1995 National Medal of Science
1989 Nobel Prize in Chemistry
1988 Heineken Prize
1987 U.S. Steel Award in Molecular Biology
1985 Pfizer Award in Enzyme Chemistry
1980 USPHS Research Career Development Award
1. Berman Andrea J; Gooding Anne R; Cech Thomas R. Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Molecular and cellular biology 2010;30(20):4965-76.
2. Qiao Feng; Goodrich Karen J; Cech Thomas R. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4914-8.
3. Zaug Arthur J; Podell Elaine R; Nandakumar Jayakrishnan; Cech Thomas R. Functional interaction between telomere protein TPP1 and telomerase. Genes & development 2010;24(6):613-22.
4. Latrick Chrysa M; Cech Thomas R. POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. The EMBO journal 2010;29(5):924-33.
5. Nandakumar Jayakrishnan; Podell Elaine R; Cech Thomas R. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):651-6.
6. Cech Thomas R. Crawling out of the RNA world. Cell 2009;136(4):599-602.
7. Vicens Quentin; Cech Thomas R. A natural ribozyme with 3’,5’ RNA ligase activity. Nature chemical biology 2009;5(2):97-9.
8. Zappulla David C; Roberts Jennifer N; Goodrich Karen J; Cech Thomas R.; Wuttke Deborah S Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic acids research 2009;37(2):354-67.
9. Cech T R Evolution of biological catalysis: ribozyme to RNP enzyme. Cold Spring Harbor symposia on quantitative biology 2009;74():11-6.
10. Vicens Quentin; Paukstelis Paul J; Westhof Eric; Lambowitz Alan M; Cech Thomas R. Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA (New York, N.Y.) 2008;14(10):2013-29.
11. Zaug Arthur J; Podell Elaine R; Cech Thomas R. Mutation in TERT separates processivity from anchor-site function. Nature structural & molecular biology 2008;15(8):870-2.
12. Qiao Feng; Cech Thomas R. Triple-helix structure in telomerase RNA contributes to catalysis. Nature structural & molecular biology 2008;15(6):634-40.
13. Mozdy Amy D; Podell Elaine R; Cech Thomas R. Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Molecular and cellular biology 2008;28(12):4152-61.
14. Arai Ken-ichi; Cech Thomas; Chameau Jean-Lou; Horn Paul; Mattaj Iain; Potocnik Janez; Wiley John The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century? EMBO reports 2007;8(9):804-10.
15. Cech Tom; Dixon Jack; Meehan Avice; Briggs Josie; Rhodes Carl A reply from HHMI. The Journal of experimental medicine 2007;204(8):1731; author reply 1731.
16. Cech Tom; Dixon Jack; Meehan Avice; Briggs Josie; Rhodes Carl A reply from Howard Hughes Medical Institute (HHMI). The Journal of cell biology 2007;178(3):343; discussion 343.
17. Cech Thomas R. On the occasion of the 25th anniversary of the discovery of catalytic RNA. Biological chemistry 2007;388(7):661-2.
18. Vicens Quentin; Gooding Anne R; Laederach Alain; Cech Thomas R. Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA (New York, N.Y.) 2007;13(4):536-48.
19. Wang Feng; Podell Elaine R; Zaug Arthur J; Yang Yuting; Baciu Paul; Cech Thomas R.; Lei Ming The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 2007;445(7127):506-10.
20. Mozdy Amy D; Cech Thomas R. Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency. RNA (New York, N.Y.) 2006;12(9):1721-37.
21. Jacobs Steven A; Podell Elaine R; Cech Thomas R. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nature structural & molecular biology 2006;13(3):218-25.
22. Guo Feng; Gooding Anne R; Cech Thomas R. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA (New York, N.Y.) 2006;12(3):387-95.
23. Vicens Quentin; Cech Thomas R. Atomic level architecture of group I introns revealed. Trends in biochemical sciences 2006;31(1):41-51.
24. Zappulla D C; Cech T R RNA as a flexible scaffold for proteins: yeast telomerase and beyond. Cold Spring Harbor symposia on quantitative biology 2006;71():217-24.
25. Cech Thomas; Kennedy Donald Doing more for Kate. Science (New York, N.Y.) 2005;310(5755):1741.
26. Cech Tom Meeting a fork in the road: an interview with Tom Cech. Interview by Jane Gitschier. PLoS genetics 2005;1(6):e76.
27. Zappulla David C; Goodrich Karen; Cech Thomas R. A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nature structural & molecular biology 2005;12(12):1072-7.
28. Cech Thomas R. Fostering innovation and discovery in biomedical research. JAMA : the journal of the American Medical Association 2005;294(11):1390-3.
29. Opresko Patricia L; Mason Penelope A; Podell Elaine R; Lei Ming; Hickson Ian D; Cech Thomas R.; Bohr Vilhelm A POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. The Journal of biological chemistry 2005;280(37):32069-80.
30. Zaug Arthur J; Podell Elaine R; Cech Thomas R. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10864-9.
31. Jacobs Steven A; Podell Elaine R; Wuttke Deborah S; Cech Thomas R. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein science : a publication of the Protein Society 2005;14(8):2051-8.
32. Lei Ming; Zaug Arthur J; Podell Elaine R; Cech Thomas R. Switching human telomerase on and off with hPOT1 protein in vitro. The Journal of biological chemistry 2005;280(21):20449-56.
33. Mandell Jeffrey G; Goodrich Karen J; Bähler Jürg; Cech Thomas R. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. The Journal of biological chemistry 2005;280(7):5249-57.
34. Mandell Jeffrey G; Bähler Jürg; Volpe Thomas A; Martienssen Robert A; Cech Thomas R. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome biology 2005;6(1):R1.
35. Cech Thomas R.; Rubin Gerald M Nurturing interdisciplinary research. Nature structural & molecular biology 2004;11(12):1166-9.
36. Lei Ming; Podell Elaine R; Cech Thomas R. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nature structural & molecular biology 2004;11(12):1223-9.
37. Guo Feng; Gooding Anne R; Cech Thomas R. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Molecular cell 2004;16(3):351-62.
38. Cech Thomas R. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Bioscience reports 2004;24(4-5):362-85.
39. Zappulla David C; Cech Thomas R. Yeast telomerase RNA: a flexible scaffold for protein subunits. Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10024-9.
40. Aigner Stefan; Cech Thomas R. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA (New York, N.Y.) 2004;10(7):1108-18.
41. Cech Thomas R.; Bond Enriqueta Managing your own lab. Science (New York, N.Y.) 2004;304(5678):1717.
42. Cech Thomas R. RNA finds a simpler way. Nature 2004;428(6980):263-4.
43. Cech Thomas R. Beginning to understand the end of the chromosome. Cell 2004;116(2):273-9.
44. Bryan Tracy M; Goodrich Karen J; Cech Thomas R. Tetrahymena telomerase is active as a monomer. Molecular biology of the cell 2003;14(12):4794-804.
45. Lei Ming; Podell Elaine R; Baumann Peter; Cech Thomas R. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature 2003;426(6963):198-203.
46. Seto Anita G; Umansky Kfir; Tzfati Yehuda; Zaug Arthur J; Blackburn Elizabeth H; Cech Thomas R. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA (New York, N.Y.) 2003;9(11):1323-32.
47. Classen Scott; Lyons Dan; Cech Thomas R.; Schultz Steve C Sequence-specific and 3’-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit. Biochemistry 2003;42(31):9269-77.
48. Colgin Lorel M; Baran Katherine; Baumann Peter; Cech Thomas R.; Reddel Roger R Human POT1 facilitates telomere elongation by telomerase. Current biology : CB 2003;13(11):942-6.
49. Aigner Stefan; Postberg Jan; Lipps Hans J; Cech Thomas R. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry 2003;42(19):5736-47.
50. Cech Thomas R.; Eddy Sean R; Eisenberg David; Hersey Karen; Holtzman Steven H; Poste George H; Raikhel Natasha V; Scheller Richard H; Singer David B; Waltham Mary C; Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant physiology 2003;132(1):19-24.
51. Förstemann Klaus; Zaug Arthur J; Cech Thomas R.; Lingner Joachim Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic acids research 2003;31(6):1646-55.
52. Cech Thomas R. Rebalancing teaching and research. Science (New York, N.Y.) 2003;299(5604):165.
53. Friedman Katherine L; Heit Jeremy J; Long David M; Cech Thomas R. N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex. Molecular biology of the cell 2003;14(1):1-13.
54. Lei Ming; Baumann Peter; Cech Thomas R. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry 2002;41(49):14560-8.
55. Seto Anita G; Livengood April J; Tzfati Yehuda; Blackburn Elizabeth H; Cech Thomas R. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes & development 2002;16(21):2800-12.
56. Cech T R Ribozymes, the first 20 years. Biochemical Society transactions 2002;30(Pt 6):1162-6.
57. Baumann Peter; Podell Elaine; Cech Thomas R. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Molecular and cellular biology 2002;22(22):8079-87.
58. Guo Feng; Cech Thomas R. Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nature structural biology 2002;9(11):855-61.
59. Doudna Jennifer A; Cech Thomas R. The chemical repertoire of natural ribozymes. Nature 2002;418(6894):222-8.
60. Guo Feng; Cech Thomas R. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA (New York, N.Y.) 2002;8(5):647-58.
61. Livengood April J; Zaug Arthur J; Cech Thomas R. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Molecular and cellular biology 2002;22(7):2366-74.
62. Jarstfer Michael B; Cech Thomas R. Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation. Biochemistry 2002;41(1):151-61.
63. Cech Thomas R. HHMI’s attention to Wiley’s lab staff. Science (New York, N.Y.) 2002;295(5552):43.
64. Cech T Funding above and beyond scientific research. An interview with Thomas R.. Cech, President of the Howard Hughes Medical Institute in Chevy Chase, MD. Interviewed by Holger Breithaupt. EMBO reports 2001;2(9):751-4.
65. Cech T R; Egan L W; Doyle C; Gallin E; Lichtman M A; Queenan C J; Sung N The biomedical research bottleneck. Science (New York, N.Y.) 2001;293(5530):573.
66. Sperger J M; Cech T R A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry 2001;40(24):7005-16.
67. Baumann P; Cech T R Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (New York, N.Y.) 2001;292(5519):1171-5.
68. Cohen S B; Cech T R Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry. Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage … [et al.] 2001;Chapter 5():Unit 5.1.
69. Juneau K; Podell E; Harrington D J; Cech T R Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA–solvent interactions. Structure (London, England : 1993) 2001;9(3):221-31.
70. Cech T R; Leonard J S Science and business. Conflicts of interest–moving beyond disclosure. Science (New York, N.Y.) 2001;291(5506):989.
71. Silverman S K; Cech T R An early transition state for folding of the P4-P6 RNA domain. RNA (New York, N.Y.) 2001;7(2):161-6.
72. Aigner S; Lingner J; Goodrich K J; Grosshans C A; Shevchenko A; Mann M; Cech T R Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. The EMBO journal 2000;19(22):6230-9.
73. Silverman S K; Deras M L; Woodson S A; Scaringe S A; Cech T R Multiple folding pathways for the P4-P6 RNA domain. Biochemistry 2000;39(40):12465-75.
74. Baumann P; Cech T R Protection of telomeres by the Ku protein in fission yeast. Molecular biology of the cell 2000;11(10):3265-75.
75. Cech T R Structural biology. The ribosome is a ribozyme. Science (New York, N.Y.) 2000;289(5481):878-9.
76. Bryan T M; Goodrich K J; Cech T R A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. The Journal of biological chemistry 2000;275(31):24199-207.
77. Bryan T M; Goodrich K J; Cech T R Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Molecular cell 2000;6(2):493-9.
78. Haering C H; Nakamura T M; Baumann P; Cech T R Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6367-72.
79. Silverman S K; Zheng M; Wu M; Tinoco I; Cech T R Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. RNA (New York, N.Y.) 1999;5(12):1665-74.
80. Hagen M; Cech T R Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. The EMBO journal 1999;18(22):6491-500.
81. Friedman K L; Cech T R Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes & development 1999;13(21):2863-74.
82. Silverman S K; Cech T R RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry 1999;38(43):14224-37.
83. Seto A G; Zaug A J; Sobel S G; Wolin S L; Cech T R Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature 1999;401(6749):177-80.
84. Juneau K; Cech T R In vitro selection of RNAs with increased tertiary structure stability. RNA (New York, N.Y.) 1999;5(8):1119-29.
85. Silverman S K; Cech T R Energetics and cooperativity of tertiary hydrogen bonds in RNA structure. Biochemistry 1999;38(27):8691-702.
86. Bryan T M; Cech T R Telomerase and the maintenance of chromosome ends. Current opinion in cell biology 1999;11(3):318-24.
87. Jabri E; Cech T R In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. RNA (New York, N.Y.) 1998;4(12):1481-92.
88. Nakamura T M; Cooper J P; Cech T R Two modes of survival of fission yeast without telomerase. Science (New York, N.Y.) 1998;282(5388):493-6.
89. Golden B L; Gooding A R; Podell E R; Cech T R A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science (New York, N.Y.) 1998;282(5387):259-64.
90. Zhang B; Cech T R Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features. Chemistry & biology 1998;5(10):539-53.
91. Cohen S B; Cech T R A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps. RNA (New York, N.Y.) 1998;4(10):1179-85.
92. Szewczak A A; Podell E R; Bevilacqua P C; Cech T R Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis. Biochemistry 1998;37(32):11162-70.
93. Bryan T M; Sperger J M; Chapman K B; Cech T R Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8479-84.
94. Froelich-Ammon S J; Dickinson B A; Bevilacqua J M; Schultz S C; Cech T R Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes & development 1998;12(10):1504-14.
95. Bevilacqua P C; George C X; Samuel C E; Cech T R Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry 1998;37(18):6303-16.
96. Hammond P W; Cech T R Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation. Biochemistry 1998;37(15):5162-72.
97. Lingner J; Cech T R Telomerase and chromosome end maintenance. Current opinion in genetics & development 1998;8(2):226-32.
98. Nakamura T M; Cech T R Reversing time: origin of telomerase. Cell 1998;92(5):587-90.
99. Jabri E; Aigner S; Cech T R Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry 1997;36(51):16345-54.
100. Zhang B; Cech T R Peptide bond formation by in vitro selected ribozymes. Nature 1997;390(6655):96-100.
101. Cech T R; Nakamura T M; Lingner J Telomerase is a true reverse transcriptase. A review. Biochemistry. Biokhimii?a 1997;62(11):1202-5.
102. Chapon C; Cech T R; Zaug A J Polyadenylation of telomerase RNA in budding yeast. RNA (New York, N.Y.) 1997;3(11):1337-51.
103. Lingner J; Cech T R; Hughes T R; Lundblad V Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11190-5.
104. Hammond P W; Cech T R dGTP-dependent processivity and possible template switching of euplotes telomerase. Nucleic acids research 1997;25(18):3698-704.
105. Tanner M A; Anderson E M; Gutell R R; Cech T R Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA (New York, N.Y.) 1997;3(9):1037-51.
106. Weinstein L B; Jones B C; Cosstick R; Cech T R A second catalytic metal ion in group I ribozyme. Nature 1997;388(6644):805-8.
107. Nakamura T M; Morin G B; Chapman K B; Weinrich S L; Andrews W H; Lingner J; Harley C B; Cech T R Telomerase catalytic subunit homologs from fission yeast and human. Science (New York, N.Y.) 1997;277(5328):955-9.
108. Golden B L; Podell E R; Gooding A R; Cech T R Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. Journal of molecular biology 1997;270(5):711-23.
109. Szewczak A A; Cech T R An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA (New York, N.Y.) 1997;3(8):838-49.
110. McConnell T S; Herschlag D; Cech T R Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction. Biochemistry 1997;36(27):8293-303.
111. Lingner J; Hughes T R; Shevchenko A; Mann M; Lundblad V; Cech T R Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (New York, N.Y.) 1997;276(5312):561-7.
112. Cooper J P; Nimmo E R; Allshire R C; Cech T R Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 1997;385(6618):744-7.
113. Tanner M A; Cech T R Joining the two domains of a group I ribozyme to form the catalytic core. Science (New York, N.Y.) 1997;275(5301):847-9.
114. Hammond P W; Lively T N; Cech T R The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Molecular and cellular biology 1997;17(1):296-308.
115. Cech T R; Lingner J Telomerase and the chromosome end replication problem. Ciba Foundation symposium 1997;211():20-8; discussion 28-34.
116. Golden B L; Gooding A R; Podell E R; Cech T R X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering. RNA (New York, N.Y.) 1996;2(12):1295-305.
117. Rusconi C P; Cech T R The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes & development 1996;10(22):2870-80.
118. Kuo L Y; Cech T R Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic acids research 1996;24(19):3722-7.
119. Lingner J; Cech T R Purification of telomerase from Euplotes aediculatus: requirement of a primer 3’ overhang. Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10712-7.
120. Cate J H; Gooding A R; Podell E; Zhou K; Golden B L; Szewczak A A; Kundrot C E; Cech T R; Doudna J A RNA tertiary structure mediation by adenosine platforms. Science (New York, N.Y.) 1996;273(5282):1696-9.
121. Cate J H; Gooding A R; Podell E; Zhou K; Golden B L; Kundrot C E; Cech T R; Doudna J A Crystal structure of a group I ribozyme domain: principles of RNA packing. Science (New York, N.Y.) 1996;273(5282):1678-85.
122. Campbell T B; Cech T R Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry 1996;35(35):11493-502.
123. Bevilacqua P C; Cech T R Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR. Biochemistry 1996;35(31):9983-94.
124. Rusconi C P; Cech T R Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila. The EMBO journal 1996;15(13):3286-95.
125. Downs W D; Cech T R Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. RNA (New York, N.Y.) 1996;2(7):718-32.
126. Cech T R; Szewczak A A Selecting apt RNAs for NMR. RNA (New York, N.Y.) 1996;2(7):625-7.
127. Golden B L; Cech T R Conformational switches involved in orchestrating the successive steps of group I RNA splicing. Biochemistry 1996;35(12):3754-63.
128. Zaug A J; Linger J; Cech T R Method for determining RNA 3’ ends and application to human telomerase RNA. Nucleic acids research 1996;24(3):532-3.
129. Strobel S A; Cech T R Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5’-splice site selection and transition state stabilization. Biochemistry 1996;35(4):1201-11.
130. Weeks K M; Cech T R Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science (New York, N.Y.) 1996;271(5247):345-8.
131. Tanner M; Cech T Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus. RNA (New York, N.Y.) 1996;2(1):74-83.
132. Nakamura T M; Wang Y H; Zaug A J; Griffith J D; Cech T R Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy. The EMBO journal 1995;14(19):4849-59.
133. Lingner J; Cooper J P; Cech T R Telomerase and DNA end replication: no longer a lagging strand problem? Science (New York, N.Y.) 1995;269(5230):1533-4.
134. Campbell T B; Cech T R Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA. RNA (New York, N.Y.) 1995;1(6):598-609.
135. Weeks K M; Cech T R Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5’ splice site domain. Cell 1995;82(2):221-30.
136. Fang G; Cech T R Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. The Journal of cell biology 1995;130(2):243-53.
137. Weeks K M; Cech T R Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry 1995;34(23):7728-38.
138. Hicke B; Rempel R; Maller J; Swank R A; Hamaguchi J R; Bradbury E M; Prescott D M; Cech T R Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation. Nucleic acids research 1995;23(11):1887-93.
139. Zaug A J; Cech T R Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA (New York, N.Y.) 1995;1(4):363-74.
140. Tanner M A; Cech T R An important RNA tertiary interaction of group I and group II introns is implicated in gram-positive RNase P RNAs. RNA (New York, N.Y.) 1995;1(4):349-50.
141. Cech T Group I introns: new molecular mechanisms for mRNA repair. Bio/technology (Nature Publishing Company) 1995;13(4):323-6.
142. McConnell T S; Cech T R A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction. Biochemistry 1995;34(12):4056-67.
143. Doudna J A; Cech T R; Sullenger B A Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2355-9.
144. Doudna J A; Cech T R Self-assembly of a group I intron active site from its component tertiary structural domains. RNA (New York, N.Y.) 1995;1(1):36-45.
145. Strobel S A; Cech T R Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science (New York, N.Y.) 1995;267(5198):675-9.
146. Zaug A J; Dávila-Aponte J A; Cech T R Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu). Biochemistry 1994;33(49):14935-47.
147. Pyle A M; Moran S; Strobel S A; Chapman T; Turner D H; Cech T R Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry 1994;33(46):13856-63.
148. Strobel S A; Cech T R; Usman N; Beigelman L The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA. Biochemistry 1994;33(46):13824-35.
149. Cech T R; Uhlenbeck O C Ribozymes. Hammerhead nailed down. Nature 1994;372(6501):39-40.
150. Cech T R Chromosome end games. Science (New York, N.Y.) 1994;266(5184):387-8.
151. Sullenger B A; Cech T R Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing. Nature 1994;371(6498):619-22.
152. Murphy F L; Wang Y H; Griffith J D; Cech T R Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme. Science (New York, N.Y.) 1994;265(5179):1709-12.
153. Lingner J; Hendrick L L; Cech T R Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes & development 1994;8(16):1984-98.
154. Laggerbauer B; Murphy F L; Cech T R Two major tertiary folding transitions of the Tetrahymena catalytic RNA. The EMBO journal 1994;13(11):2669-76.
155. Downs W D; Cech T R A tertiary interaction in the Tetrahymena intron contributes to selection of the 5’ splice site. Genes & development 1994;8(10):1198-211.
156. Cech T R; Damberger S H; Gutell R R Representation of the secondary and tertiary structure of group I introns. Nature structural biology 1994;1(5):273-80.
157. Hicke B J; Willis M C; Koch T H; Cech T R Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine. Biochemistry 1994;33(11):3364-73.
158. Murphy F L; Cech T R GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain. Journal of molecular biology 1994;236(1):49-63.
159. Wang Y H; Murphy F L; Cech T R; Griffith J D Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy. Journal of molecular biology 1994;236(1):64-71.
160. Strobel S A; Cech T R Translocation of an RNA duplex on a ribozyme. Nature structural biology 1994;1(1):13-7.
161. Cech T R The efficiency and versatility of catalytic RNA: implications for an RNA world. Gene 1993;135(1-2):33-6.
162. Strobel S A; Cech T R Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme. Biochemistry 1993;32(49):13593-604.
163. Sullenger B A; Cech T R Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science (New York, N.Y.) 1993;262(5139):1566-9.
164. Willis M C; Hicke B J; Uhlenbeck O C; Cech T R; Koch T H Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins. Science (New York, N.Y.) 1993;262(5137):1255-7.
165. Fang G; Cech T R Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein. Biochemistry 1993;32(43):11646-57.
166. Cech T R RNA. Fishing for fresh catalysts. Nature 1993;365(6443):204-5.
167. McConnell T S; Cech T R; Herschlag D Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding. Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8362-6.
168. Fang G; Cech T R The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA. Cell 1993;74(5):875-85.
169. Herschlag D; Eckstein F; Cech T R The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction. Biochemistry 1993;32(32):8312-21.
170. Herschlag D; Eckstein F; Cech T R Contributions of 2’-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA. Biochemistry 1993;32(32):8299-311.
171. Zaug A J; McEvoy M M; Cech T R Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem. Biochemistry 1993;32(31):7946-53.
172. Fang G; Cech T R Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits. Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6056-60.
173. Ishikawa F; Matunis M J; Dreyfuss G; Cech T R Nuclear proteins that bind the pre-mRNA 3’ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Molecular and cellular biology 1993;13(7):4301-10.
174. Murphy F L; Cech T R An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme. Biochemistry 1993;32(20):5291-300.
175. Fang G; Gray J T; Cech T R Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit. Genes & development 1993;7(5):870-82.
176. Cech T R Catalytic RNA: structure and mechanism. Biochemical Society transactions 1993;21(2):229-34.
177. Wang J F; Downs W D; Cech T R Movement of the guide sequence during RNA catalysis by a group I ribozyme. Science (New York, N.Y.) 1993;260(5107):504-8.
178. Piccirilli J A; Vyle J S; Caruthers M H; Cech T R Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature 1993;361(6407):85-8.
179. Legault P; Herschlag D; Celander D W; Cech T R Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis. Nucleic acids research 1992;20(24):6613-9.
180. Cech T R; Herschlag D; Piccirilli J A; Pyle A M RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. The Journal of biological chemistry 1992;267(25):17479-82.
181. Pyle A M; Murphy F L; Cech T R RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature 1992;358(6382):123-8.
182. Piccirilli J A; McConnell T S; Zaug A J; Noller H F; Cech T R Aminoacyl esterase activity of the Tetrahymena ribozyme. Science (New York, N.Y.) 1992;256(5062):1420-4.
183. Wang J F; Cech T R Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme. Science (New York, N.Y.) 1992;256(5056):526-9.
184. Zaug A J; Cech T R The intervening sequence RNA of Tetrahymena is an enzyme. 1986. Biotechnology (Reading, Mass.) 1992;24():57-62.
185. Heuer T S; Chandry P S; Belfort M; Celander D W; Cech T R Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core. Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11105-9.
186. Young B; Herschlag D; Cech T R Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity. Cell 1991;67(5):1007-19.
187. Gray J T; Celander D W; Price C M; Cech T R Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell 1991;67(4):807-14.
188. Fang G W; Cech T R Molecular cloning of telomere-binding protein genes from Stylonychia mytilis. Nucleic acids research 1991;19(20):5515-8.
189. Gampel A; Cech T R Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes & development 1991;5(10):1870-80.
190. Dávila-Aponte J A; Huss V A; Sogin M L; Cech T R A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus. Nucleic acids research 1991;19(16):4429-36.
191. Grosshans C A; Cech T R A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3’ end blocked for transesterification. Nucleic acids research 1991;19(14):3875-80.
192. Herschlag D; Piccirilli J A; Cech T R Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom. Biochemistry 1991;30(20):4844-54.
193. Zahler A M; Williamson J R; Cech T R; Prescott D M Inhibition of telomerase by G-quartet DNA structures. Nature 1991;350(6320):718-20.
194. Pyle A M; Cech T R Ribozyme recognition of RNA by tertiary interactions with specific ribose 2’-OH groups. Nature 1991;350(6319):628-31.
195. Woodson S A; Cech T R Alternative secondary structures in the 5’ exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA. Biochemistry 1991;30(8):2042-50.
196. Cech T R RNA editing: world’s smallest introns? Cell 1991;64(4):667-9.
197. Celander D W; Cech T R Visualizing the higher order folding of a catalytic RNA molecule. Science (New York, N.Y.) 1991;251(4992):401-7.
198. Herschlag D; Cech T R Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site. Biochemistry 1990;29(44):10172-80.
199. Herschlag D; Cech T R Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry 1990;29(44):10159-71.
200. Pyle A M; McSwiggen J A; Cech T R Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8187-91.
201. Raghuraman M K; Cech T R Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein. Nucleic acids research 1990;18(15):4543-52.
202. Downs W D; Cech T R An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme. Biochemistry 1990;29(23):5605-13.
203. Cech T R Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Bioscience reports 1990;10(3):239-61.
204. Trattnig S; Stiglbauer R; Ungersböck K; Cech T; Schindler E; Imhof H [Magnetic resonance tomography of the failed back surgery syndrome: a comparison with computed tomography]. RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1990;152(4):369-73.
205. Herschlag D; Cech T R DNA cleavage catalysed by the ribozyme from Tetrahymena. Nature 1990;344(6265):405-9.
206. Celander D W; Cech T R Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms. Biochemistry 1990;29(6):1355-61.
207. Hicke B J; Celander D W; MacDonald G H; Price C M; Cech T R Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1481-5.
208. Latham J A; Zaug A J; Cech T R Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence. Methods in enzymology 1990;181():558-69.
209. Cech T R Self-splicing of group I introns. Annual review of biochemistry 1990;59():543-68.
210. Williamson J R; Raghuraman M K; Cech T R Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell 1989;59(5):871-80.
211. Young B; Cech T R Specificity for 3’,5’-linked substrates in RNA-catalyzed RNA polymerization. Journal of molecular evolution 1989;29(6):480-5.
212. Murphy F L; Cech T R Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme. Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9218-22.
213. Raghuraman M K; Cech T R Assembly and self-association of oxytricha telomeric nucleoprotein complexes. Cell 1989;59(4):719-28.
214. Flor P J; Flanegan J B; Cech T R A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. The EMBO journal 1989;8(11):3391-9.
215. Yarus M; Levine J; Morin G B; Cech T R A Tetrahymena intron nucleotide connected to the GTP/arginine site. Nucleic acids research 1989;17(17):6969-81.
216. Barfod E T; Cech T R The conserved U.G pair in the 5’ splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Molecular and cellular biology 1989;9(9):3657-66.
217. Grosshans C A; Cech T R Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme. Biochemistry 1989;28(17):6888-94.
218. Latham J A; Cech T R Defining the inside and outside of a catalytic RNA molecule. Science (New York, N.Y.) 1989;245(4915):276-82.
219. Cech T R RNA chemistry. Ribozyme self-replication? Nature 1989;339(6225):507-8.
220. Raghuraman M K; Dunn C J; Hicke B J; Cech T R Oxytricha telomeric nucleoprotein complexes reconstituted with synthetic DNA. Nucleic acids research 1989;17(11):4235-53.
221. McSwiggen J A; Cech T R Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting. Science (New York, N.Y.) 1989;244(4905):679-83.
222. Woodson S A; Cech T R Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition. Cell 1989;57(2):335-45.
223. Price C M; Cech T R Properties of the telomeric DNA-binding protein from Oxytricha nova. Biochemistry 1989;28(2):769-74.
224. Cech T R RNA as an enzyme. Biochemistry international 1989;18(1):7-14.
225. Cech T R Conserved sequences and structures of group I introns: building an active site for RNA catalysis–a review. Gene 1988;73(2):259-71.
226. Zaug A J; Grosshans C A; Cech T R Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes. Biochemistry 1988;27(25):8924-31.
227. Cech T R Ribozymes and their medical implications. JAMA : the journal of the American Medical Association 1988;260(20):3030-4.
228. Price J V; Cech T R Determinants of the 3’ splice site for self-splicing of the Tetrahymena pre-rRNA. Genes & development 1988;2(11):1439-47.
229. Morin G B; Cech T R Telomeric repeats of Tetrahymena malaccensis mitochondrial DNA: a multimodal distribution that fluctuates erratically during growth. Molecular and cellular biology 1988;8(10):4450-8.
230. Barfod E T; Cech T R Deletion of nonconserved helices near the 3’ end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity. Genes & development 1988;2(6):652-63.
231. Cech T R G-strings at chromosome ends. Nature 1988;332(6167):777-8.
232. Been M D; Cech T R RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. Science (New York, N.Y.) 1988;239(4846):1412-6.
233. Morin G B; Cech T R Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena. Cell 1988;52(3):367-74.
234. Morin G B; Cech T R Phylogenetic relationships and altered genome structures among Tetrahymena mitochondrial DNAs. Nucleic acids research 1988;16(1):327-46.
235. Kim S H; Cech T R Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8788-92.
236. Zaug A J; Cech T R Self-splicing RNA and an RNA enzyme in Tetrahymena. The Journal of protozoology 1987;34(4):416-7.
237. Price C M; Cech T R Telomeric DNA-protein interactions of Oxytricha macronuclear DNA. Genes & development 1987;1(8):783-93.
238. Burke J M; Belfort M; Cech T R; Davies R W; Schweyen R J; Shub D A; Szostak J W; Tabak H F Structural conventions for group I introns. Nucleic acids research 1987;15(18):7217-21.
239. Been M D; Cech T R Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence. Cell 1987;50(6):951-61.
240. Price J V; Engberg J; Cech T R 5’ exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5’ splice site in the 3’ exon. Journal of molecular biology 1987;196(1):49-60.
241. Cech T R The chemistry of self-splicing RNA and RNA enzymes. Science (New York, N.Y.) 1987;236(4808):1532-9.
242. Tanner N K; Cech T R Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila. Biochemistry 1987;26(12):3330-40.
243. Been M D; Barfod E T; Burke J M; Price J V; Tanner N K; Zaug A J; Cech T R Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity. Cold Spring Harbor symposia on quantitative biology 1987;52():147-57.
244. Zaug A J; Been M D; Cech T R The Tetrahymena ribozyme acts like an RNA restriction endonuclease. Nature 1986;324(6096):429-33.
245. Cech T R RNA as an enzyme. Scientific American 1986;255(5):64-75.
246. Been M D; Cech T R One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. Cell 1986;47(2):207-16.
247. Morin G B; Cech T R The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats. Cell 1986;46(6):873-83.
248. Bass B L; Cech T R Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor. Biochemistry 1986;25(16):4473-7.
249. Zaug A J; Cech T R The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase. Biochemistry 1986;25(16):4478-82.
250. Garriga G; Lambowitz A M; Inoue T; Cech T R Mechanism of recognition of the 5’ splice site in self-splicing group I introns. Nature 1986;322(6074):86-9.
251. Cech T R A model for the RNA-catalyzed replication of RNA. Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4360-3.
252. Inoue T; Sullivan F X; Cech T R New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing. Journal of molecular biology 1986;189(1):143-65.
253. Burke J M; Irvine K D; Kaneko K J; Kerker B J; Oettgen A B; Tierney W M; Williamson C L; Zaug A J; Cech T R Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor. Cell 1986;45(2):167-76.
254. Zaug A J; Cech T R The intervening sequence RNA of Tetrahymena is an enzyme. Science (New York, N.Y.) 1986;231(4737):470-5.
255. Cech T R The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell 1986;44(2):207-10.
256. Cech T R Biologic catalysis by RNA. Harvey lectures 1986;82():123-44.
257. Cech T R; Bass B L Biological catalysis by RNA. Annual review of biochemistry 1986;55():599-629.
258. Been M D; Cech T R Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure. Nucleic acids research 1985;13(23):8389-408.
259. Inoue T; Sullivan F X; Cech T R Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5’ exons. Cell 1985;43(2 Pt 1):431-7.
260. Tanner N K; Cech T R Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites. Nucleic acids research 1985;13(21):7759-79.
261. Tanner N K; Cech T R Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes. Nucleic acids research 1985;13(21):7741-58.
262. Zaug A J; Kent J R; Cech T R Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis. Biochemistry 1985;24(22):6211-8.
263. Zaug A J; Cech T R Oligomerization of intervening sequence RNA molecules in the absence of proteins. Science (New York, N.Y.) 1985;229(4718):1060-4.
264. Sullivan F X; Cech T R Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice. Cell 1985;42(2):639-48.
265. Price J V; Cech T R Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli. Science (New York, N.Y.) 1985;228(4700):719-22.
266. Price J V; Kieft G L; Kent J R; Sievers E L; Cech T R Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA. Nucleic acids research 1985;13(6):1871-89.
267. Inoue T; Cech T R Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America 1985;82(3):648-52.
268. Cech T R Self-splicing RNA: implications for evolution. International review of cytology 1985;93():3-22.
269. Gottschling D E; Cech T R Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex. Cell 1984;38(2):501-10.
270. Zaug A J; Kent J R; Cech T R A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA. Science (New York, N.Y.) 1984;224(4649):574-8.
271. Bass B L; Cech T R Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA. Nature 1984;308(5962):820-6.
272. Palen T E; Cech T R Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of Tetrahymena. Cell 1984;36(4):933-42.
273. Pardue M L; Fostel J M; Cech T R DNA-protein interactions in the Drosophila virilis mitochondrial chromosome. Nucleic acids research 1984;12(4):1991-9.
274. Cech T R RNA splicing: three themes with variations. Cell 1983;34(3):713-6.
275. Cech T R; Tanner N K; Tinoco I; Weir B R; Zuker M; Perlman P S Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences. Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):3903-7.
276. Brehm S L; Cech T R Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo. Biochemistry 1983;22(10):2390-7.
277. Gottschling D E; Palen T E; Cech T R Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic acids research 1983;11(7):2093-109.
278. Palen T E; Cech T R Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease. Nucleic acids research 1983;11(7):2077-91.
279. Zaug A J; Grabowski P J; Cech T R Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction. Nature 1983;301(5901):578-83.
280. Kruger K; Grabowski P J; Zaug A J; Sands J; Gottschling D E; Cech T R Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 1982;31(1):147-57.
281. Zaug A J; Cech T R The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA. Nucleic acids research 1982;10(9):2823-38.
282. Cech T R; Zaug A J; Grabowski P J In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell 1981;27(3 Pt 2):487-96.
283. Cech T R; Brehm S L Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia. Nucleic acids research 1981;9(14):3531-43.
284. Cech T R Alkaline gel electrophoresis of deoxyribonucleic acid photoreacted with trimethylpsoralen: rapid and sensitive detection of interstrand cross-links. Biochemistry 1981;20(6):1431-7.
285. Grabowski P J; Zaug A J; Cech T R The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell 1981;23(2):467-76.
286. Potter D A; Fostel J M; Berninger M; Pardue M L; Cech T R DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):4118-22.
287. Cech T R; Karrer K M Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo. Journal of molecular biology 1980;136(4):395-416.
288. Zaug A J; Cech T R In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena. Cell 1980;19(2):331-8.
289. Cech T R; Rio D C Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping. Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):5051-5.
290. Cech T; Pathak M A; Biswas R K An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives. Biochimica et biophysica acta 1979;562(2):342-60.
291. Cech T R; Potter D; Pardue M L Chromatin structure in living cells. Cold Spring Harbor symposia on quantitative biology 1978;42 Pt 1():191-8.
292. Cech T; Potter D; Pardue M L Electron microscopy of DNA cross-linked with trimethylpsoralen: a probe for chromatin structure. Biochemistry 1977;16(24):5313-21.
293. Cech T; Pardue M L Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure. Cell 1977;11(3):631-40.
294. Cech T R; Pardue M L Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences. Proceedings of the National Academy of Sciences of the United States of America 1976;73(8):2644-8.
295. Wiesehahn G; Cech T R; Hearst J E A study of DNA denaturation in the ultracentrifuge. Biopolymers 1976;15(8):1591-613.
296. Cech T R; Reisler F; Hearst J E Partial denaturation of mouse DNA in preparative CsCl density gradients at alkaline pH. Biochemistry 1976;15(9):1865-73.
297. Cech T R; Hearst J E Organization of highly repeated sequences in mouse main-band DNA. Journal of molecular biology 1976;100(3):227-56.
298. Cech T R; Hearst J E An electron microscopic study of mouse foldback DNA. Cell 1975;5(4):429-46.
299. Hearst J E; Cech T R; Marx K A; Rosenfeld A; Allen J R Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA. Cold Spring Harbor symposia on quantitative biology 1974;38():329-39.
300. Cech T R; Rosenfeld A; Hearst J E Characterization of the most rapidly renaturing sequences in mouse main-band DNA. Journal of molecular biology 1973;81(3):299-325.
Videos of Thomas R. Cech
Photos of Thomas R. Cech
