1977 Dickson Prize and Medal in Medicine, University of Pittsburgh
1979 CIBA-Geigy Drew Award
1980 The New York Academy of Sciences Award in Biological and Medical Sciences
1986 Pfizer Biomedical Research Award
1987 3M Life Sciences Award of the Federation of American Societies for Experimental Biology
1987 Mental Health Research Achievement Award, National Mental Health Association
1988 Robert and Adele Blank Award Lecture, New York University
1989 Bristol-Myers Award for Distinguished Achievement in Neuroscience Research (jointly with J Axelrod and A Carlsson)
1991 National Academy of Sciences Award in the Neurosciences
1992 Goodman and Gilman Award in Receptor Pharmacology
1993 Karl Spencer Lashley Prize, American Philosophy Society
1994 Ralph W Gerard Prize in Neuroscience, Society for Neuroscience
1996 The Biochemical Society, Thudichum Medal
1996 Lieber Prize for Outstanding Achievement in Schizophrenia Research
1997 Charles A Dana Award for Pioneering Achievements in Health (shared with E Kandel)
1998 Metropolitan Life Foundation Award for Medical Research
1999 Ellison Medical Foundation Senior Scholar Award
2000 Nobel Prize in Physiology or Medicine
1. Tian Y, Bustos V, Flajolet M, Greengard P A small-molecule enhancer of autophagy decreases levels of A beta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J 2011 JUN;25(6):1934-1942
2. Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Neve RL, Greengard P, Kim Y, Morrison JH I kappa B kinase regulates social defeat stress-induced synaptic and behavioral plasticity. PMID 21209217 Journal of neuroscience 2011 Jan 5; 31(1):314-321
3. Schaefer A, Tarakhovsky A, Greengard P Epigenetic Mechanisms of Mental Retardation. PMID 21141728 EPIGENETICS AND DISEASE: PHARMACEUTICAL OPPORTUNITIES 2011;125-146
4. Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. PROC NAT ACAD SCI USA 2011 MAY 31;108(22):9262-9267
5. Paille V, Picconi B, Bagetta V, Ghiglieri V, Sgobio C, Di Filippo M, Viscomi MT, Giampa C, Fusco FR, Gardoni F, Bernardi G, Greengard P, Di Luca M, Calabresi P Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition. PMID 20962239 J NEUROSCI 2010 OCT 20;30(42):14182-14193
6. Zhang YF, Kurup P, Xu JA, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model. PMID 20956308 PMCID 2973892 PROC NAT ACAD SCI USA 2010 NOV 2;107(44):19014-19019
7. Fichter KM, Flajolet M, Greengard P, Vu TQ Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots. PMID 20940319 PMCID 2972942 PROC NAT ACAD SCI USA 2010 OCT 26;107(43):18658-18663
8. Bendor J, Lizardi-Ortiz JE, Westphalen RI, Brandstetter M, Hemmings HC Jr, Sulzer D, Flajolet M, Greengard P AGAP1/AP-3-dependent endocytic recycling of M-5 muscarinic receptors promotes dopamine release. PMID 20664521 EMBO J 2010 AUG 18;29(16):2813-2826
9. Schaefer A, Im HI, Veno MT, Fowler CD, Min A, Intrator A, Kjems J, Kenny PJ, O’Carroll D, Greengard P Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. PMID 20643829 PMCID 2931161 J EXP MED 2010 AUG 30;207(9):1843-1851
10. Flajolet M, Wang H, Greengard P mGluR5 and its medical implications. M S-MED SCI 2010 AUG-SEP;26(8-9):678-680
11. He G, Luo WJ, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP, Greengard P Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease. PMID 20811458 PMCID 2936959 NATURE 2010 SEP 2;467(7311):95-NIL_129
12. Bateup HS, Santini E, Shen WX, Birnbaum S, Valjent E, Surmeier DJ, Fisone G, Nestler EJ, Greengard P Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. PMID 20682746 PMCID 2930415 PROC NAT ACAD SCI USA 2010 AUG 17;107(33):14845-14850
13. Warner-Schmidt JL, Chen EY, Zhang XQ, Marshall JJ, Morozov A, Svenningsson P, Greengard P A Role for p11 in the Antidepressant Action of Brain-Derived Neurotrophic Factor. PMID 20691415 PMCID 2929288 BIOL PSYCHIAT 2010 SEP 15;68(6):528-535
14. Alexander B, Warner-Schmidt J, Eriksson TM, Tamminga C, Arango-Lievano M, Ghose S, Vernov M, Stavarache M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens. PMID 20962330 PMCID 3026098 SCI TRANSL MED 2010 OCT 20;2(54):NIL_14-NIL_22
15. Porton B, Rodriguiz RM, Phillips LE, Gilbert JW, Feng J, Greengard P, Kao HT, Wetsel WC Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. PMID 20050925 PMCID 2878384 GENES BRAIN BEHAV 2010 APR;9(3):257-268
16. Glausier JR, Maddox M, Hemmings HC Jr, Nairn AC, Greengard P, Muly EC LOCALIZATION OF DOPAMINE- AND cAMP-REGULATED PHOSPHOPROTEIN-32 AND INHIBITOR-1 IN AREA 9 OF MACACA MULATTA PREFRONTAL CORTEX. PMID 20156529 PMCID 2863358 NEUROSCIENCE 2010 MAY 5;167(2):428-438
17. Hara M, Fukui R, Hieda E, Kuroiwa M, Bateup HS, Kano T, Greengard P, Nishi A Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons. PMID 20236221 PMCID 2861145 J NEUROCHEM 2010 MAY;113(4):1046-1059
18. Valjent E , Bertran-Gonzalez J , Aubier B , Greengard P , Herve D , Girault JA Mechanisms of Locomotor Sensitization to Drugs of Abuse in a Two- Injection Protocol. PMID 19759531 PMCID 2794893 NEUROPSYCHOPHARMACOLOGY 2010 JAN;35(2):401-415
19. Zhang Y, Chen K, Baron M, Teylan MA, Kim Y, Song ZH, Greengard P, Wong STC A neurocomputational method for fully automated 3D dendritic spine detection and segmentation of medium-sized spiny neurons. PMID 20100579 NEUROIMAGE 2010 MAY 1;50(4):1472-1484
20. Maze I, Covington HE III, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren YH, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity. PMID 20056891 SCIENCE 2010 JAN 8;327(5962):213-216
21. Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P Neurogenic and chronic behavioural effects of fluoxetine are attenuated in p11 KO mice. EUR NEUROPSYCHOPHARMACOL 2010 MAR;20():S6-S7
22. Kurup P, Zhang YF, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ A beta-Mediated NMDA Receptor Endocytosis in Alzheimer’s Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61. PMID 20427654 PMCID 2868326 J NEUROSCI 2010 APR 28;30(17):5948-5957
23. Netzer WJ, Powell C, Nong Y, Blundell J, Wong LL, Duff K, Flajolet M, Greengard P Lowering beta-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model. PMID 20532168 PMCID 2880593 PLOS ONE 2010 JUN 3;5(6):148-152
24. Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P Neurogenic Effects of Fluoxetine Are Attenuated in p11 (S100A10) Knockout Mice. PMID 20227680 BIOL PSYCHIAT 2010 JUN 1;67(11):1048-1056
25. Ceglia I, Kim Y, Nairn AC, Greengard P Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization. PMID 20403076 J NEUROCHEM 2010 JUL;114(1):182-190
26. Zhou MM, Rebholz H, Brocia C, Warner-Schmidt JL, Fienberg AA, Nairn AC, Greengard P, Flajolet M Forebrain overexpression of CK1 delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. PMID 20145109 PROC NAT ACAD SCI USA 2010 MAR 2;107(9):4401-4406
27. Zelenina M , Nishi A , Uematsu K , Heiman M , Greengard P , Aperia A INTRACELLULAR CA2+SIGNALING OF METABOTROPIC GLUTAMATE RECEPTOR 5 IS REGULATED BY THE RECEPTOR PHOSPHORYLATION. GLIA 2009 OCT;57(13):S73-S74
28. Wang H , Westin L , Nong Y , Birnbaum S , Bendor J , Brismar H , Nestler E , Aperia A , Flajolet M , Greengard P Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling. PMID 20007903 SCIENCE 2009 DEC 11;326(5959):1554-1557
29. Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, Tarakhovsky A, Greengard P Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex. PMID 20005824 NEURON 2009 DEC 10;64(5):678-691
30. Santini E, Heiman M, Greengard P, Valjent E, Fisone G Inhibition of mTOR Signaling in Parkinson’s Disease Prevents L-DOPA-Induced Dyskinesia. PMID 19622833 SCI SIGNAL 2009 JUL 21;2(80):NIL_32-NIL_41
31. Endo S , Shutoh F , Le Dinh T , Okamoto T , Ikeda T , Suzuki M , Kawahara S , Yanagihara D , Sato Y , Yamada K , Sakamoto T , Kirino Y , Hartell NA , Yamaguchi K , Itohara S , Nairn AC , Greengard P , Nagao S , Ito M Dual involvement of G-substrate in motor learning revealed by gene deletion. PMID 1928432 PMCID 2642668 PROC NAT ACAD SCI USA 2009 MAR 3;106(9):3525-3530
32. McAvoy T , Zhou MM , Greengard P , Nairn AC Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. PMID 19218462 PMCID 2651273 PROC NAT ACAD SCI USA 2009 MAR 3;106(9):3531-3536
33. Tekinay AB , Nong Y , Miwa JM , Lieberam I , Ibanez-Tallon I , Greengard P , Heintz N A role for LYNX2 in anxiety-related behavior. PMID 19246390 PMCID 2657456 PROC NAT ACAD SCI USA 2009 MAR 17;106(11):4477-4482
34. Greengard P Signal Transduction Pathways used by Therapeutic Agents and Drugs of Abuse. BIOL PSYCHIAT 2009 APR 15;65(8):163S
35. Warner-Schmidt JL , Flajolet M , Maller A , Chen EY , Qi HS , Svenningsson P , Greengard P Role of p11 in Cellular and Behavioral Effects of 5-HT4 Receptor Stimulation. PMID 19211900 J NEUROSCI 2009 FEB 11;29(6):1937-1946
36. Santini E , Alcacer C , Cacciatore S , Heiman M , Herve D , Greengard P , Girault JA , Valjent E , Fisone G l-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. PMID 19187092 J NEUROCHEM 2009 FEB;108(3):621-633
37. Silva OABDE , Rebelo S , Vieira SI , Gandy S , Silva EFDE , Greengard P Enhanced generation of Alzheimer’s amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. PMID 19012746 J NEUROCHEM 2009 JAN;108(2):319-330
38. Kim Y , Teylan MA , Baron M , Sands A , Nairn AC , Greengard P Methylphenidate-induced dendritic spine formation and Delta FosB expression in nucleus accumbens. PMID 19202072 PMCID PMC2650365 PROC NAT ACAD SCI USA 2009 FEB 24;106(8):2915-2920
39. Rebholz H , Nishi A , Liebscher S , Nairn AC , Flajolet M , Greengard P CK2 negatively regulates G alpha(s) signaling. PMID 19666609 PMCID 2729026 PROC NAT ACAD SCI USA 2009 AUG 18;106(33):14096-14101
40. Bertran-Gonzalez J , Hakansson K , Borgkvist A , Irinopoulou T , Brami-Cherrier K , Usiello A , Greengard P , Herve D , Girault JA , Valjent E , Fisone G Histone H3 Phosphorylation is Under the Opposite Tonic Control of Dopamine D2 and Adenosine A2A Receptors in Striatopallidal Neurons. PMID 19158668 NEUROPSYCHOPHARMACOLOGY 2009 JUN;34(7):1710-1720
41. Hansen C , Howlin J , Tengholm A , Dyachok O , Vogel WF , Nairn AC , Greengard P , Andersson T Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner. PMID 19651774 J BIOL CHEM 2009 OCT 2;284(40):27533-27543
42. Zhang YW , Liu SJ , Zhang X , Li WB , Chen YM , Huang XM , Sun LW , Luo WJ , Netzer WJ , Threadgill R , Wiegand G , Wang RS , Cohen SN , Greengard P , Liao FF , Li LM , Xu HX A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer’s beta-Amyloid Levels and Tau Phosphorylation. PMID 19914182 NEURON 2009 NOV 12;64(3):328-340
43. Zhang X , Andren PE , Greengard P , Svenningsson P Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism. PMID 18256188 PMCID PMC2538893 PROC NAT ACAD SCI USA 2008 FEB 12;105(6):2163-2168
44. Flajolet M , Wang ZF , Futter M , Shen WX , Nuangchamnong N , Bendor J , Wallach I , Nairn AC , Surmeier DJ , Greengard P FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. PMID 18953346 NAT NEUROSCI 2008 DEC;11(12):1402-1409
45. Borgkvist A , Marcellino D , Fuxe K , Greengard P , Fisone G Regulation of DARPP-32 phosphorylation by Delta(9)- tetrahydrocannabinol. PMID 17686497 NEUROPHARMACOLOGY 2008 JAN;54(1):31-35
46. Borgkvist A , Nestler EJ , Greengard P , Fisone G , Brene S Involvement of DARPP-32, FosB, and dynorphin in voluntary wheel running. EUR NEUROPSYCHOPHARMACOL 2008 MAR;18():S5-S6
47. Kitaoka S , Furuyashiki T , Nishi A , Shuto T , Koyasu S , Matsuoka T , Miyasaka M , Greengard P , Narumiya S Prostaglandin E-2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum. PMID 18032663 J PHARMACOL SCI 2008;106():67P
48. Kuroiwa M , Bateup HS , Greengard P , Nishi A Neuronal type specific regulation of DARPP-32 phosphorylation in the striatum of D1R/D2R-DARPP-32 mice. J PHARMACOL SCI 2008;106():189P
49. Kao HT , Li P , Chao HM , Janoschka S , Pham K , Feng J , Mcewen BS , Greengard P , Pieribone VA , Porton B Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. J COMP NEUROL 2008 APR 20;507(6):1860-1870
50. Taylor KN , Alexander BL , Warner-Schmidt J , Musatov S , Flajolet M , Greengard P , Kaplitt MG AAV-mediated knockdown of p11 in the adult mouse nucleus accumbens results in depressive behaviors. J AMER GERIAT SOC 2008 APR;56(4):S151
51. Charlton JJ , Allen PB , Psifogeorgou K , Chakravarty S , Gomes I , Neve RL , Devi LA , Greengard P , Nestler EJ , Zachariou V Multiple actions of spinophilin regulate mu opioid receptor function. NEURON 2008 APR 24;85(2):238-247
52. Gitler D , Cheng Q , Greengard P , Augustine GJ Synapsin IIa Controls the Reserve Pool of Glutamatergic Synaptic Vesicles. J NEUROSCI 2008 OCT 22;28(43):10835-10843
53. Bateup HS , Svenningsson P , Kuroiwa M , Gong S , Nishi A , Heintz N , Greengard P Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. PMID 18622401 PMCID 2737705 NAT NEUROSCI 2008 AUG;11(8):932-939
54. Muly EC , Nairn AC , Greengard P , Rainnie DG Subcellular distribution of the Rho-GEF Lfc in primate prefrontal cortex: Effect of neuronal activation. J COMP NEUROL 2008 JUN 20;508(6):927-939
55. Shen WX , Flajolet M , Greengard P , Surmeier DJ Dichotomous dopaminergic control of striatal synaptic plasticity. SCIENCE 2008 AUG 8;321(5890):848-851
56. Stipanovich A , Valjent E , Matamales M , Nishi A , Ahn JH , Maroteaux M , Bertran-Gonzalez J , Brami-Cherrier K , Enslen H , Corbille AG , Filhol O , Nairn AC , Greengard P , Herve D , Girault JA A phosphatase cascade by which rewarding stimuli control nucleosomal response. PMID 18496528 NATURE 2008 JUN 12;453(7197):879-NIL_23
57. Pulipparacharuvil S , Renthal W , Hale CF , Taniguchi M , Xiao GH , Kumar A , Russo SJ , Sikder D , Dewey CM , Davis MM , Greengard P , Nairn AC , Nestler EJ , Cowan CW Cocaine regulates MEF2 to control synaptic and behavioral plasticity. NEURON 2008 AUG 28;59(4):621-633
58. O’Sullivan GJ , Dunleavy M , Hakansson K , Clementi M , Kinsella A , Croke DT , Drago J , Fienberg AA , Greengard P , Sibley DR , Fisone G , Henshall DC , Waddington JL Dopamine D-1 vs D-5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. NEUROPHARMACOLOGY 2008 JUN;54(7):1051-1061
59. O’Sullivan GJ , Durdeay M , Hakansson K , Croke DT , Drago J , Fienberg A , Greengard P , Sibley D , Fisone G , Henshall DC , Waddington J Dopamine D1-like receptor-dependent induction of seizures involves DARPP-32 and ERK1/2 signalling. INT J NEUROPSYCHOPHARMACOL 2008 JUL;11():94
60. Oumata N , Bettayeb K , Ferandin Y , Demange L , Lopez-Giral A , Goddard ML , Myrianthopoulos V , Mikros E , Flajolet M , Greengard P , Meijer L , Galons H Roscovitine-derived, dual-specificity inhibitors of cyclin- dependent kinases and casein kinases 1. J MED CHEM 2008 SEP 11;51(17):5229-5242
61. Nishi A , Kuroiwa M , Miller DB , O’Callaghan JP , Bateup HS , Shuto T , Sotogaku N , Fukuda T , Heintz N , Greengard P , Snyder GL Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum. PMID 18923023 J NEUROSCI 2008 OCT 15;28(42):10460-10471
62. Meyer DA , Richer E , Benkovic SA , Hayashi K , Kansy JW , Hale CF , Moy LY , Kim Y , O’Callaghan JP , Tsai LH , Greengard P , Nairn AC , Cowan CW , Miller DB , Antich P , Bibb JA Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. PROC NAT ACAD SCI USA 2008 NOV 25;105(47):18561-18566
63. Lagace DC , Benavides DR , Kansy JW , Mapelli M , Greengard P , Bibb JA , Eisch AJ Cdk5 is essential for adult hippocampal neurogenesis. PROC NAT ACAD SCI USA 2008 NOV 25;105(47):18567-18571
64. Kitaoka S , Furuyashiki T , Nishi A , Shuto T , Koyasu S , Matsuoka T , Greengard P , Narumiya S Prostaglandin E receptor EP1 amplifies dopaminergic signaling in the striatum. NEUROSCI RES 2008;61():S81
65. Heiman M , Schaefer A , Gong S , Peterson JD , Day M , Ramsey KE , Suarez-Farinas M , Schwarz C , Stephan DA , Surmeier DJ , Greengard P , Heintz N A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types. PMID 19013281 PMCID 2696821 CELL 2008 NOV 14;135(4):738-748
66. Doyle JP , Dougherty JD , Heiman M , Schmidt EF , Stevens TR , Ma G , Bupp S , Shrestha P , Shah RD , Doughty ML , Gong S , Greengard P , Heintz N Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types. PMID19013282 CELL 2008 NOV 14;135(4):749-762
67. Sung JY , Engmann O , Teylan MA , Nairn AC , Greengard P , Kim Y WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. PROC NAT ACAD SCI USA 2008 FEB 26;105(8):3112-3116
68. Santini E , Valjent E , Usiello A , Carta M , Borgkvist A , Girault JA , Herve D , Greengard P , Fisone G Critical involvement of cAMP/DARPP-32 and extracellular signal- regulated protein kinase signaling in L-DOPA-induced dyskinesia. J NEUROSCI 2007 JUN 27;27(26):6995-7005
69. Svenningsson P , Bateup H , Qi H , Takamiya K , Huganir RL , Spedding M , Roth BL , McEwen BS , Greengard P Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine. EUR J NEUROSCI 2007 DEC;26(12):3509-3517
70. Svenningsson P , Greengard P Molecular mechanisms and clinical evidence of acceleration of antidepressant response: Fact or fiction?. BIOL PSYCHIAT 2007 APR 15;61(8):197S
71. Svenningsson P , Greengard P p11 (S100A10) – an inducible adaptor protein that modulates neuronal functions. CURR OPIN PHARMACOL 2007 FEB;7(1):27-32
72. Ahn JH , McAvoy T , Rakhilin SV , Nishi A , Greengard P , Nairn AC Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56 delta subunit. PMCID 1815292 PROC NAT ACAD SCI USA 2007 FEB 20;104(8):2979-2984
73. Wang X , Zeng WZ , Kim MS , Allen PB , Greengard P , Muallem S Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. PMCID 1888664 EMBO J 2007 JUN 6;26(11):2768-2776
74. Schaefer A , O’Carroll D , Tan CL , Hillman D , Sugimori M , Llinas R , Greengard P Cerebellar neuro degeneration in the absence of microRNAs. PMCID 2118654 J EXP MED 2007 JUL 9;204(7):1553-1558
75. Luo WJ , Dou F , Rodina A , Chip S , Kim J , Zhao Q , Moulick K , Aguirre J , Wu N , Greengard P , Chiosis G Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. PMCID 1890525 PROC NAT ACAD SCI USA 2007 MAY 29;104(22):9511-9516
76. Siksou L , Rostaing P , Lechaire JP , Boudier T , Ohtsuka T , Fejtova A , Kao HT , Greengard P , Gundelfinger ED , Triller A , Marty S Three-dimensional architecture of presynaptic terminal cytomatrix. J NEUROSCI 2007 JUN 27;27(26):6868-6877
77. Ahn JH , Sung JY , McAvoy T , Nishi A , Janssens V , Goris J , Greengard P , Nairn AC The B ’’/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. PMCID 1887582 PROC NAT ACAD SCI USA 2007 JUN 5;104(23):9876-9881
78. Flajolet M , He G , Heiman M , Lin A , Nairn AC , Greengard P Regulation of Alzheimer’s disease amyloid-beta formation by casein kinase I. PMCID 1820725 PROC NAT ACAD SCI USA 2007 MAR 6;104(10):4159-4164
79. Heintz N , Hatten ME , Gong SC , Myriam H , Schaefcr A , Doyle J , Stevens T , Dougherty J , Greengard P Molecular definition of CNS cell types and their physiologic responses in health and disease. FASEB J 2007 APR;21(5):A201
80. Borgkvist A , Usiello A , Greengard P , Fisone G Activation of the cAMP/PKA/DARPP-32 signaling pathway is required for morphine psychomotor stimulation but not for morphine reward. NEUROPSYCHOPHARMACOLOGY 2007 SEP;32(9):1995-2003
81. Svenningsson P , Tzavara ET , Qi HS , Carruthers R , Witkin JM , Nomikos GG , Greengard P Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J NEUROSCI 2007 APR 11;27(15):4201-4209
82. Sahlin C , Lord A , Magnusson K , Englund H , Almeida CG , Greengard P , Nyberg F , Gouras GK , Lannfelt L , Nilsson LNG The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase. J NEUROCHEM 2007 MAY;101(3):854-862
83. Kitaoka S , Furuyashiki T , Nishi A , Shuto T , Koyasu S , Matsuoka T , Miyasaka M , Greengard P , Narumiya S Prostaglandin E-2 acts on EP1 receptor and amplifies both dopamine D-1 and D-2 receptor signaling in the striatum. J NEUROSCI 2007 NOV 21;27(47):12900-12907
84. Barbano PE , Spivak M , Flajolet M , Nairn AC , Greengard P , Greengard L A mathematical tool for exploring the dynamics of biological networks. PMCID 2148263 PROC NAT ACAD SCI USA 2007 DEC 4;104(49):19169-19174
85. Hawasli AH , Benavides DR , Nguyen C , Kansy JW , Hayashi K , Chambon P , Greengard P , Powell CM , Cooper DC , Bibb JA Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. NAT NEUROSCI 2007 JUL;10(7):880-886
86. Zhang Y , Svenningsson P , Picetti R , Schlussman SD , Nairn AC , Ho A , Greengard P , Kreek MJ Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32. J NEUROSCI 2006 MAR 8;26(10):2645-2651
87. Greengard P Signal transduction pathways used by therapeutic agents and drugs of abuse. NEUROPSYCHOPHARMACOLOGY 2006 DEC;31():S63
88. Scott L , Zelenin S , Malmersjo S , Kowalewski JM , Markus EZ , Nairn AC , Greengard P , Brismar H , Aperia A Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines. PMCID 1334633 PROC NAT ACAD SCI USA 2006 JAN 17;103(3):762-767
89. Lee KW , Kim Y , Kim AM , Helmin K , Nairn AC , Greengard P Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. PMCID 1413917 PROC NAT ACAD SCI USA 2006 FEB 28;103(9):3399-3404
90. Rogers JP , Beuscher AE , Flajolet M , McAvoy T , Nairn AC , Olson AJ , Greengard P Discovery of protein phosphatase 2C inhibitors by virtual screening. PMCID 2538531 J MED CHEM 2006 MAR 9;49(5):1658-1667
91. Hakansson K , Galdi S , Hendrick J , Snyder G , Greengard P , Fisone G Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D-2 receptors. J NEUROCHEM 2006 JAN;96(2):482-488
92. Venton BJ , Seipel AT , Phillips PEM , Wetsel WC , Gitler D , Greengard P , Augustine GJ , Wightman RM Cocaine increases dopamine release by mobilization of a synapsin- dependent reserve pool. J NEUROSCI 2006 MAR 22;26(12):3206-3209
93. Allen PB , Zachariou V , Svenningsson P , Lepore AC , Centonze D , Costa C , Rossi S , Bender G , Chen G , Feng J , Snyder GL , Bernardi G , Nestler EJ , Yan Z , Calabresi P , Greengard P Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. NEUROSCIENCE 2006;140(3):897-911
94. Yabuuchi K , Kuroiwa M , Shuto T , Sotogaku N , Snyder GL , Higashi H , Tanaka M , Greengard P , Nishi A Role of adenosine A(1), receptors in the modulation of dopamine D-1, and adenosine A(2a) receptor signaling in the neostriatum. NEUROSCIENCE 2006;141(1):19-25
95. Svenningsson P , Chergui K , Rachleff I , Flajolet M , Zhang XQ , El Yacoubi M , Vaugeois JM , Nomikos GG , Greengard P Alterations in 5-HT1B receptor function by p11 in depression- like states. SCIENCE 2006 JAN 6;311(5757):77-80
96. Cai DM , Zhong MH , Wang RS , Netzer WJ , Shields D , Zheng H , Sisodia SS , Foster DA , Gorelick FS , Xu HX , Greengard P Phospholipase D1 corrects impaired beta APP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons. PMCID 1413666 PROC NAT ACAD SCI USA 2006 FEB 7;103(6):1936-1940
97. Scott L , Zelenin S , Malmersjo S , Kowalewski JM , Zettergren-Markus E , Nairn AC , Greengard P , Brismar H , Aperia A Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines. EUR NEUROPSYCHOPHARMACOL 2006 MAR;16():S34-S35
98. Kim Y , Sung JY , Ceglia I , Lee KW , Ahn JH , Halford JM , Kim AM , Kwak SP , Park JB , Ryu SH , Schenck A , Bardoni B , Scott JD , Nairn AC , Greengard P Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. NATURE 2006 AUG 17;442(7104):814-817
99. Cai DM , Netzer WJ , Zhong MH , Lin YX , Du GW , Frohman M , Foster DA , Sisodia SS , Xu HX , Gorelick FS , Greengard P Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. PMCID 1413665 PROC NAT ACAD SCI USA 2006 FEB 7;103(6):1941-1946
100. Liu WH , Yuen EY , Allen PB , Feng J , Greengard P , Yan Z Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. PMCID 1838752 PROC NAT ACAD SCI USA 2006 NOV 28;103(48):18338-18343
101. Hansen C , Greengard P , Nairn AC , Andersson T , Vogel WF Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1. EXP CELL RES 2006 DEC 10;312(20):4011-4018
102. Kao HT , Rodriguiz R , Gilbert J , Feng J , Greengard P , Porton B , Wetsel W Behavioral studies in synapsin III knockout mice: Relevance to schizophrenia. AM J MED GENET PART B 2006 OCT 5;141B(7):783
103. Svenningsson P , Greengard P A master regulator in the brain. SCIENTIST 2006 OCT;20(10):40-47
104. Ehrman LA , Williams MT , Schaefer TL , Gudelsky GA , Reed TM , Fienberg AA , Greengard P , Vorhees CV Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice. GENES BRAIN BEHAV 2006 OCT;5(7):540-551
105. Scott L , Zelenin S , Malmersjo S , Kowalewski JM , Zettergren-Markus E , Nairn AC , Greengard P , Brismar H , Aperia A Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines. EUR NEUROPSYCHOPHARMACOL 2006 SEP;16():S170
106. Yan L , Bobula JM , Svenningsson P , Greengard P , Silver R DARPP-32 involvement in the photic pathway of the circadian system. J NEUROSCI 2006 SEP 13;26(37):9434-9438
107. Zachariou V , Sgambato-Faure V , Sasaki T , Svenningsson P , Berton O , Fienberg AA , Nairn AC , Greengard P , Nestler EJ Phosphorylation of DARPP-32 at threonine-34 is required for cocaine action. NEUROPSYCHOPHARMACOLOGY 2006 MAR;31(3):555-562
108. Futter M , Uematsu K , Bullock SA , Kim Y , Hemmings HC Jr , Nishi A , Greengard P , Nairn AC Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). PMCID 552943 PROC NAT ACAD SCI USA 2005 MAR 1;102(9):3489-3494
109. Valjent E , Pascoli V , Svenningsson P , Paul S , Enslen H , Corvol JC , Stipanovich A , Caboche J , Lombroso PJ , Nairn AC , Greengard P , Herve D , Girault JA Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. PMCID 544317 PROC NAT ACAD SCI USA 2005 JAN 11;102(2):491-496
110. Chergui K , Svenningsson P , Greengard P Physiological role for casein kinase 1 in glutamatergic synaptic transmission. J NEUROSCI 2005 JUL 13;25(28):6601-6609
111. Stenh C , Englund H , Lord A , Johansson AS , Almeida CG , Gellerfors P , Greengard P , Gouras GK , Lannfelt L , Nilsson LNG Amyloid-beta oligomers are inefficiently measured by enzyme- linked immunosorbent assay. ANN NEUROL 2005 JUL;58(1):147-150
112. Bordelon JR , Smith Y , Howell LL , Greengard P , Muly EC Differential localization of protein phosphatase-1 (PP1) isoforms at axospinous synapses: Response to haloperidol and cocaine treatment. PMCID 2586106 BIOL PSYCHIAT 2005 APR 15;57(8):42S
113. Ryan XZP , Alldritt J , Svenningsson P , Allen PB , Wu GY , Nairn AC , Greengard P The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. NEURON 2005 JUL 7;47(1):85-100
114. Brady AE , Wang Q , Allen PB , Rizzo M , Greengard P , Limbird LE alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of G(i) proteins and is preferentially induced by the alpha(2A)-subtype. MOL PHARMACOL 2005 MAY;67(5):1690-1696
115. Wang Q , Zhao JL , Lefkowitz R , Greengard P , Limbird L Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. FASEB J 2005 MAR 7;19(5):A1099
116. Snyder EM , Nong Y , Almeida CG , Paul S , Moran T , Choi EY , Nairn AC , Salter MW , Lombroso PJ , Gouras GK , Greengard P Regulation of NMDA receptor trafficking by amyloid-beta. NAT NEUROSCI 2005 AUG;8(8):1051-1058
117. Almeida CG , Tampellini D , Takahashi RH , Greengard P , Lin MT , Snyder EM , Gouras GK Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. NEUROBIOL DISEASE 2005 NOV;20(2):187-198
118. Hamada M , Hendrick JP , Ryan GR , Kuroiwa M , Higashi H , Tanaka M , Nairn AC , Greengard P , Nishi A Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons. J PHARMACOL EXP THER 2005 NOV;315(2):872-878
119. Svenningsson P , Nairn AC , Greengard P DARPP-32 mediates the actions of multiple drugs of abuse. AAPS J 2005;7(2):NIL_88-NIL_95
120. Jin M , Bateup H , Padovan JC , Greengard P , Nairn AC , Chait BT Quantitative analysis of protein phosphorylation in mouse brain by hypothesis-driven multistage mass spectrometry. ANAL CHEM 2005 DEC 15;77(24):7845-7851
121. Uematsu K , Futter M , Hsieh-Wilson LC , Higashi H , Maeda H , Nairn AC , Greengard P , Nishi A Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways. J NEUROCHEM 2005 DEC;95(6):1642-1652
122. Andersson M , Usiello A , Borgkvist A , Pozzi L , Dominguez C , Fienberg AA , Svenningsson P , Fredholm BB , Borrelli E , Greengard P , Fisone G Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons. J NEUROSCI 2005 SEP 14;25(37):8432-8438
123. Wang XH , Zeng WZ , Soyombo AA , Tang W , Ross EM , Barnes AP , Milgram SL , Penninger JM , Allen PB , Greengard P , Muallem S Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein- coupled receptors. NAT CELL BIOL 2005 APR;7(4):405-411
124. Hilfiker S, Benfenati F, Doussau FDR, Nairn AC, Czernik AJ, Augustine GJ, Greengard P Structural domains involved in the regulation of transmitter release by synapsins. J NEUROSCI 2005 MAR 9;25(10):2658-2669
125. Takahashi S, Ohshima T, Cho A, Sreenath T, Iadarola MJ, Pant HC, Kim Y, Nairn AC, Brady RO, Greengard P, Kulkarni AB Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. PMCID 547862 PROC NAT ACAD SCI USA 2005 FEB 1;102(5):1737-1742
126. Nishi A , Watanabe Y , Higashi H , Tanaka M , Nairn AC , Greengard P Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. PMCID 545831 PROC NAT ACAD SCI USA 2005 JAN 25;102(4):1199-1204
127. Lin TH, Huang YC, Chin ML, Chen YC, Jeng HH, Lin FM, Shiao MS, Horiuchi A, Greengard P, Nairn AC, Huang HB Letter to the Editor: H-1 N-15 and C-13 resonance assignments of DARPP-32 (dopamine and cAMP-regulated phosphoprotein Mr. 32000) – a protein inhibitor of protein phosphatase-1 JOURNAL OF BIOMOLECULAR NMR 2004 APR;28(4):413-414
128. Mayerhofer A, Fritz S, Mani S, Kumar TR, Thalhammer A, Ingrassia P, Fienberg AA, Greengard P Ovarian function and morphology after deletion of the DARPP-32 gene in mice. EXP CLIN ENDOCRINOL DIABETES 2004 SEP;112(8):451-457
129. Hamada M, Higashi H, Nairn AC, Greengard P, Nishi A Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. J NEUROCHEM 2004 SEP;90(5):1094-1103
130. Nally RE, Kinsella A, Tighe O, Croke DT, Fienberg AA, Greengard P, Waddington JL Ethologically based resolution of D-2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3 ’, 5 ’-monophosphate-regulated phosphoprotein of 32 kDa ’knockout’ mutants congenic on the C57BL/6 genetic bacER - J PHARMACOL EXP THER 2004 SEP;310(3):1281-1287
131. Nairn AC, Svenningsson P, Nishi A, Fisone G, Girault JA, Greengard P The role of DARPP-32 in the actions of drugs of abuse. NEUROPHARMACOLOGY 2004;47():14-23
132. Greengard P Neurobiology of synaptic transmission. BIOL PSYCHIAT 2004 APR 15;55():96S
133. Wang Q, Zhao JL, Brady A, Lefkowitz R, Greengard P, Limbird L Spinophilin is a functional antagonist of arrestin in vitro and in vivo. FASEB J 2004 MAY 14;18(8):C159
134. Giovedi S, Vaccaro P, Valtorta F, Darchen F, Greengard P, Cesareni G, Benfenati F Synapsin is a novel Rab3 effector protein on small synaptic vesicles – I. Identification and characterization of the synapsin I-Rab3 interactions in vitro and in intact nerve terminals. J BIOL CHEM 2004 OCT 15;279(42):43760-43768
135. Muly EC, Allen P, Mazloom M, Aranbayeva Z, Greenfield AT, Greengard P Subcellular distribution of neurabin immunolabeling in primate prefrontal cortex: Comparison with spinophilin. CEREB CORTEX 2004 DEC;14(12):1398-1407
136. Nally R, Kinsella A, Tighe O, Croke D, Fienberg A, Greengard P, Waddington J Loss and conservation of distinct D-2-like dopamine receptor- mediated behavioural phenotypes in mutants with congenic DARPP-32. J PSYCHOPHARMACOL 2004 SEP;18(3):A30
137. Giovedi S, Darchen F, Valtorta F, Greengard P, Benfenati F Synapsin is a novel Rab3 effector protein on small synaptic vesicles – II. Functional effects of the Rab3A-synapsin I interaction. J BIOL CHEM 2004 OCT 15;279(42):43769-43779
138. Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XZP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, Meijer L Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. ONCOGENE 2004 MAY 27;23(25):4400-4412
139. Lee SJ, Romeo RD, Svenningsson P, Campomanes CR, Allen PB, Greengard P, McEwen BS Estradiol affects spinophilin protein differently in gonadectomized males and females. NEUROSCIENCE 2004;127(4):983-988
140. Grossman SD, Futter M, Snyder GL, Allen PB, Nairn AC, Greengard P, Hsieh-Wilson LC Spinophilin is phosphorylated by Ca2+/calmodulin-dependent protein kinase II resulting in regulation of its binding to F- actin. J NEUROCHEM 2004 JUL;90(2):317-324
141. Ouimet CC, Katona I, Allen P, Freund TF, Greengard P Cellular and subcellular distribution of spinophilin, a PP1 regulatory protein that bundles F-actin in dendritic spines. J COMP NEUROL 2004 NOV 22;479(4):374-388
142. Polychronopoulos P, Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager G, Nagy SR, Han DH, Denison M, Ffrench M, Ryan XP, Magiatis P, Greengard P, Skaltsounis L, Meijer L Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the anti-proliferative effects of indirubins. TOXICOL APPL PHARMACOL 2004 JUN 15;197(3):216
143. Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn AC, Surmeier DJ, Greengard P A network of control mediated by regulator of calcium/calmodulin- dependent signaling. SCIENCE 2004 OCT 22;306(5296):698-701
144. Gitler D , Takagishi Y , Feng J , Ren Y , Rodriguiz RM , Wetsel WC , Greengard P , Augustine GJ Different presynaptic roles of Synapsins at excitatory and inhibitory synapses. J NEUROSCI 2004 DEC 15;24(50):11368-11380
145. Valjent E , Pascoli V , Corvol J , Svenningsson P , Stipanovich A , Enslen H , Caboche J , Nairn AC , Greengard P , Herve D , Girault J ERK, a phosphatase-regulated coincidence detector, critical for the actions of drugs of abuse in the striatum. INT J NEUROPSYCHOPHARMACOL 2004 JUN;7():S145
146. Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu HX Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. J BIOL CHEM 2004 SEP 24;279(39):40560-40566
147. Svenningsson P , Tzavara ET , Carruthers R , Nomikos GG , Greengard P Diverse psychotomimetics act through a common signaling pathway. EUR NEUROPSYCHOPHARMACOL 2004 OCT;14():S117-S118
148. Meijer L, Flajolet M, Greengard P Pharmacological inhibitors of glycogen synthase kinase 3. TRENDS PHARMACOL SCI 2004 SEP;25(9):471-480
149. Stenh C , Englund H , Almeida C , Greengard P , Nilsson L , Gouras G , Lannfelt L The arctic APP mutation affects A beta production and its site of cellular aggregation in Alzheimer’s disease. NEUROBIOL AGING 2004 JUL;25():S76
150. Almeida CG , Takahashi RH , Yu FM , Lin MT , Greengard P , Snyder EM , Gouras GK A beta 42 accumulation in endosomes is associated with synaptic alterations. NEUROBIOL AGING 2004 JUL;25():S444
151. Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases JOURNAL OF MEDICINAL CHEMISTRY 2004 Feb;47(4):935-946
152. Svenningsson P, Nishi A, Fisone G, Girault JA, Nairn AC, Greengard P DARPP-32: An integrator of neurotransmission. ANNU REV PHARMACOL TOXICOL 2004;44():269-296
153. Girault JA, Greengard P The neurobiology of dopamine signaling. ARCH NEUROL 2004 MAY;61(5):641-644
154. Gitler D, Xu YM, Kao HT, Lin DY, Lim SM, Feng J, Greengard P, Augustine GJ Molecular determinants of synapsin targeting to presynaptic terminals. J NEUROSCI 2004 APR 7;24(14):3711-3720
155. Chen GJ, Greengard P, Yan Z Potentiation of NMDA receptor currents by dopamine D-1 receptors in prefrontal cortex. PMCID 356995 PROC NAT ACAD SCI USA 2004 FEB 24;101(8):2596-2600
156. Li CJ, Brake WG, Romeo RD, Dunlop JC, Gordon M, Buzescu R, Magarinos AM, Allen PB, Greengard P, Luine V, McEwen BS Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice. PMCID 357073 PROC NAT ACAD SCI USA 2004 FEB 17;101(7):2185-2190
157. Chergui K, Svenningsson P, Greengard P Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. PMCID 357074 PROC NAT ACAD SCI USA 2004 FEB 17;101(7):2191-2196
158. Muly EC, Smith Y, Allen P, Greengard P Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: Localization to and within dendritic spines JOURNAL OF COMPARATIVE NEUROLOGY 2004 Feb;469(2):185-197
159. Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. PMCID 406487 PROC NAT ACAD SCI USA 2004 MAY 4;101(18):7187-7192
160. Tang Y, Janssen WGM, Hao JD, Roberts JA, McKay H, Lasley B, Allen PB, Greengard P, Rapp PR, Kordower JH, Hof PR, Morrison JH Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys CEREBRAL CORTEX 2004 FEB;14(2):215-223
161. Wang Q, Zhao JL, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. SCIENCE 2004 JUN 25;304(5679):1940-1944
162. Svenningsson P, Nomikos GG, Greengard P Response to comment on ’Diverse psychotomimetics act through a common signaling pathway’. SCIENCE 2004 JUL 9;305(5681):NIL_2-NIL_3
163. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor NATURE MEDICINE 2004 JAN;10(1):55-63
164. Nishi A, Liu F, Matsuyama S, Hamada M, Higashi H, Nairn AC, Greengard P Metabotropic mGlu5 receptors regulate adenosine A(2A) receptor signaling. PMCID 298771 PROC NAT ACAD SCI USA 2003 FEB 4;100(3):1322-1327
165. Watanabe T, Silva EFDCE, Huang HB, Starkova N, Kwon YG, Horiuchi A, Greengard P, Nairn AC Preparation and characterization of recombinant protein phosphatase I PROTEIN PHOSPHATASES 2003 ;366():321-338
166. Cai DM, Leem JY, Greenfield JP, Wang P, Kim BS, Wang RS, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu HX Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J BIOL CHEM 2003 JAN 31;278(5):3446-3454
167. Norrholm SD, Bibb JA, Nestler EJ, Ouimet CC, Taylor JR, Greengard P Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. NEUROSCIENCE 2003;116(1):19-22
168. Hsieh-Wilson LC, Benfenati F, Snyder GL, Allen PB, Nairn AC, Greengard P Phosphorylation of spinophilin modulates its interaction with actin filaments. J BIOL CHEM 2003 JAN 10;278(2):1186-1194
169. Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. J BIOL CHEM 2003 APR 18;278(16):13819-13828
170. Kruse MS, Adachi S, Scott L, Holtback U, Greengard P, Aperia A, Brismar H Recruitment of renal dopamine 1 receptors requires an intact microtubulin network. PFLUGERS ARCH-EUR J PHYSIOL 2003 FEB;445(5):534-539
171. Picconi B, Centonze D, Hakansson K, Bernardi G, Greengard P, Fisone G, Cenci MA, Calabresi P Loss of bidirectional striatal synaptic plasticity in L-DOPA- induced dyskinesia. NAT NEUROSCI 2003 MAY;6(5):501-506
172. Chi P, Greengard P, Ryan TA Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. NEURON 2003 APR 10;38(1):69-78
173. Endo S, Nairn AC, Greengard P, Ito M Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor. NEUROSCI RES 2003 JAN;45(1):79-89
174. Lindgren N, Usiello A, Goiny M, Haycock J, Erbs E, Greengard P, Hokfelt T, Borrelli E, Fisone G Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites. PROC NAT ACAD SCI USA 2003 APR 1;100(7):4305-4309
175. Norrholm SD, Bibb JA, Nestler EJ, Ouimet CC, Taylor JR, Greengard P Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5 (vol 116, pg 19, 2003). NEUROSCIENCE 2003;119(2):619
176. Sabo SL, Ikin AF, Buxbaum JD, Greengard P The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. J NEUROSCI 2003 JUL 2;23(13):5407-5415
177. Lidow MS, Koh PO, Zhang L, Castner SA, Allen PB, Greengard P, Goldman-Rakic PS Effects of chronic haloperidol treatment on microtubule- associated protein-2, spinophilin, and synaptophysin in the brain of young rhesus monkeys. BIOL PSYCHIAT 2003 APR 15;53(8):110S-111S
178. Bloom O, Evergren E, Tomilin N, Kjaerulff O, Low P, Brodin L, Pieribone VA, Greengard P, Shupliakov O Colocalization of synapsin and actin during synaptic vesicle recycling. J CELL BIOL 2003 MAY 26;161(4):737-747
179. Pozzi L, Hakansson K, Usiello A, Borgkvist A, Lindskog M, Greengard P, Fisone G Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum. J NEUROCHEM 2003 JUL;86(2):451-459
180. Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE Spinophilin stabilizes cell surface expression of alpha(2B)- adrenergic receptors. J BIOL CHEM 2003 AUG 22;278(34):32405-32412
181. Nally R, McNamara F, Clifford J, Kinsella A, Tighe O, Croke D, Fienberg A, Greengard P, Waddington J Congenic DARPP-32 ’knockout’: topographical assessment of ethological and dopamine receptor agonist-induced behavioural phenotype. J PSYCHOPHARMACOL 2003 SEP;17(3):A75
182. Greengard P The neurobiology of synaptic transmission. J PHARMACOL SCI 2003;91():2P
183. Nishi A, Higashi H, Greengard P Glutamatergic modulation of dopamine/DARPP-32 signaling in neostriatal neurons. J PHARMACOL SCI 2003;91():51P
184. Svenningsson P, Tzavara ET, Carruthers R, Rachleff I, Wattler S, Nehls M, McKinzie DL, Fienberg AA, Nomikos GG, Greengard P Diverse psychotomimetics act through a common signaling pathway. SCIENCE 2003 NOV 21;302(5649):1412-1415
185. Netzer WJ, Dou F, Cai DM, Veach D, Jean S, Li YM, Bornamann WG, Clarkson B, Xu HX, Greengard P Gleevec inhibits beta-amyloid production but not Notch cleavage. PROC NAT ACAD SCI USA 2003 OCT 14;100(21):12444-12449 PMCID 218777
186. Hao JD, Janssen WGM, Tang Y, Roberts JA, McKay H, Lasley B, Allen PB, Greengard P, Rapp PR, Kordower JH, Hof PR, Morrison JH Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys. J COMP NEUROL 2003 OCT 27;465(4):540-550
187. Snyder GL, Galdi S, Feinberg AA, Allen P, Nairn AC, Greengard P Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists. NEUROPHARMACOLOGY 2003 NOV;45(6):703-713
188. Nally RE, McNamara FN, Clifford JJ, Kinsella A, Tighe O, Croke DT, Fienberg AA, Greengard P, Waddington JL Topographical assessment of ethological and dopamine receptor agonist-induced behavioral phenotype in mutants with congenic DARPP-32 ’knockout’. NEUROPSYCHOPHARMACOLOGY 2003 DEC;28(12):2055-2063
189. Fukui R, Svenningsson P, Matsuishi T, Higashi H, Nairn AC, Greengard P, Nishi A Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice. J NEUROCHEM 2003 DEC;87(6):1391-1401
190. Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XZP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P GSK-3-selective inhibitors derived from Tyrian purple indirubins CHEMISTRY & BIOLOGY 2003 DEC;10(12):1255-1266
191. Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. PMCID 307683 Proc Nat Acad Sci 2003 Dec;100(26):16006-16011
192. Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu HX Chaperones increase association of tau protein with microtubules. PROC NAT ACAD SCI USA 2003 JAN 21;100(2):721-726
193. Carr AN, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Jing SL, Allen PB, Greengard P, Yatani A, Hoit BD, Grupp IL, Hajjar RJ, DePaoli-Roach AA, Kranias EG Type 1 phosphatase, a negative regulator of cardiac function. MOL CELL BIOL 2002 JUN;22(12):4124-4135
194. Liu F, Virshup DM, Nairn AC, Greengard P Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J BIOL CHEM 2002 NOV 22;277(47):45393-45399
195. Alves SE, Hoskin E, Lee SJ, Brake WG, Ferguson D, Luine V, Allen PB, Greengard P, McEwen BS Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus. SYNAPSE 2002 AUG;45(2):143-151
196. Yan Z, Chi P, Bibb JA, Ryan TA, Greengard P Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. J PHYSIOL-LONDON 2002 MAY 1;540(3):761-770
197. Gasparini L, Netzer WJ, Greengard P, Xu HX Does insulin dysfunction play a role in Alzheimer’s disease?. TRENDS PHARMACOL SCI 2002 JUN;23(6):288-293
198. Greengard P The neurobiology of dopamine signaling. CATECHOLAMINE RESEARCH: FROM MOLECULAR INSIGHTS TO CLINICAL MEDICINE 2002;163-164
199. Knockaert M, Greengard P, Meijer L Pharmacological inhibitors of cyclin-dependent kinases. TRENDS PHARMACOL SCI 2002 SEP;23(9):417-425
200. Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. NAT NEUROSCI 2002 MAY;5(5):431-437
201. Lindskog M, Svenningsson P, Pozzi L, Kim Y, Fienberg AA, Bibb JA, Fredholm BB, Nairn AC, Greengard P, Fisone G Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. NATURE 2002 AUG 15;418(6899):774-778
202. Xu H, Greenfield JP, Cai D, Leung LW, Kassik K, Rodriguez-Boulan E, Greengard P Hormonal control of cerebral amyloidogenesis in Alzheimer’s diseases. J NEUROCHEM 2002 JUN;81():82
203. Scott L, Kruse MS, Forssberg H, Brismar H, Greengard P, Aperia A Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation. PROC NAT ACAD SCI USA 2002 FEB 5;99(3):1661-1664
204. Shupliakov O, Bloom O, Gustafsson JS, Kjaerulff O, Low P, Tomilin N, Pieribone VA, Greengard P, Brodin L Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton. PROC NAT ACAD SCI USA 2002 OCT 29;99(22):14476-14481
205. Luo W, Han P, Kim B, Honig G, Greengard P, Xu H Regulation of BACE expression by estrogen. NEUROBIOL AGING 2002 JUL-AUG;23(1):S14
206. Netzer W, Dou F, Greengard P, Xu HX Does a protein folding defect contribute to gamma-secretase activity?. NEUROBIOL AGING 2002 JUL-AUG;23(1):S191
207. Takahashi RH, Milner TA, Li F, Bartscher J, Lin M, Beal MF, Gouras GK, Yamaguchi H, Greengard P Regulation of subcellular neuronal A beta 42 accumulation with aging. NEUROBIOL AGING 2002 JUL-AUG;23(1):S396
208. Cai D, Greenfield JP, Greengard P, Xu H, Thinakaran G, Sisodia S, Gandy S A potential role of presenilins in regulating the intracellular trafficking and metabolism of the beta-amyloid precursor protein. NEUROBIOL AGING 2002 JUL-AUG;23(1):S558
209. Matsuyama S, Higashi H, Maeda H, Greengard P, Nishi A Neurotensin regulates DARPP-32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors. J NEUROCHEM 2002 APR;81(2):325-334
210. Irwin N, Chao S, Goritchenko L, Horiuchi A, Greengard P, Nairn AC, Benowitz LI Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. PROC NAT ACAD SCI USA 2002 SEP 17;99(19):12427-12431
211. Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu HX, Greengard P, Gouras GK Intraneuronal Alzheimer A beta 42 accumulates in multivesicular bodies and is associated with synaptic pathology. AMER J PATHOL 2002 NOV;161(5):1869-1879
212. Nishi A, Greengard P Interaction of dopamine/DARPP-32 signaling with glutamate in neostriatal neurons. NEUROPHARMACOLOGY 2002 AUG;43(2):301
213. Flores-Hernandez J, Cepeda C, Hernandez-Echeagaray E, Calvert CR, Jokel ES, Fienberg AA, Greengard P, Levine MS Dopamine enhancement of NMDA currents in dissociated medium- sized striatal neurons: Role of D1 receptors and DARPP-32. J NEUROPHYSIOL 2002 DEC;88(6):3010-3020
214. Pieribone VA, Porton B, Rendon B, Feng J, Greengard P, Ka HT Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain. J COMP NEUROL 2002 DEC 9;454(2):105-114
215. Yamagata Y, Jovanovic JN, Czernik AJ, Greengard P, Obata K Bidirectional changes in synapsin I phosphorylation at MAP kinase-dependent sites by acute neuronal excitation in vivo. J NEUROCHEM 2002 MAR;80(5):835-842
216. Svenningsson P, Tzavara ET, Liu F, Fienberg AA, Nomikos GG, Greengard P DARPP-32 mediates serotonergic neurotransmission in the forebrain. PROC NAT ACAD SCI USA 2002 MAR 5;99(5):3188-3193
217. Greenfield JP, Leung LW, Cai DM, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu HX Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J BIOL CHEM 2002 APR 5;277(14):12128-12136
218. Svenningsson P, Tzavara ET, Witkin JM, Fienberg AA, Nomikos GG, Greengard P Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). PROC NAT ACAD SCI USA 2002 MAR 5;99(5):3182-3187
219. Zachariou V, Benoit-Marand M, Allen PB, Ingrassia P, Fienberg AA, Gonon F, Greengard P, Picciotto MR Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or inhibitor 1. BIOL PSYCHIAT 2002 APR 15;51(8):612-620
220. Nishi A, Bibb JA, Matsuyama S, Hamada M, Higashi H, Nairn AC, Greengard P Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A. J NEUROCHEM 2002 MAY;81(4):832-841
221. Reed TM, Repaske DR, Snyder GL, Greengard P, Vorhees CV Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. J NEUROSCI 2002 JUN 15;22(12):5188-5197
222. Menegon A, Verderio C, Leoni C, Benfenati F, Czernik AJ, Greengard P, Matteoli M, Valtorta F Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neurons. J NEUROSCI 2002 AUG 15;22(16):7016-7026
223. Greengard P The neurobiology of dopamine signaling. EUR PSYCHIAT 2002 MAY;17():38S
224. Albert KA, Hemmings HC Jr , Adamo AIB, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE Jr , Greengard P Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. ARCH GEN PSYCHIAT 2002 AUG;59(8):705-712
225. Koh PO, Ashiwel US, Levenson R, Allen PB, Greengard P, Goldman-Rakic PS, Lidow MS Analysis of the levels of D2 dopamine receptor-interacting proteins, neuronal Ca2+sensor-1 (NCS-1), filamin-A, and spinophilin in the dorsolateral prefrontal cortex of schizophrenic, bipolar, and depressive patients. BIOL PSYCHIAT 2002 APR 15;51(8):44S
226. Grossman SD, Hsieh-Wilson LC, Allen PB, Nairn AC, Greengard P The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines. NEUROMOL MED 2002;2(1):61-69
227. Feng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Ferreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P Regulation of neurotransmitter release by synapsin III. J NEUROSCI 2002 JUN 1;22(11):4372-4380
228. Humeau Y, Doussau F, Vitiello F, Greengard P, Benfenati F, Poulain B Synapsin controls both reserve and releasable synaptic vesicle pools during neuronal activity and short-term plasticity in Aplysia. J NEUROSCI 2001 JUN 15;21(12):4195-4206
229. Chi P, Greengard P, Ryan TA Synapsin dispersion and reclustering during synaptic activity. NAT NEUROSCI 2001 DEC;4(12):1187-1193
230. Snyder GL, Yan Z, Galdi S, Allen PB, Fienberg AA, Bibb JA, Huganir RL, Nairn AC, Greengard P A D1-receptor/PKA/DARPP-32/PPI pathway regulates ampa receptor phosphorylation and conductance in the neostriatum. BRIT J PHARMACOL 2001 MAY;133():NIL_137
231. Yan RQ, Han P, Miao H, Greengard P, Xu HX The transmembrane domain of the Alzheimer’s beta-secretase (BACE1) determines its late Golgi localization and access to beta-amyloid precursor protein (APP) substrate. J BIOL CHEM 2001 SEP 28;276(39):36788-36796
232. Sabo SL, Ikin AF, Buxbaum JD, Greengard P The Alzheimer amyloid precursor protein (APP) and FE65, an APP- binding protein, regulate cell movement. J CELL BIOL 2001 JUN 25;153(7):1403-1414
233. Lidow MS, Song ZM, Castner SA, Allen PB, Greengard P, Goldman-Rakic PS Antipsychotic treatment induces alterations in dendrite- and spine-associated proteins in dopamine-rich areas of the primate cerebral cortex. BIOL PSYCHIAT 2001 JAN 1;49(1):1-12
234. Risinger FO, Freeman PA, Greengard P, Fienberg AA Motivational effects of ethanol in DARPP-32 knock-out mice. J NEUROSCI 2001 JAN 1;21(1):340-348
235. Watanabe T, Huang HB, Horiuchi A, Silva EFD, Hsieh-Wilson L, Allen PB, Shenolikar S, Greengard P, Nairn AC Protein phosphatase 1 regulation by inhibitors and targeting subunits. PROC NAT ACAD SCI USA 2001 MAR 13;98(6):3080-3085
236. Hilfiker S, Czernik AJ, Greengard P, Augustine GJ Tonically active protein kinase A regulates neurotransmitter release at the squid giant synapse. J PHYSIOL-LONDON 2001 FEB 15;531(1):141-146
237. Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease – A property common to most cycline- dependent kinase inhibitors?. J BIOL CHEM 2001 JAN 5;276(1):251-260
238. Greengard P Beyond the dopamine receptor. BIOL PSYCHIAT 2001 APR 15;49(8):2S
239. Huang HB, Chen YC, Horiuchi A, Tsai LH, Liu HT, Chyan CL, Hsieh MJ, Liu CK, Lin FM, Greengard P, Nairn AC, Shiao MS, Lin TH Letter to the Editor: Backbone H-1, N-15, and C-13 resonance assignments of ARPP-19. J BIOMOL NMR 2001 APR;19(4):383-384
240. Calabresi P, Gubellini P, Centonze D, Picconi B, Bernardi G, Chergui K, Fienberg AA, Greengard P Stimulation of D1/PKA/DARPP-32/PP-1 pathway is required for corticostriatal LTD and LTP. BRIT J PHARMACOL 2001 MAY;133():NIL_138
241. Nairn AC, Greengard P A novel cyclin provides a link between dopamine and RNA processing. NEURON 2001 OCT 25;32(2):174-176
242. Eklof AC, Holtback U, Svennilson J, Fienberg A, Greengard P, Aperia A Increased blood pressure and loss of ANP-induced natriuresis in mice lacking DARPP-32 gene. CLIN EXP HYPERTENSION 2001 AUG;23(6):449-460
243. Carr AN, Schmidt AG, Suzuki Y, Del Monte F, Allen PB, Greengard P, Grupp IL, Holt BD, Hajjar RJ, Depaoli-Roach AA, Kranias EG The type-1 phosphatase activity is a critical determinant of cardiac function and remodeling in heart failure. CIRCULATION 2001 OCT 23;104(17):82
244. Brake WG, Alves SE, Dunlop JC, Lee SJ, Bulloch K, Allen PB, Greengard P, McEwen BS Novel target sites for estrogen action in the dorsal hippocampus: An examination of synaptic proteins. ENDOCRINOLOGY 2001 MAR;142(3):1284-1289
245. Bibbb JA, Nishi A, O’Callaghan JP, Ule J, Lan M, Snyder GL, Horiuchi A, Saito T, Hisanaga S, Czernik AJ, Nairn AC, Greengard P Phosphorylation of protein phosphatase inhibitor-1 by Cdk5. J BIOL CHEM 2001 APR 27;276(17):14490-14497
246. Calabresi P, Gubellini P, Picconi B, Centonze D, Pisani A, Bonsi P, Greengard P, Hipskind RA, Borrelli E, Bernardi G Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine. J NEUROSCI 2001 JUL 15;21(14):5110-5120
247. Liu F, Ma XH, Ule J, Bibb JA, Nishi A, DeMaggio AJ, Yan Z, Nairn AC, Greengard P Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors. PROC NAT ACAD SCI USA 2001 SEP 25;98(20):11062-11068
248. Kao HT, Porton B, Pieribone V, DeLisi LE, Greengard P, Saunders R, Cardno AG, McCarthy G, O’Donovan MC, Owen MJ Synapsin III: A candidate schizophrenia susceptibility gene that regulates neurogenesis. AMER J MED GENET 2001 OCT 8;105(7):589
249. Greengard P The neurobiology of dopamine signaling. BIOSCIENCE REP 2001 JUN;21(3):247-269
250. Greengard P Neuroscience – The neurobiology of slow synaptic transmission. SCIENCE 2001 NOV 2;294(5544):1024-1030
251. Muly EC, Greengard P, Goldman-Rakic PS Distribution of protein phosphatases-1 alpha and -1-gamma 1 and the D-1 dopamine receptor in primate prefrontal cortex: Evidence for discrete populations of spines. J COMP NEUROL 2001 NOV 19;440(3):261-270
252. Bibb JA, Chen JS, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. NATURE 2001 MAR 15;410(6826):376-380
253. Carr AN, Sutliff RL, Weber CS, Allen PB, Greengard P, de Lanerolle P, Kranias EG, Paul RJ Is myosin phosphatase regulated in vivo by inhibitor-1? Evidence from inhibitor-1 knockout mice. J PHYSIOL-LONDON 2001 JUL 15;534(2):357-366
254. Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu HX Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen- activated protein kinase signaling. J NEUROSCI 2001 APR 15;21(8):2561-2570
255. Gouras GK, Xu HX, Gross RS, Greenfield JP, Hai B, Wang R, Greengard P Testosterone reduces neuronal secretion of Alzheimer’s beta- amyloid peptides. PROC NAT ACAD SCI USA 2000 FEB 1;97(3):1202-1205
256. Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA-J AM MED ASSN 2000 MAR 22;283(12):1571-1577
257. Feng J, Yan Z, Ferreira A, Tomizawa K, Liauw JA, Zhuo M, Allen PB, Ouimet CC, Greengard P Spinophilin regulates the formation and function of dendritic spines. PROC NAT ACAD SCI USA 2000 AUG 1;97(16):9287-9292
258. Bibb JA, Yan Z, Svenningsson P, Snyder GL, Pieribone VA, Horiuchi A, Nairn AC, Messer A, Greengard P Severe deficiencies in dopamine signaling in presymptomatic Huntington’s disease mice. PROC NAT ACAD SCI USA 2000 JUN 6;97(12):6809-6814
259. Svenningsson P, Lindskog M, Ledent C, Parmentier M, Greengard P, Fredholm BB, Fisone G Regulation of the phosphorylation of the dopamine- and cAMP- regulated phosphoprotein of 32 kDa in vivo by dopamine D-1, dopamine D-2, and adenosine A(2A) receptors. PROC NAT ACAD SCI USA 2000 FEB 15;97(4):1856-1860
260. Heyser CJ, Fienberg AA, Greengard P, Gold LH DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task. BRAIN RES 2000 JUN 9;867(1-2):122-130
261. Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, Bibb JA, Snyder GL, Greengard P, Zaharevitz DW, Gussio R, Senderowicz AM, Sausville EA, Kunick C, Meijer L Paullones are potent inhibitors of glycogen synthase kinase-3 beta and cyclin-dependent kinase 5/p25. EUR J BIOCHEM 2000 OCT;267(19):5983-5994
262. Mani SK, Fienberg AA, O’Callaghan JP, Snyder GL, Allen PB, Dash PK, Moore AN, Mitchell AJ, Bibb J, Greengard P, O’Malley BW Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice. SCIENCE 2000 FEB 11;287(5455):1053-1056
263. Allen PB, Hvalby O, Jensen V, Errington ML, Ramsay M, Chaudhry FA, Bliss TVP, Storm-Mathisen J, Morris RGM, Andersen P, Greengard P Protein phosphatase-1 regulation in the induction of long-term potentiation: Heterogeneous molecular mechanisms. J NEUROSCI 2000 MAY 15;20(10):3537-3543
264. Ferreira A, Kao HT, Feng J, Rapoport M, Greengard P Synapsin III: Developmental expression, subcellular localization, and role in axon formation. J NEUROSCI 2000 MAY 15;20(10):3736-3744
265. Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu HX, Greengard P, Relkin NR Intraneuronal A beta 42 accumulation in human brain. AMER J PATHOL 2000 JAN;156(1):15-20
266. Caporaso GL, Bibb JA, Snyder GL, Valle C, Rakhilin S, Fienberg AA, Hemmings HC Jr , Nairn AC, Greengard P Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia. NEUROPHARMACOLOGY 2000;39(9):1637-1644
267. Huang H, Chen Y, Tsai L, Wang H, Lin FM, Horiuchi A, Greengard P, Nairn AC, Shiao MS, Lin TH Letter to the Editor: Backbone H-1, N-15, and C-13 resonance assignments of inhibitor-2 – a protein inhibitor of protein phosphatase-1. J BIOMOL NMR 2000 AUG;17(4):359-360
268. Svenningsson P, Fienberg AA, Allen PB, Le Moine C, Lindskog M, Fisone G, Greengard P, Fredholm BB Dopamine D-1 receptor-induced gene transcription is modulated by DARPP-32. J NEUROCHEM 2000 JUL;75(1):248-257
269. Calabresi P, Gubellini P, Centonze D, Picconi B, Bernardi G, Chergui K, Svenningsson P, Fienberg AA, Greengard P Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. J NEUROSCI 2000 NOV 15;20(22):8443-8451
270. Menegon A, Dunlap DD, Castano F, Benfenati F, Czernik AJ, Greengard P, Valtorta F Use of phosphosynapsin I-specific antibodies for image analysis of signal transduction in single nerve terminals. J CELL SCI 2000 OCT;113(20):3573-3582
271. Flores-Hernandez J, Hernandez S, Snyder GL, Yan Z, Fienberg AA, Moss SJ, Greengard P, Surmeier DJ D-1 dopamine receptor activation reduces GABA(A) receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade. J NEUROPHYSIOL 2000 MAY;83(5):2996-3004
272. Snyder GL, Allen PB, Fienberg AA, Valle CG, Huganir RL, Nairn AC, Greengard P Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo. J NEUROSCI 2000 JUN 15;20(12):4480-4488
273. Nishi A, Bibb JA, Snyder GL, Higashi H, Nairn AC, Greengard P Amplification of dopaminergic signaling by a positive feedback loop. PROC NAT ACAD SCI USA 2000 NOV 7;97(23):12840-12845
274. Menegon A, Verderio C, Benfenati F, Czernik AJ, Greengard P, Matteoli M, Valtorta F Activity of pre-and post-synaptic CA2+/calmodulin-dependent protein kinase II in developing neurons. EUR J NEUROSCI 2000;12():279
275. Jovanovic JN, Czernik AJ, Fienberg AA, Greengard P, Sihra TS Synapsins as mediators of BDNF-enhanced neurotransmitter release. NAT NEUROSCI 2000 APR;3(4):323-329
276. Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T Neuron-specific phosphorylation of Alzheimer’s beta-amyloid precursor protein by cyclin-dependent kinase 5. J NEUROCHEM 2000 SEP;75(3):1085-1091
277. Aizman O, Brismar H, Uhlen P, Zettergren E, Levey AI, Forssberg H, Greengard P, Aperia A Anatomical and physiological evidence for D-1 and D-2 dopamine receptor colocalization in neostriatal neurons. NAT NEUROSCI 2000 MAR;3(3):226-230
278. Fienberg AA, Greengard P The DARPP-32 knockout mouse. BRAIN RES REV 2000 MAR;31(2-3):313-319
279. Greenfield JP, Xu HX, Greengard P, Gandy S, Seeger M Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer’s amyloid- beta precursor protein. J BIOL CHEM 1999 NOV 26;274(48):33843-33846
280. Holtback U, Brismar H, DiBona GF, Fu M, Greengard P, Aperia A Receptor recruitment: A mechanism for interactions between G protein-coupled receptors. PROC NAT ACAD SCI USA 1999 JUN 22;96(13):7271-7275
281. Sabo SL, Lanier LM, Ikin AF, Khorkova O, Sahasrabudhe S, Greengard P, Buxbaum JD Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J BIOL CHEM 1999 MAR 19;274(12):7952-7957
282. Carr AN, Sutliff RL, Allen PB, Weber CS, Greengard P, Kranias EG, Paul RJ Protein phosphatase inhibitor-1 gene ablation does not affect tonic or phasic vascular smooth muscle contractility. BIOPHYS J 1999 JAN;76(1):A290
283. Carr AN, Sato Y, Neirouz Y, Schmidt A, Hoit BD, Grupp IL, Allen PB, Greengard P, Kranias EG Gene ablation of protein phosphatase inhibitor-1 is associated with depressed cardiac contractility and decreased phospholamban phosphorylation. CIRCULATION 1999 NOV 2;100(18):763
284. Isohara T, Horiuchi A, Watanabe T, Ando K, Czernik AJ, Uno I, Greengard P, Nairn AC, Suzuki T Phosphorylation of the cytoplasmic domain of Alzheimer’s beta- amyloid precursor protein at Ser655 by a novel protein kinase. BIOCHEM BIOPHYS RES COMMUN 1999 MAY 10;258(2):300-305
285. Scrimgeour AG, Allen PB, Fienberg AA, Greengard P, Lawrence JC Jr Inhibitor-1 is not required for the activation of glycogen synthase by insulin in skeletal muscle. J BIOL CHEM 1999 JUL 23;274(30):20949-20952
286. Hilfiker S, Pieribone VA, Nordstedt C, Greengard P, Czernik AJ Regulation of synaptotagmin I phosphorylation by multiple protein kinases. J NEUROCHEM 1999 SEP;73(3):921-932
287. Cheng SXJ, Aizman O, Nairn AC, Greengard P, Aperia A [Ca2+](i) determines the effects of protein kinases A and C on activity of rat renal Na+, K+-ATPase. J PHYSIOL-LONDON 1999 JUL 1;518(1):37-46
288. Nishi A, Snyder GL, Fienberg AA, Fisone G, Aperia A, Naim AC, Greengard P Requirement for DARPP-32 in mediating effect of dopamine D2 receptor activation. EUR J NEUROSCI 1999 JUL;11(7):2589-2592
289. Mayerhofer A, Hemmings HC Jr , Snyder GL, Greengard P, Boddien S, Berg U, Brucker C Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. J CLIN ENDOCRINOL METAB 1999 JAN;84(1):257-264
290. Hiroi N, Fienberg AA, Haile CN, Alburges M, Hanson GR, Greengard P, Nestler EJ Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. EUR J NEUROSCI 1999 MAR;11(3):1114-1118
291. Hilfiker S, Greengard P, Augustine GJ Coupling calcium to SNARE-mediated synaptic vesicle fusion. NAT NEUROSCI 1999 FEB;2(2):104-106
292. Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. BIOCHEMISTRY-USA 1999 APR 6;38(14):4365-4373
293. Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells. PROC NAT ACAD SCI USA 1999 MAR 2;96(5):2467-2472
294. Watanabe T, Sukegawa J, Sukegawa I, Tomita S, Iijima K, Oguchi S, Suzuki T, Nairn AC, Greengard P A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer’s amyloid precursor protein. J NEUROCHEM 1999 FEB;72(2):549-556
295. Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu HX Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. PROC NAT ACAD SCI USA 1999 JAN;96(2):742-747
296. Yan Z, Hsieh-Wilson L, Feng JA, Tomizawa K, Allen PB, Fienberg AA, Nairn AC, Greengard P Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. NAT NEUROSCI 1999 JAN;2(1):13-17
297. Fienberg AA, Nordstedt C, Belting HG, Czernik AJ, Nairn AC, Gandy S, Greengard P, Ruddle FH Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6. J EXP ZOOL 1999 APR 15;285(1):76-84
298. Hilfiker S, Pieribone VA, Czernik AJ, Kao HT, Augustine GJ, Greengard P Synapsins as regulators of neurotransmitter release. PHIL TRANS ROY SOC LONDON B 1999 FEB 28;354(1381):269-279
299. Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn AC, Kirino Y, Greengard P, Suzuki T Role of phosphorylation of Alzheimer’s amyloid precursor protein during neuronal differentiation. J NEUROSCI 1999 JUN 1;19(11):4421-4427
300. Lindskog M, Svenningsson P, Fredholm B, Greengard P, Fisone G mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons. EUR J NEUROSCI 1999 JUN;11(6):2182-2186
301. Greengard P, Allen PB, Nairn AC Beyond the dopamine receptor: the DARPP-32/Protein phosphatase-1 cascade. NEURON 1999 JUL;23(3):435-447
302. Nishi A, Snyder GL, Nairn AC, Greengard P Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons. J NEUROCHEM 1999 MAY;72(5):2015-2021
303. Lindskog M, Svenningsson P, Fredholm BB, Greengard P, Fisone G Activation of dopamine D-2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms. NEUROSCIENCE 1999 FEB;88(4):1005-1008
304. Porton B, Kao TT, Greengard P Characterization of transcripts from the synapsin III gene locus. J NEUROCHEM 1999 DEC;73(6):2266-2271
305. Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC Jr , Nairn AC, Greengard P Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. NATURE 1999 DEC 9;402(6762):669-671
306. Heierhorst J, Mitchelhill KI, Mann RJ, Tiganis T, Czernik AJ, Greengard P, Kemp BE Synapsins as major neuronal Ca2+/S100A1-interacting proteins. BIOCHEM J 1999 DEC 1;344():577-583
307. Huang HB, Horiuchi A, Watanabe T, Shih SR, Tsay HJ, Li HC, Greengard P, Nairn AC Characterization of the inhibition of protein phosphatase-1 by DARPP-32 and inhibitor-2. J BIOL CHEM 1999 MAR 19;274(12):7870-7878
308. Ouimet CC, Langley-Gullion KC, Greengard P Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen. BRAIN RES 1998 OCT;808(1):8-12
309. Desdouits F, Siciliano JC, Nairn AC, Greengard P, Girault JA Dephosphorylation of Ser-137 in DARPP-32 by protein phosphatases 2A and 2C: different roles in vitro and in striatonigral neurons. BIOCHEM J 1998 FEB;330():211-216
310. Allen PB, Kwon YG, Nairn AC, Greengard P Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. J BIOL CHEM 1998 FEB;273(7):4089-4095
311. Desdouits-Magnen J, Desdouits F, Takeda S, Syu LJ, Saltiel AR, Buxbaum JD, Czernik AJ, Nairn AC, Greengard P Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. J NEUROCHEM 1998 FEB;70(2):524-530
312. Ferreira A, Chin LS, Li L, Lanier LM, Kosik KS, Greengard P Distinct roles of synapsin I and synapsin II during neuronal development. MOL MED 1998 JAN;4(1):22-28
313. Svenningsson P, Lindskog M, Rognoni F, Fredholm BB, Greengard P, Fisone G Activation of adenosine A(2A) and dopamine D-1 receptors stimulates cyclic AMP dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons. NEUROSCIENCE 1998 MAY;84(1):223-228
314. Schiffmann SN, Desdouits F, Menu R, Greengard P, Vincent JD, Vanderhaeghen JJ, Girault JA Modulation of the voltage-gated sodium current in rat striatal neurons by DARPP-32, an inhibitor of protein phosphatase. EUR J NEUROSCI 1998 APR;10(4):1312-1320
315. Xu HX, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. NATURE MED 1998 APR;4(4):447-451
316. Fisone G, Snyder GL, Aperia A, Greengard P Na+,K+-ATPase phosphorylation in the choroid plexus: Synergistic regulation by serotonin/protein kinase C and isoproterenol/cAMP- PK/PP-1 pathways. MOL MED 1998 APR;4(4):258-265
317. Hilfiker S, Schweizer FE, Kao HT, Czernik AJ, Greengard P, Augustine GJ Two sites of action for synapsin domain E in regulating neurotransmitter release. NAT NEUROSCI 1998 MAY;1(1):29-35
318. Greengard P, Nairn AC, Girault JA, Ouimet CC, Snyder GL, Fisone G, Allen PB, Fienberg A, Nishi A The DARPP-32 protein phosphatase-1 cascade: a model for signal integration. BRAIN RES REV 1998 MAY;26(2-3):274-284
319. Benfenati F, Onofri F, Vaccaro P, Giovedi S, Valtorta F, Greengard P Regulation of synaptic vesicle trafficking by protein phosphorylation. EUR J NEUROSCI 1998;10():108
320. Greengard P, Fienberg A DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. BIOL PSYCHIAT 1998 APR;43():78S
321. Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P A third member of the synapsin gene family. PROC NAT ACAD SCI USA 1998 APR;95(8):4667-4672
322. Fienberg AA, Hiroi N, Mermelstein PG, Song WJ, Snyder GL, Nishi A, Cheramy A, O’Callaghan JP, Miller DB, Cole DG, Corbett R, Haile CN, Cooper DC, Onn SP, Grace AA, Ouimet CC, White FJ, Hyman SE, Surmeier DJ, Girault JA, Nestler EJ, Greengard P DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. SCIENCE 1998 AUG;281(5378):838,839-842
323. Brismar H, Asghar M, Carey RM, Greengard P, Aperia A Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane. PROC NAT ACAD SCI USA 1998 MAY;95(10):5573-5578
324. Meredith JM, Moffatt CA, Auger AP, Snyder GL, Greengard P, Blaustein JD Mating-related stimulation induces phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in progestin receptor- containing areas in the female rat brain. J NEUROSCI 1998 DEC;18(23):10189-10195
325. Buxbaum JD, Ikin A, Luo Y, Naslund J, Sabo S, Vincent B, Watanabe T, Greengard P Regulation of APP metabolism by protein phosphorylation. PROGRESS IN ALZHEIMER’S AND PARTINSON’S DISEASES 1998;133-140
326. Buxbaum JD, Ikin A, Luo Y, Naslund J, Sabo S, Vincent B, Watanabe T, Greengard P App localization and trafficking in the central nervous system. PROGRESS IN ALZHEIMER’S AND PARTINSON’S DISEASES 1998;487-494
327. Gouras GK, Xu HX, Jovanovic JN, Buxbaum JD, Wang R, Greengard P, Relkin NR, Gandy S Generation and regulation of beta-amyloid peptide variants by neurons. J NEUROCHEM 1998 NOV;71(5):1920-1925
328. Snyder GL, Fienberg AA, Huganir RL, Greengard P A dopamine D1 receptor protein kinase A dopamine- and cAMP- regulated phosphoprotein (M-r 32 kDa) protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor. J NEUROSCI 1998 DEC;18(24):10297-10303
329. McAvoy T, Nairn AC, Greengard P, Hemmings HC Jr Identification and purification of protein phosphatase 1 binding proteins in rat brain. FASEB J 1998 APR 24;12(8):A1300
330. Kwon YG, Allen PB, Konarska M, Greengard P, Nairn AC Characterization of PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. FASEB J 1998 APR 24;12(8):A1300
331. Belusa R, Wang ZM, Matsubara T, Sahlgren B, Dulubova I, Nairn AC, Ruoslahti E, Greengard P, Aperia A Mutation of the protein kinase C phosphorylation site on rat alpha 1 Na+,K+-ATPase alters regulation of intracellular Na+ and pH and influences cell shape and adhesiveness. J BIOL CHEM 1997 AUG;272(32):20179-20184
332. Vaccaro P, Dente L, Onofri F, Zucconi A, Martinelli S, Valtorta F, Greengard P, Cesareni G, Benfenati F Anti-synapsin monoclonal antibodies: epitope mapping and inhibitory effects on phosphorylation and Grb2 binding. MOL BRAIN RES 1997 DEC;52(1):1-16
333. Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T The cytoplasmic domain of Alzheimer’s amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. MOL MED 1997 FEB;3(2):111-123
334. Stefani G, Kao HT, Pieribone V, Benfenati F, Greengard P Synapsin isoforms from lamprey: Evolutionary and functional significance. PFLUGERS ARCH-EUR J PHYSIOL 1997 JUN;434(2):R9
335. Cheng XJ, Fisone G, Aizman O, Aizman R, Levenson R, Greengard P, Aperia A PKA-mediated phosphorylation and inhibition of Na+-K+-ATPase in response to beta-adrenergic hormone. AMER J PHYSIOL-CELL PHYSIOL 1997 SEP;42(3):C893-C9
336. Allen PB, Ouimet CC, Greengard P Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. PROC NAT ACAD SCI USA 1997 SEP;94(18):9956-9961
337. Cheng XJ, Aizman O, Aperia A, Greengard P, Nairn AC [Ca2+]i modulates the effects of PKA and PKC activation on renal Na+,K+-ATPase (NKA). J AMER SOC NEPHROL 1997 SEP;8():31A
338. Svennilson J, Eklof AC, Lofstedt M, Feinberg A, Greengard P, Aperia A Role of the dopamine regulated phosphoprotein DARPP32 in the late embryonic development of the rat kidney. J AMER SOC NEPHROL 1997 SEP;8():367A
339. Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, St George-Hyslop P, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S Evidence for phosphorylation and oligomeric assembly of presenilin 1. PROC NAT ACAD SCI USA 1997 MAY;94(10):5090-5094
340. Kwon YG, Lee SY, Choi YW, Greengard P, Nairn AC Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. PROC NAT ACAD SCI USA 1997 MAR;94(6):2168-2173
341. Huang HB, Horiuchi A, Goldberg J, Greengard P, Nairn AC Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding. PROC NAT ACAD SCI USA 1997 APR;94(8):3530-3535
342. Kwon YG, Huang HB, Desdouits F, Girault JA, Greengard P, Nairn AC Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. PROC NAT ACAD SCI USA 1997 APR;94(8):3536-3541
343. Xu HX, Sweeney D, Wang R, Thinakaran G, Lo ACY, Sisodia SS, Greengard P, Gandy S Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. PROC NAT ACAD SCI USA 1997 APR;94(8):3748-3752
344. Schnabel R, Metzger M, Jiang SC, Hemmings HC Jr, Greengard P, Braun K Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain. J COMP NEUROL 1997 NOV;388(1):146-168
345. Onofri F, Giovedi S, Vaccaro P, Czernik AJ, Valtorta F, De Camilli P, Greengard P, Benfenati F Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity. PROC NAT ACAD SCI USA 1997 OCT;94(22):12168-12173
346. Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. BIOCHEMISTRY-USA 1997 APR;36(15):4643-4649
347. Nishi A, Snyder GL, Greengard P Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J NEUROSCI 1997 NOV;17(21):8147-8155
348. Nowicki S, Chen SL, Aizman O, Cheng XJ, Li DL, Nowicki C, Nairn A, Greengard P, Aperia A 20-hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C – Role in regulation of rat renal Na+,K+-ATPase. J CLIN INVEST 1997 MAR;99(6):1224-1230
349. Blank T, Nijholt I, Teichert U, Kugler H, Behrsing H, Fienberg A, Greengard P, Spiess J The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses. PROC NAT ACAD SCI USA 1997 DEC;94(26):14859-14864
350. Nielander HB, Onofri F, Schaeffer E, Menegon A, Fesce R, Valtorta F, Greengard P, Benfenati F Phosphorylation-dependent effects of synapsin IIa on actin polymerization and network formation. EUR J NEUROSCI 1997 DEC;9(12):2712-2722
351. Cheng XJ, Hoog JO, Nairn AC, Greengard P, Aperia A Regulation of rat Na+-K+-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA. AMER J PHYSIOL-CELL PHYSIOL 1997 DEC;42(6):C1981-C
352. Stefani G, Onofri F, Valtorta F, Vaccaro P, Greengard P, Benfenati F Kinetic analysis of the phosphorylation-dependent interactions of synapsin I with rat brain synaptic vesicles. J PHYSIOL-LONDON 1997 NOV;504(3):501-515
353. Ikin AF, Annaert WG, Takei K, De Camilli P, Jahn R, Greengard P, Buxbaum JD Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. J BIOL CHEM 1996 DEC;271(50):31783-31786
354. Kao HT, Stefani G, Han HQ, Pieribone VA, Greengard P Synapsin isoforms from primitive vertebrates: Evolutionary and functional significance Biol. Psychiat. 1996;39(7):322-322
355. Jovanovic JN, Benfenati F, Siow YL, Sihra TS, Sanghera JS, Pelech SL, Greengard P, Czernik AJ Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions Proc. Natl. Acad. Sci. U. S. A. 1996;93(8):3679-36
356. Ikin A, Annaert WG, Takei K, De Camilli P, Jahn R, Greengard P, Buxbaum JD Amyloid protein precursor (APP) is enriched in Rab5-containing, vesicular organelles. MOL BIOL CELL 1996 DEC;7():326A
357. Hilfiker-Rothenfluh S, Greengard P, Czernik AJ Phosphorylation of synaptotagmin I by CaM kinase II, protein kinase C and casein kinase II in vitro and in vivo. MOL BIOL CELL 1996 DEC;7():446A
358. Zhou ZM, Smith JD, Greengard P, Gandy S Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E Mol. Med. 1996;2(2):175-180
359. Desdouits F, Buxbaum JD, DesdouitsMagnen J, Nairn AC, Greengard P Amyloid beta peptide formation in cell-free preparations – Regulation by protein kinase C, calmodulin, and calcineurin J. Biol. Chem. 1996;271(40):24670-24674
360. Jovanovic JN, Sihra TS, Nairn AC, Greengard P, Czernik AJ Regulation of MAP kinase activity and phosphorylation of synapsin I in presynaptic nerve terminals. MOL BIOL CELL 1996 DEC;7():654A
361. Lu B, Czernik AJ, Popov S, Wang T, Poo MM, Greengard P Expression of synapsin I correlates with maturation of the neuromuscular synapse Neuroscience 1996;74(4):1087-1097
362. Ryan TA, Li LA, Chin LS, Greengard P, Smith SJ Synaptic vesicle recycling in synapsin I knock-out mice J. Cell Biol. 1996;134(5):1219-1227
363. Cheng XJ, Fisone G, Aizman O, Aizman R, Levenson R, Greengard P, Aperia A Phosphorylation & inhibition of renal Na,K-ATPase in response to beta-adrenergic hormone. J. Am. Soc. Nephrol. 1996;7(9):A0152-A0152
364. Logvinenko NS, Dulubova I, Fedosova N, Larsson SH, Nairn AC, Esmann M, Greengard P, Aperia A Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K+-ATPase affects its conformational equilibrium Proc. Natl. Acad. Sci. U. S. A. 1996;93(17):9132-9
365. Gnegy ME, Iwata SI, Hewlett K, Ferrell ST, Czernik AJ, Greengard P, Meiri KF Phosphorylation of synapsin I and GAP-43 in rat striatum In amphetamine sensitization (AMP-SEN). Faseb J. 1996;10(3):2590-2590
366. Xu HX, Sweeney D, Greengard P, Gandy S Metabolism of Alzheimer beta-amyloid precursor protein: Regulation by protein kinase A in intact cells and in a cell-free system Proc. Natl. Acad. Sci. U. S. A. 1996;93(9):4081-40
367. Qian YF, Chao DS, Santillano DR, Cornwell TL, Nairn AC, Greengard P, Lincoln TM, Bredt DS cGMP-dependent protein kinase in dorsal root ganglion: Relationship with nitric oxide synthase and nociceptive neurons J. Neurosci. 1996;16(10):3130-3138
368. Buxbaum JD, Greengard P Regulation of APP processing by intra- and intercellular signals Neurobiology of Alzheimer’S Disease Annals of the
369. Ferreira A, Li L, Chin LS, Greengard P, Kosik KS Postsynaptic element contributes to the delay in synaptogenesis in synapsin I-deficient neurons. MOL CELL NEUROSCI 1996;8(4):286-299
370. Petanceska S, Thinakaran G, Sisodia S, Greengard P, Gandy S Effects of wortmannin and BFA on processing of the amyloid precursor protein. MOL BIOL CELL 1996 DEC;7():78A
371. Kaplitt M, Gouras GK, Makimura H, Jovanovic J, Sweeney D, Greengard P, Relkin NR, Gandy S Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer’s disease – Therapeutic implications. APOLIPOPROTEIN E GENOTYPING IN ALZHEIMER’S DISEASE
372. Alder J, Kanki H, Valtorta F, Greengard P, Poo M Overexpression of synaptophysin enhances neurotransmitter secretion at Xenopus neuromuscular synapses. Journal of neuroscience. 1995;15:511-519
373. Desdouits F, Cheetham JJ, Huang HB, Kwon YG, da Cruz e Silva EF, Denefle P, Ehrlich ME, Nairn AC, Greengard P, Girault JA Mechanisms of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptides. Biochemical & biophysical research communications. 1995;206:652-658
374. Valtorta F, Iezzi N, Benfenati F, Lu B, Poo M, Greengard P Accelerated structural maturation induced by synapsin I at developing neuromuscular synapses of Xenopus laevis. European journal of neuroscience. 1995;7:261-270
375. Greengard P, Snyder G, Fisone G, Aperia A Interactions of signal transduction pathways in the nervous system Challenges and Perspectives in Neuroscience Wenner
376. Surmeier DJ, Bargas J, Hemmings HC, Nairn AC, Greengard P Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron. 1995;14:385-397
377. Fisone G, Snyder GL, Fryckstedt J, Caplan MJ, Aperia A, Greengard P Na+,K+-ATPase in the choroid plexus. Journal of biological chemistry. 1995;270:2427-2430
378. Snyder GL, Fisone G, Greengard P Phosphorylation of DARPP-32 is regulated by GABA in rat striatum and substantia nigra. Journal of neurochemistry. 1994;63:1766-1771
379. Chilcote TJ, Siow YL, Schaeffer E, Greengard P, Thiel G Synapsin IIa bundles actin filaments. Journal of neurochemistry. 1994;63:1568-1571
380. Schaeffer E, Alder J, Greengard P, Poo M Synapsin IIa accelerates functional development of neuromuscular synapses. Proc Nat Acad Sci 1994;91:3882-3886
381. Aperia A, Holtback U, Syren M-L, Svensson L-B, Fryckstedt J, Greengard P Activation/deactivation of renal Na+,K+-ATPase: a final common pathway for regulation of natriuresis. FASEB journal. 1994;8:436-439
382. Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO journal. 1994;13:1114-1122
383. Brene S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. Journal of neuroscience. 1994;14:985-998
384. Fisone G, Cheng SX-J, Nairn AC, Czernik AJ, Hemmings HC, Hoog J-O, Bertorello AM, Kaiser R, Bergman T, Jornvall H, Aperia A, Greengard P Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K+-ATPase and effects of site-directed mutagenesis. Journal of biological chemistry. 1994;269:9368-9373
385. Chin L-S, Li L, Greengard P Neuron-specific expression of the synapsis II gene is directed by a specific core promoter and upstream regulatory elements. Journal of biological chemistry. 1994;269:18507-18513
386. Dohadwala M, da Cruz e Silva EF, Hall FL, Williams RT, Carbonaro-Hall DA, Nairn AC, Greengard P, Berndt N Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases. Proc Nat Acad Sci 1994;91:6408-6412
387. McPherson PS, Czernik AJ, Chilcote TJ, Onofri F, Benfenati F, Greengard P, Schlessinger J, De Camilli P Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. Proc Nat Acad Sci 1994;91:6486-6490
388. Naslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE, Winblad B, Greengard P, Nordstedt C, Terenius L Relative abundance of Alzheimer A-beta amyloid peptide variants in Alzheimer disease and normal aging. Proc Nat Acad Sci 1994;91:8378-8382
389. Han H-Q, Greengard P Remodeling of cytoskeletal architecture of nonneuronal cells induce by synapsin. Proc Nat Acad Sci 1994;91:8557-8561
390. Gandy S, Greengard P Regulated cleavage of the Alzheimer amyloid precursor protein: molecular and cellular basis. Biochimie. 1994;76:300-303
391. Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. Journal of biological chemistry. 1994;269:13065-13068
392. Buxbaum JD, Ruefli AA, Parker CA, Cypess AM, Greengard P Calcium regulated processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Nat Acad Sci 1994;91:4489-4493
393. Miles K, Audigier SSM, Greengard P, Huganir RL Autoregulation of phosphorylation of the nicotinic acetylcholine receptor. Journal of neuroscience. 1994;14:3271-3279
394. Caporaso GL, Takei K, Gandy SE, Matteoli M, Mundigl O, Greengard P, De Camilli P Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. Journal of neuroscience. 1994;14:3122-3138
395. Ferreira A, Kosik KS, Greengard P, Han H-Q Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. Science. 1994;264:977-979
396. Gandy S, Greengard P Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease. International review of neurobiology. 1994;36:29-50
397. Hvalby O, Hemmings HC, Paulsen O, Czernik AJ, Nairn AC, Godfraind J-M, Jensen V, Raastad M, Storm JF, Andersen P, Greengard P Specificity of protein kinase inhibitor peptides and induction of long-term potentiation. Proc Nat Acad Sci 1994;91:4761-4765
398. Greengard P, Valtorta F, Czernik AJ, Benfenati F Synaptic vesicle phosphoproteins and regulation of synaptic function. Science. 1993;259:780-785
399. Rubenstein JL, Greengard P, Czernik AJ Calcium-dependent serine phosphorylation of synaptophysin. Synapse. 1993;13:161-172
400. Snyder GL, Fisone G, Morino P, Gundersen V, Ottersen OP, Hokfelt T, Greengard P Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum. Proceedings of the National Academy of Sciences. 1993;90:11277-11281
401. Benfenati F, Valtorta F, Rossi MC, Onofri F, Sihra T, Greengard P Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures. Journal of cell biology. 1993;123:1845-1855
402. Buxbaum JD, Christensen JL, Fuefli AA, Greengard P, Loring JF Expression of APP in brains of transgenic mice containing the entire human APP gene. Biochemical & biophysical research communications. 1993;197:639-645
403. Knops J, Gandy S, Greengard P, Lieberburg I, Sinha S Serine phosphorylation of the secreted extracellular domain of APP. Biochemical & biophysical research communications. 1993;197:380-385
404. Ibarra F, Aperia A, Svensson L-B, Eklof A-C, Greengard P Bidirectional regulation of Na+,K+-ATPase activity by dopamine and an alpha-adrenergic agonist. Proc Nat Acad Sci 1993;90:21-24
405. Gandy SE, Caporaso GL, Buxbaum JD, de Cruz Silva O, Iverfeldt K, Nordstedt C, Suzuki T, Czernik AJ, Nairn AC, Greengard P Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein. Annals of the New York Academy of Sciences. 1993;695:117-121
406. Ceccaldi PE, Benfenati F, Chieregatti E, Greengard P, Valtorta F Rapid binding of synapsin I to F- and G-actin. A study using fluorescence resonance energy transfer. FEBS letters. 1993;329:301-305
407. Walaas SI, Greengard P ARPP-39, a membrane-associated substrate for cyclic AMP-dependent protein kinase present in neostriatal neurons. Journal of molecular neuroscience. 1993;4:73-88
408. Nordstedt C, Caporaso GL, Thyberg J, Gandy SE, Greengard P Identification of the Alzheimer beta/A4 amyloid precursor proteins in clathrin-coated vesicles purified from PC12 cells. Journal of biological chemistry. 1993;268:608-612
409. Tsou K, Snyder GL, Greengard P Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, in the substantia nigra. Proc Nat Acad Sci 1993;90:3462-3465
410. Neyroz P, Desdouits F, Benfenati F, Knutson JR, Greengard P, Girault J-A Study of the conformation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by fluorescence spectroscopy. Journal of biological chemistry. 1993;268:24022-24031
411. de Crux e Silva OAB, Iverfeldt K, Oltersdorf T, Sinha S, Leiberburg I, Ramadhadran TV, Suzuki T, Sisodia SS, Gandy S, Greengard P Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail. Neuroscience. 1993;57:873-877
412. Lu B, Fu W-m, Greengard P, Poo M-m Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction. Nature. 1993;363:76-79
413. Iverfeldt K, Walaas SI, Greengard P Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration. Proc Nat Acad Sci 1993;90:4146-4150
414. Li L, Suzuki T, Mori N, Greengard P Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proc Nat Acad Sci 1993;90:1460-1464
415. Tsou K, Girault J-A, Greengard P Dopamine D1 agonist SKF 38393 increases the state of phosphorylation of ARPP-21 in substantia nigra. Journal of neurochemistry. 1993;60:1043-1046
416. Gustafson EL, Ehrlich ME, Trivedi P, Greengard P Developmental regulation of phosphoprotein gene expression in the caudate-putamen of rat: an in situ hybridization study. Neuroscience. 1992;51:65-75
417. Gandy SE, Buxbaum JD, Suzuki T, Ramabhadran TV, Caporaso GL, Nairn AC, Greengard P The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of Alzheimer beta/A4-amyloid precursor protein: some technical notes. Neurobiology of aging. 1992;13:601-603
418. Mandell JW, Czernik AJ, De Camilli P, Greengard P, Townes-Anderson E Differential expression of synapsins I and II among rat retinal synapses. Journal of neuroscience. 1992;12:1736-1749
419. Gandy SE, Caporaso GL, Ramabhadran TV, Suzuki T, Buxbaum JD, Nordstedt C, Iverfeldt K, Czernik AJ, Nairn AC, Greengard P Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine. Annals of the New York Academy of Sciences. 1992;674:203-217
420. Aperia A, Ibarra F, Svensson L-B, Klee C, Greengard P Calcineurin mediates alpha-adrenergic stimulation of Na+,K+-ATPase activity of renal tubule cells. Proceedings of the National Academy of Sciences. 1992;89:7394-7397
421. Snyder GL, Girault J-A, Chen JYC, Czernik AJ, Kebabian JW, Nathanson JA, Greengard P Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine. Journal of neuroscience. 1992;12:3071-3083
422. Gandy S, Greengard P Amyloidogenesis in Alzheimer’s disease: some possible therapeutic opportunities. Trends in pharmacological sciences. 1992;13:108-113
423. Valtorta F, Greengard P, Fesce R, Chieregatti E, Benfenati F Effects of the neuronal phosphoprotein synapsin I on actin polymerization. 1. Evidence for a phosphorylation-dependent nucleating effect. Journal of biological chemistry. 1992;267:11281-11288
424. Fesce R, Benfenati F, Greengard P, Valtorta F Effects of the neuronal phosphoprotein synapsin I on actin polymerization. 2. Analytical interpretation of kinetic curves. Journal of biological chemistry. 1992;267:11289-11299
425. Hemmings HC, Girault J-A, Nairn AC, Bertuzzi G, Greengard P Distribution of protein phosphatase inhibitor-1 in brain and peripheral tissues of various species: comparison with DARPP-32. Journal of neurochemistry. 1992;59:1053-1061
426. Lu B, Greengard P, Poo M-m Exogenous synapsin 1 promotes functional maturation of developing neuromuscular synapses. Neuron. 1992;8:521-529
427. Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC Phosphorylation of the cystic fibrosis transmembrane conductance regulator. Journal of biological chemistry. 1992;267:12742-12752
428. Caporaso GL, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proceedings of the National Academy of Sciences. 1992;89:3055-3059
429. Suzuki T, Nairn AC, Gandy SE, Greengard P Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C. Neuroscience. 1992;48:755-761
430. Gandy SE, Bhasin R, Ramabhadran TV, Koo EH, Price DL, Goldgaber D, Greengard P Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment. Journal of neurochemistry. 1992;58:383-386
431. Nichols RA, Chilcote TJ, Czernik AJ, Greengard P Synapsin I regulates glutamate release from rat brain synaptosomes. Journal of neurochemistry. 1992;58:783-785
432. Girault J-A, Chamak B, Bertuzzi G, Tixier H, Wang JKT, Pang DT, Greengard P Protein phosphotyrosine in mouse brain: developmental changes and regulation by epidermal growth factor, type I insulin-like growth factor, and insulin. Journal of neurochemistry. 1992;58:518-528
433. Benfenati F, Valtorta F, Chieregatti E, Greengard P Interaction of free and synaptic vesicle-bound synapsin I with F-actin. Neuron. 1992;8:377-386
434. Alder J, Xie Z-P, Valtorta F, Greengard P, Poo M-m Antibodies to synaptophysin interfere with transmitter secretion at neuromuscular synapses. Neuron. 1992;9:759-768
435. Torri Tarelli F, Bossi M, Fesce R, Greengard P, Valtorta F Synapsin I partially dissociates from synaptic vesicles during exocytosis induced by electrical stimulation. Neuron. 1992;9:1143-1153
436. Ouimet CC, Lamantia AS, Goldman-Rakic P, Rakic P, Greengard P Immunocytochemical localization of DARPP-32, a dopamine and cyclic-AMP regulated phosphoprotein, in the primate brain. Journal of comparative neurology. 1992;323:209-218
437. Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski R, Jaffe EA, Gandy SE, Greengard P Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proceedings of the National Academy of Sciences. 1992;89:10075-10078
438. Siow YL, Chilcote TJ, Benfenati F, Greengard P, Thiel G Synapsin IIa: expression in insect cells, purification, and characterization. Biochemistry (American Chemical Society). 1992;31:4268-4275
439. Nordstedt C, Gandy SE, Alafuzoff I, Caporaso GL, Iverfeldt K, Grebb JA, Winblad B, Greengard P Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment. Proceedings of the National Academy of Sciences. 1991;88:8910-8914
440. Meister B, Arvidsson U, Hemmings HC, Greengard P, Hoekfelt T Dopamine- and adenosime-3’:5’-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human. Neuroscience letters. 1991;131:66-70
441. Meister B, Schultzberg M, Hemmings HC, Greengard P, Goldstein M, Hokfelt T Dopamine- and adenosine-3’,5’-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. Journal of the autonomic nervous system. 1991;36:75-84
442. Meister B, Askergren J, Tunevall G, Hemmings HC, Greengard P Identification of a dopemine- and 3’5’-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. Journal of endocrinological investigation. 1991;14:655-661
443. Ehrlich ME, Greengard P Characterization of rat ARPP-21 mRNA: sequence analysis, tissue distribution, and regulation. Journal of neurochemistry. 1991;57:1985-1991
444. Greengard P, Jen J, Nairn AC, Stevens CF Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science. 1991;253:1135-1138
445. Han H-Q, Nichols RA, Rubin MR, Baehler M, Greengard P Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb. Nature. 1991;349:697-700
446. Gustafson EL, Girault JA, Hemmings HC, Nairn AC, Greengard P Immunocytochemical localization of phosphatase inhibitor-1 in rat brain. Journal of comparative neurology. 1991;310:170-188
447. Walaas SI, Greengard P Protein phosphorylation and neuronal function. Pharmacological reviews. 1991;43:299-349
448. Aperia A, Fryckstedt J, Svensson L, Hemmings HC, Nairn AC, Greengard P Phosphorylated Mr32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K+-ATPase activity in renal tubule cells. Proceedings of the National Academy of Sciences. 1991;88:2798-2901
449. Yamagata Y, Czernik AJ, Greengard P Active catalytic fragment of Ca2+/calmodulin-dependent protein kinase II. Purification, characterization, and structural analysis. Journal of biological chemistry. 1991;266:15391-15397
450. Baehler M, Klein RL, Wang JKT, Benfenati F, Greengard P A novel synaptic vesicle-associated phosphoprotein: SVAPP-120. Journal of neurochemistry. 1991;57:423-430
451. Bertorello AM, Aperia A, Valaas SI, Nairn AC, Greengard P Phosphorylation of the catalytic subunit of Na+,K+-ATPase inhibits the activity of the enzyme. Proceedings of the National Academy of Sciences. 1991;88:11359-11362
452. Czernik AJ, Girault J-A, Nairn AC, Chen J, Snyder G, Kebabian J, Greengard P Production of phosphorylation state-specific antibodies. Methods in enzymology. 1991;201:264-283
453. Benfenati F, Valtorta F, Greengard P Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for regulation of neurotransmitter release. Proceedings of the National Academy of Sciences. 1991;88:575-579
454. Ho M, Baehler M, Czernik AJ, Schiebler W, Kezdy FJ, Kaiser ET, Greengard P Synapsin I is a highly surface-active molecule. Journal of biological chemistry. 1991;266:5600-5607
455. Llinas R, Gruner JA, Sugimori M, McGuinness TL, Greengard P Regulation by synapsin I and Ca2+-calmodulin-dependent protein kinase II of transmitter release in squid giant synapse. Journal of physiology. 1991;436:257-282
456. Thiel G, Greengard P, Suedoff TC Characterization of tissue-specific transcription by the human synapsin I gene promoter. Proceedings of the National Academy of Sciences. 1991;88:3431-3435
457. Luethi T, Haltiwanger RS, Greengard P, Baehler M Synapsins contain O-linked N-acetylglucosamine. Journal of neurochemistry. 1991;56:1493-1498
458. Schalling M, Dagerlind A, Goldstein M, Ehrlich M, Greengard P, Hoekfelt T Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland. European journal of pharmacology. Molecular pharmacology section. 1990;188:277-281
459. Fried G, Greengard P Neuropeptide Y inhibits phosphorylation of 87-kDa protein in rat vas deferens. Annals of the New York Academy of Sciences. 1990;611:353-354
460. Lin J-W, Sugimori M, Llinas RR, McGuinness TL, Greengard P Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse. Proceedings of the National Academy of Sciences. 1990;87:8257-8261
461. Horiuchi A, Williams KR, Kurihara T, Nairn AC, Greengard P Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19. Journal of biological chemistry. 1990;265:9476-9484
462. Ouimet CC, Wang JKT, Walaas SI, Albert KA, Greengard P Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain. Journal of neuroscience. 1990;10:1683-1698
463. Girault J-A, Horiuchi A, Gustafson EL, Rosen NL, Greengard P Differential expression of ARPP-16 and ARPP-19, two highly related cAMP-regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regions. Journal of neuroscience. 1990;10:1124-1133
464. Ouimet CC, Greengard P Distribution of DARPP-32 in the basal ganglia: an electron microscopic study. Journal of neurocytology. 1990;19:39-52
465. Bertorello AM, Hopfield JF, Aperia A, Greengard P Inhibition by dopamine of (Na+ + K+)ATPase activity in neostriatal neurons through D1 and D2 dopamine receptor synergism. Nature. 1990;347:386-388
466. Halpain S, Greengard P Activation of NMDA receptors induced rapid dephosphorylation of the cytoskeletal protein MAP2. Neuron. 1990;5:237-246
467. Girault J-A, Walaas SI, Hemmings HC, Greengard P ARPP-21, a cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: tissue distribution and regulation of phosphorylation in rat brain. Neuroscience. 1990;37:317-325
468. Piomelli D, Greengard P Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling. Trends in pharmacological sciences. 1990;11:367-373
469. Saez JC, Nairn AC, Czernik AJ, Spray DC, Hertzberg EL, Greengard P, Bennett MVL Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. European journal of biochemistry. 1990;192:263-273
470. Girault JA, Halpain S, Greengard P Excitatory amino acid antagonists and Parkinson’s disease. Trends in neurosciences. 1990;13:325-326
471. Mandell JW, Townes-Anderson E, Czernik AJ, Cameron R, Greengard P, De Camilli P Synapsins in the vertebrate retina: absence from ribbon synapses and heterogeneous distribution among conventional synapses. Neuron. 1990;5:19-23
472. Gustafson EL, Greengard P Localization of DARPP-32 immunoreactive neurons in the bed nucleus of the stria terminalis and central nucleus of the amygdala: co-distribution with axons containing tyrosine hydroxylase, vasoactive intestinal polypeptide, and calcitonin gene-regulated peptide. Experimental brain research. 1990;79:447-458
473. Thiel G, Sudhoff TC, Greengard P Synapsin II: mapping of a domain in the NH2-terminal region which binds to small synaptic vesicles. Journal of biological chemistry. 1990;265:16527-16533
474. Berger B, Febvret A, Greengard P, Goldman-Rakic PS DARPP-32, a phosphoprotein enriched in dopaminoceptive neurons bearing dipamine D1 receptors: distribution in the cerbral cortex of the newborn and adult rhesus monkey. Journal of comparative neurology. 1990;299:327-348
475. Halpain S, Girault J-A, Greengard P Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. nature. 1990;343:369-372
476. Schalling M, Djurfeldt M, Hoekfelt T, Ehrlich M, Kurihara T, Greengard P Distribution and cellular localization of DARPP-32 mRNA in rat brain. MOlecular brain research. 1990;7:139-149
477. Nichols RA, Sihra TS, Czernik AJ, Nairn AC, Greengard P Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes. Nature. 1990;343:647-651
478. Torri-Tarelli F, Villa A, Valtorta F, De Camilli P, Greengard P, Ceccarelli B Redistribution of synaptophysin and synapsin I during alpha-latrotoxin-induced release of neurotransmitter at the neuromuscular junction. Journal of cell biology. 1990;110:449-459
479. Grebb JA, Girault J-A, Ehrlich M, Greengard P Chronic treatment of rats with SCH-23390 or raclopride does not affect the concentrations of DARPP-32 or its mRNA in dopamine-innervated brain regions. Journal of neurochemistry. 1990;55:204-207
480. Baehler, M, Benfenati, F, Valtorta, F, Greengard P The synapsins and the regulation of synaptic function. Bioessays. 1990;12:259-263
481. Benfenati F, Neyroz P, Baehler M, Masotti L, Greengard P Time-resolved fluorescence study of the neuron-specific phosphoprotein synapsin I. Evidence for phosphorylation-dependent conformational changes. Journal of biological chemistry. 1990;265:2584-2595
482. Buxbaum JD, Gandy SE, Cicchetti P, Ehrlich ME, Czernik AJ, Fracasso RP, Ramabhadran TV, Unterbeck AJ, Greengard P Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proceedings of the National Academy of Sciences. 1990;87:6003-6006
483. De Camilli P, Benfenati F, Valtorta F, Greengard P The synapsins. Annual review of cell biology. 1990;6:433-460
484. Ehrlich ME, Kurihara T, Greengard P Rat DARPP-32: cloning, sequencing, and characterization of the cDNA. Journal of molecular neuroscience. 1990;2:1-10
485. Hemmings HC, Nairn AC, Elliott JI, Greengard P Synthetic peptide analogs of DARPP-32(mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Journal of biological chemistry. 1990;265:369-376
486. Sugrue MM, Brugge JS, Marshak DR, Greengard P, Gustafson EL Immunocytochemical localization of the neuron-specific form of the c-src gene product, pp60c-src(+), in rat brain. Journal of neuroscience. 1990;10:2513-2527
487. Huganir RL, Greengard P Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron. 1990;5:555-567
488. Gandy SE, Grebb JA, Rosen N, Albert KA, Devinsky O, Blumberg H, Anderson N, Cedarbaum JM, Porter RJ, Sedvall G, Posner JB, Greengard P General assay for phosphoproteins in cerebrospinal fluid: a candidate marker for paraneoplastic cerebellar degeneration. Annals of neurology. 1990;28:829-833
489. Grebb JA, Greengard P An analysis of synapsin II, a neuronal phosphoprotein, in postmortem brain tissue from alcoholic and neuropsychiatrically ill adults and medically ill children and young adults. Archives of general psychiatry. 1990;47:1149-1156
490. Ehrlich ME, Rosen NL, Kurihara T, Shalaby IA, Greengard P DARPP-32 development in the caudate nucleus is independent of afferent input from the substantia nigra. Developmental brain research. 1990;54:257-263
491. Girault J-A, Hemmings HC, Zorn SH, Gustafson EL, Greengard P Characterization in mammalian brain of a DARPP-32 serine kinase identical to casein kinase II. Journal of neurochemistry. 1990;55:1772-1783
492. Walaas SI, Perdahl-Wallace E, Winblad B, Greengard P Protein phosphorylation systems in postmortem human brain. Journal of molecular neuroscience. 1989;1:105-116
493. Walaas SI, Gorelick FS, Greengard P Presence of calcium/calmodulin-dependent protein kinase II in nerve terminals of rat brain. Synapse. 1989;3:356-362
494. Valtorta F, Tarelli FT, Campanati L, Villa A, Greengard P Synaptophysin and synapsin I as tools for the study of the exo-endocytotic cycle. Cell biology international reports. 1989;13:1023-1038
495. Benfenati F, Valtorta F, Baehler M, Greengard P Synapsin I, a neuron-specific phosphoprotein interacting with small synaptic vesicles and F-actin. Cell biology international reports. 1989;13:1007-1021
496. Nichols RA, Wu WC-S, Haycock JW, Greengard P Introduction of impermeant molecules into synaptosomes using freeze/thaw permeabilization. Journal of neurochemistry. 1989;52:521-529
497. Walaas SI, Girault J-A, Greengard P Localization of cyclic GMP-dependent protein kinase in rat basal ganglia neurons. Journal of molecular neuroscience. 1989;1:243-250
498. McGuinness TL, Brady ST, Gruner JA, Sugimori M, Llinas R, Greengard P Phosphorylation-dependent inhibition by synapsin I of organelle movement in squid axoplasm. Journal of neuroscience. 1989;9:4138-4149
499. Rosen A, Nairn AC, Greengard P, Cohn ZA, Aderem A Bacterial lipopolysaccharide regulates the phosphorylation of the 68K protein kinase C substrate in macrophages. Journal of biological chemistry. 1989;264:9118-9121
500. Stumpo DJ, Graff JM, Albert KA, Greengard P, Blackshear PJ Nucleotide sequence of a cDNA for the bovine myristoylated alanine-rich C kinase substrate (MARCKS). Nucleic acids research. 1989;17:3987-3988
501. Stumpo DJ, Graff JM, Albert KA, Greengard P, Blackshear PJ Molecular cloning, characterization, and expression of a cDNA encoding the ”80- to 87-kDa” myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proceedings of the National Academy of Sciences. 1989;86:4012-4016
502. Girault J-A, Hemmings HC, Williams KR, Nairn AC, Greengard P Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. Journal of biological chemistry. 1989;264:21748-21759
503. Li M, McCann JD, Anderson MP, Clancy JP, Liedtke CM, Nairn AC, Greengard P, Welsh MJ Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia. Science. 1989;244:1353-1356
504. Mackie K, Sorkin BC, Nairn AC, Greengard P, Edelman GM, Cunningham BA Identification of two protein kinases that phosphorylate the neural cell-adhesion molecule, N-CAM. Journal of neuroscience. 1989;9:1883-1896
505. Miles K, Greengard P, Huganir RL Calcitonin gene-related peptide regulates phosphorylation on the nicotinic acetylcholine receptor in rat myotubes. Neuron. 1989;2:1517-1524
506. Sihra TS, Wang JKT, Gorelick FS, Greengard P Translocation of synapsin I in response to depolarization of isolated nerve terminals. PMCID 298224 Proceedings of the National Academy of Sciences. 1989;86:8108-8112
507. Meister B, Fryckstedt J, Schalling M, Cortes R, Hokfelt T, Aperia A, Hemmings HC, Nairn AC, Ehrlich M, Greengard P Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells. Proceedings of the National Academy of Sciences. 1989;86:8068-8072
508. Straalfors P, Hemmings HC, Greengard P Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical. European journal of biochemistry. 1989;180:143-148
509. Girault J-A, Raisman-Vozari R, Agid Y, Greengard P Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy. PMCID 286939 Proceedings of the National Academy of Sciences. 1989;86:2493-2497
510. Kurihara T, Ehrlich ME, Horiuchi J, Nasu T, Greengard P ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. 2. Molecular cloning and nucleotide sequence. Journal of neuroscience. 1989;9:3638-3644
511. Williams KR, Hemmings HC, LoPresti MB, Greengard P ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. 1. Amino acid sequence of ARPP-21B from bovine caudate nucleus. Journal of neuroscience. 1989;9:3631-3637
512. Bahinski A, Nairn AC, Greengard P, Gadsby DC Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature. 1989;340:718-721
513. Wang JKT, Walaas SI, Sihra TS, Aderem A, Greengard P Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals. PMCID 286890 Proceedings of the National Academy of Sciences. 1989;86:2253-2256
514. Gustafson EL, Ouimet CC, Greengard P Spatial relationship of the striatonigral and mesostriatal pathways: double-label immunocytochemistry for DARPP-32 and tyrosine hydroxylase. Brain research. 1989;491:297-306
515. Walaas SI, Wang JKT, Albert KA, Greengard P Calcium/diacylglycerol-dependent protein kinase and its major 87-kilodalton protein substrate are differentially distributed in rat basal ganglia. Journal of neurochemistry. 1989;53:1199-1202
516. Hemmings HC, Greengard P ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. 1. Purification and characterization of the protein from bovine caudate nucleus. Journal of neuroscience. 1989;9:851-864
517. Ouimet CC, Hemmings HC, Greengard P ARRP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. 2. Immunocytochemical localization in rat brain. Journal of neuroscience. 1989;9:865-875
518. Walaas SI, Sedvall G, Greengard P Dopamine-regulated phosphorylation of synaptic vesicle-associated proteins in rat neostriatum and substantia nigra. Neuroscience. 1989;29:9-19
519. Suedhof TC, Czernik AJ, Kao H-T, Takei K, Johnston PA, Horiuchi A, Kanazir SD, Wagner MA, Perin MS, De Camilli P, Greengard P Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. Science. 1989;245:1474-1480
520. Girault J-A, Gorelick FS, Greengard P Improving the quality of immunoblots by chromatography of polyclonal antisera on keratin affinity columns. Analytical biochemistry. 1989;182:193-196
521. Walaas SI, Cala S, Greengard P Localization of ARPP-90, a major 90 kiloDalton basal ganglio-enriched substrate for cyclic AMP-dependent protein kinase, in srtiatonigral neurons in the rat brain. Molecular brain research. 1989;5:149-157
522. Hemmings HC, Nairn AC, McGuinness TL, Huganir RL, Greengard P Role of protein phosphorylation in neuronal signal transduction. FASEB journal. 1989;3:1583-1592
523. Meister B, Villar MJ, Schalling M, Ehrlich M, Greengard P, Hokfelt T Demonstration of DARPP-32 in piyuicytes of the neurohypophysis – decreased expression after administraction of hyperosmotic stimuli. Acta physiologica scandinavica. 1989;137:461-462
524. Piomelli D, Wang JK, Sihra TS, Nairn AC, Czernik AJ, Greengard P Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites. PMCID 298320 Proceedings of the National Academy of Sciences. 1989;86:8550-8554
525. Cohn PJ, Strong JA, Azhderian EM, Nairn AC, Greengard P, Kaczmarek LK Protein kinase inhibitors selectively block phorobol ester- or forskolin-induced changes in excitability of Aplysia neurons. Journal of neuroscience. 1989;9:473-479
526. Won L, Price S, Wainer BH, Hoffmann PC, Bolam JP, Greengard P, Heller A Correlated light and electron microscopic study of dopaminergic neurons and their synaptic junctions with DARPP-32-containing cells in three-dimensional reaggregate tissue culture. Journal of comparative neurology. 1989;289:165-177
527. Grebb JA, Browning MD, Valerius P, Borg S, Sedvall G, Greengard P An analysis of postmortem brain samples from 32 alcoholic and nonalcoholic individuals for protein III, a neuronal phosphoprotein. Alcoholism: clinical & experimental research. 1989;13:673-679
528. Hemmings HC, Girault J-A, Williams KR, LoPresti MB, Greengard P ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. Journal of biological chemistry. 1989;264:7726-7733
529. Navone F, Di Gioia G, Jahn R, Browning M, Greengard P, De Camilli P Microvesicles of the neurohypophysis are biochemically related to small synaptic vesicles of presynaptic nerve terminals. Journal of cell biology. 1989;109:3425-3433
530. Valtorta F, Jahn R, Fesce R, Greengard P, Ceccarelli B Synaptophysin (P38) at the frog neuromuscular junction: its incorporation into the axolemma and recycling after intense quantal secretion. Journal of cell biology. 1988;107:2717-2727
531. Pang DT, Wang JKT, Valtorta F, Benfenati F, Greengard P Protein tyrosine phosphorlyation in synaptic vesicles. Proceedings of the National Academy of Sciences. 1988;85:762-766
532. Meister B, Hoekfelt T, Tsuruo Y, Hemmings H, Ouimet C, Greengard P, Goldstein M DARPP-32, a dopamine- and cyclic AMP-regulated phosphoprotein in tanycytes of the mediobasal hypothalamus: distribution and relation to dopamine and luteinizing hormone-releasing hormone neurons and other glial elements. Neuroscience. 1988;27:607-622
533. Gorelick FS, Wang JKT, Lai Y, Nairn AC, Greengard P Autophosphorylation and activation of Ca2+/calmodulin-dependent protein kinase II in intact nerve terminals. Journal of biological chemistry. 1988;263:17209-17212
534. Walaas SI, Browning MD, Greengard P Synapsin Ia, synapsin Ib, protein IIIa, and protein IIIb, four related synaptic vesicle-associated phosphoproteins, share regional and cellular localization in rat brain. Journal of neurochemistry. 1988;51:1214-1220
535. Nairn AC, Hemmings HC, Walaas SI, Greengard P DARPP-32 and phosphatase inhibitor 1, two structurally related inhibitors of protein phosphatase-1, are both present in striatonigral neurons. Journal of neurochemistry. 1988;50:257-262
536. Haycock JW, Browning MD, Greengard P Cholinergic regulation of protein phosphorylation in bovine adrenal chromaffin cells. Proceedings of the National Academy of Sciences. 1988;85:1677-1681
537. Aderem AA, Albert KA, Keum MM, Wang JKT, Greengard P, Cohn ZA Stimulus-dependent myristoylation of a major substrate for protein kinase C. Nature. 1988;332:362-364
538. Valtorta F, Villa A, Jahn R, De Camilli P, Greengard P, Ceccarelli, B Localization of synapsin I at the frog neuromuscular junction. Neuroscience. 1988;24:593-603
539. Hirano AA, Greengard P, Huganir RL Protein tyrosine kinase activity and its endogenase substrates in rat brain: a subcellular and regional survey. Journal of neurochemistry. 1988;50:1447-1455
540. Thiel G, Czernik AJ, Gorelick F, Nairn AC, Greengard P Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity. Proceedings of the National Academy of Sciences. 1988;85:6337-6341
541. Audigier SMP, Wang JKT, Greengard P Membrane depolarization and carbamoylcholine stimulate phosphatidylinositol turnover in intact nerve terminals. Proceedings of the National Academy of Sciences. 1988;85:2859-2863
542. Wang JKT, Walaas SI, Greengard P Protein phosphorylation in nerve terminals: comparison of calcium/calmodulin-dependent and calcium/diacylglycerol-dependent systems. Journal of neuroscience. 1988;8:281-288
543. Kurihara T, Lewis RM, Eisler J, Greengard P Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Journal of neuroscience. 1988;8:508-517
544. Walaas SI, Lustig A, Greengard P, Brugge JS Widespread distribution of the c-src gene product in nerve cells and axon terminals in the adult rat brain. Molecular brain research. 1988;3:215-222
545. Gandy S, Czernik AJ, Greengard P Phosphorylation of Alzheimer disease amyloid precursor peptide kinase C and Ca2+/calmodulin-dependent protein kinase II. Proceedings of the National Academy of Sciences. 1988;85:6218-6221
546. Haycock JW, Greengard P, Browning MD Cholinergic regulation of protein III phosphorylation in bovine adrenal chromaffin cells. Journal of neuroscience. 1988;8:3233-3239
547. Weeks G, Picciotto M, Nairn AC, Walaas SI, Greengard P Purification and characterization of PCPP-260: a Purkinje cell-enriched cyclic AMP-regulated membrane phosphoprotein of Mr 260,000. Synapse. 1988;2:89-96
548. Walaas SI, Lai Y, Gorelick FS, DeCamilli P, Moretti M, Greengard P Cell-specific localization of the alpha-subunit of calcium/calmodulin-dependent protein kinase II in Purkinjee cells in rodent cerebellum. Molecular brain research. 1988;4:233-242
549. Walaas IS, Jahn R, Greengard P Quantitation of nerve terminal populations: synaptic vesicle-associated proteins as markers for synaptic density in the rat neostriatum. Synapse. 1988;2:516-520
550. Girault J-A, Shalaby IA, Rosen NL, Greengard P Regulation by cAMP and vasoactive intestinal peptide of phosphorylation of specific proteins in striatal cells in culture. Proceedings of the National Academy of Sciences. 1988;85:7790-7794
551. Greengard P, Browning MD Studies of the physiological role of specific neuronal phosphoproteins. Advances in second messenger & phosphoprotein research. 1988;21:133-146
552. Hopfield JF, Tank DW, Greengard P, Huganir RL Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation. Nature. 1988;336:677-680
553. Li M, McCann JD, Liedtke CM, Nairn AC, Greengard P, Welsh MJ Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Nature. 1988;331:358-360
554. Meister B, Fried G, Hokfelt T, Hemmings HC, Greengard P Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs. Proceedings of the National Academy of Sciences. 1988;85:8713-8716
555. Foster GA, Schultzberg M, Kokfelt T, Goldstein M, Hemmings HC, Ouimet CC, Walaas SI, Greengard P Ontogeny of the dopamine and cyclic adenosine-3’:5’-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system. International journal of developmental neuroscience. 1988;6:367-386
556. Agnati LF, Fuxe K, Zoli M, Ferraguti F, Benfenati F, Ouimet CC, Walaas SI, Hemmings HC, Goldstein M, Greengard P Morphometrical evidence for a complex organization of tyrosine hydroxylase-, enkephalin- and darpp-32-like immunoreactive patches and their codistribution at three rostrocaudal levels in the rat neostriatum. Neuroscience. 1988;27:785-797
557. Parks TP, Nairn AC, Greengard P, Jamieson JD The cyclic nucleotide-dependent phosphorylation of aortic smooth muscle membrane proteins. Archives of biochemistry & biophysics. 1987;255:361-371
558. Hemmings HC, Walaas SI, Ouimet CC, Greengard P Dopaminergic regulation of protein phosphorylation in the striatum: DARPP-32. Trends in neurosciences. 1987;10:377-383
559. Suedhof TC, Lottspeich F, Greengard P, Mehl E, Jahn R The cDNA and derived amino acid sequences for rat and human synaptophysin. Nucleic acids research. 1987;15:9607
560. Huganir RL, Greengard P Regulation of receptor function by protein phosphorylation. Trends in pharmacological sciences. 1987;8:472-477
561. Albert KA, Nairn AC, Greengard P The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization. Proceedings of the National Academy of Sciences. 1987;84:7046-7050
562. Jahn R, Navone F, Greengard P, De Camilli P Biochemical and immunocytochemical characterization of p38, an integral membrane glycoprotein of small synaptic vesicles. Annals of the New York Academy of Sciences. 1987;493:497-499
563. Foster GA, Schultzberg M, Hoekfelt T, Goldstein M, Hemmings HC, Ouimet CC, Walaas SI, Greengard P Development of a dopamine- and cyclic adenosine 3’:5’-monophosphate-regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation. Journal of neuroscience. 1987;7:1994-2018
564. Czernik AJ, Pang DT, Greengard P Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. Proceedings of the National Academy of Sciences. 1987;84:7518-7522
565. Hu G-Y, Hvalby O, Walaas SI, Albert KA, Skjeflo P, Andersen P, Greengard P Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation. Nature. 1987;328:426-429
566. Suedhof TC, Lottspeich F, Greengard P, Mehl E, Jahn R A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science. 1987;238:1142-1144
567. Miles K, Anthony DT, Rubin LL, Greengard P, Huganir RL Regulation of nicotinic acetylcholine receptor phosphorylation in rat myotubes by forskolin and cAMP. Proceedings of the National Academy of Sciences. 1987;84:6591-6595
568. Nairn AC, Greengard P Purification and characterization of Ca2+/calmodulin-dependent protein kinase I from bovine brain. Journal of biological chemistry. 1987;262:7273-7281
569. Nichols RA, Haycock JW, Wang JKT, Greengard P Phorbol ester enhancement of neurotransmitter release from rat brain synaptosomes. Journal of neurochemistry. 1987;48:615-621
570. Browning MD, Huang C-K, Greengard P Similarities between protein IIIa and protein IIIb, two prominent synaptic vesicle-associated phosphoproteins. Journal of neuroscience. 1987;7:847-853
571. Baehler M, Greengard P Synapsin I bundles F-actin in a phosphorylation-dependent manner. Nature. 1987;326:704-707
572. Hammond C, Paupardin-Tritsch D, Nairn AC, Greengard P, Gerschenfeld HM Cholecystokinin induces a decrease in Ca2+ current in snail neurons that appears to be mediated by protein kinase C. Nature. 1987;325:809-811
573. Thomas NE, Bramson HN, Nairn AC, Greengard P, Fry DC, Mildvan AS, Kaiser ET Distinguishing among protein kinases by substrate specificities. Biochemistry. 1987;26:4471-4474
574. Romano C, Nichols RA, Greengard P Synapsin I in PC12 cells. 2. Evidence for regulation by NGF of phosphorylation at a novel site. Journal of neuroscience. 1987;7:1300-1306
575. Romano C, Nichols RA, Greengard P, Greene LA Synapsin I in PC12 cells. 1. Characterization of the phosphoprotein and effect of chronic NGF treatment. Journal of neuroscience. 1987;7:1294-1299
576. Lai Y, Nairn AC, Gorelick F, Greengard P Ca2+/calmodulin-dependent protein kinase II: identification of autophosphorylation sites responsible for generation of Ca2+/calmodulin-independence. Proceedings of the National Academy of Sciences. 1987;84:5710-5714
577. Baehler M, Greengard P Synapsin I bundles F-actin in a phosphorylation-dependent manner. Nature. 1987;362:704-707
578. Hemmings HC, Nairn AC, Greengard P Protein kinases and phosphoproteins in the nervous system. Association for Research in Nervous & Mental Disease research. 1986;64:47-69
579. Saez JC, Spray DC, Nairn AC, Hertzberg E, Greengard P, Bennett MVL cAMP increases junctional conductance and stimulates phosphorylation of the 27kDa principal gap junction polypeptide. Proceedings of the National Academy of Sciences. 1986;83:2473-2477
580. Nestler EJ, Greengard P Synapsin I: a review of its distribution and biological regulation. Progress in brain research. 1986;69:323-339
581. Navone F, Jahn R, Di Gioia G, Stukenbrok H, Greengard P, De Camilli P Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. Journal of cell biology. 1986;103:2511-2527
582. Everitt BJ, Meister B, Hokfelt T, Melander T, Terenius L, Rokaeus A, Theodorsson-Norheim E, Dockray G, Edwardson J, Cuello C, Elde R, Goldstein M, Hemmings H, Ouimet C, Walaas I, Greengard P, Vale W, Weber E, Wu J-Y, Chang K-J The hypothalamic arcuate nucleus-median eminence complex: immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons. Brain research reviews. 1986;11:97-155
583. Schiebler W, Jahn R, Doucet J-P, Rothlein J, Greengard P Characterization of synapsin I binding to small synaptic vesicles. Journal of biological chemistry. 1986;261:8383-8390
584. Lai Y, Nairn AC, Greengard P Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II. Proceedings of the National Academy of Sciences. 1986;83:4253-4257
585. Huganir RL, Delcour AH, Greengard P, Hess GP Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature. 1986;321:774-776
586. De Camilli P, Greengard P Synapsin I: a synaptic vesicle-associated neuronal phosphoprotein. Biochemical pharmacology. 1986;35:4349-4357
587. Hoekfelt T, Everitt B, Meister B, Melander T, Schalling M, Johansson O, Lundberg JM, Hulting A-L, Werner S, Cuello C, Hemmings H, Ouimet C, Walaas I, Greengard P, Goldstein M Neurons with multiple messengers with special reference to neuroendocrine systems. Recent progress in hormone research. 1986;42:1-70
588. Paupardin-Tritsch D, Hammond C, Gerschenfeld HM, Nairn AC, Greengard P cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones. Nature. 1986;323:812-814
589. Stone RA, Laties AM, Hemmings HC, Ouimet CC, Greengard P DARPP-32 in the ciliary epithelium of the eye: A neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells. Journal of histochemistry & cytochemistry. 1986;34:1465-1468
590. Greengard P Cell biological approaches to brain function: introduction. Annual review of physiology. 1986;48:415-416
591. Hemmings HC, Greengard P DARPP-32, a dopamine- and adenosine 3’:5’-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distribution. Journal of neuroscience. 1986;6:1469-1481
592. Valtorta F, Schiebler W, Jahn R, Ceccarelli B, Greengard P A solid-phase assay for the phosphorylation of proteins blotted on nitrocellulose membrane filters. Analytical biochemistry. 1986;158:130-137
593. Williams KR, Hemmings HC, Lopresti MB, Konigsberg WH, Greengard P DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1. Journal of biological chemistry. 1986;261:1890-1903
594. Mackie K, Lai Y, Nairn AC, Greengard P, Pitt BR, Lazo JS Protein phosphorylation in cultured endothelial cells. Journal of cellular physiology. 1986;128:367-374
595. Albert KA, Walaas SI, Wang JK-T, Greengard P Widespread occurrence of ”87kDa,” a major specific substrate for protein kinase C. Proceedings of the National Academy of Sciences. 1986;83:2822-2826
596. Walaas SI, Nairn AC, Greengard P PCPP-260, a Purkinje cell-specific cyclic AMP-regulated membrane phosphoprotein of Mr 260,000. Journal of neuroscience. 1986;6:954-961
597. Hemmings HC, Greengard P DARPP-32, a dopamine-regulated phosphoprotein. Progress in brain research. 1986;69:149-159
598. Browning MD, Huganir R, Greengard P Protein phosphorylation and neuronal function. Journal of neurochemistry. 1985;45:11-23
599. DeRiemer SA, Greengard P, Kaczmarek LK Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous system. Journal of neuroscience. 1985;5:2672-2676
600. Nairn AC, Hemmings HC, Greengard P Protein kinases in the brain. Annual review of biochemistry. 1985;54:931-976
601. Treiman M, Greengard P D-1 and D-2 dopaminergic receptors regulate protein phosphorylation in the rat neurohypophysis. Neuroscience. 1985;15:713-722
602. Jahn R, Schiebler W, Ouimet C, Greengard P A 38,000 dalton membrane protein (p38) present in synaptic vesicles. Proceedings of the National Academy of Sciences. 1985;82:4137-4141
603. DeRiemer SA, Strong JA, Albert KA, Greengard P, Kaczmarek LK Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C. Nature. 1985;313:3l3-316
604. McGuinness TL, Lai Y, Greengard P Ca2+/calmaodulin-dependent protein kinase II: isozymic forms from rat forebrain and cerebellum. Journal of biological chemistry. 1985;260:1696-1704
605. Mobley P, Greengard P Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex. Proceedings of the National Academy of Sciences. 1985;82:945-947
606. DeRiemer SA, Strong JA, Albert KA, Greengard P, Kaczmarek LK Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C. Nature. 1985;313:313-316
607. Goelz SE, Nestler EJ, Greengard P Phylogenetic survey of proteins related to synapsin I and biochemical analysis of four such proteins from fish brain. Journal of neurochemistry. 1985;45:63-72
608. Llinas R, McGuinness T, Leonard CS, Sugimori M, Greengard P Intraterminal injection of synapsin I or of calcium/calmodulin-dependent protein kinase II alters neurotransmitter reslease at the squid giant synapse. Proceedings of the National Academy of Sciences. 1985;82:3035-3039
609. Nestler EJ, Walaas SI, Greengard P Neuronal phosphoproteins: physiological and clinical implications. Science. 1984;225:1357-1364
610. Nestler EJ, Greengard P Neuron-specific phosphoproteins in mammalian brain. Advances in cyclic nucleotide & protein phosphorylation research. 1984;17:483-488
611. Palfrey HC, Lai Y, Greengard P Calmodulin-dependent protein kinase from avian erythrocytes. Progress in clinical & biological research. 1984;165:291-308
612. DeRiemer SA, Kaczmarek LK, Lai Y, McGuiness TL, Greengard P Calcium/calmodulin-dependent protein phosphorylation in the nervous system of Aplysia. Journal of neuroscience. 1984;4:1618-1625
613. King MM, Huang CY, Chock BP, Nairn AC, Hemmings HC, Chan K-FJ, Greengard P Mammalian brain phosphoproteins as substrates for calcineurin. Journal of biological chemistry. 1984;259:8080-8083
614. Hemmings HC, Greengard P, Tung HYL, Cohen P DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature. 1984;310:503-505
615. Ouimet CC, McGuinness TL, Greengard P Immunocytochemical localization of calcium/calmodulin-dependent protein kinase II in rat brain. Proceedings of the National Academy of Sciences. 1984;81:5604-5608
616. Jahn R, Schiebler W, Greengard P A quantitative dot-immunobinding assay for proteins using nitrocellulose membrane filters. Proceedings of the National Academy of Sciences. 1984;81:1684-1687
617. Huganir RL, Miles K, Greengard P Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase. Proceedings of the National Academy of Sciences. 1984;81:6968-6972
618. Detre JA, Nairn AC, Aswad DW, Greengard P Localization in mammalian brain of G-substrate, a specific substrate for guanosine 3’,5’-cyclic monophosphate-dependent protein kinase. Journal of neuroscience. 1984;4:2843-2849
619. Hemmings HC, Nairn AC, Aswad DW, Greengard P DARPP-32, a dopamine and adenosine 3’:5’-monophosphate regulated phosphoprotein enriched in dopamine-innervated brain regions. 2. Purification and characterization of the phosphoprotein from bovine caudate nucleus. Journal of neuroscience. 1984;4:99-110
620. Kelly PT, McGuinness TL, Greengard P Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase. Proceedings of the National Academy of Sciences. 1984;81:945-949
621. Albert KA, Wu WC-S, Nairn AC, Greengard P Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation. Proceedings of the National Academy of Sciences. 1984;81:3622-3625
622. De Camilli P, Mialler PE, Levitt P, Walter U, Greengard P Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker. Neuroscience. 1984;11:761-817
623. Levitt P, Rakic P, De Camilli P, Greengard P Emergence of cyclic guanosine 3’:5’-monophosphate-dependent protein kinase immunoreactivity in developing Rhesus monkey cerebellum: correlative immunocytochemical and electron microscopic analysis. Journal of neuroscience. 1984;4:2553-2564
624. Navone F, Greengard P, De Camilli P Synapsin I in nerve terminals: selective association with small synaptic vesicles. Science. 1984;226:1209-1211
625. Ouimet CC, Miller PE, Hemmings HC, Walaas SI, Greengard P DARPP-32, a dopamine and adenosoine 3’:5’-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. 3. Immunocytochemical localization. Journal of neuroscience. 1984;4:111-124
626. Perdahl E, Adolfsson R, Alafuzoff I, Albert KA, Nestler EJ, Greengard P, Winblad B Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and multiinfarct dementia. Journal of neural transmission. 1984;60:133-141
627. Walaas SI, Greengard P DARPP-32, a dopamine and adenosine 3’:3’-monophosphate regulated phosphoprotein enriched in dopamine-innervated brain regions. 1. Regional and cellular distribution in the rat brain. Journal of neuroscience. 1984;4:84-98
628. Alabert KA, Helmer-Matyjek D, Nairn AC, Mueller TH, Haycock JW, Greene L, Golstein M, Greengard P Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. Proceedings of the National Academy of Sciences. 1984;24:7713-7717
629. Hemmings HC, Williams KR, Konigsberg WH, Greengard P DARPP-32, a dopamine- and adenosine 3’:5’-monophosphate-regulated neuronal phosophoprotein. 1. Amino acid sequence around the phosphorylated threonine. Journal of biological chemistry. 1984;259:14486-14490
630. Perdahl E, Wu WC-S, Browning MD, Winblad B, Greengard P Protein III, a neuron-specific phosphoprotein: variant forms found in human brain. Neurobehavioral toxicology & teratology. 1984;6:425-431
631. Albert KA, Helmer-Matyjek E, Nairn AC, Mueller TH, Haycock JW, Greene L, Goldstein M, Greengard P Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. Proceedings of the National Academy of Sciences. 1984;81:7713-7717
632. Hemmings HC, Nairn AC, Greengard P DARPP-32, a dopamine- and adenosine 3’:5’-monophosphate-regulated neuronal phosphoprotein. 2. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor-1. Journal of biological chemistry. 1984;259:14491-14497
633. Walaas SI, Nairn AC, Greengard P Regional distribution of calcium- and cyclic adenosine 3’5’-monophosphate-regulated protein phosphorylation systems in mammalian brain. 2. Soluble systems. Journal of neuroscience. 1983;3:302-311
634. Kennedy MB, McGuinness T, Greengard P A calcium/calmodulin-dependent protein kinase activity from mammalian brain that phosphorylates Synapsin I: partial purification and characterization. Journal of neuroscience. 1983;3:818-831
635. DeGennaro LJ, Kanazir SD, Wallace WC, Lewis RM, Greengard P Neuron-specific phosphoproteins as models for neuronal gene expression. Cold Spring Harbor symposia on quantitative biology. 1983;48:337-345
636. Huttner WB, Schiebler W, Greengard P, De Camilli P Synapsin I (protein I), a nerve terminal-specific phosphoprotein. 3. Its association with synaptic vesicles studied in a highly-purified synapltic vesicle preparation. Journal of cell biology. 1983;96:1374-1388
637. Walter U, Greengard P Photoaffinity labeling of the regulatory subunit of cyclic AMP-dependent protein kinase. Methods in enzymology. 1983;99:154-162
638. Dolphin AC, Detre JA, Schlichter DJ, Nairn AC, Yeh HH, Woodward DJ, Greengard P Cyclic nucleotide-dependent protein kinases and some major substrates in the rat cerebellum after neonatal X-irradiation. Journal of neurochemistry. 1983;40:577-581
639. De Camilli P, Cameron R, Greengard P Synapsin I (protein I), a nerve terminal-specific phosphoprotein. 1. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections. Journal of cell biology. 1983;96:1337-1354
640. De Camilli P, Harris SM, Huttner WB, Greengard P Synapsin I (protein I), a nerve terminal-specific phosphoprotein. 2. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. Journal of cell biology. 1983;96:1355-1373
641. Lewis RM, Wallace WC, Kanazir SD, Greengard P Expression of cell-type-specific neuronal phosphoproteins. Cold Spring Harbor symposia on quantitative biology. 1983;48:347-354
642. McGuinness TL, Lai Y, Greengard P, Woodgett JR, Cohen P A multifunctional calmodulin-dependent protein kinase: similarities between skeletal muscle glycogen synthase kinase and a brain Synapsin I kinase. FEBS letters. 1983;163:329-334
643. Nairn AC, Greengard P Cyclic GMP-dependent protein phosprylation in mammalian brain. Federation proceedings. 1983;42:3107-3113
644. Nestler EJ, Greengard P Protein phosphorylation in the brain. Nature. 1983;305:583-588
645. Palfrey HC, Rothlein JE, Greengard P Calmodulin-dependent protein kinase and associated substrates in Torpedo electric organ. Journal of biological chemistry. 1983;258:9496-9503
646. Tank DW, Huganir RL, Greengard P, Webb WW Patch-recorded single-channel currents of the purified and reconstituted Torpedo acetylcholine receptor. Proceedings of the National Academy of Sciences. 1983;80:5129-5133
647. Walaas SI, Aswad DW, Greengard P A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature . 1983;301:69-71
648. Walaas SI, Nairn AC, Greengard P Regional distribution of calcium- and cyclic adenosine 3’:5’-monophosphate-regulated protein phosphorylation systems in mammalian brain. l. Particulate systems. Journal of neuroscience. 1983;3:291-301
649. Huganir RL, Greengard P cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor. Proceedings of the National Academy of Sciences. 1983;80:1130-1134
650. Tsou K, Greengard P Regulation of phosphorylation of proteins I, IIIa and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents. Proceedings of the National Academy of Sciences. 1982;79:6075-6079
651. Fried G, Nestler EJ, De Camilli P, Stjaerne L, Olson L, Lundberg JM, Hoekfelt T, Ouimet CC, Greengard P Cellular and subcellular localization of protein I in the peripheral nervous system. Proceedings of the National Academy of Sciences. 1982;79:2717-2721
652. Huang C-K, Browning MD, Greengard P Purification and characterization of protein IIIb, a mammalian brain phosphoprotein. Journal of biological chemistry. 1982;257:6524-6528
653. Nestler EJ, Greengard P Distribution of protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion. Journal of neuroscience. 1982;2:1011-1023
654. Nestler EJ, Zatz M, Greengard P A diurnal rhythm in pineal protein I content mediated by beta-adrenergic neurotransmission. Science. 1982;217:357-359
655. Palfrey HC, Schiebler W, Greengard P A major calmodulin-binding protein common to various vertebrate tissues. Proceedings of the National Academy of Sciences. 1982;79:3780-3784
656. Nestler EJ, Greengard P Nerve impulses increase the phosphorylation state of protein I in rabbit superior cervical ganglion. Nature. 1982;296:452-454
657. Robinson NL, Cox PM, Greengard P Glutamate regulates adenylate cyclase and guanylate cyclase activities in an isolated membrane preparation from insect muscle. Nature. 1982;296:354-356
658. Wu WC-S, Walaas SI, Nairn AC, Greengard P Calcium/phospholipid regulates phosphorylation of a Mr ”87k” substrate protein in brain synaptosomes. Proceedings of the National Academy of Sciences. 1982;79:5249-5253
659. Nairn AC, Detre JA, Casnellie JE, Greengard P Serum antibodies that distinguish between the phospho- and dephospho-forms of a phosphoprotein. Nature. 1982;299:734-736
660. Castellucci VF, Nairn A, Greengard P, Schwartz JH, Kandel ER Inhibitor of adenosine 3’:5’-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia. Journal of neuroscience. 1982;2:1673-1681
661. Goelz SE, Nestler EJ, Chehrazi B, Greengard P Distribution of protein I in mammalian brain as determined by a detergent-based radioimmunoassay. Proceedings of the National Academy of Sciences. 1981;78:2130-2134
662. Palfrey HC, Greengard P Hormone-sensitive ion transport systems in erythrocytes as models for epithelial ion pathways. Annals of the New York Academy of Sciences. 1981;372:291-308
663. Aswad DW, Greengard P A specific substrate from rabbit cerebellum for guanosine 3’:5’-monophosphate-dependent protein kinase. 2. Kinetic studies on its phosphorylation by guanosine 3’:5’-monophosphate-dependent and adenosine 3’:5’-monophosphate-dependent protein kinases. Journal of biological chemistry. 1981;256:3494-3500
664. Aitken A, Bilham T, Cohen P, Aswad D, Greengard P A specific substrate from rabbit cerebellum for guanosine-3’:5’-monophosphate-dependent protein kinase. 3. Amino acid sequences at the two phosphorylation sites. Journal of biological chemistry. 1981;256:3501-3506
665. Walter U, Greengard P Cyclic AMP-dependent and cyclic GMP-dependent protein kinases of nervous tissue. Current topics in cellular regulation. 1981;19:219-256
666. Huttner WB, DeGennaro LJ, Greengard P Differential phosphorylation of multiple sites in purified Protein I by cyclic AMP-dependent and calcium-dependent protein kinases. Journal of biological chemistry. 1981;256:1482-1488
667. Kennedy MB, Greengard P Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate Protein I at distinct sites. Proceedings of the National Academy of Sciences. 1981;78:1293-1297
668. Dolphin AC, Greengard P Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus. Journal of neuroscience. 1981;1:192-203
669. Aswad DW, Greengard P A specific substrate from rabbit cerebellum for guanosine 3’:5’-monophosphate-dependent protein kinase. 1. Purification and characterization. Journal of biological chemistry. 1981;256:3487-3493
670. Theoharides TC, Sieghart W, Greengard P, Douglas WW Somatostatin-induced phosphorylation of mast cell proteins. Biochemical pharmacology. 1981;30:2735-2736
671. Walter U, De Camilli P, Lohmann SM, Miller P, Greengard P Regulation and cellular localization of cAMP-dependent and cGMP-dependent protein kinases. Cold Spring Harbor conferences on cell proliferation. 1981;8:141-157
672. Sieghart W, Theoharides TC, Douglas WW, Greengard P Phosphorylation of a single mast cell protein in response to drugs that inhibit secretion. Biochemical pharmacology. 1981;30:2737-2738
673. Liu AY-C, Walter U, Greengard P Steroid hormones may regulate autophosphorylation of adenosine 3’:5’-monophosphate-dependent protein kinase in target tissues. European journal of biochemistry. 1981;114:539-548
674. Dolphin AC, Greengard P Serotonin stimulates phosphorylation of protein I in the facial motor nucleus of rat brain. Nature. 1981;289:76-79
675. Greengard P Intracellular signals in the brain. Harvey lectures. 1981;75:277-331
676. Dolphin AC, Greengard P Presence of protein I, a phosphoprotein associated with synaptic vesicles, in cerebellar granule cells. Journal of neurochemistry. 1981;36:1627-1631
677. Nestler EJ, Rainbow TC, McEwen BS, Greengard P Corticosterone increases the amount of protein I, a neuron-specific phosphoprotein, in rat hippocampus. Science. 1981;212:1162-1164
678. Lohmann SM, Walter U, Miller PE, Greengard P, De Camilli P Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain. Proceedings of the National Academy of Sciences. 1981;78:653-657
679. Sieghart W, Schulman H, Greengard P Neuronal localization of Ca2+-dependent protein phosphorylation in brain. Journal of neurochemistry. 1980;34:548-553
680. Rudolph SA, Greengard P Effects of catecholamines and prostaglandin E1 on cyclic AMP, cation fluxes, and protein phosphorylation in the frog erythrocyte. Journal of biological chemistry. 1980;255:8534-8540
681. Palfrey HC, Feit PW, Greengard P cAMP-stimulated cation cotransport in avian erythrocytes: inhibition by ”loop” diuretics. American journal of physiology. 1980;238:C139-C148
682. Theoharides TC, Sieghart W, Greengard P, Douglas WW Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein. Science . 1980;207:80-82
683. Palfrey HC, Feit PW, Greengard P Specific inhibition by ”loop” diuretics of an anion-dependent Na+ + K+ cotransport system in avian erythrocytes. Annals of the New York Academy of Sciences. 1980;341:134-138
684. Walter U, Miller P, Wilson F, Menkes D, Greengard P Immunological distrinction between guanosine 3’:5’-monophosphate-dependent and adenosine 3’:5’-monophosphate-dependent protein kinases. Journal of biological chemistry. 1980;255:3757-3762
685. Casnellie JE, Ives HE, Jamieson JD, Greengard P Cyclic GMP-dependent protein phosprylation in intact medial tissue and isolated cells from vascular smooth muscle. Journal of biological chemistry. 1980;255:3770-3776
686. Ives HE, Casnellie JE, Greengard P, Jamieson JD Subcellular localization of cyclic GMP-dependent protein kinases and its substrates in vascular smooth muscle. Journal of biological chemistry. 1980;255:3777-3785
687. Alper SL, Beam KG, Greengard P Hormonal control of Na+-K+ cotransport in turkey erythrocytes: multiple site phosphorylation of goblin, a high molecular weight protein of the plasma membrane. Journal of biological chemistry. 1980;255:4864-4871
688. Lohmann SM, Walter U, Greengard P Identification of endogenous substrate proteins for cAMP-dependent protein kinase in bovine brain. Journal of biological chemistry. 1980;255:9985-9992
689. Palfrey HC, Alper SL, Greengard P Protein phosphorylation and the regulation of cation cotransport. Journal of experimental biology. 1980;89:103-115
690. Alper SL, Palfrey HC, DeRiemer SA, Greengard P Hormonal control of protein phosphorylation in turkey erythrocytes. Phosphorylation by cAMP-dependent and Ca2+-dependent protein kinases of distinct sites in goblin, a high molecular weight protein of the plasma membrane. Journal of biological chemistry. 1980;255:11029-11039
691. Yamazaki A, Sen I, Bitensky MW, Casnellie JE, Greengard P Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase. Journal of biological chemistry. 1980;255:11619-11624
692. Schlichter DJ, Detre JA, Aswad DW, Chehrazi B, Greengard P Localization of cyclic GMP-dependent protein kinase and substrate in mammalian cerebellum. Proceedings of the National Academy of Sciences. 1980;77:5537-5541
693. Nestler EJ, Greengard P Dopamine and depolarizing agents regulate the state of phosphorylation of Protein I in the mammalian superior cervical sympathetic ganglion. Proceedings of the National Academy of Sciences. 1980;77:7479-7483
694. Kaczmarek LK, Jennings KR, Strumwasser F, Mairn AC, Walter U, Wilson FD, Greengard P Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proceedings of the National Academy of Sciences. 1980;77:7487-7491
695. Castellucci VF, Kandel ER, Schwartz JH, Wilson FD, Nairn AC, Greengard P Intracellular injection of the catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia. Proceedings of the National Academy of Sciences. 1980;77:7492-7496
696. Dolphin AC, Goelz SE, Greengard P Neuronal protein phosphorylation: recent studies concerning Protein I, a synapse-specific phosphoprotein. Pharmacology, biochemistry & behavior. 1980;13:169-174
697. Kanof PD, Greengard P Pharmacological properties of histamine-sensitive adenylate cyclase from mammalian brain. Journal of pharmacology & experimental therapeutics. 1979;209:87-96
698. Kanof PD, Greengard P Pharmacological properties of histamine-sensitive adenylate cyclase from guinea pig cardiac ventricular muscle. Molecular pharmacology. 1979;15:445-461
699. Ueda T, Greengard P, Berzins K, Cohen RS, Blomberg F, Grab DJ, Siekevitz P Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase. Journal of cell biology. 1979;83:308-319
700. Greengard P Cyclic nucleotides, phosphorylated proteins and the nervous system. Federation proceedings. 1979;38:2208-2217
701. Greengard P Some chemical aspects of neurotransmitter action. Trends in pharmacological sciences. 1979;1:27-29
702. Rudolph SA, Hegstrand LR, Greengard P, Malawista SE The interaction of colchicine with hormone-sensitive adenylate cyclase in human leukocytes. Molecular pharmacology. 1979;16:805-812
703. Sieghart W, Forn J, Greengard P Ca2+ and cyclic AMP regulate phosphorylation of same two membrane-associated proteins specific to nerve tissue. Proceedings of the National Academy of Sciences. 1979;76:2475-2479
704. Strombom U, Forn J, Dolphin AC, Greengard P Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents. Proceedings of the National Academy of Sciences. 1979;76:4687-4690
705. Huttner WB, Greengard P Multiple phosphorylation sites in Protein I and their differential regulation by cyclic AMP and calcium. Proceedings of the National Academy of Sciences. 1979;76:5402-5406
706. De Camilli P, Ueda T, Bloom FE, Battenberg E, Greengard P Widespread distribution of Protein I in the central and peripheral nervous systems. Proceedings of the National Academy of Sciences. 1979;76:5977-5981
707. Walter U, Lohmann SM, Sieghart W, Greengard P Identification of the cyclic AMP-dependent protein kinase responsible for endogenous phosphorylation of substrate proteins in synaptic membrane fraction from rat brain. Journal of biological chemistry. 1979;254:12235-12239
708. Walter U, Costa MRC, Breakefield XO, Greengard P Presence of free cyclic AMP receptor protein and regulation of its level by cyclic AMP in neuroblastoma-glioma hybrid cells. Proceedings of the National Academy of Sciences. 1979;76:3251-3255
709. Krieger NR, Bunney BS, Greengard P Localization of dopamine-sensitive adenylate cyclase activity within laminae of the rat prefrontal cortex. Brain research. 1979;179:171-175
710. Bloom FE, Ueda T, Battenberg E, Greengard P Immunocytochemical localization, in synapses, of Protein I, an endogenous substrate for protein kinases in mammalian brain. Proceedings of the National Academy of Sciences. 1979;76:5982-5986
711. Greengard P Cyclic nucleotide and protein phosphorylation mechanisms in the central nervous system. Nobel symposium. 1979;42:157-172
712. Sieghart W, Strombom U, Walter U, Greengard P Drug interactions with cyclic nucleotide and protein phosphorylation systems. Progress in clinical & biological research. 1979;27:123-134
713. Beam KG, Alper SL, Palade GE, Greengard P Hormonally regulated phosphoprotein of turkey erythrocytes: localization to plasma membrane. Journal of cell biology. 1979;83:1-15
714. Schulman H, Greengard P Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein. Nature. 1978;271:478-479
715. Schlichter DJ, Casnellie JE, Greengard P An endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum. Nature. 1978;273:61-62
716. Casnellie JE, Schlichter DJ, Walter U, Greengard P Photoaffinity labeling of a guanosine 3’:5’-monophosphate-dependent protein kinase from vascular smooth muscle. Journal of biological chemistry. 1978;253:4771-4776
717. Walter U, Kanof P, Schulman H, Greengard P Adenosine 3’:5’-monophosphate receptor proteins in mammalian brain. Journal of biological chemistry. 1978;253:6275-6280
718. Kanof PD, Greengard P Brain histamine receptors as targets for antidepressant drugs. Nature. 1978;272:329-333
719. Sieghart W, Theoharides TC, Alpaer SL, Douglas WW, Greengard P Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell. Nature. 1978;275:329-331
720. Lohmann SM, Ueda T, Greengard P Ontogeny of synaptic phosphoproteins in brain. Proceedings of the National Academy of Sciences. 1978;75:4037-4041
721. Study RE, Greengard P Regulation by histamine of cyclic nucleotide levels in sympathetic ganglia. Journal of pharmacology & experimental therapeutics. 1978;207:767-778
722. Nestler EJ, Beam KG, Greengard P Nicotinic cholinergic stimulation increases GMP levels in vertebrate skeletal muscle. Nature. 1978;275:451-453
723. Sieghart W, Forn J, Schwarcz R, Coyale JT, Greengard P Neuronal localization of specific brain phosphoproteins. Brain research. 1978;156:345-350
724. Forn J, Greengard P Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices. Proceedings of the National Academy of Sciences. 1978;75:5195-5199
725. Schulman H, Greengard P Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by ”calcium-dependent regulator”. Proceedings of the National Academy of Sciences. 1978;75:5432-5436
726. Study RE, Breakefield XO, Bartfai T, Greengard P Voltage-sensitive calcium channels regulate guanosine 3’:5’-cyclic monophosphate levels in neuroblastoma cells. Proceedings of the National Academy of Sciences. 1978;75:6295-6299
727. Walter U, Greengard P Quantitative labeling of the regulatory subunit of Type II cAMP-dependent protein kinase from bovine heart by a photoaffinity analog. Journal of cyclic nucleotide research. 1978;4:437-444
728. Lohmann SM, Walter U, Greengard P Protein kinases in developing rat brain. Journal of cyclic nucleotide research. 1978;4:445-452
729. Bartfai T, Study RE, Greengard P Muscarinic stimulation and cGMP synthesis in the nervous system. Advances in behavioral biology. 1978;24:285-295
730. Bartfai T, Breakefield XO, Greengard P Regulation of synthesis of guanosine 3’:5’-cyclic monophosphate in naeuroblastoma cells. Biochemical journal. 1978;176:119-127
731. Greengard P Phosphorylated proteins as physiological effectors. Science. 1978;199:146-152
732. Uno I, Ueda T, Greengard P Enzyme systems involved in phosphorylation and dephosphorylation of two endogenous phosphoproteins in neuronal membranes. Archives of biochemistry & biophysics. 1977;183:480-489
733. Uno I, Ueda T, Greengard P Adenosine 3’:5’-monophosphate-regulated phosphoprotein system of neuronal membranes. 2. Solubilization, purification, and some properties of an endogenous adenosine 3’:5’-monophosphate-dependent protein kinase. Journal of biological chemistry. 1977;252:5164-5174
734. Ueda T, Greengard P Adenosine 3’:5’-monophosphate-regulated phosphoprotein system of neuronal membranes. 1. Solubilization, purification, and some properties of an endogenous phosphoprotein. Journal of biological chemistry. 1977;252:5155-5163
735. Kanof PD, Hegstrand LR, Greengard P Biochemical characterization of histamine-sensitive adenylate cyclase in mammalian brain. Archives of biochemistry & biophysics. 1977;182:321-334
736. Krueger BK, Forn J, Greengard P Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes. Journal of biological chemistry. 1977;252:2764-2773
737. Rudolph SA, Schafer DE, Greengard P Effects of cholera enterotoxin in catecholamine-stimulated changes in cation fluxes, cell volume, and cyclic AMP levels in the turkey erythrocyte. Journal of biological chemistry. 1977;252:7132-7139
738. Krieger NR, Kauer JS, Shepherd GM, Greengard P Dopamine-sensitive adenylate cyclase within laminae of the olfactory tubercle. Brain research. 1977;131:303-312
739. Nathanson JA, Greengard P ”Second messengers” in the brain. Scientific American. 1977;237(2):108-119
740. Kanof P, Ueda T, Uno I, Greengard P Cyclic nucleotides and phosphorylated proteins in neuronal function. Neuroscience symposia. 1977;2:399-434
741. Walter U, Uno I, Liu AY-C, Greengard P Study of autophosphorylation of isoenzymes of cyclic AMP-dependent protein kinases. Journal of biological chemistry. 1977;252:6588-6590
742. Rudolph SA, Greengard P, Malawista SE Effects of colchicine on cyclic AMP levels in human leukocytes. Proceedings of the National Academy of Sciences. 1977;74:3404-3408
743. Walter U, Uno I, Liu AY-C, Greengard P Identification, characterization, and quantitative measurement of cyclic AMP receptor proteins in cytosol of various tissues using a photoaffinity ligand. Journal of biological chemistry. 1977;252:6494-6500
744. Beam KG, Nestler EJ, Greengard P Increased cyclic GMP levels associated with contraction in muscle fibres of the giant barnacle. Nature. 1977;267:534-536
745. Uno I, Ueda T, Greengard P Differences in properties of cytosol and membrane-derived protein kinases. Journal of biological chemistry. 1976;251:2192-2195
746. Forn J, Greengard P Regulation by lipolytic and antilipolytic compounds of the phosphorylation of specific proteins in isolated intact fat cells. Archives of biochemistry & biophysics. 1976;176:721-733
747. Hegstrand LR, Kanof PD, Greengard P Histamine-sensitive adenylate cyclase in mammalian brain. Nature . 1976;260:163-165
748. Liu AY-C, Greengard P Regulation by steroid hormones of phosphorylation of specific protein common to several target organs. Proceedings of the National Academy of Sciences. 1976;73:568-572
749. Greengard P The action of antipsychotic drugs on dopamine-stimulated adenylate cyclase activity. Wenner-Gren Center international symposium series. 1976;25:271-283
750. Greengard P Possible role for cyclic nucleotides and phosphorylated membrane proteins in the postsynaptic actions of neurotransmitters. Nature. 1976;260:101-108
751. Beam KG, Greengard P Cyclic nucleotides, protein phosphorylation and synaptic function. Cold Spring Harbor symposia on quantitative biology. 1976;40:157-168
752. McGuinness TL, Lai Y, Ouimet CC, Greengard P Calcium/calmodulin-dependent protein phosphorylation in the nervous system. Symposia of the Society for Experimental Biology. 1976;30:291-305
753. Krueger BK, Forn J, Walters JR, Roth RH, Greengard P Stimulation by dopamine of adenosine cyclic r’:5’-monophosphate formation in rat caudate nucleus: effect of lesions of the nigro-neostriatal pathway. Molecular pharmacology. 1976;12:639-648
754. Kebabian JW, Bloom FE, Steiner AL, Greengard P Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstraction. Science. 1975;190:157-159
755. Pomerantz AH, Rudolph SA, Haley BE, Greengard P Photoaffinity labeling of a protein kinase from bovine brain with 8-azidoadenosine 3’:5’-monophosphate. Biochemistry. 1975;14:3858-3862
756. Ueda T, Rudolph SA, Greengard P Solubilization of a phosphoprotein and its associated cyclic AMP-dependent protein kinase and phosphoprotein phosphatase from synaptic membrane fractions, and some kinetic evidence for their existence as a complex. Archives of biochemistry & biophysics. 1975;170:492-503
757. Morgenroth VH, Hegstrand LR, Roth RH, Greengard P Evidence for involvement of protein kinase in the activation by adenosine 3’:5’-monophosphate of brain tyrosine 3-monooxygenase. Journal of biological chemistry. 1975;250:1946-1948
758. Sloboda RD, Rudolph SA, Rosenbaum JL, Greengard P Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein. Proceedings of the National Academy of Sciences. 1975;72:177-181
759. Malkinson AM, Krueger BK, Rudolph SA, Casnellie JE, Haley BE, GReengard P Widespread occurence of a specific protein in vertebrate tissues, and regulation of cyclic AMP and its endogenous phosphorylation and dephosphorylation. Metabolism. 1975;24:331-341
760. Maeno H, Ueda T, Greengard P Adenosine 3’5’-monophosphate-dependent protein phosphatase activity in synaptic membrane fractions. Journal of cyclic nucleotide research. 1975;1:37-48
761. Kebabian JW, Steiner AL, Greengard P Muscarinic cholinergic regulation of cyclic guanosine 3’:5’-monophosphate in autonomic ganglia: possible role in synaptic transmission. Journal of pharmacology & experimental therapeutics. 1975;193:474-488
762. Walton KG, DeLorenzo RJ, Curran PF, Greengard P Regulation of protein phosphorylation and sodium transport in toad bladder. Journal of general physiology. 1975;65:153-177
763. Greengard P Cyclic nucleotides, protein phosphorylation, and neuronal function. Advances in cyclic nucleotide research. 1975;5:585-601
764. Kebabian JW, Clement-Cormier YC, Petzold GL, Greengard P Chemistry of dopamine receptors. Advances in neurology. 1975;9:1-11
765. Greengard P Presynaptic and postsynaptic roles of cyclic AMP and protein phosphorylation at catecholaminergic synapses. Chemical tools in catecholamine research. 1975;2:249-256
766. Krueger BK, Forn J, Greengard P Dopamine-sensitive adenylate cyclase and protein phosphorylation in the rat caudate nucleus. Modern pharmacology-toxicology. 1975;3:123-147
767. Clement-Cormier YC, Parrish RG, Petzold GL, Kebabian JW, Greengard P Characterization of a dopamine-sensitive adenylate cyclase in the rat caudate nucleus. Journal of neurochemistry. 1975;25:143-149
768. Liu AY-C, Greengard P Aldosterone-induced increase in protein phosphatase activity of toad bladder. Proceedings of the National Academy of Sciences. 1974;71:3869-3873
769. Kalix P, McAfee DA, Schorderet M, Greengard P Pharmacological analysis of synaptically mediated increase in cyclic adenosine monophosphate in rabbit superior cervical ganglion. Journal of pharmacology & experimental therapeutics. 1974;188:676-687
770. Forn J, Krueger BK, Greengard P Adenosine 3’:5’-monophosphate content in rat caudate nucleus: demonstration of dopaminergic and adrenergic receptors. Science. 1974;186:1118-1120
771. Weight FF, Petzold G, Greengard P Guanosine 3’,5’-monophosphate in sympathetic ganglia: increase associated with synaptic transmission. Science. 1974;186:942-944
772. Rudolph SA, Greengard P Regulation of protein phosphorylation and membrane permeability by abeta-adrenergic agents and cyclic adenosine 3’:5”-monophosphate in the avian erythrocyte. Journal of biological chemistry. 1974;249:5684-5687
773. Greengard P Biochemical characterization of the dopamine receptor in the mammalian caudate nucleus. Journal of psychiatric research. 1974;11:87-90
774. Nathanson JA, Greengard P Serotonin-sensitive adenylate cyclase in neural tissue and its similarity to the serotonin receptor: a possible site of action of lysergic acid diethylamide. Proceedings of the National Academy of Sciences. 1974;71:797-801
775. Kuo JF, Greengard P Purification and characterization of cyclic GMP-dependent protein kinases. Methods in enzymology. 1974.;38:329-350
776. Kuo JF, Greengard P Assay of cyclic GMP by activation of cyclic GMP-dependent protein kinase. Methods in enzymology. 1974;38:90-95
777. Maeno H, Reyes PL, Ueda T, Rudolph SA, Greengard P Autophosphorylation of adenosine 3’:5”-monophosphate-dependent protein kinase from bovine brain. Archives of biochemistry & biophysics. 1974;164:551-559
778. Casnellie JE, Greengard P Guanosine 3’:5’-cyclic monophosphate-dependent phosphorylation of endogenous substrate proteins in membranes of mammalian smooth muscle. Proceedings of the National Academy of Sciences. 1974;71:1891-1895
779. Clement-Cormier YC, Kababian JW, Petzold GL, Greengard P Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs. Proceedings of the National Academy of Sciences. 1974;71:1113-1117
780. Greengard P, Kebabian JW Role of cyclic AMP in synaptic transmission in the mammalian peripheral nervous system. Federation proceedings. 1974;33:1059-1067
781. Ueda T, Maeno H, Greengard P Regulation of endogenous phosphorylation of specific proteins in synaptic membrane fractions from rat brain by adenosine 3’:5’-monophosphate. Journal of biological chemistry. 1973;248:8295-8305
782. Nathanson JA, Greengard P Octopamine-sensitive adenylate cyclase: evidence for a biological role of octopamine in nervous tissue. Science. 1973;180:308-310
783. DeLorenzo RJ, Greengard P Activation by adenosine 3’:5’-monophosphate of a membrane-bound phosphoprotein phosphatase from toad bladder. Proceedings of the National Academy of Sciences. 1973;70:1831-1835
784. Miyamoto E, Petzold GL, Kuo JF, Greengard P Dissociation and activation of adenosine 3’:5’-monophosphate-dependent and guanosine 3’:5’-monophosphate-dependent protein kinases by cyclic nucleotides and by sybstrate proteins. Journal of biological chemistry. 1973;248:179-189
785. Donnelly TE, Kuo JF, Miyamoto E, Greengard P Protein kinase modulator from lobster tail muscle. 2. Effects of the modulator on holoenzyme and catalytic subunit of guanosine 3’:5’-monophosphate-dependent and adenosine 3’:5’-monophosphate-dependent protein kinases. Journal of biological chemistry. 1973;248:199-203
786. Donnelly TE, Kuo JF, Reyes PL, Liu YP, Greengard P Protein kinase modulator from lobster tail muscle. 1. Stimulatory and inhibitory effects of the modulator on the phosphorylation of substrate proteins by guanosine 3’:5’-monophosphate-dependent and adenosine 3’:5’-monophosphate-dependent protein kinases. Journal of biological chemistry. 1973;248:190-198
787. DeLorenzo RJ, Walton KG, Curran PF, Greengard P Regulation of phosphorylation of a specific protein in toad-bladder membrane by antidiuretic hormone and cyclic AMP, and its possible relationship to membrane permeability changes. Proceedings of the National Academy of Sciences. 1973;70:880-884
788. Kebabian JW, Kuo JF, Greengard P Determination of relative levels of cyclic AMP in tissues or cells prelabeled with radioactive adenine. Advances in cyclic nucleotide research. 1972;2:131-137
789. Kuo JF, Greengard P An assay method for cyclic AMP and cyclic GMP based upon their abilities to activate cyclic AMP-dependent and cyclic GMP-dependent protein kinases. Advances in cyclic nucleotide research. 1972;2:41-50
790. Greengard P, McAfee DA, Kebabian JW On the mechanism of action of cyclic AMP and its role in synaptic transmission. Advances in cyclic nucleotide research. 1972;1:337-355
791. Greengard P, McAfee DA Adenosine 3’:5’-cyclic monophosphate as a mediator in the action of neurohumoral agents. Biochemical Society symposium. 1972;36:87-102
792. Maeno H, Greengard P Phosphoprotein phosphatases from rat cerebral cortex: subcellular distribution and characterization. Journal of biological chemistry. 1972;247:3269-3277
793. McAfee DA, Greengard P Adenosine 3’:5’-monophosphate: electrophysiological evidence for a role in synaptic transmission. Science. 1972;178:310-312
794. Johnson EM, Ueda T, Maeno H, Greengard P Adenosine 3’:5’-monophosphate-dependent phosphorylation of a specific protein in synaptic membrane fractions from rat cerebrum. Journal of biological chemistry. 1972;247:5650-5652
795. Lee TP, Kuo JF, Greengard P Role of muscarinic cholinergic receptors in regulation of guanosine 3’:5’-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle. Proceedings of the National Academy of Sciences. 1972;69:3287-3291
796. Tsien RW, Giles W, Greengard P Cyclic AMP mediates the effects of adrenaline on the action potential plateau of cardiac Purkinje fibres. Nature. 1972;240:181-183
797. Kebabian JW, Petzold GL, Greengard P Dopamine-sensitive adenylate cyclase in the caudate nucleus of rat brain and its similarity to the ”dopamine receptor”. Proceedings of the National Academy of Sciences. 1972;69:2145-2149
798. Kuo JF, Lee T-P, Reyes PL, Walton K, Donnelly T, Greengard P Cyclic nucleotide-dependent protein kinases. 10. An assay method for the measurement of guanosine 3’:5’-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. Journal of biological chemistry. 1972;247:16-22
799. Greengard P On the reactivity and mechanism of action of cyclic nucleotides. Annals of the New York Academy of Sciences. 1971;185:18-26
800. Greengard P, Kuo J-F, Mitamoto E Studies on the mechanism of action of cyclic AMP in nervous and other tissues. Advances in enzyme regulation. 1971;9:113-125
801. McAfee DA, Schorderet M, Greengard P Adenosine 3’:5’-monophosphate in nervous tissue: increase associated with synaptic transmission. Science. 1971;171:1156-1158
802. Rudolph SA, Johnson EM, Greengard P The enthalpy of hydrolysis of various 3’:5’- and 2’:3’-cyclic nucleotides. Journal of biological chemistry. 1971;246:1271-1273
803. Maeno H, Johnson EM, Greengard P Subcellular distribution of adenosine 3’:5’-monophosphate-dependent protein kinase in rat brain. Journal of biological chemistry. 1971;246:134-142
804. Miyamoto E, Petzold GL, Harris JS, Greengard P Dissociation and concomitant activation of adenosine 3’:5’-monophosphate-dependent protein kinase by histone. Biochemical & biophysical research communications. 1971;44:305-312
805. Lee T-P, Kuo JF, Greengard P Regulation of mycardial cyclic AMP by isoproterenol, glucagon and acetylcholine. Biochemical & biophysical research communications.. 1971;45:991-997
806. Kuo JF, Wyatt GR, Greengard P Cyclic nucleotide-dependent protein kinases. 9. Partial purification and some properties of guanosine 3’:5’-monophosphate-dependent and adenosine 3’:5’-monophosphate-dependent protein kinases from various tissue and species of arthropoda. Journal of biological chemistry. 1971;246:7159-7167
807. Johnson EM, Maeno H, Greengard P Phosphorylation of endogenous protein of rat abrain by cyclic adenosine 3’:5’-monophosphate-dependent protein kinease. Journal of biological chemistry. 1971;246:7731-7739
808. Florendo NT, Barrnett RJ, Greengard P Cyclic 3’:5’-nucleotide phosphodiesterase: cytochemical localization in cerebral cortex. Science. 1971;173:745-748
809. Hayaishi O, Greengard P, Colowick SP On the equilibrium of the adenylate cyclase reaction. Journal of biological chemistry. 1971;246:5840-5843
810. Kebabian JW, Greengard P Dopamine-sensitive adenyl cyclase: possible role in synaptic transmission. Science. 1971;174:1346-1349
811. Greengard P, Kuo JF On the mechanism of action of cyclic AMP. Advances in biochemical psychopharmacology. 1970;3:287-306
812. Kuo JF, Greengard P Stimulation of adenosine 3’:5’-monophosphate-dependent and guanosine 3’:5’-monophosphate-dependent protein kinases by some analogs of adenosine 3’:5’-monophosphate. Biochemical & biophysical research communications. 1970;40:1032-1038
813. Reik L, Petzold GL, Higgins JA, Greengard P, Barrnett RJ Hormone-sensitive adenyl cyclase: cytochemical localization in rat liver. Science. 1970;168:382-384
814. Kuo JF, Greengard P Cyclic nucleotide-dependent protein kinases. 7. Comparison of various histones as substractes for adenosine 3’:5’-monophosphate-dependent and guanosine 3’:5’-monophosphate-dependent protein kinases. Biochimica et biophysica acta. 1970;212:434-440
815. Kuo JF, Greengard P Cyclic nucleotide-dependent protein kinases. 6. Isolation and partial purification of a protein kinase activated by guanosine 3’:5’-monophosphate. Journal of biological chemistry. 1970;245:2493-2498
816. Kuo JF, Krueger BK, Sanes JR, Greengard P Cyclic nucleotide-dependent protein kinases. 5. Preparation and properties of adenosine 3’:5’-monophosphate-dependent protein kinase from various bovine tissues. Biochimica et biophysica acta. 1970;212:79-91
817. Kuo JF, Greengard P Cyclic nucleotide-dependent protein kinases. 8. An assay method for the measurement of adenosine 3’:5’-monophosphate in various tissues and a study of agents influencing its level in adipose cells. Journal of biological chemistry. 1970;245:4067-4073
818. Greengard P, Rudolph SA, Sturtevant JM Enthalpy of hydrolysis of the 3’ bond of adenosine 3’:5’-monophosphate and guanosine 3’:5’-monophosphate. Journal of biological chemistry. 1969;244:4798-4800
819. Burns JJ, Azarnoff DL, Bain JA, Brodie BB, Cosmides GJ, Dearborn EH, DuBois KP, Gillette JR, Goldberg L, Goldenthal EI, Greengard P, LaDu BN, Mandel HG, Mannering GJ, Oates JA, Peck HM, Shore PA, Way EL Application of metabolic data to the evaluation of drugs. Clinical pharmacology & therapeutics. 1969;10:607-634
820. Miyamoto E, Kuo JF, Greengard P Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3’:5’-monophosphate-dependent protein kinase from bovine brain. Journal of biological chemistry. 1969;244:6395-6402
821. Kuo JF, Greengard P An adenosine 3’:5’-monophosphate-dependent protein kinase from Escherichia coli. Journal of biological chemistry. 1969;244:3417-3419
822. Miyamoto E, Kuo JF, Greengard P Adenosine 3’:5’-monophosphate-dependent protein kinase from brain. Science. 1969;165:63-65
823. den Hertog A, Greengard P, Ritchie JM On the metabolic basis of nervous activity. Journal of physiology. 1969;204:511-521
824. Greengard P, Petrack B, Kalinsky HJ Identification of hormonally controlled endogenous inhibitor of liver nicotinamide deamidase. Biochimica et biophysica acta. 1969;184:148-153
825. Kuo JF, Greengard P Cyclic nucleotide-dependent protein kinases. 4. Widespread occurrence of adenosine 3’:5’-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Proceedings of the National Academy of Sciences. 1969;64:1349-1355
826. Greengard P, Kalinsky HJ, Manning TJ Tryptophan pyrrolase activity during pregnancy. Biochimica et biophysica acta. 1968;156:198-199
827. Greengard P, Kalinsky H, Manning TJ, Zak SB Prevention and remission by adrenocortical steroids of nicotinamide deficiency disease. 2. A study of the mechanism. Journal of biological chemistry. 1968;243:4216-4221
828. Greengard P, Petrack B, Kalinsky HJ Effect of hypophysectomy on pyridine nucleotide metabolism: the role of nicotinamide. Journal of biological chemistry. 1967;242:152-154
829. Greengard P, Psychoyos S, Tallan HH, Cooper DY, Rosenthal O, Estabrook RW Aldosterone synthesis by adrenal mitochondria. 3. Participation of cytochrome P-450. Archives of biochemistry & biophysics. 1967;121:298-303
830. Quinn GP, Cohn MM, Reid MB, GReengard P, Weiner M The effect of formulation on phenmetrazine plasma levels in man studied by a sensitive analytic method. Clinical pharmacology & therapeutics. 1967;8:369-373
831. Berg BN, Sigg EB, Greengard P Maintenance of pregnancy in protein-deficient rats by adrenocortical steroid or ACTH administration. Endocrinology. 1967;80:829-834
832. Gluecksohn-Waelsch S, Greengard P, Quinn GP, Teicher LS Genetic variations of an oxidase in mammals. Journal of biological chemistry. 1967;242:1271-1273
833. Tallan HH, Psychoyos S, Greengard P Aldosterone synthesis by adrenal mitochondria. 2. The effect of citric acid cycle intermediates: identification of the soluble stimulatory factor as fumarase. Journal of biological chemistry. 1967;242:1912-1914
834. Ritchie JM, Greengard P On the mode of action of local anesthetics. Annual review of pharmacology. 1966;6:405-430
835. Psychoyos S, Tallan HH, Greengard P Aldosterone synthesis by adrenal mitochondria. Journal of biological chemistry. 1966;241:2949-2956
836. Quinn GP, Greengard P, Reid MB Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism. Molecular pharmacology. 1966;2:347-351
837. Greengard P, Sigg EB, Fratta I, Zak SB Prevention and remission by adrenocortical steroids of nicotinamide deficiency disorders and of 6-aminonicotinamide toxicity in rats and dogs. Journal of pharmacology & experimental therapeutics. 1966;154:624-631
838. Quinn GP, Greengard P The pathway for the biosynthesis of N1-methyl-4-pyridone-3-carboxamide. Archives of biochemistry & biophysics. 1966;115:146-152
839. Maerki F, Greengard P Nicotinamide deamidase in Ehrlich ascites tumor cells. Biochimica et biophysica acta. 1966;113:587-594
840. Petrack B, Greengard P, Kalinsky H On the relative efficacy of nicotinamide and nicotinic acid as precursors of nicotinamide adenine dinucleotide. Journal of biological chemistry. 1966;241:2367-2372
841. Ritchie JM, Ritchie B, Greengard P The active structure of local anesthetics. Journal of pharmacology & experimental therapeutics. 1965;150:152-159
842. Greengard P, Quinn GP, Reid MB Identification of hormones affecting pyridine nucleotide metabolism of rat liver. Journal of biological chemistry. 1965;240:486-490
843. Petrack B, Greengard P, Craston A, Sheppy F Nicotinamide deamidase from mammalian liver. Journal of biological chemistry. 1965;240:1725-1730
844. Ritchie JM, Ritchie B, Greengard P The effect of the nerve sheath on the action of local anesthetics. Journal of pharmacology & experimental therapeutics. 1965;150:160-164
845. Greengard P, Quinn GP, Reid MB Pituitary influence on pyridine nucleotide metabolism of rat liver. Journal of biological chemistry. 1964;239:1887-1892
846. Fratta I, Zak SB, Greengard P, Sigg EB Fetal death from nicotinamide deficient diet and its prevention by chlorpromazine and imipramine. Science. 1964;145:1429-1430
847. Greengard P, Petrack B, Craston A, Kalinsky HJ Release of inhibition of rat liver nicotinamide deamidase by hypophysectomy. Biochemical & biophysical research communications. 1963;13:478-482
848. Petrack B, Greengard P, Craston A, Kalinsky HJ Nicotinamide deamidase in rat liver and the biosynthesis of NAD. Biochemical & biophysical research communications. 1963;13:472-477
849. Zak SB, Tallan HH, Quinn GP, Fratta I, Greengard P The determination and physiological distribution of dipyridamole and its glucuronides in biological material. Journal of pharmacology & experimental therapeutics. 1963;141:392-398
850. Greengard P, Straub RW Metabolic studies on the hyperpolarization following activity in mammalian non-myelinated nerve fibres. Journal of physiology. 1962;161:414-423
851. Greengard P, Quinn GP Metabolic effects of tranquilizers and hypophysectomy. Annals of the New York Academy of Sciences. 1962;96:179-184
852. Greengard P, Quinn GP, Landrau MA Hormonal effects on DPN concentration in rat liver. Biochimica et biophysica acta. 1961;47:614-616
853. Greengard P, Kalinsky H, Petrack B Effect of hypophysectomy on liver diphosphopyridine nucleotide: the role of nicotinamide. Biochimica et biophysica acta. 1961;52:408-409
854. Ritchie JM, Greengard P On the active structure of local anesthetics. Journal of pharmacology & experimental therapeutics. 1961;133:241-245
855. Chirigos MA, Greengard P, Udenfriend S Uptake of tyrosine by rat brain in vivo. Journal of biological chemistry. 1960;235:2075-2079
856. Greengard P, Straub RW Restoration by barium of action potentials in sodium-deprived mammalian B and C fibres. Journal of physiology. 1959;145:562-569
857. Greengard P, Straub RW Effect of frequency of electrical stimulation on the concentration of intermediary metabolites in mammalian non-myelinated fibres. Journal of physiology. 1959;148:353-361
858. Greengard P, Minnaert K, Slater EC, Betel I Yield of oxidative phosphorylation associated with the oxidation of succinate to fumarate. Journal of biochemistry. 1959;73:637-646
859. Greengard P, Straub RW After-potentials in mammalian non-myelinated nerve fibres. Journal of physiology. 1958;144:442-462
860. Greengard P Determination of intermediary metabolites by enzymic fluorimetry. Nature. 1956;178:632-634
861. Greengard P, Brink F, Colowick SP Some relationships between the action potential, oxygen consumption and coenzyme content in degenerati9ng peripheral axons. Journal of cellular & comparative physiology. 1954;44:395-420
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