Ferid Murad

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1965 Alfred S. Maschke Award for Clinical Excellence (Western Reserve University

1965 Mosby Book Award (Western Reserve University

1966 Diplomate of the National Board of Medical Examiners

1972 – 1977 Research Career Development Award

1974 Diplomat of the American Board of Internal Medicine

1988 American Heart Association – Ciba Award Recipient

1996 Albert and Mary Lasker Award for Basic Research

1998 Nobel Prize in Physiology or Medicine

1998 Award from Chairman Yassar Arafat

1998 Resolution from the City of Houston, Texas

1998 Resolution from the State of Texas

1998 Resolution from the United States House of Representatives

1999 Old Gold Award, DePauw University

1999 Life of Quality Award for Sheltering Arms

1999 Honor of the Nation Award from the President of Albania

1999 Sagamore Wabash Award, The Highest honor from the Governor of Indiana

1999 The Albanian American National Council Award

1999 Distinguished Alumnus Award, Case Western Reserve University School of Medicine

1999 Golden Plate Award from the American Academy of Achievement

1999 Honorary Citizen, Gostivar, Macedonia

1999 Resolution from Lake County, Indiana

2000 to present Honorary Director, Epithelial Cell Biology Res. Ctr Chinese Univ. of Hong Kong

2000 Macedonian Medal of St. Apostle Paul

2000 Consulting Editor, News in Physiological Sciences

2000 Baxter Award for Distinguished Research in the Biomedical

2000 Sciences Association of American Medical Colleges (AAMC)

2000 Science and Technology Consultant, Shenzhen, China

2002 Honorary Professor, Soochow University, Suzhou, China

2002 Honorary Professor, Shanghai Second Medical University

2003 Honorary Professor; Shanghai University of Traditional Medicine

2002-05 Scientific Steering Committee China Nat. Center for Biotechnology

2002-05 Scientific Steering Committee National Institute of Biological Science, Beijing

2002-present Honorary Board Member – World High Tech Society

2003 Honorary Member, Islamic Academy of Sciences

2004 Honorary Member, World Innovation Foundation

2004 Fellow, European Academy of Sciences

2004 Honorary Member, The National Society of High School Scholars

2004 Member, International Advisory Board for Shanghai Xuhui District

2005 Santiago Grisolia Award – Valencia, Spain

2005 Editorial Board, Cell Biology International

2005 American Society Clinical Pharmacology Research Prize

2005 Jury Member Premios Rey Jaime I Prize of Spain

2005 Whiting High School Wall of Fame

Vladislav G Sharin; Kalpana Mujoo; Alexander Y Kots; Emil Martin; Ferid Murad; Iraida G Sharina Nitric oxide receptor soluble guanylyl cyclase undergoes splicing regulation in differentiating human embryonic cells. Stem cells and development 2011;20(7):1287-93.

Antonio R Martins; Cesar A B Zanella; Fabiola C R Zucchi; Thaís C D Dombroski; Edmar T Costa; Liliane M Guethe; Alina O Oliveira; Ana L F Donatti; Luciano Neder; Leila Chimelli; et al. Immunolocalization of nitric oxide synthase isoforms in human archival and rat tissues, and cultured cells. Journal of neuroscience methods 2011;198(1):16-22.

Yong-Liang Xue; Hai-Xia Shi; Ferid Murad; Ka Bian Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. Vascular health and risk management 2011;7():273-80.

Ya-juan Li; Jun-Xiang Bao; Jin-wen Xu; Ferid Murad; Ka Bian Vascular dilation by paeonol–a mechanism study. Vascular pharmacology 2010;53(3-4):169-76.

Tri M Bui-Nguyen; Suresh B Pakala; Divijendranatha Reddy Sirigiri; Emil Martin; Ferid Murad; Rakesh Kumar Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator. The Journal of biological chemistry 2010;285(10):6980-6.

Marcia H M Cardoso; Rafael P Morganti; Sergio Lilla; Ferid Murad; Gilberto De Nucci; Edson Antunes; Sisi Marcondes The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion. European journal of pharmacology 2010;627(1-3):229-34.

Jessica Tao Li; Chandra Somasundaram; Ka Bian; Weijun Xiong; Faiz Mahmooduddin; Rahul K Nath; Ferid Murad Nitric oxide signaling and neural stem cell differentiation in peripheral nerve regeneration. Eplasty 2010;10():e42.

Kalpana Mujoo; Vladislav G Sharin; Emil Martin; Byung-Kwon Choi; Courtney Sloan; Lubov E Nikonoff; Alexander Y Kots; Ferid Murad Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2010;22(1):43-50.

Ferid Murad; Roger Barber A hypothesis about cellular signaling with nitric oxide in the earliest life forms in evolution. Free radical biology & medicine 2009;47(9):1325-7.

Eric A Tanifum; Alexander Y Kots; Byung-Kwon Choi; Ferid Murad; Scott R Gilbertson Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis. Bioorganic & medicinal chemistry letters 2009;19(11):3067-71.

Hiroaki Inaba; Kazuya Hokamura; Kazuhiko Nakano; Ryota Nomura; Kazufumi Katayama; Atsushi Nakajima; Hideo Yoshioka; Kazuhiro Taniguchi; Yoshinori Kamisaki; Takashi Ooshima; et al. Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen. FEBS letters 2009;583(1):128-34.

Nathan S Bryan; Ka Bian; Ferid Murad Discovery of the nitric oxide signaling pathway and targets for drug development. Frontiers in bioscience : a journal and virtual library 2009;14():1-18.

Alexander Y Kots; Emil Martin; Iraida G Sharina; Ferid Murad A short history of cGMP, guanylyl cyclases, and cGMP-dependent protein kinases. Handbook of experimental pharmacology 2009;(191):1-14.

Kalpana Mujoo; Vladislav G Sharin; Nathan S Bryan; Joshua S Krumenacker; Courtney Sloan; Shanaz Parveen; Lubov E Nikonoff; Alexander Y Kots; Ferid Murad Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells. Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18924-9.

Haifeng Zhu; Xiaofei Wei; Ka Bian; Ferid Murad Effects of nitric oxide on skin burn wound healing. Journal of burn care & research : official publication of the American Burn Association 2008;29(5):804-14.

Alexander Y Kots; Byung-Kwon Choi; Maria E Estrella-Jimenez; Cirle A Warren; Scott R Gilbertson; Richard L Guerrant; Ferid Murad Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea. Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8440-5.

Ferid Murad Nitric oxide and cyclic guanosine monophosphate signaling in the eye. Canadian journal of ophthalmology. Journal canadien d’ophtalmologie 2008;43(3):291-4.

Iraida G Sharina; Filip Jelen; Elena P Bogatenkova; Anthony Thomas; Emil Martin; Ferid Murad Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity. The Journal of biological chemistry 2008;283(22):15104-13.

Ka Bian; Marie-Françoise Doursout; Ferid Murad Vascular system: role of nitric oxide in cardiovascular diseases. Journal of clinical hypertension (Greenwich, Conn.) 2008;10(4):304-10.

Suresh K Rayala; Emil Martin; Iraida G Sharina; Poonam R Molli; Xiaoping Wang; Raymond Jacobson; Ferid Murad; Rakesh Kumar Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics. Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19470-5.

Aurora R Seminara; Peter P Ruvolo; Ferid Murad LPS/IFNgamma-induced RAW 264.7 apoptosis is regulated by both nitric oxide-dependent and -independent pathways involving JNK and the Bcl-2 family. Cell cycle (Georgetown, Tex.) 2007;6(14):1772-8.

Haifeng Zhu; Bian Ka; Ferid Murad Nitric oxide accelerates the recovery from burn wounds. World journal of surgery 2007;31(4):624-31.

K S Madhusoodanan; Ferid Murad NO-cGMP signaling and regenerative medicine involving stem cells. Neurochemical research 2007;32(4-5):681-94.

Ka Bian; Ferid Murad Nitric oxide signaling in vascular biology. Journal of the American Society of Hypertension : JASH 2007;1(1):17-29.

Kalpana Mujoo; Joshua S Krumenacker; Yoshiko Wada; Ferid Murad Differential expression of nitric oxide signaling components in undifferentiated and differentiated human embryonic stem cells. Stem cells and development 2006;15(6):779-87.

Ferid Murad Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. The New England journal of medicine 2006;355(19):2003-11.

Emil Martin; Vladimir Berka; Elena Bogatenkova; Ferid Murad; Ah-Lim Tsai Ligand selectivity of soluble guanylyl cyclase: effect of the hydrogen-bonding tyrosine in the distal heme pocket on binding of oxygen, nitric oxide, and carbon monoxide. The Journal of biological chemistry 2006;281(38):27836-45.

Ka Bian; Yan Ke; Yoshinori Kamisaki; Ferid Murad Proteomic modification by nitric oxide. Journal of pharmacological sciences 2006;101(4):271-9.

Joshua S Krumenacker; Ferid Murad NO-cGMP signaling in development and stem cells. Molecular genetics and metabolism 2006;87(4):311-4.

Linda Thompson; Illarion Turko; Ferid Murad Mass spectrometry-based relative quantification of human neutrophil peptides 1, 2, and 3 from biological samples. Molecular immunology 2006;43(9):1485-9.

Sisi Marcondes; Marcia H M Cardoso; Rafael P Morganti; Sara M Thomazzi; Sergio Lilla; Ferid Murad; Gilberto De Nucci; Edson Antunes Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: a role for alpha-actinin nitration. Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3434-9.

Cemil Göçmen; H Sinem Büyüknacar; Alexander Ya Kots; Ferid Murad; Olcay Kiroglu; Eda Karabal Kumcu The relaxant activity of 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]-pyridazine 1,5,6-trioxide in the mouse corpus cavernosum. The Journal of pharmacology and experimental therapeutics 2006;316(2):753-61.

Joshua S Krumenacker; Shoji Katsuki; Alexander Kots; Ferid Murad Differential expression of genes involved in cGMP-dependent nitric oxide signaling in murine embryonic stem (ES) cells and ES cell-derived cardiomyocytes. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;14(1):1-11.

Md Badiul Bhuiyan; Ferid Murad; Michael E Fant The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide. Cell communication and signaling : CCS 2006;4():4.

Joshua S Krumenacker; Alexander Kots; Ferid Murad Effects of the JNK inhibitor anthra[1,9-cd]pyrazol-6(2H)-one (SP-600125) on soluble guanylyl cyclase alpha1 gene regulation and cGMP synthesis. American journal of physiology. Cell physiology 2005;289(4):C778-84.

Emil Martin; Kazimierz Czarnecki; Vasanthi Jayaraman; Ferid Murad; James Kincaid Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase. Journal of the American Chemical Society 2005;127(13):4625-31.

Ka Bian; Meng Zhong; Yael Harari; Mildred Lai; Norman Weisbrodt; Ferid Murad Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):3936-41.

Emil Martin; Vladimir Berka; Ah-Lim Tsai; Ferid Murad Soluble guanylyl cyclase: the nitric oxide receptor. Methods in enzymology 2005;396():478-92.

Illarion V Turko; Ferid Murad Mapping sites of tyrosine nitration by matrix-assisted laser desorption/ionization mass spectrometry. Methods in enzymology 2005;396():266-75.

Ferid Murad Some highlights of a 47 year career in research. Cellular and molecular life sciences : CMLS 2005;62(1):1-3.

Weimin Deng; Qin Han; Lianming Liao; Changhong Li; Wei Ge; Zhigang Zhao; Shengguo You; Hongye Deng; Ferid Murad; Robert C H Zhao Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue. Tissue engineering 2005;11(1-2):110-9.

Khalid A Hanafy; Emil Martin; Ferid Murad CCTeta, a novel soluble guanylyl cyclase-interacting protein. The Journal of biological chemistry 2004;279(45):46946-53.

Ferid Murad Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Bioscience reports 2004;24(4-5):452-74.

Ferid Murad Ferid Murad, MD, PhD: a conversation with the editor. The American journal of cardiology 2004;94(1):75-91.

Joshua S Krumenacker; Khalid A Hanafy; Ferid Murad Regulation of nitric oxide and soluble guanylyl cyclase. Brain research bulletin 2004;62(6):505-15.

I Ruiz-Stewart; S R Tiyyagura; J E Lin; S Kazerounian; G M Pitari; S Schulz; E Martin; F Murad; S A Waldman Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism. Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):37-42.

Paul Jurasz; David Alonso; Susana Castro-Blanco; Ferid Murad; Marek W Radomski Generation and role of angiostatin in human platelets. Blood 2003;102(9):3217-23.

Iraida G Sharina; Emil Martin; Anthony Thomas; Karen L Uray; Ferid Murad CCAAT-binding factor regulates expression of the beta1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11523-8.

Illarion V Turko; Ferid Murad Quantitative protein profiling in heart mitochondria from diabetic rats. The Journal of biological chemistry 2003;278(37):35844-9.

Illarion V Turko; Li Li; Kulwant S Aulak; Dennis J Stuehr; Jui-Yoa Chang; Ferid Murad Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes. The Journal of biological chemistry 2003;278(36):33972-7.

Emil Martin; Iraida Sharina; Alexander Kots; Ferid Murad A constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation. Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9208-13.

Yasuyuki Irie; Makio Saeki; Yoshinori Kamisaki; Emil Martin; Ferid Murad Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins. Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5634-9.

Ka Bian; Zhonghong Gao; Norman Weisbrodt; Ferid Murad The nature of heme/iron-induced protein tyrosine nitration. Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5712-7.

Ferid Murad The excitement and rewards of research with our discovery of some of the biological effects of nitric oxide. Circulation research 2003;92(4):339-41.

Oladapo Adewuya; Yasuyuki Irie; Ka Bian; Edore Onigu-Otite; Ferid Murad Mechanism of vasculitis and aneurysms in Kawasaki disease: role of nitric oxide. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;8(1):15-25.

Ka Bian; Ferid Murad Nitric oxide (NO)–biogeneration, regulation, and relevance to human diseases. Frontiers in bioscience : a journal and virtual library 2003;8():d264-78.

Illarion V Turko; Ferid Murad Protein nitration in cardiovascular diseases. Pharmacological reviews 2002;54(4):619-34.

I V Turko; S Marcondes; F Murad Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase. American journal of physiology. Heart and circulatory physiology 2001;281(6):H2289-94.

E Martin; Y C Lee; F Murad YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):12938-42.

K Bian; F Murad Diversity of endotoxin-induced nitrotyrosine formation in macrophage-endothelium-rich organs. Free radical biology & medicine 2001;31(4):421-9.

R V Mendes; A R Martins; G de Nucci; F Murad; F A Soares Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin’s lymphomas and multiple myeloma. Histopathology 2001;39(2):172-8.

N Ishii; K P Patel; P H Lane; T Taylor; K Bian; F Murad; J S Pollock; P K Carmines Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus. Journal of the American Society of Nephrology : JASN 2001;12(8):1630-9.

K A Hanafy; J S Krumenacker; F Murad NO, nitrotyrosine, and cyclic GMP in signal transduction. Medical science monitor : international medical journal of experimental and clinical research 2001;7(4):801-19.

S Marcondes; I V Turko; F Murad Nitration of succinyl-CoA:3-oxoacid CoA-transferase in rats after endotoxin administration. Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7146-51.

D Mailman; S Guntuku; M B Bhuiyan; F Murad Organ sites of lipopolysaccharide-induced nitric oxide production in the anesthetized rat. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2001;5(3):243-51.

K Bian; Y Harari; M Zhong; M Lai; G Castro; N Weisbrodt; F Murad Down-regulation of inducible nitric-oxide synthase (NOS-2) during parasite-induced gut inflammation: a path to identify a selective NOS-2 inhibitor. Molecular pharmacology 2001;59(4):939-47.

J S Krumenacker; S M Hyder; F Murad Estradiol rapidly inhibits soluble guanylyl cyclase expression in rat uterus. Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):717-22.

K L Davis; E Martin; I V Turko; F Murad Novel effects of nitric oxide. Annual review of pharmacology and toxicology 2001;41():203-36.

J Kildsgaard; T J Hollmann; K W Matthews; K Bian; F Murad; R A Wetsel Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5406-9.

Z J Chen; Z H Miao; M Vetter; N Dulin; S Liu; D Che; B Hughes; F Murad; J Douglas; C H Chang Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Biochemical and biophysical research communications 2000;278(1):106-11.

Y C Lee; E Martin; F Murad Human recombinant soluble guanylyl cyclase: expression, purification, and regulation. Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10763-8.

I G Sharina; J S Krumenacker; E Martin; F Murad Genomic organization of alpha1 and beta1 subunits of the mammalian soluble guanylyl cyclase genes. Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10878-83.

E Martin; K Davis; K Bian; Y C Lee; F Murad Cellular signaling with nitric oxide and cyclic guanosine monophosphate. Seminars in perinatology 2000;24(1):2-6.

B Balabanli; Y Kamisaki; E Martin; F Murad Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine. Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13136-41.

F Murad Cellular signaling with nitric oxide and cyclic GMP. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica … [et al.] 1999;32(11):1317-27.

K Bian; K Davis; J Kuret; L Binder; F Murad Nitrotyrosine formation with endotoxin-induced kidney injury detected by immunohistochemistry. The American journal of physiology 1999;277(1 Pt 2):F33-40.

F Murad Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Bioscience reports 1999;19(3):133-54.

Y Kamisaki; K Wada; K Bian; B Balabanli; K Davis; E Martin; F Behbod; Y C Lee; F Murad An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11584-9.

F Murad Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone? Recent progress in hormone research 1998;53():43-59; discussion 59-60.

R C Zanardo; E Costa; H H Ferreira; E Antunes; A R Martins; F Murad; G De Nucci Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):14111-4.

F Murad What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle? Circulation 1997;95(5):1101-3.

F Murad The 1996 Albert Lasker Medical Research Awards. Signal transduction using nitric oxide and cyclic guanosine monophosphate. JAMA : the journal of the American Medical Association 1996;276(14):1189-92.

A Papapetropoulos; G Abou-Mohamed; N Marczin; F Murad; R W Caldwell; J D Catravas Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta. British journal of pharmacology 1996;118(6):1359-66.

A Papapetropoulos; C Y Go; F Murad; J D Catravas Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells. British journal of pharmacology 1996;117(1):147-55.

L J McDonald; F Murad Nitric oxide and cyclic GMP signaling. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1996;211(1):1-6.

A Papapetropoulos; N Marczin; G Mora; A Milici; F Murad; J D Catravas Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA, and protein levels by cAMP-elevating agents. Hypertension 1995;26(4):696-704.

J Xie; P Roddy; T K Rife; F Murad; A P Young Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription. Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1242-6.

A P Young; F Murad; H Vaessin; J Xie; T K Rife Transcription of the human neuronal nitric oxide synthase gene in the central nervous system is mediated by multiple promoters. Advances in pharmacology (San Diego, Calif.) 1995;34():91-112.

W A Buechler; S Singh; J Aktas; S Müller; F Murad; R Gerzer High-level expression of biologically active soluble guanylate cyclase using the baculovirus system is strongly heme-dependent. Advances in pharmacology (San Diego, Calif.) 1995;34():293-303.

L J McDonald; F Murad Nitric oxide and cGMP signaling. Advances in pharmacology (San Diego, Calif.) 1995;34():263-75.

H Sheng; K Ishii; U Förstermann; F Murad Mechanism of bradykinin-induced cyclic GMP accumulation in bovine tracheal smooth muscle. Lung 1995;173(6):373-83.

B Wendland; F E Schweizer; T A Ryan; M Nakane; F Murad; R H Scheller; R W Tsien Existence of nitric oxide synthase in rat hippocampal pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2151-5.

M Hirata; F Murad Interrelationships of cyclic GMP, inositol phosphates, and calcium. Advances in pharmacology (San Diego, Calif.) 1994;26():195-216.

F Murad Cyclic GMP: synthesis, metabolism, and function. Introduction and some historical comments. Advances in pharmacology (San Diego, Calif.) 1994;26():1-5.

M Nakane; F Murad Cloning of guanylyl cyclase isoforms. Advances in pharmacology (San Diego, Calif.) 1994;26():7-18.

D C Leitman; S A Waldman; F Murad Regulation of particulate guanylate cyclase by natriuretic peptides and Escherichia coli heat-stable enterotoxin. Advances in pharmacology (San Diego, Calif.) 1994;26():67-86.

F Murad Regulation of cytosolic guanylyl cyclase by nitric oxide: the NO-cyclic GMP signal transduction system. Advances in pharmacology (San Diego, Calif.) 1994;26():19-33.

T D Warner; J A Mitchell; H Sheng; F Murad Effects of cyclic GMP on smooth muscle relaxation. Advances in pharmacology (San Diego, Calif.) 1994;26():171-94.

F Murad The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication. Recent progress in hormone research 1994;49():239-48.

W R Tracey; J S Pollock; F Murad; M Nakane; U Förstermann Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells. The American journal of physiology 1994;266(1 Pt 1):C22-8.

J S Pollock; M Nakane; L D Buttery; A Martinez; D Springall; J M Polak; U Förstermann; F Murad Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. The American journal of physiology 1993;265(5 Pt 1):C1379-87.

H Sheng; G D Gagne; T Matsumoto; M F Miller; U Förstermann; F Murad Nitric oxide synthase in bovine superior cervical ganglion. Journal of neurochemistry 1993;61(3):1120-6.

J A Mitchell; K L Kohlhaas; R Sorrentino; T D Warner; F Murad; J R Vane Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors. British journal of pharmacology 1993;109(1):265-70.

M Nakane; H H Schmidt; J S Pollock; U Förstermann; F Murad Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS letters 1993;316(2):175-80.

F Murad; U Forstermann; M Nakane; J Pollock; R Tracey; T Matsumoto; W Buechler The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication. Advances in second messenger and phosphoprotein research 1993;28():101-9.

C S Wilcox; W J Welch; F Murad; S S Gross; G Taylor; R Levi; H H Schmidt Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):11993-7.

H Sheng; M L Hughes; F Murad; C A Briggs Evidence that nitric oxide mediates the cyclic GMP response to synaptic activity in the rat superior cervical ganglion. Brain research 1992;597(2):343-5.

T Matsumoto; J A Mitchell; H H Schmidt; K L Kohlhaas; T D Warner; U Förstermann; F Murad Nitric oxide synthase in ferret brain: localization and characterization. British journal of pharmacology 1992;107(3):849-52.

H H Schmidt; G D Gagne; M Nakane; J S Pollock; M F Miller; F Murad Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(10):1439-56.

J S Pollock; V Klinghofer; U Förstermann; F Murad Endothelial nitric oxide synthase is myristylated. FEBS letters 1992;309(3):402-4.

M Yonemaru; K Ishii; F Murad; T A Raffin Atriopeptin-induced increases in endothelial cell permeability are associated with elevated cGMP levels. The American journal of physiology 1992;263(3 Pt 1):L363-9.

C J Hassall; M J Saffrey; A Belai; C H Hoyle; E W Moules; J Moss; H H Schmidt; F Murad; U Förstermann; G Burnstock Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart. Neuroscience letters 1992;143(1-2):65-8.

A Belai; H H Schmidt; C H Hoyle; C J Hassall; M J Saffrey; J Moss; U Förstermann; F Murad; G Burnstock Colocalization of nitric oxide synthase and NADPH-diaphorase in the myenteric plexus of the rat gut. Neuroscience letters 1992;143(1-2):60-4.

T D Warner; G P Budzik; T Matsumoto; J A Mitchell; U Förstermann; F Murad Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA. British journal of pharmacology 1992;106(4):948-52.

H Sheng; H H Schmidt; M Nakane; J A Mitchell; J S Pollock; U Föstermann; F Murad Characterization and localization of nitric oxide synthase in non-adrenergic non-cholinergic nerves from bovine retractor penis muscles. British journal of pharmacology 1992;106(4):768-73.

T D Warner; H H Schmidt; J Kuk; J A Mitchell; F Murad Human brain contains a metalloprotease that converts big endothelin-1 to endothelin-1 and is inhibited by phosphoramidon and EDTA. British journal of pharmacology 1992;106(3):505-6.

J A Mitchell; K L Kohlhaas; T Matsumoto; J S Pollock; U Förstermann; T D Warner; H H Schmidt; F Murad Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages. Molecular pharmacology 1992;41(6):1163-8.

H H Schmidt; J S Pollock; M Nakane; U Förstermann; F Murad Ca2+/calmodulin-regulated nitric oxide synthases. Cell calcium 1992;13(6-7):427-34.

T D Warner; H H Schmidt; F Murad Interactions of endothelins and EDRF in bovine native endothelial cells: selective effects of endothelin-3. The American journal of physiology 1992;262(5 Pt 2):H1600-5.

H H Schmidt; T D Warner; F Murad Double-edged role of endogenous nitric oxide. Lancet 1992;339(8799):986.

M J Saffrey; C J Hassall; C H Hoyle; A Belai; J Moss; H H Schmidt; U Förstermann; F Murad; G Burnstock Colocalization of nitric oxide synthase and NADPH-diaphorase in cultured myenteric neurones. Neuroreport 1992;3(4):333-6.

H H Schmidt; T D Warner; M Nakane; U Förstermann; F Murad Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Molecular pharmacology 1992;41(4):615-24.

H H Schmidt; R M Smith; M Nakane; F Murad Ca2+/calmodulin-dependent NO synthase type I: a biopteroflavoprotein with Ca2+/calmodulin-independent diaphorase and reductase activities. Biochemistry 1992;31(12):3243-9.

U Förstermann; H H Schmidt; K L Kohlhaas; F Murad Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-beta. European journal of pharmacology 1992;225(2):161-5.

H H Schmidt; T D Warner; K Ishii; H Sheng; F Murad Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science (New York, N.Y.) 1992;255(5045):721-3.

Z W Hu; K Honda; F Murad; B B Hoffman Prolonged exposure to catecholamines enhances sensitivity of smooth muscle relaxation induced by sodium nitroprusside and atriopeptin. The Journal of pharmacology and experimental therapeutics 1992;260(2):756-61.

T D Warner; J A Mitchell; P D’Orleans-Juste; K Ishii; U Förstermann; F Murad Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of biologically active endothelin-1 by rapid bioassay. Molecular pharmacology 1992;41(2):399-403.

F Murad; U Forstermann; M Nakane; H Schmidt; J Pollock; H Sheng; T Matsumoto; T Warner; J Mitchell; R Tracey The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues. Japanese journal of pharmacology 1992;58 Suppl 2():150P-157P.

J S Pollock; M Nakane; U Förstermann; F Murad Particulate and soluble bovine endothelial nitric oxide synthases are structurally similar proteins yet different from soluble brain nitric oxide synthase. Journal of cardiovascular pharmacology 1992;20 Suppl 12():S50-3.

T D Warner; G P Budzik; J A Mitchell; Z J Huang; F Murad Detection by bioassay and specific enzyme-linked immunosorbent assay of phosphoramidon-inhibitable endothelin-converting activity in brain and endothelium. Journal of cardiovascular pharmacology 1992;20 Suppl 12():S19-21.

H H Schmidt; F Murad Purification and characterization of a human NO synthase. Biochemical and biophysical research communications 1991;181(3):1372-7.

Y Horio; F Murad Purification of guanylyl cyclase from rod outer segments. Biochimica et biophysica acta 1991;1133(1):81-8.

J S Pollock; U Förstermann; J A Mitchell; T D Warner; H H Schmidt; M Nakane; F Murad Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10480-4.

K Ishii; T D Warner; H Sheng; F Murad Endothelin increases cyclic GMP levels in LLC-PK1 porcine kidney epithelial cells via formation of an endothelium-derived relaxing factor-like substance. The Journal of pharmacology and experimental therapeutics 1991;259(3):1102-8.

M Nakane; J Mitchell; U Förstermann; F Murad Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase. Biochemical and biophysical research communications 1991;180(3):1396-402.

U Förstermann; H H Schmidt; J S Pollock; H Sheng; J A Mitchell; T D Warner; M Nakane; F Murad Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochemical pharmacology 1991;42(10):1849-57.

J A Mitchell; H Sheng; U Förstermann; F Murad Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle. British journal of pharmacology 1991;104(2):289-91.

R R Fiscus; H L Zhou; X Wang; C Han; S Ali; C D Joyce; F Murad Calcitonin gene-related peptide (CGRP)-induced cyclic AMP, cyclic GMP and vasorelaxant responses in rat thoracic aorta are antagonized by blockers of endothelium-derived relaxant factor (EDRF). Neuropeptides 1991;20(2):133-43.

K Ishii; H Sheng; T D Warner; U Förstermann; F Murad A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts. The American journal of physiology 1991;261(2 Pt 2):H598-603.

H Sheng; K Ishii; F Murad Generation of an endothelium-derived relaxing factor-like substance in bovine tracheal smooth muscle. The American journal of physiology 1991;260(6 Pt 1):L489-93.

J A Mitchell; U Förstermann; T D Warner; J S Pollock; H H Schmidt; M Heller; F Murad Endothelial cells have a particulate enzyme system responsible for EDRF formation: measurement by vascular relaxation. Biochemical and biophysical research communications 1991;176(3):1417-23.

U Förstermann; J S Pollock; H H Schmidt; M Heller; F Murad Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1788-92.

J Chen; B Chang; M Williams; F Murad Sodium nitroprusside degenerates cultured rat striatal neurons. Neuroreport 1991;2(3):121-3.

Y Horio; F Murad Solubilization of guanylyl cyclase from bovine rod outer segments and effects of lowering Ca2+ and nitro compounds. The Journal of biological chemistry 1991;266(6):3411-5.

H H Schmidt; J S Pollock; M Nakane; L D Gorsky; U Förstermann; F Murad Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):365-9.

W A Buechler; M Nakane; F Murad Expression of soluble guanylate cyclase activity requires both enzyme subunits. Biochemical and biophysical research communications 1991;174(1):351-7.

K Ishii; T D Warner; H Sheng; F Murad Endothelin-1 stimulates cyclic GMP formation in porcine kidney epithelial cells via activation of the L-arginine-dependent soluble guanylate cyclase pathway. Journal of cardiovascular pharmacology 1991;17 Suppl 7():S246-50.

D C Leitman; S A Waldman; F Murad Identification of atrial natriuretic peptide receptors in cultured cells. Methods in enzymology 1991;195():436-46.

S A Waldman; D C Leitman; F Murad Copurification of atrial natriuretic peptide receptor and particulate guanylyl cyclase. Methods in enzymology 1991;195():397-404.

S A Waldman; D C Leitman; F Murad Immunoaffinity purification of soluble guanylyl cyclase. Methods in enzymology 1991;195():391-6.

K Ishii; B Chang; J F Kerwin; F L Wagenaar; Z J Huang; F Murad Formation of endothelium-derived relaxing factor in porcine kidney epithelial LLC-PK1 cells: an intra- and intercellular messenger for activation of soluble guanylate cyclase. The Journal of pharmacology and experimental therapeutics 1991;256(1):38-43.

M Nakane; K Arai; S Saheki; T Kuno; W Buechler; F Murad Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung. The Journal of biological chemistry 1990;265(28):16841-5.

U Förstermann; L D Gorsky; J S Pollock; K Ishii; H H Schmidt; M Heller; F Murad Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin. Molecular pharmacology 1990;38(1):7-13.

K Ishii; J F Kerwin; F Murad N omega-nitro-L-arginine: a potent inhibitor of the L-arginine-dependent soluble guanylate cyclase activation pathway in LLC-PK1 cells. Canadian journal of physiology and pharmacology 1990;68(6):749-51.

U Förstermann; L D Gorsky; J S Pollock; H H Schmidt; M Heller; F Murad Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain. Biochemical and biophysical research communications 1990;168(2):727-32.

C H Chang; K P Kohse; B Chang; M Hirata; B Jiang; J E Douglas; F Murad Characterization of ATP-stimulated guanylate cyclase activation in rat lung membranes. Biochimica et biophysica acta 1990;1052(1):159-65.

S Saheki; T Kuno; C Tanaka; N Takeuchi; F Murad Radiation inactivation target-size analysis of soluble guanylate cyclase. Biochimica et biophysica acta 1990;1051(3):306-9.

L D Gorsky; U Förstermann; K Ishii; F Murad Production of an EDRF-like activity in the cytosol of N1E-115 neuroblastoma cells. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(5):1494-500.

K Ishii; B Chang; J F Kerwin; Z J Huang; F Murad N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation. European journal of pharmacology 1990;176(2):219-23.

M Hirata; K P Kohse; C H Chang; T Ikebe; F Murad Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells. The Journal of biological chemistry 1990;265(3):1268-73.

F Murad; K Ishii; U Förstermann; L Gorsky; J F Kerwin; J Pollock; M Heller EDRF is an intracellular second messenger and autacoid to regulate cyclic GMP synthesis in many cells. Advances in second messenger and phosphoprotein research 1990;24():441-8.

U Förstermann; K Ishii; L D Gorsky; F Murad The cytosol of N1E-115 neuroblastoma cells synthesizes an EDRF-like substance that relaxes rabbit aorta. Naunyn-Schmiedeberg’s archives of pharmacology 1989;340(6 Pt 2):771-4.

S A Waldman; R M Rapoport; R R Fiscus; D C Leitman; L Y Chang; F Murad Regulation of particulate guanylate cyclase by atriopeptins: relation between peptide structure, receptor binding, and enzyme kinetics. Biochimica et biophysica acta 1989;999(2):157-62.

S A Waldman; D C Leitman; L Y Chang; F Murad Comparison of particulate guanylate cyclase in cells with and without atrial natriuretic peptide receptor binding activity. Molecular and cellular biochemistry 1989;90(1):19-25.

B M Bennett; D C Leitman; H Schröder; J H Kawamoto; K Nakatsu; F Murad Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines. The Journal of pharmacology and experimental therapeutics 1989;250(1):316-23.

M Hirata; C H Chang; F Murad Stimulatory effects of atrial natriuretic factor on phosphoinositide hydrolysis in cultured bovine aortic smooth muscle cells. Biochimica et biophysica acta 1989;1010(3):346-51.

R M Rapoport; M Ashraf; F Murad Effects of melittin on endothelium-dependent relaxation and cyclic GMP levels in rat aorta. Circulation research 1989;64(3):463-73.

K Ishii; F Murad ANP relaxes bovine tracheal smooth muscle and increases cGMP. The American journal of physiology 1989;256(3 Pt 1):C495-500.

S A Waldman; F Murad Atrial natriuretic peptides: receptors and second messengers. BioEssays : news and reviews in molecular, cellular and developmental biology 1989;10(1):16-9.

M Nakane; S Saheki; T Kuno; K Ishii; F Murad Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung. Biochemical and biophysical research communications 1988;157(3):1139-47.

B M Bennett; H Schröder; L D Hayward; S A Waldman; F Murad Effect of in vitro organic nitrate tolerance on relaxation, cyclic GMP accumulation, and guanylate cyclase activation by glyceryl trinitrate and the enantiomers of isoidide dinitrate. Circulation research 1988;63(4):693-701.

F Murad Role of cyclic GMP in the mechanism of action of nitrovasodilators, endothelium-dependent agents and atrial natriuretic peptide. Biochemical Society transactions 1988;16(4):490-2.

C R Molina; M B Fowler; S McCrory; C Peterson; B D Myers; J S Schroeder; F Murad Hemodynamic, renal and endocrine effects of atrial natriuretic peptide infusion in severe heart failure. Journal of the American College of Cardiology 1988;12(1):175-86.

D L Song; K P Kohse; F Murad Brain natriuretic factor. Augmentation of cellular cyclic GMP, activation of particulate guanylate cyclase and receptor binding. FEBS letters 1988;232(1):125-9.

S A Waldman; D C Leitman; J Andresen; F Murad Guanylate cyclase and the adrenal natriuretic factor receptor. Science (New York, N.Y.) 1988;240(4853):805-6.

H Schröder; D C Leitman; B M Bennett; S A Waldman; F Murad Glyceryl trinitrate-induced desensitization of guanylate cyclase in cultured rat lung fibroblasts. The Journal of pharmacology and experimental therapeutics 1988;245(2):413-8.

B D Myers; C Peterson; C Molina; S J Tomlanovich; L D Newton; R Nitkin; H Sandler; F Murad Role of cardiac atria in the human renal response to changing plasma volume. The American journal of physiology 1988;254(4 Pt 2):F562-73.

D C Leitman; V L Agnost; R M Catalano; H Schröder; S A Waldman; B M Bennett; J J Tuan; F Murad Atrial natriuretic peptide, oxytocin, and vasopressin increase guanosine 3’,5’-monophosphate in LLC-PK1 kidney epithelial cells. Endocrinology 1988;122(4):1478-85.

D C Leitman; J W Andresen; R M Catalano; S A Waldman; J J Tuan; F Murad Atrial natriuretic peptide binding, cross-linking, and stimulation of cyclic GMP accumulation and particulate guanylate cyclase activity in cultured cells. The Journal of biological chemistry 1988;263(8):3720-8.

R R Fiscus; F Murad cGMP-dependent protein kinase activation in intact tissues. Methods in enzymology 1988;159():150-9.

F Murad; D Leitman; S Waldman; C H Chang; M Hirata; K Kohse Effects of nitrovasodilators, endothelium-dependent vasodilators, and atrial peptides on cGMP. Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():1005-9.

R M Rapoport; F Murad Effects of ethacrynic acid and cystamine on sodium nitroprusside-induced relaxation, cyclic GMP levels and guanylate cyclase activity in rat aorta. General pharmacology 1988;19(1):61-5.

S A Waldman; F Murad Biochemical mechanisms underlying vascular smooth muscle relaxation: the guanylate cyclase-cyclic GMP system. Journal of cardiovascular pharmacology 1988;12 Suppl 5():S115-8.

C R Molina; J W Andresen; R M Rapoport; S Waldman; F Murad Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. Journal of cardiovascular pharmacology 1987;10(4):371-8.

F Murad; D C Leitman; B M Bennett; C Molina; S A Waldman Regulation of guanylate cyclase by atrial natriuretic factor and the role of cyclic GMP in vasodilation. The American journal of the medical sciences 1987;294(3):139-43.

S A Waldman; F Murad Cyclic GMP synthesis and function. Pharmacological reviews 1987;39(3):163-96.

R M Rapoport; S A Waldman; R Ginsburg; C R Molina; F Murad Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery. Journal of cardiovascular pharmacology 1987;10(1):82-9.

D C Leitman; V L Agnost; J J Tuan; J W Andresen; F Murad Atrial natriuretic factor and sodium nitroprusside increase cyclic GMP in cultured rat lung fibroblasts by activating different forms of guanylate cyclase. The Biochemical journal 1987;244(1):69-74.

D C Leitman; F Murad Atrial natriuretic factor receptor heterogeneity and stimulation of particulate guanylate cyclase and cyclic GMP accumulation. Endocrinology and metabolism clinics of North America 1987;16(1):79-105.

R R Fiscus; B T Robles; S A Waldman; F Murad Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. Journal of neurochemistry 1987;48(2):522-8.

F Murad; S Waldman; C Molina; B Bennett; D Leitman Regulation and role of guanylate cyclase-cyclic GMP in vascular relaxation. Progress in clinical and biological research 1987;249():65-76.

Y Kamisaki; S A Waldman; F Murad The involvement of catalytic site thiol groups in the activation of soluble guanylate cyclase by sodium nitroprusside. Archives of biochemistry and biophysics 1986;251(2):709-14.

S A Waldman; R M Rapoport; R Ginsburg; F Murad Desensitization to nitroglycerin in vascular smooth muscle from rat and human. Biochemical pharmacology 1986;35(20):3525-31.

D C Leitman; J W Andresen; T Kuno; Y Kamisaki; J K Chang; F Murad Identification of multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells. The Journal of biological chemistry 1986;261(25):11650-5.

F Murad Cyclic guanosine monophosphate as a mediator of vasodilation. The Journal of clinical investigation 1986;78(1):1-5.

Y Kamisaki; S Saheki; M Nakane; J A Palmieri; T Kuno; B Y Chang; S A Waldman; F Murad Soluble guanylate cyclase from rat lung exists as a heterodimer. The Journal of biological chemistry 1986;261(16):7236-41.

R M Rapoport; R Ginsburg; S A Waldman; F Murad Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro. European journal of pharmacology 1986;124(1-2):193-6.

T Kuno; J W Andresen; Y Kamisaki; S A Waldman; L Y Chang; S Saheki; D C Leitman; M Nakane; F Murad Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. The Journal of biological chemistry 1986;261(13):5817-23.

D C Leitman; R R Fiscus; F Murad Forskolin, phosphodiesterase inhibitors, and cyclic AMP analogs inhibit proliferation of cultured bovine aortic endothelial cells. Journal of cellular physiology 1986;127(2):237-43.

T Kuno; Y Kamisaki; S A Waldman; J Gariepy; G Schoolnik; F Murad Characterization of the receptor for heat-stable enterotoxin from Escherichia coli in rat intestine. The Journal of biological chemistry 1986;261(3):1470-6.

D C Leitman; F Murad Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells. Biochimica et biophysica acta 1986;885(1):74-9.

R M Rapoport; R J Winquist; E P Baskin; E P Faison; S A Waldman; F Murad Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas. European journal of pharmacology 1986;120(1):123-6.

M B Draznin; R M Rapoport; F Murad Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta. The International journal of biochemistry 1986;18(10):917-28.

D C Leitman; J W Andresen; T Kuno; Y Kamisaki; J K Chang; F Murad Identification of two binding sites for atrial natriuretic factor in endothelial cells: evidence for a receptor subtype coupled to guanylate cyclase. Transactions of the Association of American Physicians 1986;99():103-13.

S A Waldman; T Kuno; Y Kamisaki; L Y Chang; J Gariepy; P O’Hanley; G Schoolnik; F Murad Intestinal receptor for heat-stable enterotoxin of Escherichia coli is tightly coupled to a novel form of particulate guanylate cyclase. Infection and immunity 1986;51(1):320-6.

F Murad; S A Waldman; R R Fiscus; R M Rapoport Regulation of cyclic GMP synthesis and the interactions with calcium. Journal of cardiovascular pharmacology 1986;8 Suppl 8():S57-60.

R M Rapoport; S A Waldman; K Schwartz; R J Winquist; F Murad Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. European journal of pharmacology 1985;115(2-3):219-29.

R R Fiscus; R M Rapoport; S A Waldman; F Murad Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. Biochimica et biophysica acta 1985;846(1):179-84.

R M Rapoport; K Schwartz; F Murad Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circulation research 1985;57(1):164-70.

S A Waldman; R M Rapoport; R R Fiscus; F Murad Effects of atriopeptin on particulate guanylate cyclase from rat adrenal. Biochimica et biophysica acta 1985;845(2):298-303.

R M Rapoport; K Schwartz; F Murad Effects of Na+,K+-pump inhibitors and membrane depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP accumulation in rat aorta. European journal of pharmacology 1985;110(2):203-9.

D C Leitman; S A Waldman; R M Rapoport; F Murad Specific atrial natriuretic factor receptors mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and smooth muscle cells. Transactions of the Association of American Physicians 1985;98():243-52.

S A Waldman; L Y Chang; F Murad A two-step procedure for obtaining highly purified particulate guanylate cyclase from rat lung. Preparative biochemistry 1985;15(3):103-19.

F Murad; R M Rapoport; R Fiscus Role of cyclic-GMP in relaxations of vascular smooth muscle. Journal of cardiovascular pharmacology 1985;7 Suppl 3():S111-8.

S A Waldman; R M Rapoport; F Murad Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. The Journal of biological chemistry 1984;259(23):14332-4.

R J Winquist; E P Faison; S A Waldman; K Schwartz; F Murad; R M Rapoport Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7661-4.

R G Pearl; M H Rosenthal; F Murad; J P Ashton Aminophylline potentiates sodium nitroprusside-induced hypotension in the dog. Anesthesiology 1984;61(6):712-5.

R M Rapoport; M B Draznin; F Murad Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circulation research 1984;55(4):468-79.

R M Rapoport; F Murad Effect of cyanide on nitrovasodilator-induced relaxation, cyclic GMP accumulation and guanylate cyclase activation in rat aorta. European journal of pharmacology 1984;104(1-2):61-70.

S A Waldman; M S Sinacore; J A Lewicki; L Y Chang; F Murad Selective activation of particulate guanylate cyclase by a specific class of porphyrins. The Journal of biological chemistry 1984;259(7):4038-42.

S A Waldman; P O’Hanley; S Falkow; G Schoolnik; F Murad A simple, sensitive, and specific assay for the heat-stable enterotoxin of Escherichia coli. The Journal of infectious diseases 1984;149(1):83-9.

R M Rapoport; M B Draznin; F Murad Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983;306(5939):174-6.

J A Lewicki; B Chang; F Murad Quantification of guanylate cyclase concentrations by a direct double determinant tandem immunoradiometric assay. The Journal of biological chemistry 1983;258(6):3509-15.

R M Rapoport; F Murad Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circulation research 1983;52(3):352-7.

R M Rapoport; F Murad Effect of ouabain and alterations in potassium concentration on relaxation induced by sodium nitroprusside. Blood vessels 1983;20(5):255-64.

R M Rapoport; M B Draznin; F Murad Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Transactions of the Association of American Physicians 1983;96():19-30.

R M Rapoport; F Murad Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. Journal of cyclic nucleotide and protein phosphorylation research 1983;9(4-5):281-96.

S A Waldman; J A Lewicki; L Y Chang; F Murad Highly purified particulate guanylate cyclase from rat lung: characterization and comparison with soluble guanylate cyclase. Molecular and cellular biochemistry 1983;57(2):155-66.

R R Fiscus; R M Rapoport; F Murad Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta. Journal of cyclic nucleotide and protein phosphorylation research 1983;9(6):415-25.

R M Rapoport; M B Draznin; F Murad Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proceedings of the National Academy of Sciences of the United States of America 1982;79(21):6470-4.

R N Greenberg; R L Guerrant; B Chang; D C Robertson; F Murad Inhibition of Escherichia coli heat-stable enterotoxin effects on intestinal guanylate cyclase and fluid secretion by quinacrine. Biochemical pharmacology 1982;31(11):2005-9.

H J Brandwein; J A Lewicki; S A Waldman; F Murad Effect of GTP analogues on purified soluble guanylate cyclase. The Journal of biological chemistry 1982;257(3):1309-11.

M A Ariano; J A Lewicki; H J Brandwein; F Murad Immunohistochemical localization of guanylate cyclase within neurons of rat brain. Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1316-20.

R N Greenberg; F Murad; R L Guerrant Lanthanum chloride inhibition of the secretory response to Escherichia coli heat-stable enterotoxin. Infection and immunity 1982;35(2):483-8.

S A Waldman; J A Lewicki; H J Brandwein; F Murad Partial purification and characterization of particulate guanylate cyclase from rat liver after solubilization with trypsin. Journal of cyclic nucleotide research 1982;8(6):359-70.

J A Lewicki; H J Brandwein; C K Mittal; W P Arnold; F Murad Properties of purified soluble guanylate cyclase activated by nitric oxide and sodium nitroprusside. Journal of cyclic nucleotide research 1982;8(1):17-25.

H Brandwein; J Lewicki; F Murad Production and characterization of monoclonal antibodies to soluble rat lung guanylate cyclase. Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4241-5.

H J Brandwein; J A Lewicki; F Murad Reversible inactivation of guanylate cyclase by mixed disulfide formation. The Journal of biological chemistry 1981;256(6):2958-62.

T Dohi; F Murad Effects of pyruvate and other metabolites on cyclic GMP levels in incubations of rat hepatocytes and kidney cortex. Biochimica et biophysica acta 1981;673(1):14-25.

F Murad; J A Lewicki; H J Brandwein; C K Mittal; S A Waldman Guanylate cyclase: purification, properties, free radical activation, radiolabeling, and preparation of hybridoma antibodies. Advances in cyclic nucleotide research 1981;14():229-39.

M O Thorner; J T Hackett; F Murad; R M MacLeod Calcium rather than cyclic AMP as the physiological intracellular regulator of prolactin release. Neuroendocrinology 1980;31(6):390-402.

G Brooker; F Murad Automated ”Gamma-flo” radioimmunoassay of urinary cyclic AMP. Clinical chemistry 1980;26(12):1738-40.

R N Greenberg; F Murad; B Chang; D C Robertson; R L Guerrant Inhibition of Escherichia coli heat-stable enterotoxin by indomethacin and chlorpromazine. Infection and immunity 1980;29(3):908-13.

R L Guerrant; J M Hughes; B Chang; D C Robertson; F Murad Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: studies of tissue specificity, potential receptors, and intermediates. The Journal of infectious diseases 1980;142(2):220-8.

J A Lewicki; H J Brandwein; S A Waldman; F Murad Purified guanylate cyclase: characterization, iodination and preparation of monoclonal antibodies. Journal of cyclic nucleotide research 1980;6(4):283-96.

J M Braughler; C K Mittal; F Murad Effects of thiols, sugars, and proteins on nitric oxide activation of guanylate cyclase. The Journal of biological chemistry 1979;254(24):12450-4.

K Ichihara; M El-Zayat; C K Mittal; F Murad Fatty acid activation of guanylate cyclase from fibroblasts and liver. Archives of biochemistry and biophysics 1979;197(1):44-51.

C K Mittal; J M Braughler; K Ichihara; F Murad Synthesis of adenosine 3’,5’-monophosphate by guanylate cyclase, a new pathway for its formation. Biochimica et biophysica acta 1979;585(3):333-42.

K Ichihara; F Murad Guanylate cyclase activity in rat liver and other tissues with starvation and streptozotocin-induced diabetes mellitus. Archives of biochemistry and biophysics 1979;194(1):292-8.

E J Neer; F Murad Separation of soluble adenylate and guanylate cyclases from the mature rat testis. Biochimica et biophysica acta 1979;583(4):531-4.

J M Braughler; C K Mittal; F Murad Purification of soluble guanylate cyclase from rat liver. Proceedings of the National Academy of Sciences of the United States of America 1979;76(1):219-22.

F Murad; W P Arnold; C K Mittal; J M Braughler Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP. Advances in cyclic nucleotide research 1979;11():175-204.

D L Garbers; F Murad Guanylate cyclase assay methods. Advances in cyclic nucleotide research 1979;10():57-67.

C K Mittal; W P Arnold; F Murad Characterization of protein inhibitors of guanylate cyclase activation from rat heart and bovine lung. The Journal of biological chemistry 1978;253(4):1266-71.

J M Hughes; F Murad; B Chang; R L Guerrant Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli. Nature 1978;271(5647):755-6.

M J Bergman; R L Guerrant; F Murad; S H Richardson; D Weaver; G L Mandell Interaction of polymorphonuclear neutrophils with Escherichia coli. Effect of enterotoxin on phagocytosis, killing, chemotaxis, and cyclic AMP. The Journal of clinical investigation 1978;61(2):227-34.

F Murad; C K Mittal; W P Arnold; S Katsuki; H Kimura Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. Advances in cyclic nucleotide research 1978;9():145-58.

W P Arnold; R Aldred; F Murad Cigarette smoke activates guanylate cyclase and increases guanosine 3’,5’-monophosphate in tissues. Science (New York, N.Y.) 1977;198(4320):934-6.

C K Mittal; F Murad Properties and oxidative regulation of guanylate cyclase. Journal of cyclic nucleotide research 1977;3(6):381-91.

C K Mittal; F Murad Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3’,5’-monophosphate formation. Proceedings of the National Academy of Sciences of the United States of America 1977;74(10):4360-4.

S Katsuki; W P Arnold; F Murad Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues. Journal of cyclic nucleotide research 1977;3(4):239-47.

W P Arnold; C K Mittal; S Katsuki; F Murad Nitric oxide activates guanylate cyclase and increases guanosine 3’:5’-cyclic monophosphate levels in various tissue preparations. Proceedings of the National Academy of Sciences of the United States of America 1977;74(8):3203-7.

C K Mittal; H Kimura; F Murad Purification and properties of a protein required for sodium azide activation of guanylate cyclase. The Journal of biological chemistry 1977;252(12):4384-90.

C K Mittal; F Murad Formation of adenosine 3’:5’-monophosphate by preparations of guanylate cyclase from rat liver and other tissues. The Journal of biological chemistry 1977;252(10):3136-40.

K Ichihara; J Larner; H Kimura; F Murad Activation of liver guanylate cyclase by bile salts and contaminants in crude secretin and pancreozymin preparations. Biochimica et biophysica acta 1977;481(2):734-40.

S Katsuki; F Murad Regulation of adenosine cyclic 3’,5’-monophosphate and guanosine cyclic 3’,5’-monophosphate levels and contractility in bovine tracheal smooth muscle. Molecular pharmacology 1977;13(2):330-41.

S Katsuki; W Arnold; C Mittal; F Murad Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. Journal of cyclic nucleotide research 1977;3(1):23-35.

H Kimura; C K Mittal; F Murad Appearance of magnesium guanylate cyclase activity in rat liver with sodium azide activation. The Journal of biological chemistry 1976;251(24):7769-73.

W E Criss; F Murad; H Kimura; H P Morris Properties of guanylate cyclase in adult rat liver and several Morris hepatomas. Biochimica et biophysica acta 1976;445(2):500-8.

W E Criss; F Murad Urinary excretion of cyclic guanosine 3’:5’-monophosphate and cyclic adenosine 3’:5’-monophosphate in rats bearing transplantable liver and kidney tumors. Cancer research 1976;36(5):1714-6.

W E Criss; F Murad; H Kimura Properties of guanylate cyclase from rat kidney cortex and transplantable kidney tumors. Journal of cyclic nucleotide research 1976;2(1):11-9.

H Kimura; C K Mittal; F Murad Activation of guanylate cyclase from rat liver and other tissues by sodium azide. The Journal of biological chemistry 1975;250(20):8016-22.

H Kimura; C K Mittal; F Murad Increases in cyclic GMP levels in brain and liver with sodium azide an activator of guanylate cyclase. Nature 1975;257(5528):700-2.

F Murad; H Kimura; H A Hopkins; W B Looney; C J Kovacs Increased urinary excretion of cyclic guanosine monophosphate in rats bearing Morris hepatoma 3924A. Science (New York, N.Y.) 1975;190(4209):58-60.

H Kimura; F Murad Subcellular localization of guanylate cyclase. Life sciences 1975;17(6):837-43.

H Kimura; F Murad Localization of particulate guanylate cyclase in plasma membranes and microsomes of rat liver. The Journal of biological chemistry 1975;250(12):4810-7.

H Kimura; F Murad Increased particulate and decreased soluble guanylate cyclase activity in regenerating liver, fetal liver, and hepatoma. Proceedings of the National Academy of Sciences of the United States of America 1975;72(5):1965-9.

F Murad; W W Moss; J Johanson; R F Selden Urinary excretion of adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate in normal children and those with cystic fibrosis. The Journal of clinical endocrinology and metabolism 1975;40(4):552-9.

H Kimura; F Murad Two forms of guanylate cyclase in mammalian tissues and possible mechanisms for their regulation. Metabolism: clinical and experimental 1975;24(3):439-45.

M J McLean; R A Lapsley; K Shigenobu; F Murad; N Sperelakis High cyclic AMP levels in young chick embryonic hearts. Developmental biology 1975;42(1):196-201.

C K Mittal; H Kimura; F Murad Requirement for a macromolecular factor for sodium azide activation of guanulate cyclase. Journal of cyclic nucleotide research 1975;1(6):261-9.

F Murad Mechanism of action of some bronchodilators. Cyclic nucleotide metabolism in tracheal preparations. The American review of respiratory disease 1974;110(6 Pt 2):111-8.

H Kimura; F Murad Evidence for two different forms of guanylate cyclase in rat heart. The Journal of biological chemistry 1974;249(21):6910-6.

H Kimura; E Thomas; F Murad Effects of decapitation, ether and pentobarbital on guanosine 3’,5’-phosphate and adenosine 3’,5’-phosphate levels in rat tissues. Biochimica et biophysica acta 1974;343(3):519-28.

F Murad; H Kimura Cyclic nucleotide levels in incubations of guinea pig trachea. Biochimica et biophysica acta 1974;343(2):275-86.

H Kimura; F Murad Nonenzymatic formation of guanosine 3’:5’-monophosphate from guanosine triphosphate. The Journal of biological chemistry 1974;249(1):329-31.

A G Gilman; F Murad Assay of cyclic nucleotides by receptor protein binding displacement. Methods in enzymology 1974;38():49-61.

F Murad Techniques for the formation, partial purification, and assay of a cyclic AMP inhibitor. Methods in enzymology 1974;38():273-83.

F Murad Beta-blockade of epinephrine-induced cyclic AMP formation in heart, liver, fat and trachea. Biochimica et biophysica acta 1973;304(1):181-7.

E W Thomas; F Murad; W B Looney; H P Morris Adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate: concentrations in Morris hepatomas of different growth rates. Biochimica et biophysica acta 1973;297(2):564-7.

F Murad Clinical studies and applications of cyclic nucleotides. Advances in cyclic nucleotide research 1973;3():355-83.

F Murad; C Y Pak Urinary excretion of adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate. The New England journal of medicine 1972;286(26):1382-7.

F Murad; A G Gilman Adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate: a simultaneous protein binding assay. Biochimica et biophysica acta 1971;252(2):397-400.

V C Manganiello; F Murad; M Vaughan Effects of lipolytic and antilipolytic agents on cyclic 3’,5’-adenosine monophosphate in fat cells. The Journal of biological chemistry 1971;246(7):2195-202.

F Murad; V Manganiello; M Vaughan A simple, sensitive protein-binding assay for guanosine 3’:5’-monophosphate. Proceedings of the National Academy of Sciences of the United States of America 1971;68(4):736-9.

T P Stossel; F Murad; R J Mason; M Vaughan Regulation of glycogen metabolism in polymorphonuclear leukocytes. The Journal of biological chemistry 1970;245(22):6228-34.

F Murad; V Manganiello; M Vaughan Effects of guanosine 3’,5’-monophosphate on glycerol production and accumulation of adenosine 3’,5’-monophosphate by fat cells. The Journal of biological chemistry 1970;245(13):3352-60.

F Murad; T W Rall; M Vaughan Conditions for the formation, partial purification and assay of an inhibitor of adenosine 3’,5’-monophosphate. Biochimica et biophysica acta 1969;192(3):430-45.

M Vaughan; F Murad Adenyl cyclase activity in particles from fat cells. Biochemistry 1969;8(7):3092-9.

F Murad; M Vaughan Effect of glucagon on rat heart adenyl cyclase. Biochemical pharmacology 1969;18(5):1053-9.

F Murad Effect of glucagon on heart. The New England journal of medicine 1968;279(8):434-5.

F MURAD; Y M CHI; T W RALL; E W SUTHERLAND Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3’,5’-phosphate by preparations from cardiac muscle and liver. The Journal of biological chemistry 1962;237():1233-8.