1985 Member, National Academy of Sciences
1989 Albert Lasker Basic Medical Research Award
1994 Nobel Prize in Physiology or Medicine
1997 Doctor of Medical (Hon.), Yale University
Andrejs M Krumins; Alfred G Gilman Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins. The Journal of biological chemistry 2006;281(15):10250-62.
Scott K Gibson; Alfred G Gilman Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors. Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):212-7.
Gregory G Tall; Alfred G Gilman Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes. Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16584-9.
Gregory G Tall; Alfred G Gilman Purification and functional analysis of Ric-8A: a guanine nucleotide exchange factor for G-protein alpha subunits. Methods in enzymology 2004;390():377-88.
Mark E Hatley; Steve W Lockless; Scott K Gibson; Alfred G Gilman; Rama Ranganathan Allosteric determinants in guanine nucleotide-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14445-50.
Zhu Chen; Malavika Raman; Linda Chen; Sheu Fen Lee; Alfred G Gilman; Melanie H Cobb TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. The Journal of biological chemistry 2003;278(25):22278-83.
Gregory G Tall; Andrejs M Krumins; Alfred G Gilman Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. The Journal of biological chemistry 2003;278(10):8356-62.
Alfred G Gilman; Melvin I Simon; Henry R Bourne; Bruce A Harris; Rochelle Long; Elliott M Ross; James T Stull; Ronald Taussig; Henry R Bourne; Adam P Arkin; et al. Overview of the Alliance for Cellular Signaling. Nature 2002;420(6916):703-6.
Joseph A Duncan; Alfred G Gilman Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo. The Journal of biological chemistry 2002;277(35):31740-52.
Andrejs M Krumins; Alfred G Gilman Assay of RGS protein activity in vitro using purified components. Methods in enzymology 2002;344():673-85.
John J G Tesmer; Roger K Sunahara; David A Fancy; Alfred G Gilman; Stephen R Sprang Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. Methods in enzymology 2002;345():198-206.
Mark E Hatley; Alfred G Gilman; Roger K Sunahara Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods in enzymology 2002;345():127-40.
A G Gilman Cross talk: interview with Al Gilman. Molecular interventions 2001;1(1):14-21.
M E Hatley; B K Benton; J Xu; J P Manfredi; A G Gilman; R K Sunahara Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase. The Journal of biological chemistry 2000;275(49):38626-32.
J J Tesmer; C W Dessauer; R K Sunahara; L D Murray; R A Johnson; A G Gilman; S R Sprang Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry 2000;39(47):14464-71.
A G Gilman Wrong signals about alliance’s scope and aim. Nature 2000;408(6809):133.
C V Carman; J L Parent; P W Day; A N Pronin; P M Sternweis; P B Wedegaertner; A G Gilman; J L Benovic; T Kozasa Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. The Journal of biological chemistry 1999;274(48):34483-92.
B A Posner; A G Gilman; B A Harris Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. The Journal of biological chemistry 1999;274(43):31087-93.
L T Chen; A G Gilman; T Kozasa A candidate target for G protein action in brain. The Journal of biological chemistry 1999;274(38):26931-8.
J J Tesmer; R K Sunahara; R A Johnson; G Gosselin; A G Gilman; S R Sprang Two-metal-Ion catalysis in adenylyl cyclase. Science (New York, N.Y.) 1999;285(5428):756-60.
B A Posner; S Mukhopadhyay; J J Tesmer; A G Gilman; E M Ross Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue. Biochemistry 1999;38(24):7773-9.
C W Dessauer; J J Tesmer; S R Sprang; A G Gilman The interactions of adenylate cyclases with P-site inhibitors. Trends in pharmacological sciences 1999;20(5):205-10.
C Huang; J A Duncan; A G Gilman; S M Mumby Persistent membrane association of activated and depalmitoylated G protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):412-7.
B E Snow; A M Krumins; G M Brothers; S F Lee; M A Wall; S Chung; J Mangion; S Arya; A G Gilman; D P Siderovski A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13307-12.
M P Panchenko; K Saxena; Y Li; S Charnecki; P M Sternweis; T F Smith; A G Gilman; T Kozasa; E J Neer Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure. The Journal of biological chemistry 1998;273(43):28298-304.
C W Dessauer; J J Tesmer; S R Sprang; A G Gilman Identification of a Gialpha binding site on type V adenylyl cyclase. The Journal of biological chemistry 1998;273(40):25831-9.
T Ingi; A M Krumins; P Chidiac; G M Brothers; S Chung; B E Snow; C A Barnes; A A Lanahan; D P Siderovski; E M Ross; et al. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7178-88.
B A Posner; M B Mixon; M A Wall; S R Sprang; A G Gilman The A326S mutant of Gialpha1 as an approximation of the receptor-bound state. The Journal of biological chemistry 1998;273(34):21752-8.
B E Snow; R A Hall; A M Krumins; G M Brothers; D Bouchard; C A Brothers; S Chung; J Mangion; A G Gilman; R J Lefkowitz; et al. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. The Journal of biological chemistry 1998;273(28):17749-55.
M J Hart; X Jiang; T Kozasa; W Roscoe; W D Singer; A G Gilman; P C Sternweis; G Bollag Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science (New York, N.Y.) 1998;280(5372):2112-4.
T Kozasa; X Jiang; M J Hart; P M Sternweis; W D Singer; A G Gilman; G Bollag; P C Sternweis p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science (New York, N.Y.) 1998;280(5372):2109-11.
R K Sunahara; A Beuve; J J Tesmer; S R Sprang; D L Garbers; A G Gilman Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. The Journal of biological chemistry 1998;273(26):16332-8.
Y Li; P M Sternweis; S Charnecki; T F Smith; A G Gilman; E J Neer; T Kozasa Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase. The Journal of biological chemistry 1998;273(26):16265-72.
J A Duncan; A G Gilman A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). The Journal of biological chemistry 1998;273(25):15830-7.
H C Lin; J A Duncan; T Kozasa; A G Gilman Sequestration of the G protein beta gamma subunit complex inhibits receptor-mediated endocytosis. Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5057-60.
D M Berman; A G Gilman Mammalian RGS proteins: barbarians at the gate. The Journal of biological chemistry 1998;273(3):1269-72.
A S Raw; D E Coleman; A G Gilman; S R Sprang Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 –> Val mutant of Gialpha1. Biochemistry 1997;36(50):15660-9.
J J Tesmer; R K Sunahara; A G Gilman; S R Sprang Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (New York, N.Y.) 1997;278(5345):1907-16.
R K Sunahara; J J Tesmer; A G Gilman; S R Sprang Crystal structure of the adenylyl cyclase activator Gsalpha. Science (New York, N.Y.) 1997;278(5345):1943-7.
C Huang; J R Hepler; L T Chen; A G Gilman; R G Anderson; S M Mumby Organization of G proteins and adenylyl cyclase at the plasma membrane. Molecular biology of the cell 1997;8(12):2365-78.
C W Dessauer; A G Gilman The catalytic mechanism of mammalian adenylyl cyclase. Equilibrium binding and kinetic analysis of P-site inhibition. The Journal of biological chemistry 1997;272(44):27787-95.
C W Dessauer; T T Scully; A G Gilman Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase. The Journal of biological chemistry 1997;272(35):22272-7.
R K Sunahara; C W Dessauer; R E Whisnant; C Kleuss; A G Gilman Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase. The Journal of biological chemistry 1997;272(35):22265-71.
E R Nekrasova; D M Berman; R R Rustandi; H E Hamm; A G Gilman; V Y Arshavsky Activation of transducin guanosine triphosphatase by two proteins of the RGS family. Biochemistry 1997;36(25):7638-43.
C Huang; J R Hepler; A G Gilman; S M Mumby Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6159-63.
C Kleuss; A G Gilman Gsalpha contains an unidentified covalent modification that increases its affinity for adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6116-20.
J J Tesmer; D M Berman; A G Gilman; S R Sprang Structure of RGS4 bound to AlF4–activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell 1997;89(2):251-61.
J R Hepler; D M Berman; A G Gilman; T Kozasa RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):428-32.
A M Berghuis; E Lee; A S Raw; A G Gilman; S R Sprang Structure of the GDP-Pi complex of Gly203–>Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis. Structure (London, England : 1993) 1996;4(11):1277-90.
H C Lin; A G Gilman Regulation of dynamin I GTPase activity by G protein betagamma subunits and phosphatidylinositol 4,5-bisphosphate. The Journal of biological chemistry 1996;271(45):27979-82.
C W Dessauer; B A Posner; A G Gilman Visualizing signal transduction: receptors, G-proteins, and adenylate cyclases. Clinical science (London, England : 1979) 1996;91(5):527-37.
D M Berman; T Kozasa; A G Gilman The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. The Journal of biological chemistry 1996;271(44):27209-12.
J A Duncan; A G Gilman Autoacylation of G protein alpha subunits. The Journal of biological chemistry 1996;271(38):23594-600.
D M Berman; T M Wilkie; A G Gilman GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell 1996;86(3):445-52.
C W Dessauer; A G Gilman Purification and characterization of a soluble form of mammalian adenylyl cyclase. The Journal of biological chemistry 1996;271(28):16967-74.
R E Whisnant; A G Gilman; C W Dessauer Interaction of the two cytosolic domains of mammalian adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6621-5.
T Kozasa; A G Gilman Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma. The Journal of biological chemistry 1996;271(21):12562-7.
W Schreibmayer; C W Dessauer; D Vorobiov; A G Gilman; H A Lester; N Davidson; N Dascal Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits. Nature 1996;380(6575):624-7.
J R Hepler; G H Biddlecome; C Kleuss; L A Camp; S L Hofmann; E M Ross; A G Gilman Functional importance of the amino terminus of Gq alpha. The Journal of biological chemistry 1996;271(1):496-504.
C A Doupnik; C W Dessauer; V Z Slepak; A G Gilman; N Davidson; H A Lester Time resolved kinetics of direct G beta 1 gamma 2 interactions with the carboxyl terminus of Kir3.4 inward rectifier K+ channel subunits. Neuropharmacology 1996;35(7):923-31.
R K Sunahara; C W Dessauer; A G Gilman Complexity and diversity of mammalian adenylyl cyclases. Annual review of pharmacology and toxicology 1996;36():461-80.
M A Wall; D E Coleman; E Lee; J A Iñiguez-Lluhi; B A Posner; A G Gilman; S R Sprang The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell 1995;83(6):1047-58.
M B Mixon; E Lee; D E Coleman; A M Berghuis; A G Gilman; S R Sprang Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science (New York, N.Y.) 1995;270(5238):954-60.
W J Tang; A G Gilman Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. Science (New York, N.Y.) 1995;268(5218):1769-72.
A G Gilman Nobel Lecture. G proteins and regulation of adenylyl cyclase. Bioscience reports 1995;15(2):65-97.
T Kozasa; A G Gilman Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. The Journal of biological chemistry 1995;270(4):1734-41.
R Taussig; A G Gilman Mammalian membrane-bound adenylyl cyclases. The Journal of biological chemistry 1995;270(1):1-4.
C Kleuss; A S Raw; E Lee; S R Sprang; A G Gilman Mechanism of GTP hydrolysis by G-protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9828-31.
D E Coleman; A M Berghuis; E Lee; M E Linder; A G Gilman; S R Sprang Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (New York, N.Y.) 1994;265(5177):1405-12.
W J Chang; Y S Ying; K G Rothberg; N M Hooper; A J Turner; H A Gambliel; J De Gunzburg; S M Mumby; A G Gilman; R G Anderson Purification and characterization of smooth muscle cell caveolae. The Journal of cell biology 1994;126(1):127-38.
D E Coleman; E Lee; M B Mixon; M E Linder; A M Berghuis; A G Gilman; S R Sprang Crystallization and preliminary crystallographic studies of Gi alpha 1 and mutants of Gi alpha 1 in the GTP and GDP-bound states. Journal of molecular biology 1994;238(4):630-4.
S M Mumby; C Kleuss; A G Gilman Receptor regulation of G-protein palmitoylation. Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2800-4.
K D Wickman; J A Iñiguez-Lluhl; P A Davenport; R Taussig; G B Krapivinsky; M E Linder; A G Gilman; D E Clapham Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature 1994;368(6468):255-7.
R Taussig; W J Tang; J R Hepler; A G Gilman Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. The Journal of biological chemistry 1994;269(8):6093-100.
N Ueda; J A Iñiguez-Lluhi; E Lee; A V Smrcka; J D Robishaw; A G Gilman G protein beta gamma subunits. Simplified purification and properties of novel isoforms. The Journal of biological chemistry 1994;269(6):4388-95.
J R Hepler; T Kozasa; A G Gilman Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells. Methods in enzymology 1994;237():191-212.
E Lee; M E Linder; A G Gilman Expression of G-protein alpha subunits in Escherichia coli. Methods in enzymology 1994;237():146-64.
R Taussig; W J Tang; A G Gilman Expression and purification of recombinant adenylyl cyclases in Sf9 cells. Methods in enzymology 1994;238():95-108.
S B Lee; S H Shin; J R Hepler; A G Gilman; S G Rhee Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits. The Journal of biological chemistry 1993;268(34):25952-7.
T Kozasa; J R Hepler; A V Smrcka; M I Simon; S G Rhee; P C Sternweis; A G Gilman Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9176-80.
R Taussig; J A Iñiguez-Lluhi; A G Gilman Inhibition of adenylyl cyclase by Gi alpha. Science (New York, N.Y.) 1993;261(5118):218-21.
J R Hepler; T Kozasa; A V Smrcka; M I Simon; S G Rhee; P C Sternweis; A G Gilman Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. The Journal of biological chemistry 1993;268(19):14367-75.
J Iñiguez-Lluhi; C Kleuss; A G Gilman The importance of G-protein beta lambda subunits. Trends in cell biology 1993;3(7):230-6.
M E Linder; P Middleton; J R Hepler; R Taussig; A G Gilman; S M Mumby Lipid modifications of G proteins: alpha subunits are palmitoylated. Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3675-9.
R Taussig; L M Quarmby; A G Gilman Regulation of purified type I and type II adenylylcyclases by G protein beta gamma subunits. The Journal of biological chemistry 1993;268(1):9-12.
J A Iñiguez-Lluhi; M I Simon; J D Robishaw; A G Gilman G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. The Journal of biological chemistry 1992;267(32):23409-17.
J R Hepler; A G Gilman G proteins. Trends in biochemical sciences 1992;17(10):383-7.
W J Tang; A G Gilman Adenylyl cyclases. Cell 1992;70(6):869-72.
M E Linder; A G Gilman G proteins. Scientific American 1992;267(1):56-61, 64-5.
R Taussig; S Sanchez; M Rifo; A G Gilman; F Belardetti Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins. Neuron 1992;8(4):799-809.
E Lee; R Taussig; A G Gilman The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits. The Journal of biological chemistry 1992;267(2):1212-8.
K H Muntz; P C Sternweis; A G Gilman; S M Mumby Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes. Molecular biology of the cell 1992;3(1):49-61.
W J Tang; J A Iñiguez-Lluhi; S Mumby; A G Gilman Regulation of mammalian adenylyl cyclases by G-protein alpha and beta gamma subunits. Cold Spring Harbor symposia on quantitative biology 1992;57():135-44.
W J Tang; A G Gilman Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science (New York, N.Y.) 1991;254(5037):1500-3.
B N Gao; A G Gilman Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10178-82.
P G Feinstein; K A Schrader; H A Bakalyar; W J Tang; J Krupinski; A G Gilman; R R Reed Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10173-7.
H Itoh; A G Gilman Expression and analysis of Gs alpha mutants with decreased ability to activate adenylylcyclase. The Journal of biological chemistry 1991;266(24):16226-31.
W J Tang; J Krupinski; A G Gilman Expression and characterization of calmodulin-activated (type I) adenylylcyclase. The Journal of biological chemistry 1991;266(13):8595-603.
M E Linder; I H Pang; R J Duronio; J I Gordon; P C Sternweis; A G Gilman Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma. The Journal of biological chemistry 1991;266(7):4654-9.
T Higashijima; M P Graziano; H Suga; M Kainosho; A G Gilman 19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-. The Journal of biological chemistry 1991;266(6):3396-401.
P J Casey; I H Pang; A G Gilman Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha. Methods in enzymology 1991;195():315-21.
S M Mumby; A G Gilman Synthetic peptide antisera with determined specificity for G protein alpha or beta subunits. Methods in enzymology 1991;195():215-33.
M E Linder; A G Gilman Purification of recombinant Gi alpha and Go alpha proteins from Escherichia coli. Methods in enzymology 1991;195():202-15.
M P Graziano; M Freissmuth; A G Gilman Purification of recombinant Gs alpha. Methods in enzymology 1991;195():192-202.
S M Mumby; P J Casey; A G Gilman; S Gutowski; P C Sternweis G protein gamma subunits contain a 20-carbon isoprenoid. Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5873-7.
M E Linder; D A Ewald; R J Miller; A G Gilman Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. The Journal of biological chemistry 1990;265(14):8243-51.
P J Casey; H K Fong; M I Simon; A G Gilman Gz, a guanine nucleotide-binding protein with unique biochemical properties. The Journal of biological chemistry 1990;265(4):2383-90.
A G Gilman Regulation of adenylyl cyclase by G proteins. Advances in second messenger and phosphoprotein research 1990;24():51-7.
S M Mumby; R O Heukeroth; J I Gordon; A G Gilman G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):728-32.
M Freissmuth; A G Gilman Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. The Journal of biological chemistry 1989;264(36):21907-14.
A G Gilman The Albert Lasker Medical Awards. G proteins and regulation of adenylyl cyclase. JAMA : the journal of the American Medical Association 1989;262(13):1819-25.
M P Graziano; A G Gilman Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. The Journal of biological chemistry 1989;264(26):15475-82.
M Freissmuth; P J Casey; A G Gilman G proteins control diverse pathways of transmembrane signaling. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(10):2125-31.
J Krupinski; F Coussen; H A Bakalyar; W J Tang; P G Feinstein; K Orth; C Slaughter; R R Reed; A G Gilman Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science (New York, N.Y.) 1989;244(4912):1558-64.
P J Casey; M P Graziano; A G Gilman G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. Biochemistry 1989;28(2):611-6.
M P Graziano; M Freissmuth; A G Gilman Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. The Journal of biological chemistry 1989;264(1):409-18.
A G Gilman Transmembrane signaling, G proteins, and adenylyl cyclase. Harvey lectures 1989;85():153-72.
P J Casey; A G Gilman G protein involvement in receptor-effector coupling. The Journal of biological chemistry 1988;263(6):2577-80.
S Mumby; I H Pang; A G Gilman; P C Sternweis Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain. The Journal of biological chemistry 1988;263(4):2020-6.
P J Casey; M P Graziano; M Freissmuth; A G Gilman Role of G proteins in transmembrane signaling. Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():203-8.
B Gao; S Mumby; A G Gilman The G protein beta 2 complementary DNA encodes the beta 35 subunit. The Journal of biological chemistry 1987;262(36):17254-7.
J E Buss; S M Mumby; P J Casey; A G Gilman; B M Sefton Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7493-7.
B Gao; A G Gilman; J D Robishaw A second form of the beta subunit of signal-transducing G proteins. Proceedings of the National Academy of Sciences of the United States of America 1987;84(17):6122-5.
M P Graziano; P J Casey; A G Gilman Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. The Journal of biological chemistry 1987;262(23):11375-81.
T Higashijima; K M Ferguson; P C Sternweis; M D Smigel; A G Gilman Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. The Journal of biological chemistry 1987;262(2):762-6.
T Higashijima; K M Ferguson; P C Sternweis; E M Ross; M D Smigel; A G Gilman The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins. The Journal of biological chemistry 1987;262(2):752-6.
T Higashijima; K M Ferguson; M D Smigel; A G Gilman The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go. The Journal of biological chemistry 1987;262(2):757-61.
A G Gilman G proteins: transducers of receptor-generated signals. Annual review of biochemistry 1987;56():615-49.
J D Robishaw; M D Smigel; A G Gilman Molecular basis for two forms of the G protein that stimulates adenylate cyclase. The Journal of biological chemistry 1986;261(21):9587-90.
R A Kahn; A G Gilman The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. The Journal of biological chemistry 1986;261(17):7906-11.
K M Ferguson; T Higashijima; M D Smigel; A G Gilman The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. The Journal of biological chemistry 1986;261(16):7393-9.
J D Robishaw; D W Russell; B A Harris; M D Smigel; A G Gilman Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America 1986;83(5):1251-5.
S M Mumby; R A Kahn; D R Manning; A G Gilman Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):265-9.
D C May; E M Ross; A G Gilman; M D Smigel Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins. The Journal of biological chemistry 1985;260(29):15829-33.
B A Harris; J D Robishaw; S M Mumby; A G Gilman Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science (New York, N.Y.) 1985;229(4719):1274-7.
T Katada; A G Gilman; Y Watanabe; S Bauer; K H Jakobs Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. European journal of biochemistry / FEBS 1985;151(2):431-7.
M D Smigel; K M Ferguson; A G Gilman Control of adenylate cyclase activity by G proteins. Advances in cyclic nucleotide and protein phosphorylation research 1985;19():103-11.
G M Bokoch; A G Gilman Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell 1984;39(2 Pt 1):301-8.
J B Hurley; M I Simon; D B Teplow; J D Robishaw; A G Gilman Homologies between signal transducing G proteins and ras gene products. Science (New York, N.Y.) 1984;226(4676):860-2.
T Asano; T Katada; A G Gilman; E M Ross Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles. The Journal of biological chemistry 1984;259(15):9351-4.
R A Kahn; A G Gilman ADP-ribosylation of Gs promotes the dissociation of its alpha and beta subunits. The Journal of biological chemistry 1984;259(10):6235-40.
R A Kahn; A G Gilman Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. The Journal of biological chemistry 1984;259(10):6228-34.
T Katada; J K Northup; G M Bokoch; M Ui; A G Gilman The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. The Journal of biological chemistry 1984;259(6):3578-85.
T Katada; G M Bokoch; J K Northup; M Ui; A G Gilman The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. The Journal of biological chemistry 1984;259(6):3568-77.
G M Bokoch; T Katada; J K Northup; M Ui; A G Gilman Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. The Journal of biological chemistry 1984;259(6):3560-7.
T Katada; G M Bokoch; M D Smigel; M Ui; A G Gilman The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. The Journal of biological chemistry 1984;259(6):3586-95.
A G Gilman G proteins and dual control of adenylate cyclase. Cell 1984;36(3):577-9.
D R Manning; B A Fraser; R A Kahn; A G Gilman ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation. The Journal of biological chemistry 1984;259(2):749-56.
M Smigel; T Katada; J K Northup; G M Bokoch; M Ui; A G Gilman Mechanisms of guanine nucleotide-mediated regulation of adenylate cyclase activity. Advances in cyclic nucleotide and protein phosphorylation research 1984;17():1-18.
A G Gilman Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase. The Journal of clinical investigation 1984;73(1):1-4.
J K Northup; M D Smigel; P C Sternweis; A G Gilman The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. The Journal of biological chemistry 1983;258(18):11369-76.
J K Northup; P C Sternweis; A G Gilman The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. The Journal of biological chemistry 1983;258(18):11361-8.
G M Bokoch; T Katada; J K Northup; E L Hewlett; A G Gilman Identification of the predominant substrate for ADP-ribosylation by islet activating protein. The Journal of biological chemistry 1983;258(4):2072-5.
J K Northup; M D Smigel; A G Gilman The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. The Journal of biological chemistry 1982;257(19):11416-23.
P C Sternweis; A G Gilman Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proceedings of the National Academy of Sciences of the United States of America 1982;79(16):4888-91.
L S Schleifer; R A Kahn; E Hanski; J K Northup; P C Sternweis; A G Gilman Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase. The Journal of biological chemistry 1982;257(1):20-3.
E Hanski; A G Gilman The guanine nucleotide-binding regulatory component of adenylate cyclase in human erythrocytes. Journal of cyclic nucleotide research 1982;8(5):323-36.
M D Smigel; J K Northup; A G Gilman Characteristics of the guanine nucleotide-binding regulatory component of adenylate cyclase. Recent progress in hormone research 1982;38():601-24.
E Hanski; P C Sternweis; J K Northup; A W Dromerick; A G Gilman The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein. The Journal of biological chemistry 1981;256(24):12911-9.
P C Sternweis; J K Northup; M D Smigel; A G Gilman The regulatory component of adenylate cyclase. Purification and properties. The Journal of biological chemistry 1981;256(22):11517-26.
P C Sternweis; J K Northup; E Hanski; L S Schleifer; M D Smigel; A G Gilman Purification and properties of the regulatory component (G/F) of adenylate cyclase. Advances in cyclic nucleotide research 1981;14():23-36.
J K Northup; P C Sternweis; M D Smigel; L S Schleifer; E M Ross; A G Gilman Purification of the regulatory component of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America 1980;77(11):6516-20.
L S Schleifer; J C Garrison; P C Sternweis; J K Northup; A G Gilman The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein. The Journal of biological chemistry 1980;255(7):2641-4.
A C Howlett; A G Gilman Hydrodynamic properties of the regulatory component of adenylate cyclase. The Journal of biological chemistry 1980;255(7):2861-6.
E M Ross; A G Gilman Biochemical properties of hormone-sensitive adenylate cyclase. Annual review of biochemistry 1980;49():533-64.
P C Sternweis; A G Gilman Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell. The Journal of biological chemistry 1979;254(9):3333-40.
A C Howlett; P C Sternweis; B A Macik; P M Van Arsdale; A G Gilman Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors. The Journal of biological chemistry 1979;254(7):2287-95.
E M Ross; A C Howlett; A G Gilman Identification and partial characterization of some components of hormone-stimulated adenylate cyclase. Progress in clinical and biological research 1979;31():735-49.
E M Ross; A C Howlett; K M Ferguson; A G Gilman Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. The Journal of biological chemistry 1978;253(18):6401-12.
A C Howlett; P M Van Arsdale; A G Gilman Efficiency of coupling between the beta adrenergic receptor and adenylate cyclase. Molecular pharmacology 1978;14(4):531-9.
W H Burgess; A C Howlett; R H Kretsinger; A G Gilman S49 lymphoma wild type and variant clones contain normal calcium dependent regulator. Journal of cyclic nucleotide research 1978;4(3):175-81.
E M Ross; T Haga; A C Howlett; J Schwarzmeier; L S Schleifer; A G Gilman Hormone-sensitive adenylate cyclase: resolution and reconstitution of some components necessary for regulation of the enzyme. Advances in cyclic nucleotide research 1978;9():53-68.
E M Ross; A G Gilman Resolution of some components of adenylate cyclase necessary for catalytic activity. The Journal of biological chemistry 1977;252(20):6966-9.
E M Ross; A G Gilman Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes. Proceedings of the National Academy of Sciences of the United States of America 1977;74(9):3715-9.
E M Ross; M E Maguire; T W Sturgill; R L Biltonen; A G Gilman Relationship between the beta-adrenergic receptor and adenylate cyclase. The Journal of biological chemistry 1977;252(16):5761-75.
T Haga; E M Ross; H J Anderson; A G Gilman Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America 1977;74(5):2016-20.
M E Maguire; E M Ross; A G Gilman beta-Adrenergic receptor: ligand binding properties and the interaction with adenylyl cyclase. Advances in cyclic nucleotide research 1977;8():1-83.
P A Insel; M E Maguire; A G Gilman; H R Bourne; P Coffino; K L Melmon Beta adrenergic receptors and adenylate cyclase: products of separate genes? Molecular pharmacology 1976;12(6):1062-9.
L L Brunton; R A Wiklund; P M Van Arsdale; A G Gilman Binding of (3H)prostaglandin E1 to putative receptors linked to adenylate cyclase of cultured cell clones. The Journal of biological chemistry 1976;251(10):3037-44.
M E Maguire; R A Wiklund; H J Anderson; A G Gilman Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones. The Journal of biological chemistry 1976;251(5):1221-31.
M E Maguire; P M Van Arsdale; A G Gilman An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor. Molecular pharmacology 1976;12(2):335-9.
M E Maguire; L L Brunton; R A Wiklund; H I Anderson; P M Van Arsdale; A G Gilman Hormone receptors and the control of cyclic AMP metabolism in parental and hybrid somatic cells. Recent progress in hormone research 1976;32():633-67.
M E Maguire; T W Sturgill; A G Gilman Frustration and adenylate cyclase. Metabolism: clinical and experimental 1975;24(3):287-99.
M E Maguire; T W Sturgill; H J Anderson; J D Minna; A G Gilman Hormonal control of cyclic AMP metabolism in parental and hybrid somatic cells. Advances in cyclic nucleotide research 1975;5():699-718.
R L Guerrant; L L Brunton; T C Schnaitman; L I Rebhun; A G Gilman Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infection and immunity 1974;10(2):320-7.
M E Maguire; A G Gilman Adenylate cyclase assay with adenylyl imidodiphosphate and product detection by competitive protein binding. Biochimica et biophysica acta 1974;358(1):154-63.
A G Gilman; F Murad Assay of cyclic nucleotides by receptor protein binding displacement. Methods in enzymology 1974;38():49-61.
J D Minna; A G Gilman Expression of genes for metabolism of cyclic adenosine 3’:5’-monophosphate in somatic cells. II. Effects of prostaglandin E1 and theophylline on parental and hybrid cells. The Journal of biological chemistry 1973;248(19):6618-25.
A G Gilman; J D Minna Expression of genes for metabolism of cyclic adenosine 3’:5’-monophosphate in somatic cells. I. Responses to catecholamines in parental and hybrid cells. The Journal of biological chemistry 1973;248(19):6610-7.
J A Secrist; J R Barrio; N J Leonard; C Villar-Palasi; A G Gilman Fluorescent modification of adenosine 3’,5’-monophosphate: spectroscopic properties and activity in enzyme systems. Science (New York, N.Y.) 1972;177(45):279-80.
A G Gilman; B K Schrier Adenosine cyclic 3’,5’-monophosphate in fetal rat brain cell cultures. I. Effect of catecholamines. Molecular pharmacology 1972;8(4):410-6.
A G Gilman Regulation of cyclic AMP metabolism in cultured cells of the nervous system. Advances in cyclic nucleotide research 1972;1():389-410.
A G Gilman Protein binding assays for cyclic nucleotides. Advances in cyclic nucleotide research 1972;2():9-24.
A G Gilman; M Nirenberg Regulation of adenosine 3’,5’-cyclic monophosphate metabolism in cultured neuroblastoma cells. Nature 1971;234(5328):356-8.
F Murad; A G Gilman Adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate: a simultaneous protein binding assay. Biochimica et biophysica acta 1971;252(2):397-400.
N W Seeds; A G Gilman Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures. Science (New York, N.Y.) 1971;174(6):292.
A G Gilman; M Nirenberg Effect of catecholamines on the adenosine 3’:5’-cyclic monophosphate concentrations of clonal satellite cells of neurons. Proceedings of the National Academy of Sciences of the United States of America 1971;68(9):2165-8.
A G Gilman A protein binding assay for adenosine 3’:5’-cyclic monophosphate. Proceedings of the National Academy of Sciences of the United States of America 1970;67(1):305-12.
N W Seeds; A G Gilman; T Amano; M W Nirenberg Regulation of axon formation by clonal lines of a neural tumor. Proceedings of the National Academy of Sciences of the United States of America 1970;66(1):160-7.
A G Gilman; T W Rall The role of adenosine 3’,5’-phosphate in mediating effects of thyroid-stimulating hormone on carbohydrate metabolism of bovine thyroid slices. The Journal of biological chemistry 1968;243(22):5872-81.
A G Gilman; T W Rall Factors influencing adenosine 3’,5’-phosphate accumulation in bovine thyroid slices. The Journal of biological chemistry 1968;243(22):5867-71.
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