnson, LN The crystal structure of cyclin A. Structure (London, England : 1993) 1995;3(11):1235-47.

Nebreda, AR; Gannon, JV; Hunt, T Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes. The EMBO journal 1995;14(22):5597-607.

Howe, JA; Howell, M; Hunt, T; Newport, JW Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation. Genes & development 1995;9(10):1164-76.

Kobayashi, H; Stewart, E; Poon, RY; Hunt, T Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle. The Journal of biological chemistry 1994;269(46):29153-60.

Poon, RY; Yamashita, K; Howell, M; Ershler, MA; Belyavsky, A; Hunt, T Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15. Journal of cell science 1994;107 ( Pt 10)():2789-99.

Strausfeld, UP; Howell, M; Rempel, R; Maller, JL; Hunt, T; Blow, JJ Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Current biology : CB 1994;4(10):876-83.

Fukasawa, K; Murakami, MS; Blair, DG; Kuriyama, R; Hunt, T; Fischinger, P; Vande Woude, GF Similarities between somatic cells overexpressing the mos oncogene and oocytes during meiotic interphase. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(10):1093-103.

Hunt, T Invasion of the cabbage patch (should biochemists learn the Krebs cycle or the cell cycle?) Trends in biochemical sciences 1994;19(10):395-6.

Lew, J; Huang, QQ; Qi, Z; Winkfein, RJ; Aebersold, R; Hunt, T; Wang, JH A brain-specific activator of cyclin-dependent kinase 5. Nature 1994;371(6496):423-6.

Rouse, J; Cohen, P; Trigon, S; Morange, M; Alonso-Llamazares, A; Zamanillo, D; Hunt, T; Nebreda, AR A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 1994;78(6):1027-37.

Sheets, MD; Fox, CA; Hunt, T; Vande Woude, G; Wickens, M The 3’-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation. Genes & development 1994;8(8):926-38.

Poon, RY; Hunt, T Reversible immunoprecipitation using histidine- or glutathione S-transferase-tagged staphylococcal protein A. Analytical biochemistry 1994;218(1):26-33.

Stewart, E; Kobayashi, H; Harrison, D; Hunt, T Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2. The EMBO journal 1994;13(3):584-94.

Berry, MJ; Wattam, TA; Willets, J; Lindner, N; de Graaf, T; Hunt, T; Gani, M; Davis, PJ; Porter, P Assay and purification of Fv fragments in fermenter cultures: design and evaluation of generic binding reagents. Journal of immunological methods 1994;167(1-2):173-82.

Nasmyth, K; Hunt, T Cell cycle. Dams and sluices. Nature 1993;366(6456):634-5.

Adamczewski, JP; Gannon, JV; Hunt, T Simian virus 40 large T antigen associates with cyclin A and p33cdk2. Journal of virology 1993;67(11):6551-7.

Nebreda, AR; Hill, C; Gomez, N; Cohen, P; Hunt, T The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo. FEBS letters 1993;333(1-2):183-7.

Poon, RY; Yamashita, K; Adamczewski, JP; Hunt, T; Shuttleworth, J The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. The EMBO journal 1993;12(8):3123-32.

Nebreda, AR; Hunt, T The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs. The EMBO journal 1993;12(5):1979-86.

Woodman, PG; Adamczewski, JP; Hunt, T; Warren, G In vitro fusion of endocytic vesicles is inhibited by cyclin A-cdc2 kinase. Molecular biology of the cell 1993;4(5):541-53.

Hunt, T; Kirschner, M Cell multiplication. Current opinion in cell biology 1993;5(2):163-5.

Tommasino, M; Adamczewski, JP; Carlotti, F; Barth, CF; Manetti, R; Contorni, M; Cavalieri, F; Hunt, T; Crawford, L HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A. Oncogene 1993;8(1):195-202.

Kobayashi, H; Stewart, E; Poon, R; Adamczewski, JP; Gannon, J; Hunt, T Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits. Molecular biology of the cell 1992;3(11):1279-94.

Craig, D; Howell, MT; Gibbs, CL; Hunt, T; Jackson, RJ Plasmid cDNA-directed protein synthesis in a coupled eukaryotic in vitro transcription-translation system. Nucleic acids research 1992;20(19):4987-95.

Hunt, T Cell cycle arrest and c-mos. Nature 1992;355(6361):587-8.

Hunt, T; Luca, FC; Ruderman, JV The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo. The Journal of cell biology 1992;116(3):707-24.

Bandara, LR; Adamczewski, JP; Zamanian, M; Poon, RY; Hunt, T; Thangue, NB Cyclin A recruits p33cdk2 to the cellular transcription factor DRTF1. Journal of cell science. Supplement 1992;16():77-85.

Hunt, T Cyclins and their partners: from a simple idea to complicated reality. Seminars in cell biology 1991;2(4):213-22.

Kobayashi, H; Minshull, J; Ford, C; Golsteyn, R; Poon, R; Hunt, T On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis. The Journal of cell biology 1991;114(4):755-65.

Minshull, J; Murray, A; Colman, A; Hunt, T Xenopus oocyte maturation does not require new cyclin synthesis. The Journal of cell biology 1991;114(4):767-72.

Bandara, LR; Adamczewski, JP; Hunt, T; La Thangue, NB Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature 1991;352(6332):249-51.

Watanabe, N; Hunt, T; Ikawa, Y; Sagata, N Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs. Nature 1991;352(6332):247-8.

Hunt, T Cell biology. Cell cycle gets more cyclins. Nature 1991;350(6318):462-3.

Hunt, T Cell biology. Destruction’s our delight… Nature 1991;349(6305):100-1.

Kobayashi, H; Golsteyn, R; Poon, R; Stewart, E; Gannon, J; Minshull, J; Smith, R; Hunt, T Cyclins and their partners during Xenopus oocyte maturation. Cold Spring Harbor symposia on quantitative biology 1991;56():437-47.

Hunt, T Summary: put out more flags. Cold Spring Harbor symposia on quantitative biology 1991;56():757-69.

Standart, N; Dale, M; Stewart, E; Hunt, T Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3’-untranslated region. Genes & development 1990;4(12A):2157-68.

Minshull, J; Golsteyn, R; Hill, CS; Hunt, T The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle. The EMBO journal 1990;9(9):2865-75.

Félix, MA; Labbé, JC; Dorée, M; Hunt, T; Karsenti, E Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase. Nature 1990;346(6282):379-82.

Gautier, J; Minshull, J; Lohka, M; Glotzer, M; Hunt, T; Maller, JL Cyclin is a component of maturation-promoting factor from Xenopus. Cell 1990;60(3):487-94.

Standart, N; Hunt, T Control of translation of masked mRNAs in clam oocytes. Enzyme 1990;44(1-4):106-19.

Hunt, T Embryology. Under arrest in the cell cycle. Nature 1989;342(6249):483-4.

Felix, MA; Pines, J; Hunt, T; Karsenti, E A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity. The EMBO journal 1989;8(10):3059-69.

Meijer, L; Arion, D; Golsteyn, R; Pines, J; Brizuela, L; Hunt, T; Beach, D Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. The EMBO journal 1989;8(8):2275-82.

Hunt, T Maturation promoting factor, cyclin and the control of M-phase. Current opinion in cell biology 1989;1(2):268-74.

Minshull, J; Blow, JJ; Hunt, T Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis. Cell 1989;56(6):947-56.

Felix, MA; Pines, J; Hunt, T; Karsenti, E Temporal regulation of cdc2 mitotic kinase activity and cyclin degradation in cell-free extracts of Xenopus eggs. Journal of cell science. Supplement 1989;12():99-116.

Minshull, J; Pines, J; Golsteyn, R; Standart, N; Mackie, S; Colman, A; Blow, J; Ruderman, JV; Wu, M; Hunt, T The role of cyclin synthesis, modification and destruction in the control of cell division. Journal of cell science. Supplement 1989;12():77-97.

Hunt, T Controlling mRNA lifespan. Nature 1988;334(6183):567-8.

Standart, N; Minshull, J; Pines, J; Hunt, T Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte. Developmental biology 1987;124(1):248-58.

Pines, J; Hunt, T Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs. The EMBO journal 1987;6(10):2987-95.

Standart, N; Hunt, T; Ruderman, JV Differential accumulation of ribonucleotide reductase subunits in clam oocytes: the large subunit is stored as a polypeptide, the small subunit as untranslated mRNA. The Journal of cell biology 1986;103(6 Pt 1):2129-36.

Minshull, J; Hunt, T The use of single-stranded DNA and RNase H to promote quantitative ’hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations. Nucleic acids research 1986;14(16):6433-51.

Hunt, T False starts in translational control of gene expression. Nature 1985;316(6029):580-1.

Standart, NM; Bray, SJ; George, EL; Hunt, T; Ruderman, JV The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs. The Journal of cell biology 1985;100(6):1968-76.

Sjöberg, BM; Eklund, H; Fuchs, JA; Carlson, J; Standart, NM; Ruderman, JV; Bray, SJ; Hunt, T Identification of the stable free radical tyrosine residue in ribonucleotide reductase. A sequence comparison. FEBS letters 1985;183(1):99-102.

Walker, AI; Hunt, T; Jackson, RJ; Anderson, CW Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts. The EMBO journal 1985;4(1):139-45.

Hunt, T Phosphorylation and the control of protein synthesis. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1983;302(1108):127-34.

Evans, T; Rosenthal, ET; Youngblom, J; Distel, D; Hunt, T Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 1983;33(2):389-96.

Jackson, RJ; Campbell, EA; Herbert, P; Hunt, T The preparation and properties of gel-filtered rabbit-reticulocyte lysate protein-synthesis systems. European journal of biochemistry / FEBS 1983;131(2):289-301.

Jackson, RJ; Herbert, P; Campbell, EA; Hunt, T The roles of sugar phosphates and thiol-reducing systems in the control of reticulocyte protein synthesis. European journal of biochemistry / FEBS 1983;131(2):313-24.

Hunt, T; Herbert, P; Campbell, EA; Delidakis, C; Jackson, RJ The use of affinity chromatography on 2’5’ ADP-sepharose reveals a requirement for NADPH, thioredoxin and thioredoxin reductase for the maintenance of high protein synthesis activity in rabbit reticulocyte lysates. European journal of biochemistry / FEBS 1983;131(2):303-11.

Jackson, RJ; Hunt, T The turnover of methionine in the Met-tRNA pool and the control of protein synthesis in reticulocyte lysates: no evidence that haem-deficiency promotes deacylation of Met-tRNAf. FEBS letters 1982;143(2):301-5.

Ballinger, DG; Hunt, T Fertilization of sea urchin eggs is accompanied by 40 S ribosomal subunit phosphorylation. Developmental biology 1981;87(2):277-85.

Jackson, RJ; Hunt, T Mechanisms on control of polypeptide-chain initiation in reticulocytes. Biochemical Society transactions 1980;8(4):457-8.

Rosenthal, ET; Hunt, T; Ruderman, JV Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima. Cell 1980;20(2):487-94.

Jackson, RJ; Hunt, T The use of hexose phosphates to support protein synthesis and generate [gamma-32P]ATP in reticulocyte lysates. FEBS letters 1978;93(2):235-8.

Farrell, PJ; Hunt, T; Jackson, RJ Analysis of phosphorylation of protein synthesis initiation factor eIF-2 by two-dimensional gel electrophoresis. European journal of biochemistry / FEBS 1978;89(2):517-21.

Pelham, HR; Sykes, JM; Hunt, T Characteristics of a coupled cell-free transcription and translation system directed by vaccinia cores. European journal of biochemistry / FEBS 1978;82(1):199-209.

Hunter, AR; Jackson, RJ; Hunt, T The role of complexes between the 40-S ribosomal subunit and Met-tRNA-Met-f in the initiation of protein synthesis in the wheat-germ system. European journal of biochemistry / FEBS 1977;75(1):159-70.

Hunter, AR; Farrell, PJ; Jackson, RJ; Hunt, T The role of polyamines in cell-free protein synthesis in the wheat-germ system. European journal of biochemistry / FEBS 1977;75(1):149-57.

Farrell, PJ; Balkow, K; Hunt, T; Jackson, RJ; Trachsel, H Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis. Cell 1977;11(1):187-200.

Hunter, TR; Hunt, T; Knowland, J; Zimmern, D Messenger RNA for the coat protein of tobacco mosaic virus. Nature 1976;260(5554):759-64.

Balkow, K; Hunt, T; Jackson, RJ Control of protein synthesis in reticulocyte lysates: the effect of nucleotide triphosphates on formation of the translational repressor. Biochemical and biophysical research communications 1975;67(1):366-75.

Hunter, T; Hunt, T; Jackson, RJ; Robertson, HD The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. The Journal of biological chemistry 1975;250(2):409-17.

Hunt, T The control of globin synthesis in rabbit reticulocytes. Annals of the New York Academy of Sciences 1974;241(0):223-31.

Hunt, T Colonic irrigation. Nursing mirror and midwives journal 1974;139(1):76-7.

Legon, S; Brayley, A; Hunt, T; Jackson, RJ The effect of cyclic AMP and related compounds on the control of protein synthesis in reticulocyte lysates. Biochemical and biophysical research communications 1974;56(3):745-52.

Hunt, T; Jackson, RJ The rabbit reticulocyte lysate as a system for studying mRNA. Hämatologie und Bluttransfusion 1974;14():300-7.

Mathews, MB; Hunt, T; Brayley, A Specificity of the control of protein synthesis by haemin. Nature: New biology 1973;243(129):230-3.

Darnbrough, C; Legon, S; Hunt, T; Jackson, RJ Initiation of protein synthesis: evidence for messenger RNA-independent binding of methionyl-transfer RNA to the 40 S ribosomal subunit. Journal of molecular biology 1973;76(3):379-403.

Legon, S; Jackson, RJ; Hunt, T Control of protein synthesis in reticulocyte lysates by haemin. Nature: New biology 1973;241(109):150-2.

Darnbrough, C; Hunt, T; Jackson, RJ A complex between met-tRNA F and native 40S subunits in reticulocyte lysates and its disappearance during incubation with double-stranded RNA. Biochemical and biophysical research communications 1972;48(6):1556-64.

Hunt, T; Vanderhoff, G; London, IM Control of globin synthesis: the role of heme. Journal of molecular biology 1972;66(3):471-81.

Ehrenfeld, E; Hunt, T Double-stranded poliovirus RNA inhibits initiation of protein synthesis by reticulocyte lysates. Proceedings of the National Academy of Sciences of the United States of America 1971;68(5):1075-8.

Zehavi-Willner, T; Kosower, NS; Kosower, EM; Hunt, T GSH oxidation and protein synthesis in rabbit reticulocytes. Biochemical and biophysical research communications 1970;40(1):37-42.

Hunt, T Diverticular disease of the colon. The Practitioner 1969;203(217):599-605.

Hunt, T; Hunter, A; Munro, AJ Factors affecting haemoglobin biosynthesis. The Biochemical journal 1969;113(2):5P.

Hunt, T; Hunter, T; Munro, A Control of haemoglobin synthesis: distribution of ribosomes on the messenger RNA for alpha and beta chains. Journal of molecular biology 1968;36(1):31-45.

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    Principal Scientist
    Cancer Research UK