Dr. Elizabeth Blackburn

Dr Blackburn, an Austalian-American scientist born in Tasmania.  She discovered the molecular nature of telomeres – the ends of eukaryotic chromosomes that serve as protective caps essential for preserving the genetic information – and the ribonucleoprotein enzyme, telomerase. She was awarded the Nobel Prize in 2010 for Physiology or Biology for this.


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Biologist BIOLOGIST (Molecular Biologist)
Dr Elizabeth Blackburn
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  1. American Cancer Society Medal of Honor 2000
  2. Australia Prize 1998
  3. Clowes Memorial Award 2000
  4. Eli Lilly Research Award for Microbiology and Immunology 1988
  5. Benjamin Franklin Medal 2005 (by the Franklin Institute)
  6. Gairdner Foundation International Award 1998
  7. Harvey Prize 1999
  8. Heineken Prize for Medicine 2004
  9. Horwitz Prize 2007 (with Carol W. Greider and Joseph Gall)
  10. Lasker Award 2006 (with Carol W. Greider and Jack W. Szostak)
  11. National Academy of Science Award in Molecular Biology 1990
  12. Paul Ehrlich and Ludwig Darmstaedter Prize 2009 (with Carol W. Greider)
  13. Nobel Prize for Medicine 2009 (with Carol W. Greider and Jack W. Szostak)
  14. Alfred P. Sloan Award 2001
  15. Wiley Prize in Biomedical Sciences 2006 (with Carol W. Greider)
  • 2000
    American Association for Cancer Research-G.H.A. Clowes Memorial Award
  • 2000
    Elected, Institute of Medicine
  • 2000
    American Cancer Society Medal of Honor
  • 2000
    Elected, Fellow of the American Association for the Advancement of Science
  • 2001
    AACR-Pezcoller Foundation International Award for Cancer Research
  • 2001
    General Motors Cancer Research Foundation Alfred P. Sloan Award
  • 2003
    26th Annual Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research
  • 2005
    Kirk A. Landon-American Association for Cancer Research Prize for Basic Cancer Research
  • 2005
    Benjamin Franklin Medal in Life Science
  • 2005
    New York Academy of Medicine Medal
  • 2006
    National Cancer Institute Alfred G. Knudson Award
  • 2006
    Fifth annual Wiley Prize in Biomedical Sciences
  • 2006
    Albert Lasker Award for Basic Medical Research
  • 2006
    The 25th Meyenburg Prize
  • 2006
    Elected, American Philosophical Society
  • 2007
    Elected, Australian Academy of Science
  • 2007
    TIME 100 Most Influential People in the World
  • 2008
    L’Oreal UNESCO For Women In Science Award
  • 2008
    Weizmann Women & Science Award: Weizmann Institute of Science
  • 2009
    Nobel Prize in Physiology or Medicine
  • Blackburn, E.H. and P.B. Challoner. Identification of a telomeric DNA sequence in Trypanosoma brucei. Cell 36: 447–457 (1984).
  • Shampay, J., J.W. Szostak and E.H. Blackburn. DNA sequences of telomeres maintained in yeast. Nature 310 : 154–157 (1984).
  • Bruns, P., A.L. Katzen, L. Martin and E.H. Blackburn. A drug resistant mutation in the Ribosomal DNA of Tetrahymena. Proc. Natl. Acad. Sci. USA 82: 2844–2846 (1985).
  • Spangler, E. and E.H. Blackburn. The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics Paromomycin and Hygromycin. J. Biol. Chem. 260: 6334–6340 (1985).
  • Howard, E.A. and E.H. Blackburn. Reproducible and variable genomic rearrangements occur in the developing somatic nucleus of the ciliate Tetrahymena thermophila. Molec. Cell. Biol. 5: 2039–2050 (1985).
  • Challoner, P.B., A.A. Amin, R.E. Pearlman and E.H. Blackburn. Conserved arrangements of repeated DNA sequences in the nontranscribed spacers of ciliate ribosomal RNA genes: Evidence for molecular coevolution. Nucl. Acids Res. 13: 2661–2680 (1985).
  • Greider, C.W. and E.H. Blackburn. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405–413 (1985).
  • Cherry, J.M. and E.H. Blackburn. The internally located telomeric sequences in the germline chromosomes of Tetrahymena are at the conserved ends of a family of DNA elements. Cell 43: 747–758 (1985).
  • Budarf, M.L. and E.H. Blackburn. Chromatin structure of the telomeric region and 3’ nontranscribed spacer of Tetrahymena ribosomal RNA genes. J. Biol. Chem. 261: 363–369 (1986).
  • Challoner, P.B. and E.H. Blackburn. Conservation of sequences adjacent to the telomeric C4A2 repeats of ciliate macronuclear ribosomal RNA gene molecules. Nucl. Acids Res. 14: 6299–6311 (1986).
  • Larson D.D., E.H. Blackburn, P.C. Yaeger and E. Orias. Control of rDNA Replication in Tetrahymena involves a cis-Acting Upstream Repeat of a Promoter Element. Cell 47: 229–240 (1986).
  • Budarf, M.L. and E.H. Blackburn. S1 Nuclease sensitivity of a double-stranded telomeric DNA sequence. Nucl. Acids Res. 15: 6273–6292 (1987).
  • Larson, D.D., E.A. Spangler and E.H. Blackburn. Dynamics of telomere length variation in Tetrahymena thermophila. Cell 50: 477–483 (1987).
  • Greider, C.W. and E.H. Blackburn. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two distinct primer specificity components. Cell 51: 887–898 (1987).
  • Henderson, E., C.C. Hardin, Steven K. Wolk, I. Tinoco, Jr. and E.H. Blackburn. Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base parts. Cell 51: 899–908 (1987).
  • Forney, J., E.R. Henderson and E.H. Blackburn. Identification of the telomeric sequence of the acellular slime molds Didyminum iridis and Physarum polycephalum. Nucl. Acids Res. 15: 9143– 9152 (1987).
  • Forney, J.D. and E.H. Blackburn. Developmentally controlled telomere addition in wild type and mutant paramecia. Mol. Cell. Biol. 8: 251–258 (1988).
  • Shampay, J. and E.H. Blackburn. Generation of telomere length heterogeneity in S. cerevisiae. Proc. Natl. Acad. Sci. USA 85: 534–538 (1988).
  • E. Orias, D. Larson, Y.-F. Hu, G.-L Yu, J. Karttunen, A. Lovlie, B. Haller and E.H. Blackburn. Replacement of the macronuclear ribosomal RNA genes of a mutant Tetrahymena using electroporation. Gene 70: 295–301 (1988).
  • Spangler, E.A., T. Ryan and E.H. Blackburn. Developmentally regulated telomere addition in Tetrahymena thermophila . Nucl. Acids Res. 16: 5569–5585 (1988).
  • Yu, G.-L., M. Hasson and E.H. Blackburn. Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA. Proc. Natl. Acad. Sci. USA 85: 5151–5155 (1988).
  • Henderson, E.R. and E.H. Blackburn. An Overhanging 3’ terminus is a conserved feature of telomeres. Mol. Cell. Biol. 9: 345–348 (1989).
  • Greider, C.W. and E.H. Blackburn. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331–337 (1989).
  • Yaeger, P.C., E. Orias, W.-L. Shaiu, D.D. Larson and E.H. Blackburn. The replication advantage of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila. Mol. Cell. Biol. 9: 452–460 (1989).
  • Shippen-Lentz, D. and E. H. Blackburn. Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers. Mol. Cell. Biol. 9: 2761–2764 (1989).
  • Shampay, J. and E.H Blackburn. Tetrahymena micronuclear sequences that function as telomeres in yeast. Nucl. Acids Res. 17: 3247–3260 (1989).
  • Phan, H.L., J. Forney and E.H. Blackburn. Analysis of Paramecium macronuclear DNA using pulsed field gel electrophoresis. J. Protozoology 36: 402–408 (1989).
  • Robinson, E.K., P.D. Cohen and E.H. Blackburn. A novel DNA deletion-ligation reaction catalyzed in vitro by a developmentally controlled activity from Tetrahymena cells. Cell 58: 887– 900 (1989).
  • Yu, G.-L. and E.H. Blackburn. Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector. Proc. Natl. Acad. Sci. USA 86: 8487–8491 (1989).
  • Blackburn, E.H., C.W. Greider, E. Henderson, M.S. Lee, J. Shampay, and D.-Shippen-Lentz. Recognition and elongation of telomeres by telomerase. Genome 31: 553–560 (1989).
  • Shippen-Lentz, D. and E. H. Blackburn. Functional evidence for an RNA template in telomerase. Science 247: 546–552 (1990).
  • Yu, G.-L., J.D. Bradley, L.D. Attardi and E.H. Blackburn. In vivo alteration of telomere sequences 29 and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126–132 (1990).
  • Blackburn, E.H. and V. Lundblad. RNA-dependent polymerase motifs in the EST1 protein: tentative identification of a component of an essential yeast telomerase. Cell 60: 529–530 (1990).
  • Yu, G.-L. and E.H. Blackburn. Amplification of tandemly repeated origin control sequences confers a replication advantage on rDNA replicons in Tetrahymena thermophila. Mol. Cell. Biol. 10: 2070–2080 (1990).
  • Romero, D. and E.H. Blackburn. A conserved secondary structure for telomerase RNA. Cell 67: 343–353 (1991).
  • Yu, G-L. and E.H. Blackburn. Developmentally programmed chromosome healing by telomerase in Tetrahymena. Cell 67: 823–832 (1991).
  • Wyman, C. and E.H. Blackburn. Tel-1 transposon-like elements of Tetrahymena thermophila are associated with micronuclear genome rearrangements. Genetics 128: 57–67 (1991).
  • Lundblad, V. and E.H. Blackburn. An alternate pathway for yeast telomere maintenance rescues est1- senescence. Cell 73: 347–360 (1993).
  • Lee, M. and E.H. Blackburn. Sequence-specific DNA primer effects on telomerase polymerization activity. Mol. Cell. Biol. 13: 6586–6599 (1993).
  • Shippen, D.E., E.H. Blackburn and C.M. Price. DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases. Proc. Natl. Acad. Sci. USA 91: 405–409 (1994).
  • Kapler, G.M. and E.H. Blackburn. A weak germline excision mutation blocks developmentally- controlled amplification of the rDNA minichromosome of Tetrahymena thermophila. Genes Dev. 8: 84–95 (1994).
  • Gilley, D. and E.H. Blackburn. Lack of telomere shortening during senescence in Paramecium. Proc. Natl. Acad. Sci. USA 91: 1955–1958 (1994).
  • McEachern, M.J. and E.H. Blackburn. A conserved sequence motif within the exceptionally diverse telomeric sequenced of budding yeasts. Proc. Natl. Acad. Sci. USA 91: 3453–3457. (1994).
  • Kapler, G.M., E. Orias and E.H. Blackburn. Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome. Genetics 137: 455–466 (1994).
  • Strahl, C. and E.H. Blackburn. The effects of nucleotide analogs on telomerase and telomeres in Tetrahymena. Nuc. Acids Res. 22: 893–900. (1994)
  • Bhattacharyya, A. and E.H. Blackburn. Architecture of telomerase RNA. EMBO J. 13: 5721–5731 (1994).
  • Kirk, K., and E.H. Blackburn. An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila. Genes Dev. 9: 59–71 (1995).
  • Romero, D.P. and E.H. Blackburn. Circular rDNA replicons persist in Tetrahymena thermophila transformants synthesizing GGGGTC telomeric repeats. J. Eukaryotic Micro. 42: 32–43 (1995).
  • Pan, W-J. and E.H. Blackburn. Tandem Repeats of the 5’ Non-transcribed Spacer of Tetrahymena rDNA Function as high copy number autonomous replicons in the macronucleus but do not prevent rRNA gene dosage regulation. Nuc. Acids Res. 23: 1561–1569. (1995).
  • Pan, W-J., R.C. Gallagher and E.H. Blackburn. Replication of an rDNA origin plasmid in the Tetrahymena macronucleus is prevented by transcription through the origin from an RNA polymerase I promoter. Mol. Cell. Biol. 15: 3372–3381 (1995).
  • Cohn, M., and E.H. Blackburn. Telomerase in yeast. Science 269: 396–400 (1995). 67. McEachern, M.J. and E.H. Blackburn. Runaway telomere elongation caused by telomerase RNA mutations. Nature 376: 403–409 (1995).
  • Gilley, D., M.S. Lee and E.H. Blackburn. Altering specific telomerase RNA template residues affects active site function. Genes Dev. 9: 2214–2226 (1995).
  • Strahl, C. and E.H. Blackburn. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol. Cell. Biol. 16: 53–65 (1996).
  • Gilley, D. and E.H. Blackburn. Specific RNA residue interactions required for enzymatic functions of Tetrahymena Telomerase. Mol. Cell. Biol. 16: 66–75 (1996).
  • McEachern, M.J. and E.H. Blackburn. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in K lactis lacking telomerase. Genes Dev. 10: 1822–1834 (1996).
  • Krauskopf, A. and E.H. Blackburn. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354–357 (1996).
  • Prescott, J. and E.H. Blackburn. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal non-processivity in vivo and in vitro. Genes Dev. 11:528–540 (1997).
  • Wang H. and E.H. Blackburn. De novo telomere addition by Tetrahymena telomerase in vitro. EMBO J. 16:866–879 (1997).
  • Kirk, K.E., B.P. Harmon, I.K. Reichardt, J.W. Sedat and E.H. Blackburn. Block in anaphase chromosome separation caused by a telomerase template mutation. Science 275:1478–1481 (1997).
  • Bhattacharyya, A. and E.H. Blackburn. Aspergillus nidulans maintains short telomeres throughout development. Nuc. Acids Res. 25:1426–1431 (1997).
  • Bhattacharyya, A. and E.H. Blackburn. A functional telomerase RNA swap in vivo reveals the importance of non-template RNA domains. Proc. Natl. Acad. USA 94:2823–2827 (1997).
  • Prescott, J. and E.H. Blackburn. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790–2800 (1997).
  • Wang, H., D. Gilley and E.H. Blackburn. A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase. EMBO J. 17:1152–1160 (1998).
  • Cohn, M., M.J. McEachern and E.H. Blackburn. Telomeric sequence diversity within the genus Saccharomyces. Curr. Genetics 33:83–91 (1998).
  • Gallagher, R.C. and E.H. Blackburn. A promoter region mutation affecting replication of the Tetrahymena rDNA minichromosome. Mol. Cell. Biol. 18:3021–3033 (1998).
  • Frenck, R.W., Blackburn, E.H. and K.M. Shannon. The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. USA, 95:5607–5610 (1998).
  • Cohen, P.D. and E.H. Blackburn. Two types of telomeric chromatin in Tetrahymena thermophila. J. Mol. Biol. 280:327–344 (1998).
  • Fulton, T.B. and E.H. Blackburn. Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the thirty nucleotide-long templating domain. Mol. Cell. Biol 18(9):4961–70 (1998).
  • Krauskopf, A. and E.H. Blackburn. Rap1 Protein Regulates Telomere Turnover in Yeast. Proc. Natl. Acad. Sci. USA. 95(21):12486–91 (1998).
  • Roy, J., Boswell Fulton, T. and E. H. Blackburn. Specific telomerase RNA residues distant from the template are essential for telomerase function. Genes Dev. 12(20): 3286–3300 (1998).
  • Cano, M. I., J. Dungan, N. Agabian, and E. H. Blackburn. Telomerase in Kinetoplastid Parasitic Protozoa. Proc. Natl. Acad. Sci. USA. 96: 3616–3621 (1999).
  • Zhu, J., H. Wang, J. M. Bishop, and E. H. Blackburn. Telomerase extends the lifespan of virus- transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA. 96: 3723– 3728 (1999).
  • Smith, C.D. and E.H. Blackburn. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. Journal of Cell Biology 145(2): 203–214 (1999).
  • Gilley, D. and E.H. Blackburn. The telomerase RNA pseudoknot is critical for the stable assembly of the catalytically active ribonucleoprotein. Proc. Natl. Acad. Sci. USA. 96: 6621–6625 (1999).
  • Hsu, H.-L., D. Gilley, E.H. Blackburn, and D.J. Chen. Ku is associated with the telomere in mammals. Proc. Natl. Acad. Sci. USA. 96: 12454–12458 (1999).
  • Prescott, J. and E.H. Blackburn. Telomerase RNA Template Mutations Reveal Sequence-Specific Requirements for the Activation and Repression of Telomerase Action at Telomeres. Mol. Cell. Biol. 20: 2941-2948 (2000).
  • Tzfati, Y., T.B. Fulton, J. Roy, and E.H. Blackburn. Template boundary in a yeast telomerase specified by RNA structure. Science. 288(5467):863-7 (2000).
  • Ware T.L., H. Wang, and E.H. Blackburn. Three telomerases with completely non-telomeric template replacements are catalytically active. EMBO Journal 19(12): 3119-3131 (2000).
  • McEachern, M.J., S. Iyer, T.B. Fulton, and E.H. Blackburn. Telomere fusions caused by mutating the terminal region of telomeric DNA. Proc. Natl. Acad. Sci. USA. 97: 11409-11414 (2000).
  • Kim. M.M., M.A. Rivera, I.L. Botchkina, R. Shalaby, A.D. Thor, and E.H. Blackburn. A low threshold level of expression of mutant-template telomerase RNA is sufficient to inhibit human tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 98:7982-7987 (2001).
  • Chan, S. J. Chang, J. Prescott, and E.H. Blackburn. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Current Biology 11: 1240-1250 (2001).
  • Nautiyal, S., J. DeRisi, and E.H. Blackburn. A genome-wide gene-expression response to telomerase deletion mutant of S. cerevisiae. Proc. Natl. Acad Sci. U.S.A. 99 (14):9316-21 (2002).
  • McEachern, M.J., D.H. Underwood and E.H. Blackburn. Dynamics of telomeric DNA turnover in yeast. Genetics 160: 63–73 (2002).
  • Cano, M.I.N., J.J. Blake, E.H. Blackburn, and N. Agabian A trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity. J. Biol. Chem. 277:896-906 (2002).
  • Seto, A.G., A.J. Livengood, Y. Tzfati, E.H. Blackburn, and T.R. Cech. A bulged stem tethers Est1p to telomerase RNA in budding yeasts. Genes Dev. 16: 2800-2812 (2002).
  • Comolli, L.R., I. Smirnov, L. Xu, E.H. Blackburn and T.L. James. A molecular switch underlies a human telomerase disease. Proc. Natl. Acad Sci. U.S.A. 99: 16998-17003(2002).
  • Smith, C.D., D.L. Smith, J.L. DeRisi and E.H. Blackburn. Telomeric protein distributions and remodeling through the cell cycle in S. cerevisiae. Mol. Biol. Cell 14: 556-570 (2003).
  • Ly, H., L. Xu, M. Rivera, T.G. Parslow and E.H. Blackburn. A role for a novel ‘trans-pseudoknot’ RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev 17: 1078- 1083 (2003).
  • Chan, S. and E.H. Blackburn. Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Molec Cell 11:1379-1387 (2003).
  • Tzfati, Y., Knight, Z., Roy, J. and E.H. Blackburn. A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev 17:1779-1788 (2003).
  • Kim, M.M, L. Xu and E. H. Blackburn. Catalytically normal human telomerase mutants with allele-specific biological properties. Exper Cell Res 288: 277-287 (2003).
  • Ly, H., Blackburn, E.H. and Parslow, T.G. Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol Cell Biol 23: 6849-6856 (2003).
  • Seto, A.G., K. Umansky, Y. Tzfati, A.J. Zaug, E.H. Blackburn, and T.R. Cech. A template- proximal RNA paired element contributes to S. cerevisiae telomerase activity. RNA. 9:1323-1332 (2003).
  • Lin, J., D.L. Smith and E.H. Blackburn. Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Molec. Biol. Cell 15: 1623-1634 (2004)
  • Lin, J. and E.H. Blackburn. Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev. 18: 387-396 (2004)
  • Makovets, S., I. Herskowitz and E.H. Blackburn. Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol. Cell. Biol. 24: 4019-4031 (2004).
  • Li, S., J.E. Rosenberg, A.A. Donjacour, I.L. Botchkina, Y.-K. Hom, G.R. Cunha and E.H. Blackburn. Rapid inhibition of cancer cell growth induced by lentiviral expression of mutant- template telomerase RNA constructs and anti-telomerase siRNA. Cancer Res 64: 4833-4840 (2004).
  • Nosrati, M. S. Li, S. Bagheri, D. Ginzinger, E.H. Blackburn, R.J. Debs, and M. Kashani-Sabet. Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin Cancer Res. 10:4983-4990 (2004).
  • Lin, J., H. Ly, A. Hussain, M. Abraham, S. Pearl, T.G. Parslow, Y. Tzfati and E.H. Blackburn. A universal telomerase RNA core structure includes structure motifs required for binding the telomerase reverse transcriptase protein. Proc. Natl. Acad. Sci. USA 101:14713-8 (2004).
  • Levy, D.L. and E.H. Blackburn. Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Mol. Cell. Biol. 24: 10857-10867 (2004).
  • Epel, E.S., E.H. Blackburn, J. Lin, F. Dhabar, N. Adler, J. Morrow, and R. Cawthon. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA. 101: 17312-15 (2004).
  • Rivera, M.A. and E.H. Blackburn. Processive utilization of the human telomerase template: Lack of a requirement for template switching. J Biol Chem 279: 53770-53781 (2004).
  • Xu, L. and E.H. Blackburn. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol 167: 819-830 (2004).
  • Li, S., J. Crothers, C.M. Haqq and E.H. Blackburn. Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J. Biol. Chem. 280:23709-23717 (2005).
  • Ly, H., M. Schertzer, W. Jastaniah, J. Davis, S.-L. Yong, Q. Ouyang, E.H. Blackburn, T.G. Parslow and P.M Lansdorp. Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita Blood 106: 1246- 1252 (2005).
  • Epel, E.S., J. Lin, F.H. Wilhelm, O.M. Wolkowitz, R. Cawthon, N. Adler, C. Dolbier, W.B. Mendes, and E.H. Blackburn. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31: 277-287 (2006)
  • Goldkorn, A. and E.H. Blackburn. Assembly of mutant template telomerase RNA into catalytically active telomerase ribonucleoprotein at the telomere is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Research 66 (11):5763-71 (2006).
  • Bagheri S., Nosrati M., Li S., Fong S., Torabian S., Rangel J., Moore D.H., Feerman S., Laposa R.R., Baehner F.L., Sagebiel R.W., Cleaver J.E. Haqq C., Debs R.J. Blackburn E.H. and Kashani- Sabet M. Genes and pathways downstream of telomerase in melanoma metastasis. Proc. Natl. Acad. Sci. USA 103: 11306-11311 (2006).
  • Min Hsu, Michael J. McEachern, Alain T. Dandjinou, Yehuda Tzfati, Erica Orr, Elizabeth H. Blackburn, and Neal F. Lue Telomerase core components protect Candida telomeres from aberrant overhang accumulation, PNAS, 104(28):11682-7 (2007).
  • Njajou OT, Cawthon RM, Damcott CM, Wu S-H, Ott S, Garant MJ, Blackburn EH, Mitchell BD, Shuldiner AR, Hsueh W-C. Telomere length is paternally inherited and is associated with parental lifespan. PNAS, 104 (29):12135-9 (2007).
  • Xu, L, Blackburn, EH. Human Cancer Cells Harbor T-Stumps, a Prominent Novel Class of Extremely Short Telomeres. Molecular Cell 28 (2):315-27 (2007).
  • Makovets, S., Williams, T.L., and EH Blackburn. The telotype defines the telomere state in S. cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase. Genetics 78 (1):245-57 (2008).
  • Anderson, C.M., Korkin, D., Smith, D.L., Makovets, S., Seidel, J.J., Sali, A. and E.H. Blackburn. Tel2 mediates activation and localization of ATM/Tel1 kinase to sites of DNA damage. GenesDev 22 (7):854-9 (2008).
  • Stohr, B, E.H. Blackburn. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 68 (13):5309-17 (2008).
  • Seidel, J, Anderson, CM and E.H. Blackburn. A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response. Mol Cell Biol. 28 (18):5736-46 (2008).
  • Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, Magbanua MJ, Marlin R, Yglecias L, Carroll PR, Blackburn EH. Increased telomerase activity in a cohort undergoing comprehensive lifestyle changes. Lancet Oncol. 9 (11):1048-57 (2008).
  • Wang, XY, Kam, Z, Carlton, PM, Xu, L, Seday, JW and E.H. Blackburn. Rapid Telomere Motions in Live Human Cells Analyzed by Highly Time-Resolved Microscopy. Epigenetics and Chromatin 1 (1):4 (2008).
  • Anderson, C. and E.H. Blackburn. Mec1 function in the DNA damage response does not require its interaction with Tel2. Cell Cycle. 7 (23): 3695-8 (2008).
  • Kiefer, A, Lin, J, Blackburn, E, and Epel, E. Dietary Restraint and Telomere Length in Pre- and Postmenopausal Women. Psychosomatic Medicine. Psychosom Med. 70 (8):845-9 (2008).
  • Li, S, Makovets, S, Matsuguchi, T, Blethrow, JD, Shokat, KM, and E.H. Blackburn. Cdk1- dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 136: 50-61 (2009).
  • O’Donovan, A., Lin, J., Wolkowitz, O., Dhabhar, F.S., Tillie, J.M., Blackburn, E., and Epel, E. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post- menopausal women. Brain Behav Immun. 23(4):446-449 (2009).
  • Epel, ES, Merkin, SS, Cawthon, R, Blackburn, EH, Adler, NE, Pletcher, MJ and Seeman, TE. The Rate of Leukocyte Telomere Shortening Predicts Mortality from Cardiovascular Disease in Elderly Men. Aging. 1: 81- 88. (2009)

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  • Postings

    Professor, Departments of Biochemistry and Biophysics, and Microbiology and Immunology, University of California, San Francisco