Eric F. Wieschaus

Eric Wieschaus is well known for the identification of 139 genes necessary for a fruit fly’s existence. It includes genes which are important in the formation of muscles, heads, eyes, and other body parts. Much of his research was focused on the genetic mechanisms that control embryonic development (gap genes, pair-rule genes, and segment-polarity genes) in the fruit fly Drosophila melanogaster. He collaborated with Christiane Nüsslein-Volhard for genetic research. Wieschaus received the Nobel Prize in Physiology or Medicine 1995 for his work on embryogenesis in the early Drosophila embryo sharing it with Christiane Nüsslein-Volhard and Edward B. Lewis.

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Recent Findings From Eric F. Wieschaus

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1995 Nobel Prize for Medicine

American Philosophical Society

American Academy of Arts and Sciences

Federation of American Scientists Board of Sponsors

1963 National Science Foundation Fellowship

National Academy of Sciences

Shawn C Little; Gašper Tkacik; Thomas B Kneeland; Eric F Wieschaus; Thomas Gregor The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA. PLoS biology 2011;9(3):e1000596.

Oliver Grimm; Eric Wieschaus The Bicoid gradient is shaped independently of nuclei. Development (Cambridge, England) 2010;137(17):2857-62.

Oliver Grimm; Mathieu Coppey; Eric Wieschaus Modelling the Bicoid gradient. Development (Cambridge, England) 2010;137(14):2253-64.

Xuemin Lu; Jennifer M Li; Olivier Elemento; Saeed Tavazoie; Eric F Wieschaus Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition. Development (Cambridge, England) 2009;136(12):2101-10.

Adam C Martin; Matthias Kaschube; Eric F Wieschaus Pulsed contractions of an actin-myosin network drive apical constriction. Nature 2009;457(7228):495-9.

Anna Marie Sokac; Eric Wieschaus Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization. Journal of cell science 2008;121(Pt 11):1815-24.

Anna Marie Sokac; Eric Wieschaus Local actin-dependent endocytosis is zygotically controlled to initiate Drosophila cellularization. Developmental cell 2008;14(5):775-86.

Thomas Gregor; Alistair P McGregor; Eric F Wieschaus Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos. Developmental biology 2008;316(2):350-8.

Thomas Gregor; David W Tank; Eric F Wieschaus; William Bialek Probing the limits to positional information. Cell 2007;130(1):153-64.

Thomas Gregor; Eric F Wieschaus; Alistair P McGregor; William Bialek; David W Tank Stability and nuclear dynamics of the bicoid morphogen gradient. Cell 2007;130(1):141-52.

Stefano De Renzis; Olivier Elemento; Saeed Tavazoie; Eric F Wieschaus Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo. PLoS biology 2007;5(5):e117.

Julie M Goodliffe; Michael D Cole; Eric Wieschaus Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. BMC molecular biology 2007;8():40.

Horacio M Frydman; Jennifer M Li; Drew N Robson; Eric Wieschaus Somatic stem cell niche tropism in Wolbachia. Nature 2006;441(7092):509-12.

Stefano De Renzis; J Yu; R Zinzen; Eric Wieschaus Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. Developmental cell 2006;10(2):257-64.

Thomas Gregor; William Bialek; Rob R de Ruyter van Steveninck; David W Tank; Eric F Wieschaus Diffusion and scaling during early embryonic pattern formation. Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18403-7.

Julie M Goodliffe; Eric Wieschaus; Michael D Cole Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila. Genes & development 2005;19(24):2941-6.

B Houchmandzadeh; E Wieschaus; S Leibler Precise domain specification in the developing Drosophila embryo. Physical review. E, Statistical, nonlinear, and soft matter physics 2005;72(6 Pt 1):061920.

Patrick M Ferree; Horacio M Frydman; Jennifer M Li; Jian Cao; Eric Wieschaus; William Sullivan Wolbachia utilizes host microtubules and Dynein for anterior localization in the Drosophila oocyte. PLoS pathogens 2005;1(2):e14.

Rachel E Dawes-Hoang; Kush M Parmar; Audrey E Christiansen; Chris B Phelps; Andrea H Brand; Eric F Wieschaus folded gastrulation, cell shape change and the control of myosin localization. Development (Cambridge, England) 2005;132(18):4165-78.

Nicholas S Tolwinski; Eric Wieschaus A nuclear escort for beta-catenin. Nature cell biology 2004;6(7):579-80.

Nicholas S Tolwinski; Eric Wieschaus Rethinking WNT signaling. Trends in genetics : TIG 2004;20(4):177-81.

Nicholas S Tolwinski; Eric Wieschaus A nuclear function for armadillo/beta-catenin. PLoS biology 2004;2(4):E95.

Jennifer A Zallen; Eric Wieschaus Patterned gene expression directs bipolar planar polarity in Drosophila. Developmental cell 2004;6(3):343-55.

Jeffrey H Thomas; Eric Wieschaus src64 and tec29 are required for microfilament contraction during Drosophila cellularization. Development (Cambridge, England) 2004;131(4):863-71.

Jörg Grosshans; H Arno J Müller; Eric Wieschaus Control of cleavage cycles in Drosophila embryos by frühstart. Developmental cell 2003;5(2):285-94.

Nicholas S Tolwinski; Marcel Wehrli; Anna Rives; Naz Erdeniz; Stephen DiNardo; Eric Wieschaus Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Developmental cell 2003;4(3):407-18.

Rachel E Dawes-Hoang; Jennifer A Zallen; Eric F Wieschaus Bringing classical embryology to C elegans gastrulation. Developmental cell 2003;4(1):6-8.

Thomas Lecuit; Reba Samanta; Eric Wieschaus slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo. Developmental cell 2002;2(4):425-36.

Yashi Ahmed; Ali Nouri; Eric Wieschaus Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development (Cambridge, England) 2002;129(7):1751-62.

Steven P Gross; Michael A Welte; Steven M Block; Eric F Wieschaus Coordination of opposite-polarity microtubule motors. The Journal of cell biology 2002;156(4):715-24.

Jennifer A Zallen; Yehudit Cohen; Andrew M Hudson; Lynn Cooley; Eric Wieschaus; Eyal D Schejter SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila. The Journal of cell biology 2002;156(4):689-701.

Bahram Houchmandzadeh; Eric Wieschaus; Stanislas Leibler Establishment of developmental precision and proportions in the early Drosophila embryo. Nature 2002;415(6873):798-802.

Thomas Lecuit; Eric Wieschaus Junctions as organizing centers in epithelial cells? A fly perspective. Traffic (Copenhagen, Denmark) 2002;3(2):92-7.

Christine Hunter; Patricia Sung; Eyal D Schejter; Eric Wieschaus Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions. Molecular biology of the cell 2002;13(1):146-57.

J T Blankenship; E Wieschaus Two new roles for the Drosophila AP patterning system in early morphogenesis. Development (Cambridge, England) 2001;128(24):5129-38.

R E Dawes-Hoang; E F Wieschaus Cell and developmental biology–a shared past, an intertwined future. Developmental cell 2001;1(1):27-36.

N S Tolwinski; E Wieschaus Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan. Development (Cambridge, England) 2001;128(11):2107-17.

K J Arrow; J Axelrod; B Benacerraf; P Berg; J M Bishop; N Bloembergen; H C Brown; J Cibelli; S Cohen; L N Cooper; et al. Nobel laureates’ letter to President Bush. Washington post (Washington, D.C. : 1974) 2001;():A02.

T Lecuit; E Wieschaus Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo. The Journal of cell biology 2000;150(4):849-60.

C Hunter; E Wieschaus Regulated expression of nullo is required for the formation of distinct apical and basal adherens junctions in the Drosophila blastoderm. The Journal of cell biology 2000;150(2):391-401.

J Grosshans; E Wieschaus A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila. Cell 2000;101(5):523-31.

S P Gross; M A Welte; S M Block; E F Wieschaus Dynein-mediated cargo transport in vivo. A switch controls travel distance. The Journal of cell biology 2000;148(5):945-56.

A Jazwinska; N Kirov; E Wieschaus; S Roth; C Rushlow The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. Cell 1999;96(4):563-73.

H A Müller; R Samanta; E Wieschaus Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes. Development (Cambridge, England) 1999;126(3):577-86.

Y Ahmed; S Hayashi; A Levine; E Wieschaus Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 1998;93(7):1171-82.

M A Welte; S P Gross; M Postner; S M Block; E F Wieschaus Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics. Cell 1998;92(4):547-57.

P Morize; A E Christiansen; M Costa; S Parks; E Wieschaus Hyperactivation of the folded gastrulation pathway induces specific cell shape changes. Development (Cambridge, England) 1998;125(4):589-97.

T Schüpbach; E Wieschaus Probing for gene specificity in epithelial development. The International journal of developmental biology 1998;42(3):249-55.

A Vincent; J T Blankenship; E Wieschaus Integration of the head and trunk segmentation systems controls cephalic furrow formation in Drosophila. Development (Cambridge, England) 1997;124(19):3747-54.

S Hayashi; B Rubinfeld; B Souza; P Polakis; E Wieschaus; A J Levine A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo. Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):242-7.

H A Müller; E Wieschaus armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila. The Journal of cell biology 1996;134(1):149-63.

E Wieschaus Embryonic transcription and the control of developmental pathways. Genetics 1996;142(1):5-10.

C Rauskolb; K M Smith; M Peifer; E Wieschaus extradenticle determines segmental identities throughout Drosophila development. Development (Cambridge, England) 1995;121(11):3663-73.

A Bejsovec; E Wieschaus Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. Genetics 1995;139(1):309-20.

K D Irvine; E Wieschaus fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 1994;79(4):595-606.

C Rauskolb; E Wieschaus Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. The EMBO journal 1994;13(15):3561-9.

M A Postner; E F Wieschaus The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos. Journal of cell science 1994;107 ( Pt 7)():1863-73.

P Armand; A C Knapp; A J Hirsch; E F Wieschaus; M D Cole A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis. Molecular and cellular biology 1994;14(6):4145-54.

K D Irvine; E Wieschaus Cell intercalation during Drosophila germband extension and its regulation by pair-rule segmentation genes. Development (Cambridge, England) 1994;120(4):827-41.

M Costa; E T Wilson; E Wieschaus A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell 1994;76(6):1075-89.

M Peifer; D Sweeton; M Casey; E Wieschaus wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development (Cambridge, England) 1994;120(2):369-80.

E D Schejter; E Wieschaus bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo. Cell 1993;75(2):373-85.

A Bejsovec; E Wieschaus Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development (Cambridge, England) 1993;119(2):501-17.

C Rauskolb; M Peifer; E Wieschaus extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 1993;74(6):1101-12.

M Peifer; S Orsulic; D Sweeton; E Wieschaus A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis. Development (Cambridge, England) 1993;118(4):1191-207.

M Peifer; E Wieschaus The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica. Journal of molecular evolution 1993;36(3):224-33.

E D Schejter; E Wieschaus Functional elements of the cytoskeleton in the early Drosophila embryo. Annual review of cell biology 1993;9():67-99.

M A Postner; K G Miller; E F Wieschaus Maternal effect mutations of the sponge locus affect actin cytoskeletal rearrangements in Drosophila melanogaster embryos. The Journal of cell biology 1992;119(5):1205-18.

M Peifer; P D McCrea; K J Green; E Wieschaus; B M Gumbiner The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. The Journal of cell biology 1992;118(3):681-91.

E Wieschaus; N Perrimon; R Finkelstein orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila. Development (Cambridge, England) 1992;115(3):801-11.

L S Rose; E Wieschaus The Drosophila cellularization gene nullo produces a blastoderm-specific transcript whose levels respond to the nucleocytoplasmic ratio. Genes & development 1992;6(7):1255-68.

E D Schejter; L S Rose; M A Postner; E Wieschaus Role of the zygotic genome in the restructuring of the actin cytoskeleton at the cycle-14 transition during Drosophila embryogenesis. Cold Spring Harbor symposia on quantitative biology 1992;57():653-9.

T Schüpbach; E Wieschaus Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 1991;129(4):1119-36.

D Sweeton; S Parks; M Costa; E Wieschaus Gastrulation in Drosophila: the formation of the ventral furrow and posterior midgut invaginations. Development (Cambridge, England) 1991;112(3):775-89.

M Peifer; C Rauskolb; M Williams; B Riggleman; E Wieschaus The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation. Development (Cambridge, England) 1991;111(4):1029-43.

S Parks; E Wieschaus The Drosophila gastrulation gene concertina encodes a G alpha-like protein. Cell 1991;64(2):447-58.

M Peifer; E Wieschaus The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 1990;63(6):1167-76.

B Riggleman; P Schedl; E Wieschaus Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless. Cell 1990;63(3):549-60.

D E Coulter; E A Swaykus; M A Beran-Koehn; D Goldberg; E Wieschaus; P Schedl Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern. The EMBO journal 1990;9(11):3795-804.

L Simpson; E Wieschaus Zygotic activity of the nullo locus is required to stabilize the actin-myosin network during cellularization in Drosophila. Development (Cambridge, England) 1990;110(3):851-63.

M Peifer; E Wieschaus Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity. Genes & development 1990;4(7):1209-23.

B Riggleman; E Wieschaus; P Schedl Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene. Genes & development 1989;3(1):96-113.

T Schüpbach; E Wieschaus Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. Genetics 1989;121(1):101-17.

D E Coulter; E Wieschaus Gene activities and segmental patterning in Drosophila: analysis of odd-skipped and pair-rule double mutants. Genes & development 1988;2(12B):1812-23.

E Wieschaus; D Sweeton Requirements for X-linked zygotic gene activity during cellularization of early Drosophila embryos. Development (Cambridge, England) 1988;104(3):483-93.

P T Merrill; D Sweeton; E Wieschaus Requirements for autosomal gene activity during precellular stages of Drosophila melanogaster. Development (Cambridge, England) 1988;104(3):495-509.

S B Zusman; D Sweeton; E F Wieschaus short gastrulation, a mutation causing delays in stage-specific cell shape changes during gastrulation in Drosophila melanogaster. Developmental biology 1988;129(2):417-27.

E Wieschaus; R Riggleman Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis. Cell 1987;49(2):177-84.

S B Zusman; E Wieschaus A cell marker system and mosaic patterns during early embryonic development in Drosophila melanogaster. Genetics 1987;115(4):725-36.

J P Gergen; E Wieschaus Dosage requirements for runt in the segmentation of Drosophila embryos. Cell 1986;45(2):289-99.

J Mohler; E F Wieschaus Dominant maternal-effect mutations of Drosophila melanogaster causing the production of double-abdomen embryos. Genetics 1986;112(4):803-22.

T Schupbach; E Wieschaus Germline autonomy of maternal-effect mutations altering the embryonic body pattern of Drosophila. Developmental biology 1986;113(2):443-8.

S B Zusman; E F Wieschaus Requirements for zygotic gene activity during gastrulation in Drosophila melanogaster. Developmental biology 1985;111(2):359-71.

J P Gergen; E F Wieschaus The localized requirements for a gene affecting segmentation in Drosophila: analysis of larvae mosaic for runt. Developmental biology 1985;109(2):321-35.

J Mohler; E F Wieschaus Bicaudal mutations of Drosophila melanogaster: alteration of blastoderm cell fate. Cold Spring Harbor symposia on quantitative biology 1985;50():105-11.

E Wieschaus; C Nusslein-Volhard; H Kluding Krüppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation. Developmental biology 1984;104(1):172-86.

E Wieschaus; R Nöthiger The role of the transformer genes in the development of genitalia and analia of Drosophila melanogaster. Developmental biology 1982;90(2):320-34.

E Wieschaus; C Audit; M Masson A clonal analysis of the roles of somatic cells and germ line during oogenesis in Drosophila. Developmental biology 1981;88(1):92-103.

C Nüsslein-Volhard; E Wieschaus Mutations affecting segment number and polarity in Drosophila. Nature 1980;287(5785):795-801. E Wieschaus A combined genetic and mosaic approach to the study of oogenesis in Drosophila. Basic life sciences 1980;16():85-94.

J Szabad; T Schüpbach; E Wieschaus Cell lineage and development in the larval epidermis of Drosophila melanogaster. Developmental biology 1979;73(2):256-71.

E Wieschaus; J Szabad The development and function of the female germ line in Drosophila melanogaster: a cell lineage study. Developmental biology 1979;68(1):29-46.

J L Marsh; E Wieschaus Is sex determination in germ line and soma controlled by separate genetic mechanisms? Nature 1978;272(5650):249-51.

E Wieschaus Cell lineage relationships in the Drosophila embryo. Results and problems in cell differentiation 1978;9():97-118.

J L Marsh; E Wieschaus Germ-line dependence of the maroon-like maternal effect in Drosophila. Developmental biology 1977;60(2):396-403.

J L Marsh; E B van Deusen; E Wieschaus; W J Gehring Germ line dependence of the deep orange maternal effect in Drosophila. Developmental biology 1977;56(1):195-9.

W J Gehring; E Wieschaus; M Holliger The use of ’normal’ and ’transformed’ gynandromorphs in mapping the primordial germ cells and the gonadal mesoderm in Drosophila. Journal of embryology and experimental morphology 1976;35(3):607-16.

E Wieschaus; W Gehring Clonal analysis of primordial disc cells in the early embryo of Drosophila melanogaster. Developmental biology 1976;50(2):249-63.

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    Squibb Professor in Molecular Biology
    Princeton University