Edmond H. Fischer

Edmond H. Fischer is a Swiss-American biochemist. He was awarded the Nobel Prize in Physiology or Medicine 1992. Fischer shared the prize with Edwin Krebs. Fischer and Krebs were awarded for their work on the process of reversible phosphorylation and explaining how reversible phosphorylation works as a switch to activate proteins and regulate various cellular processes. They worked on glycogen phosphorylase. It is an enzyme which has activation/inactivation triggered by hormones and calcium. During the process of working on the enzyme, they discovered reversible protein phosphorylation. Reversible phosphorylation controls a number of important metabolic processes.

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2000 Erskine Fellow, University of Canterbury, Christchurch, New Zealand

1995 Exemplary Research Award for Best Technology Transfer Grant, Colorado Advanced Software Institute, October

1994-1995 SEL Stiftungsprofessur, Technical University, Darmstadt, Germany

1994 Invited Fellow by the Japanese Government, Nara Institute of Science and Technology, October

1993 Boulder Faculty Assembly’s Excellence Award, CU-Boulder

1992 Nobel Prize in Physiology or Medicine

1989-1990 Faculty Fellowship, Council on Research and Creative Work, CU-Boulder

1982 ”Habilitation”-Scholarship, Deutsche Forschungsgemeinschaft, Carnegie Mellon University, Pittsburgh, PA

1979 Prize of the ”Friends of the University of Stuttgart” for an outstanding research paper

1977-1978 Postdoctoral Fellowship, German Academic Exchange Service, MIT, Cambridge, MA

1972-1973 Scholarship, German Academic Exchange Service, Univ. of California, Irvine, CA

1971-1972 Scholarship, German Academic Exchange Service, Univ. of British Columbia, Vancouver, Canada

1. Edmond H Fischer Phosphorylase and the origin of reversible protein phosphorylation. Biological chemistry 2010;391(2-3):131-7.

2. Edmond H Fischer Basic biological research at the dawn of a new century. Molecular neurobiology 2002;26(2-3):iii-vii.

3. D I Lurie; F Solca; E H Fischer; E W Rubel Tyrosine phosphatase SHP-1 immunoreactivity increases in a subset of astrocytes following deafferentation of the chicken auditory brainstem. The Journal of comparative neurology 2000;421(2):199-214.

4. W Maret; C Jacob; B L Vallee; E H Fischer Inhibitory sites in enzymes: zinc removal and reactivation by thionein. Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1936-40.

5. E H Fischer Cell signaling by protein tyrosine phosphorylation. Advances in enzyme regulation 1999;39():359-69.

6. E H Fischer; E W Davie Recent excitement regarding metallothionein. Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3333-4.

7. A A Reszka; J C Bulinski; E G Krebs; E H Fischer Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions. Molecular biology of the cell 1997;8(7):1219-32.

8. E H Fischer Cellular regulation by protein phosphorylation: a historical overview. BioFactors (Oxford, England) 1997;6(3):367-74.

9. H Eldar-Finkelman; G M Argast; O Foord; E H Fischer; E G Krebs Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells. Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10228-33.

10. Z Zhao; Z Tan; C D Diltz; M You; E H Fischer Activation of mitogen-activated protein (MAP) kinase pathway by pervanadate, a potent inhibitor of tyrosine phosphatases. The Journal of biological chemistry 1996;271(36):22251-5.

11. L G Borges; R A Seifert; F J Grant; C E Hart; C M Disteche; S Edelhoff; F F Solca; M A Lieberman; V Lindner; E H Fischer; et al. Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells. Circulation research 1996;79(3):570-80.

12. L Su; Z Zhao; P Bouchard; D Banville; E H Fischer; E G Krebs; S H Shen Positive effect of overexpressed protein-tyrosine phosphatase PTP1C on mitogen-activated signaling in 293 cells. The Journal of biological chemistry 1996;271(17):10385-90.

13. M Adachi; E H Fischer; J Ihle; K Imai; F Jirik; B Neel; T Pawson; S Shen; M Thomas; A Ullrich; et al. Mammalian SH2-containing protein tyrosine phosphatases. Cell 1996;85(1):15.

14. C L Law; S P Sidorenko; K A Chandran; Z Zhao; S H Shen; E H Fischer; E A Clark CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. The Journal of experimental medicine 1996;183(2):547-60.

15. J A Lorenzen; C Y Dadabay; E H Fischer COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus. The Journal of cell biology 1995;131(3):631-43.

16. A A Reszka; R Seger; C D Diltz; E G Krebs; E H Fischer Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8881-5.

17. Z Zhao; Z Tan; J H Wright; C D Diltz; S H Shen; E G Krebs; E H Fischer Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation. The Journal of biological chemistry 1995;270(20):11765-9.

18. F F Solca; D I Lurie; C D Diltz; R S Johnson; S Kumar; E W Rubel; E H Fischer Identification and purification of a chicken brain neuroglia-associated protein. The Journal of biological chemistry 1994;269(44):27559-65.

19. R Seger; D Seger; A A Reszka; E S Munar; H Eldar-Finkelman; G Dobrowolska; A M Jensen; J S Campbell; E H Fischer; E G Krebs Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. The Journal of biological chemistry 1994;269(41):25699-709.

20. P Bouchard; Z Zhao; D Banville; F Dumas; E H Fischer; S H Shen Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C. The Journal of biological chemistry 1994;269(30):19585-9.

21. M R Kuhné; Z Zhao; J Rowles; B E Lavan; S H Shen; E H Fischer; G E Lienhard Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C. The Journal of biological chemistry 1994;269(22):15833-7.

22. Z Zhao; S H Shen; E H Fischer Phorbol ester-induced expression, phosphorylation, and translocation of protein-tyrosine-phosphatase 1C in HL-60 cells. Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5007-11.

23. P Peraldi; Z Zhao; C Filloux; E H Fischer; E Van Obberghen Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5002-6.

24. G Daum; S Regenass; J Sap; J Schlessinger; E H Fischer Multiple forms of the human tyrosine phosphatase RPTP alpha. Isozymes and differences in glycosylation. The Journal of biological chemistry 1994;269(14):10524-8.

25. Z Zhao; R Larocque; W T Ho; E H Fischer; S H Shen Purification and characterization of PTP2C, a widely distributed protein tyrosine phosphatase containing two SH2 domains. The Journal of biological chemistry 1994;269(12):8780-5.

26. D E Cool; E H Fischer Protein tyrosine phosphatases in cell transformation. Seminars in cell biology 1993;4(6):443-53.

27. R Lammers; B Bossenmaier; D E Cool; N K Tonks; J Schlessinger; E H Fischer; A Ullrich Differential activities of protein tyrosine phosphatases in intact cells. The Journal of biological chemistry 1993;268(30):22456-62.

28. C V Johnson; D E Cool; M B Glaccum; N Green; E H Fischer; A Bruskin; D E Hill; J B Lawrence Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes. Genomics 1993;16(3):619-29.

29. G Daum; F Solca; C D Diltz; Z Zhao; D E Cool; E H Fischer A general peptide substrate for protein tyrosine phosphatases. Analytical biochemistry 1993;211(1):50-4.

30. Z Zhao; S H Shen; E H Fischer Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains. Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4251-5.

31. N F Zander; D E Cool; C D Diltz; L R Rohrschneider; E G Krebs; E H Fischer Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase. Oncogene 1993;8(5):1175-82.

32. S Ahmad; D Banville; Z Zhao; E H Fischer; S H Shen A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2197-201.

33. Z Zhao; P Bouchard; C D Diltz; S H Shen; E H Fischer Purification and characterization of a protein tyrosine phosphatase containing SH2 domains. The Journal of biological chemistry 1993;268(4):2816-20.

34. D E Cool; P R Andreassen; N K Tonks; E G Krebs; E H Fischer; R L Margolis Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5422-6.

35. Z Zhao; N F Zander; D A Malencik; S R Anderson; E H Fischer Continuous spectrophotometric assay of protein tyrosine phosphatase using phosphotyrosine. Analytical biochemistry 1992;202(2):361-6.

36. D Rotin; B Margolis; M Mohammadi; R J Daly; G Daum; N Li; E H Fischer; W H Burgess; A Ullrich; J Schlessinger SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. The EMBO journal 1992;11(2):559-67.

37. E H Fischer; H Charbonneau; D E Cool; N K Tonks Tyrosine phosphatases and their possible interplay with tyrosine kinases. Ciba Foundation symposium 1992;164():132-40; discussion 140-4.

38. E H Fischer; H Charbonneau; N K Tonks Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science (New York, N.Y.) 1991;253(5018):401-6.

39. N F Zander; J A Lorenzen; D E Cool; N K Tonks; G Daum; E G Krebs; E H Fischer Purification and characterization of a human recombinant T-cell protein-tyrosine-phosphatase from a baculovirus expression system. Biochemistry 1991;30(28):6964-70.

40. G Daum; N F Zander; B Morse; D Hurwitz; J Schlessinger; E H Fischer Characterization of a human recombinant receptor-linked protein tyrosine phosphatase. The Journal of biological chemistry 1991;266(19):12211-5.

41. N K Tonks; C D Diltz; E H Fischer Purification and assay of CD45: an integral membrane protein-tyrosine phosphatase. Methods in enzymology 1991;201():442-51.

42. N K Tonks; C D Diltz; E H Fischer Purification of protein-tyrosine phosphatases from human placenta. Methods in enzymology 1991;201():427-42.

43. T A Haystead; J E Weiel; D W Litchfield; Y Tsukitani; E H Fischer; E G Krebs Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. The Journal of biological chemistry 1990;265(27):16571-80.

44. D E Cool; N K Tonks; H Charbonneau; E H Fischer; E G Krebs Expression of a human T-cell protein-tyrosine-phosphatase in baby hamster kidney cells. Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7280-4.

45. W R Harris; D A Malencik; C M Johnson; S A Carr; G D Roberts; C A Byles; S R Anderson; L M Heilmeyer; E H Fischer; J W Crabb Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain. The Journal of biological chemistry 1990;265(20):11740-5.

46. M F Cicirelli; N K Tonks; C D Diltz; J E Weiel; E H Fischer; E G Krebs Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5514-8.

47. N K Tonks; C D Diltz; E H Fischer CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity. The Journal of biological chemistry 1990;265(18):10674-80.

48. N K Tonks; M F Cicirelli; C D Diltz; E G Krebs; E H Fischer Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes. Molecular and cellular biology 1990;10(2):458-63.

49. E H Fischer; N K Tonks; H Charbonneau; M F Cicirelli; D E Cool; C D Diltz; E G Krebs; K A Walsh Protein tyrosine phosphatases: a novel family of enzymes involved in transmembrane signalling. Advances in second messenger and phosphoprotein research 1990;24():273-9.

50. F Bussolino; E Fischer; F Turrini; M D Kazatchkine; P Arese Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1). The Journal of biological chemistry 1989;264(36):21711-9.

51. K M Lerea; N K Tonks; E G Krebs; E H Fischer; J A Glomset Vanadate and molybdate increase tyrosine phosphorylation in a 50-kilodalton protein and stimulate secretion in electropermeabilized platelets. Biochemistry 1989;28(24):9286-92.

52. D E Cool; N K Tonks; H Charbonneau; K A Walsh; E H Fischer; E G Krebs cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5257-61.

53. H Charbonneau; N K Tonks; S Kumar; C D Diltz; M Harrylock; D E Cool; E G Krebs; E H Fischer; K A Walsh Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5252-6.

54. E G Krebs; E H Fischer The phosphorylase b to a converting enzyme of rabbit skeletal muscle. 1956. Biochimica et biophysica acta 1989;1000():302-9.

55. E H Fischer; E G Krebs Commentary on ’The Phosphorylase b to a Converting Enzyme of Rabbit Skeletal Muscle”. Biochimica et biophysica acta 1989;1000():297-301.

56. N K Tonks; H Charbonneau; C D Diltz; E H Fischer; K A Walsh Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase. Biochemistry 1988;27(24):8695-701.

57. J A Ledbetter; N K Tonks; E H Fischer; E A Clark CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells. Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8628-32.

58. H Charbonneau; N K Tonks; K A Walsh; E H Fischer The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7182-6.

59. C P Chan; S J McNall; E G Krebs; E H Fischer Stimulation of protein phosphatase activity by insulin and growth factors in 3T3 cells. Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6257-61.

60. N K Tonks; C D Diltz; E H Fischer Characterization of the major protein-tyrosine-phosphatases of human placenta. The Journal of biological chemistry 1988;263(14):6731-7.

61. N K Tonks; C D Diltz; E H Fischer Purification of the major protein-tyrosine-phosphatases of human placenta. The Journal of biological chemistry 1988;263(14):6722-30.

62. S J McNall; E H Fischer Phosphorylase phosphatase. Comparison of active forms using peptide substrates. The Journal of biological chemistry 1988;263(4):1893-7.

63. S J McNall; L M Ballou; E Villa-Moruzzi; E H Fischer Purification and characterization of phosphorylase phosphatase from rabbit skeletal muscle. Methods in enzymology 1988;159():377-90.

64. E C Alvord; U Jahnke; E H Fischer; M W Kies; B F Driscoll; D A Compston The multiple causes of multiple sclerosis: the importance of age of infections in childhood. Journal of child neurology 1987;2(4):313-21.

65. E C Alvord; U Jahnke; E H Fischer The causes of the syndromes of Landry (1859) and of Guillain, Barré and Strohl (1916). Revue neurologique 1987;143(8-9):571-9.

66. D A Malencik; J D Scott; E H Fischer; E G Krebs; S R Anderson Association of calmodulin with peptide analogues of the inhibitory region of the heat-stable protein inhibitor of adenosine cyclic 3’,5’-phosphate dependent protein kinase. Biochemistry 1986;25(12):3502-08.

67. J D Scott; M B Glaccum; E H Fischer; E G Krebs Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1613-6.

68. J D Scott; E H Fischer; K Takio; J G Demaille; E G Krebs Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 1985;82(17):5732-6.

69. U Jahnke; E H Fischer; E C Alvord Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis. Science (New York, N.Y.) 1985;229(4710):282-4.

70. J D Scott; E H Fischer; J G Demaille; E G Krebs Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 1985;82(13):4379-83.

71. L M Ballou; E Villa-Moruzzi; E H Fischer Subunit structure and regulation of phosphorylase phosphatase. Current topics in cellular regulation 1985;27():183-92.

72. E M Reimann; K Titani; L H Ericsson; R D Wade; E H Fischer; K A Walsh Homology of the gamma subunit of phosphorylase b kinase with cAMP-dependent protein kinase. Biochemistry 1984;23(18):4185-92.

73. E Villa-Moruzzi; L M Ballou; E H Fischer Phosphorylase phosphatase. Interconversion of active and inactive forms. The Journal of biological chemistry 1984;259(9):5857-63.

74. S Shoji; L H Ericsson; K A Walsh; E H Fischer; K Titani Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3’,5’-phosphate dependent protein kinase. Biochemistry 1983;22(15):3702-9.

75. L M Ballou; D L Brautigan; E H Fischer Subunit structure and activation of inactive phosphorylase phosphatase. Biochemistry 1983;22(14):3393-9.

76. D Job; C T Rauch; E H Fischer; R L Margolis Regulation of microtubule cold stability by calmodulin-dependent and -independent phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):3894-8.

77. E A Boeker; E H Fischer Lysine decarboxylase (Escherichia coli B). Methods in enzymology 1983;94():180-4.

78. E E Bittar; G Chambers; E H Fischer The influence of injected cyclic AMP protein kinase catalytic subunit on the sodium efflux in barnacle muscle fibres. The Journal of physiology 1982;333():39-52.

79. D L Brautigan; B S Khatra; T R Soderling; E H Fischer Dephosphorylation of skeletal muscle phosphorylase, glycogen synthase, and phosphorylase kinase beta-subunit by a Mn2+-activated protein phosphatase. Archives of biochemistry and biophysics 1982;219(1):228-35.

80. J L Bohnert; D A Malencik; S R Anderson; D Teller; E H Fischer Binding of 5,5’-bis[8-(phenylamino)-1-naphthalenesulfonate] by the regulatory subunits of adenosine cyclic 3’,5’-phosphate dependent protein kinase. Biochemistry 1982;21(22):5570-6.

81. J L Bohnert; D A Malencik; S R Anderson; D Teller; E H Fischer Reconstitution of types I and II adenosine cyclic 3’,5’-phosphate dependent protein kinase. Biochemistry 1982;21(22):5563-70.

82. T Sasagawa; L H Ericsson; K A Walsh; W E Schreiber; E H Fischer; K Titani Complete amino acid sequence of human brain calmodulin. Biochemistry 1982;21(10):2565-9.

83. D L Brautigan; L M Ballou; E H Fischer Activation of skeletal muscle phosphorylase phosphatase. Effects of proteolysis and divalent cations. Biochemistry 1982;21(9):1977-82.

84. D Burger; J A Cox; E H Fischer; E A Stein The activation of rabbit skeletal muscle phosphorylase kinase requires the binding of 3 Ca2+ per delta subunit. Biochemical and biophysical research communications 1982;105(2):632-8.

85. D Job; C T Rauch; E H Fischer; R L Margolis Recycling of cold-stable microtubules: evidence that cold stability is due to substoichiometric polymer blocks. Biochemistry 1982;21(3):509-15.

86. S Pocinwong; H Blum; D Malencik; E H Fischer Phosphorylase kinase from dogfish skeletal muscle. Purification and properties. Biochemistry 1981;20(25):7219-26.

87. W E Schreiber; T Sasagawa; K Titani; R D Wade; D Malencik; E H Fischer Human brain calmodulin: isolation, characterization, and sequence of a half-molecule fragment. Biochemistry 1981;20(18):5239-45.

88. D Job; E H Fischer; R L Margolis Rapid disassembly of cold-stable microtubules by calmodulin. Proceedings of the National Academy of Sciences of the United States of America 1981;78(8):4679-82.

89. W E Schreiber; R Gentry; E H Fischer Calmodulin and cyclic nucleotide phosphodiesterase activities in erythrocytes from normal and schizophrenic subjects. Biochemical and biophysical research communications 1981;100(3):1415-21.

90. D Huchon; R Ozon; E H Fischer; J G Demaille The pure inhibitor of cAMP-dependent protein kinase initiates Xenopus laevis meiotic maturation. A 4-step scheme for meiotic maturation. Molecular and cellular endocrinology 1981;22(2):211-22.

91. S Shoji; D C Parmelee; R D Wade; S Kumar; L H Ericsson; K A Walsh; H Neurath; G L Long; J G Demaille; E H Fischer; et al. Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):848-51.

92. D Huchon; R Ozon; E H Fischer; J G Demaille [Meiotic maturation of the ovocyte of Xenopus laevis : a 4-step mechanism]. Comptes rendus des séances de l’Académie des sciences. Série III, Sciences de la vie 1981;292(1):65-7.

93. D L Brautigan; C Picton; E H Fischer Phosphorylase phosphatase complex from skeletal muscle. Activation of one of two catalytic subunits by manganese ions. Biochemistry 1980;19(25):5787-94.

94. W G Kerrick; D A Malencik; P E Hoar; J D Potter; R L Coby; S Pocinwong; E H Fischer Ca2+ and Sr2+ activation: comparison of cardiac and skeletal muscle contraction models. Pflügers Archiv : European journal of physiology 1980;386(3):207-13.

95. D L Brautigan; W G Kerrick; E H Fischer Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned muscle fibers. Proceedings of the National Academy of Sciences of the United States of America 1980;77(2):936-9.

96. C J Le Peuch; C Ferraz; M P Walsh; J G Demaille; E H Fischer Calcium and cyclic nucleotide dependent regulatory mechanisms during development of chick embryo skeletal muscle. Biochemistry 1979;18(24):5267-73.

97. E E Bittar; J Demaille; E H Fischer; R Schultz Mode of stimulation by injection of cyclic AMP and external acidification of the sodium efflux in barnacle muscle fibres. The Journal of physiology 1979;296():277-89.

98. J G Demaille; C Ferraz; E H Fischer The protein inhibitor of adenosine 3’,5’-monophosphate-dependent protein kinases. The NH2-terminal portion of the peptide chain contains the inhibitory site. Biochimica et biophysica acta 1979;586(2):374-83.

99. S Shoji; K Titani; J G Demaille; E H Fischer Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3’:5’-monophosphate-dependent protein kinase. The Journal of biological chemistry 1979;254(14):6211-4.

100. W G Kerrick; P E Hoar; D A Malencik; L Stamps; E H Fischer Characterization of Ca2+- and Sr2+-activated tension in functionally skinned chicken fibers of normal and dystrophic skeletal and normal cardiac muscle. Pflügers Archiv : European journal of physiology 1979;381(1):53-62.

101. H J Moeschler; D A Malencik; S Pocinwong; O Alaba; G L Kerrick; E H Fischer Exchange of calcium between muscle Ca2+-binding proteins. Biochimie 1979;61(5-6):615-24.

102. K Titani; A Koide; L H Ericsson; S Kumar; J Hermann; R D Wade; K A Walsh; H Neurath; E H Fischer Sequence of the carboxyl-terminal 492 residues of rabbit muscle glycogen phosphorylase including the pyridoxal 5’-phosphate binding site. Biochemistry 1978;17(26):5680-93.

103. J G Demaille; K A Peters; T P Strandjord; E H Fischer Isolation and properties of the bovine brain protein inhibitor of adenosine 3’:5’-monophosphate-dependent protein kinases. FEBS letters 1978;86(1):113-6.

104. K A Peters; J G Demaille; E H Fischer Adenosine 3’:5’-monophosphate dependent protein kinase from bovine heart. Characterization of the catalytic subunit. Biochemistry 1977;16(26):5691-7.

105. K Titani; A Koide; J Hermann; L H Ericsson; S Kumar; R D Wade; K A Walsh; H Neurath; E H Fischer Complete amino acid sequence of rabbit muscle glycogen phosphorylase. Proceedings of the National Academy of Sciences of the United States of America 1977;74(11):4762-6.

106. T C Detwiler; D Gratecos; E H Fischer Rabbit muscle phosphorylase phosphatase. 2. Kinetic properties and behavior in glycogen particles. Biochemistry 1977;16(22):4818-23.

107. D Gratecos; T C Detwiler; S Hurd; E H Fischer Rabbit muscle phosphorylase phosphatase. 1. Purification and chemical properties. Biochemistry 1977;16(22):4812-7.

108. P Lehky; M Comte; E H Fischer; E A Stein A new solid-phase chelator with high affinity and selectivity for calcium: parvalbumin-polyacrylamide. Analytical biochemistry 1977;82(1):158-69.

109. J G Demaille; K A Peters; E H Fischer Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3’,5’-monophosphate dependent protein kinases. Biochemistry 1977;16(14):3080-6.

110. H E Blum; P Lehky; L Kohler; E A Stein; E H Fischer Comparative properties of vertebrate parvalbumins. The Journal of biological chemistry 1977;252(9):2834-8.

111. J U Becker; T J Long; E H Fischer Purification and properties of debranching enzyme from dogfish muscle. Biochemistry 1977;16(2):291-7.

112. J Demaille; E Dutruge; G Baron; J F Pechère; E H Fischer A reappraisal of the relationship of phosphate-acceptor protein to parvalbumins. Biochemical and biophysical research communications 1975;67(3):1034-40.

113. D Applebaum; D L Sabo; E H Fischer; D R Morris Biodegradative ornithine decarboxylase of Escherichia coli. Purification, properties, and pyridoxal 5’-phosphate binding site. Biochemistry 1975;14(16):3675-81.

114. K Lerch; E H Fischer Amino acid sequence of two functional sites in yeast glycogen phosphorylase. Biochemistry 1975;14(9):2009-14.

115. K Lerch; L W Muir; E H Fischer Purification and properties of a yeast protein kinase. Biochemistry 1975;14(9):2015-23.

116. E H Fischer; J U Becker; H E Blum; P Lehky; D A Malencik; S Pocinwong Proceedings: Concerted regulation of carbohydrate metabolism and muscle contraction. Hoppe-Seyler’s Zeitschrift für physiologische Chemie 1975;356(4):381.

117. D L Enfield; L H Ericsson; H E Blum; E H Fischer; H Neurath Amino-acid sequence of parvalbumin from rabbit skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 1975;72(4):1309-13.

118. D A Malencik; C W Heizmann; E H Fischer Structural proteins of dogfish skeletal muscle. Biochemistry 1975;14(4):715-21.

119. P Lehky; H E Blum; E A Stein; E H Fischer Isolation and characterization of parvalbumins from the skeletal muscle of higher vertebrates. The Journal of biological chemistry 1974;249(13):4332-4.

120. D Gratecos; E H Fischer Adenosine 5’-O(3-thiotriphosphate) in the control of phosphorylase activity. Biochemical and biophysical research communications 1974;58(4):960-7.

121. H E Blum; S Pocinwong; E H Fischer A phosphate-acceptor protein related to parvalbumins in dogfish skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 1974;71(6):2198-2202.

122. J M Vidgoff; A Pocker; T L Hullar; E H Fischer Interaction of muscle glycogen phosphorylase with pyridoxal 5’-methylenephosphonate. Biochemical and biophysical research communications 1974;57(4):1166-74.

123. C W Heizmann; D A Malencik; E H Fischer Generation of parvalbumin-like proteins from troponin. Biochemical and biophysical research communications 1974;57(1):162-8.

124. D L Sabo; E H Fischer Chemical properties of Escherichia coli lysine decarboxylase including a segment of its pyridoxal 5’-phosphate binding site. Biochemistry 1974;13(4):670-6.

125. P Cohen; J C Saari; E H Fischer Comparative study of dogfish and rabbit muscle phosphorylases. Biochemistry 1973;12(26):5233-41.

126. J C Saari; E H Fischer Cyanogen bromide peptides of rabbit muscle glycogen phosphorylase. Biochemistry 1973;12(26):5225-32.

127. E A Boeker; E H Fischer; E E Snell Arginine decarboxylase from Escherichia coli. IV. Structure of the pyridoxal phosphate binding site. The Journal of biological chemistry 1971;246(22):6776-81.

128. M Fosset; L W Muir; L D Nielsen; E H Fischer Purification and properties of yeast glycogen phosphorylase a and b. Biochemistry 1971;10(22):4105-13.

129. A W Forrey; C L Sevilla; J C Saari; E H Fischer Sequence of a segment of muscle glycogen phosphorylase containing the pyridoxal 5’-phosphate binding site. Biochemistry 1971;10(16):3132-40.

130. P Cohen; T Duewer; E H Fischer Phosphorylase from dogfish skeletal muscle. Purification and a comparison of its physical properties to those of rabbit muscle phosphorylase. Biochemistry 1971;10(14):2683-94.

131. D A Walsh; C D Ashby; C Gonzalez; D Calkins; E H Fischer Krebs EG: Purification and characterization of a protein inhibitor of adenosine 3’,5’-monophosphate-dependent protein kinases. The Journal of biological chemistry 1971;246(7):1977-85.

132. A W Forrey; R B Olsgaard; C Nolan; E H Fischer Synthesis and properties of alpha and epsilon pyridoxyl lysines and their phosphorylated derivatives. Biochimie 1971;53(3):269-81.

133. H Wacker; P Lehky; E H Fischer; E A Stein Physical and chemical characterization of pig kidney particulate aminopeptidase. Helvetica chimica acta 1971;54(2):473-85.

134. R H Haschke; L M Heilmeyer; F Meyer; E H Fischer Control of phosphorylase activity in a muscle glycogen particle. 3. Regulation of phosphorylase phosphatase. The Journal of biological chemistry 1970;245(24):6657-63.

135. L M Heilmeyer; F Meyer; R H Haschke; E H Fischer Control of phosphorylase activity in a muscle glycogen particle. II. Activation by calcium. The Journal of biological chemistry 1970;245(24):6649-56.

136. F Meyer; L M Heilmeyer; R H Haschke; E H Fischer Control of phosphorylase activity in a muscle glycogen particle. I. Isolation and characterization of the protein-glycogen complex. The Journal of biological chemistry 1970;245(24):6642-8.

137. V L Seery; E H Fischer; D C Teller Subunit structure of glycogen phosphorylase. Biochemistry 1970;9(18):3591-8.

138. E Y Lee; J H Carter; L D Nielsen; E H Fischer Purification and properties of yeast amylo-1,6-glucosidase–oligo-1,4 leads to 1,4-glucantransferase. Biochemistry 1970;9(11):2347-55.

139. D P Wolf; E H Fischer; E G Krebs Amino acid sequence of the phosphorylated site in rabbit liver glycogen phosphorylase. Biochemistry 1970;9(9):1923-9.

140. P H Strausbauch; E H Fischer Structure of the binding site of pyridoxal 5’-phosphate to Escherichia coli glutamate decarboxylase. Biochemistry 1970;9(2):233-8.

141. P H Strausbauch; E H Fischer Chemical and physical properties of Escherichia coli glutamate decarboxylase. Biochemistry 1970;9(2):226-33.

142. E H Fischer; A Pocker; J C Saari The structure, function and control of glycogen phosphorylase. Essays in biochemistry 1970;6():23-68.

143. S Shaltiel; J L Hedrick; A Pocker; E H Fischer Reconstitution of apophosphorylase with pyridoxal 5’-phosphate analogs. Biochemistry 1969;8(12):5189-96.

144. A Pocker; E H Fischer Synthesis of analogs of pyridoxal 5’-phosphate. Biochemistry 1969;8(12):5181-8.

145. S Shaltiel; J L Hedrick; E H Fischer Stereospecific requirements for carbonyl reagents in the resolution and reconstitution of phosphorylase b. Biochemistry 1969;8(6):2429-36.

146. J L Hedrick; S Shaltiel; E H Fischer Conformation changes and the mechanism of resolution of glycogen phosphorylase b. Biochemistry 1969;8(6):2422-9.

147. C L Sevilla; E H Fischer The purification and properties of rat muscle glycogen phosphorylase. Biochemistry 1969;8(5):2161-71.

148. E H Fischer; S S Hurd; P Koh; D Teller The activation and inactivation of muscle phosphorylase. National Cancer Institute monograph 1967;27():47-59.

149. V L Seery; E H Fischer; D C Teller A reinvestigation of the molecular weight of glycogen phosphorylase. Biochemistry 1967;6(10):3315-27.

150. E Y Lee; L D Nielsen; E H Fischer A new glycogen-debranching enzyme system in yeast. Archives of biochemistry and biophysics 1967;121(1):245-6.

151. E H Fischer; E G Krebs Relationship of structure to function of muscle phosphorylase. Federation proceedings 1966;25(5):1511-20.

152. S S Hurd; D Teller; E H Fischer Probable formation of partially phosphorylated intermediates in the interconversions of phosphorylase A and B. Biochemical and biophysical research communications 1966;24(1):79-84.

153. J L Hedrick; S Shaltliel; E H Fischer On the role of pyridoxal 5’-phosphate in phosphorylase. 3. Physicochemical properties and reconstitution of apophosphorylase b. Biochemistry 1966;5(6):2117-25.

154. S Shaltiel; J L Hedrick; E H Fischer On the role of pyridoxal 5’-phosphate in phosphorylase. II. Resolution of rabbit muscle phosphorylase b. Biochemistry 1966;5(6):2108-16.

155. M M Appleman; E G Krebs; E H Fischer Purification and properties of inactive liver phosphorylase. Biochemistry 1966;5(6):2101-7.

156. J L Hedrick; E H Fischer On the role of pyridoxal 5’-phosphate in phosphorylase. I. Absence of classical vitamin B6–dependent enzymatic activities in muscle glycogen phosphorylase. Biochemistry 1965;4(7):1337-43.

157. W L MEYER; E H FISCHER; E G KREBS ACTIVATION OF SKELETAL MUSCLE PHOSPHORYLASE B KINASE BY CA. Biochemistry 1964;3():1033-9.

158. E G KREBS; D S LOVE; G E BRATVOLD; K A TRAYSER; W L MEYER; E H FISCHER PURIFICATION AND PROPERTIES OF RABBIT SKELETAL MUSCLE PHOSPHORYLASE B KINASE. Biochemistry 1964;3():1022-33.

159. C NOLAN; W B NOVOA; E G KREBS; E H FISCHER FURTHER STUDIES ON THE SITE PHOSPHORYLATED IN THE PHOSPHORYLASE B TO A REACTION. Biochemistry 1964;3():542-51.

160. E A STEIN; J HSIU; E H FISCHER ALPHA-AMYLASES AS CALCIUM-METALLOENZYMES. I. PREPARATION OF CALCIUM-FREE APOAMYLASES BY CHELATION AND ELECTRODIALYSIS. Biochemistry 1964;3():56-61.

161. M M APPLEMAN; A A YUNIS; E G KREBS; E H FISCHER Comparative studies on glycogen phosphorylase. V. The amino acid composition of rabbit and human skeletal muscle phosphorylase. The Journal of biological chemistry 1963;238():1358-61.

162. A A YUNIS; E H FISCHER; E G KREBS Comparative studies on glycogen phosphorylase. IV. Purification and properties of rabbit heart phosphorylase. The Journal of biological chemistry 1962;237():2809-15.

163. E G KREBS; E H FISCHER Molecular properties and transformations of glycogen phosphorylase in animal tissues. Advances in enzymology and related subjects of biochemistry 1962;24():263-90.

164. R C HUGHES; A A YUNIS; E G KREBS; E H FISCHER Comparative studies on glycogen phosphorylase. III. The phosphorylated site in human muscle phosphorylase alpha. The Journal of biological chemistry 1962;237():40-3.

165. A A YUNIS; E H FISCHER; E G KREBS Crystallization and properties of human muscle phosphorylases a and b. The Journal of biological chemistry 1960;235():3163-8.

166. E G KREBS; E H FISCHER The role of metals in the activation of muscle phosphorylase. Annals of the New York Academy of Sciences 1960;88():378-84.

167. D J GRAVES; E H FISCHER; E G KREBS Specificity studies on muscle phosphorylase phosphatase. The Journal of biological chemistry 1960;235():805-9.

168. E G KREBS; D J GRAVES; E H FISCHER Factors affecting the activity of muscle phosphorylase b kinase. The Journal of biological chemistry 1959;234():2867-73.

169. E H FISCHER; D J GRAVES; E R S CRITTENDEN; E G KREBS Structure of the site phosphorylated in the phosphorylase b to a reaction. The Journal of biological chemistry 1959;234(7):1698-704.

170. A B KENT; E G KREBS; E H FISCHER Properties of crystalline phosphorylase b. The Journal of biological chemistry 1958;232(1):549-58.

171. E G KREBS; A B KENT; E H FISCHER The muscle phosphorylase b kinase reaction. The Journal of biological chemistry 1958;231(1):73-83.

172. E H FISCHER; E G KREBS The isolation and crystallization of rabbit skeletal muscle phosphorylase b. The Journal of biological chemistry 1958;231(1):65-71.

173. E G KREBS; E H FISCHER The phosphorylase b to a converting enzyme of rabbit skeletal muscle. Biochimica et biophysica acta 1956;20(1):150-7.

174. E H FISCHER; E G KREBS Conversion of phosphorylase b to phosphorylase a in muscle extracts. The Journal of biological chemistry 1955;216(1):121-32.

175. E G KREBS; E H FISCHER Phosphorylase activity of skeletal muscle extracts. The Journal of biological chemistry 1955;216(1):113-20.

176. E H FISCHER; H M HILPERT Purification of potato phosphorylase. Experientia 1953;9(5):176-7.



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  • Postings

    Professor Emeritus of Biochemistry
    University of Washington