American Chemical Society Awards
Award for Creative Work in Organic Synthesis, 1983
Arthur C. Cope Scholar, 1986
Harrison Howe Award, Rochester Section, 1987
Remsen Award, Maryland Section, 1989
Arthur C. Cope Award, 1992
San Diego Scientist of the Year, San Diego Section, 1992
Roger Adams Award in Organic Chemistry, 1997
Top 75 Contributors to the Chemical Enterprise, 1998
Richards Medal, Northeastern Section, 1998
Carothers Award, Delaware Section, 1999
Other Awards
Allan Day Award, Philadelphia Organic Chemists Club, 1985
Dr. Paul Janssen Prize, Belgium, 1986 (1st recipient)
Prelog Medal, ETH, Switzerland, 1988
Sammet Award, Göthe University, Frankfurt-am-Main, 1988
Chemical Pioneer Award, American Institute of Chemists, 1988
Scheele Medal, Swedish Academy of Pharma Sciences, 1991
Tetrahedron Prize (with Noyori), 1993
Centenary Lectureship Medal, Royal Society of Chemistry, 1993
Cliff Hamilton Award, University of Nebraska, Lincoln, 1995
King Faisal Prize for Science, Saudi Arabia, 1995
Microbial Chemistry Medal, Kitasato Institute, Tokyo, 1997
Harvey Science & Technology Prize, Israel Inst of Tech, 1998
Rylander Award, Organic Reactions Catalysis Society, 2000
Chemical Sciences Award, National Academy of Sciences, 2000
Chiralty Medal, Italian Chemical Society, 2000
Rhone Poulenc Medal, Royal Society of Chemistry, 2000
Benjamin Franklin Medal, Franklin Institute, Philadelphia, 2001
Wolf Prize (with Kagan & Noyori), Weizmann Institute, 2001
John Scott Medal Award, City of Philadelphia, 2001
ISI Highly Cited Researchers Database, original member, 2001
Nobel Prize in Chemistry (with Knowles & Noyori), 2001
Distinguished Professor (Hon), Hong Kong Polytechnic University, Hong Kong, 2002
1. R. Vanacore, A.-J. L. Ham, M. Voehler, C. R. Sanders, T. P. Conrads, T. D. Veenstra, K. B. Sharpless, P. E. Dawson and B. G. Hudson, A Sulfilimine Bond Identified in Collagen IV, Science, 325(5945), 1230 (2009).
2. C. A. Valdez, J. C. Tripp, Y. Miyamoto, J. Kalisiak, P. Hruz, Y. S. Andersen, S. E. Brown, K. Kangas, L. V. Arzu, B. J. Davids, F. D. Gillin, J. A. Upcroft, P. Upcroft, V. V. Fokin, D. K. Smith, K. B. Sharpless and L. Eckmann, Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity against Giardia lamblia, J. Med. Chem., 52(13), 4038 (2009).
3. D. Minond, S. A. Saldanha, P. Subramaniam, M. Spaargaren, T. Spicer, J. R. Fotsing, T. Weide, V. V. Fokin, K. B. Sharpless, M. Galleni, C. Bebrone, P. Lassaux and P. Hodder, Inhibitors of VIM-2 by Screening Pharmacologically Active and Click-Chemistry Compound Libraries, Bioorg. Med. Chem., 17(14), 5027 (2009).
4. J. Kalisiak, S. A. Trauger, E. Kalisiak, H. Morita, V. V. Fokin, M. W. W. Adams, K. B. Sharpless and G. Siuzdak, Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach, J. Am. Chem. Soc., 131(1), 378 (2009).
5. T. Hirose, T. Sunazuka, A. Sugawara, A. Endo, K. Iguchi, T. Yamamoto, H. Ui, K. Shiomi, T. Watanabe, K. B. Sharpless and S. Omura, Chitinase Inhibitors: Extraction of the Active Framework from Natural Argifin and Use of In Situ Click Chemistry, J. Antibiot., 62(5), 277 (2009).
6. J. E. Hein, J. C. Tripp, L. B. Krasnova, K. B. Sharpless and V. V. Fokin, Copper(I)-Catalyzed Cycloaddition of Organic Azides and 1-Iodoalkynes, Angew. Chem., Int. Ed., 48(43), 8018 (2009).
7. H. D. Agnew, R. D. Rohde, S. W. Millward, A. Nag, W.-S. Yeo, J. E. Hein, S. M. Pitram, A. A. Tariq, V. M. Burns, R. J. Krom, V. V. Fokin, K. B. Sharpless and J. R. Heath, Iterative In Situ Click Chemistry Creates Antibody-like Protein-Capture Agents, Angew. Chem., Int. Ed., 48(27), 4944 (2009).
8. V. Fokin, V. A. Rostovtsev, L. Green, F. Himo and K. B. Sharpless, Copper-Catalysed Ligation of Azides and Acetylenes, U.S. Patent Number 7,375,234, issued May 20, 2008.
9. E. J. Yoo, M. Ahlquist, I. Bae, K. B. Sharpless, V. V. Fokin and S. Chang, Mechanistic Studies on the Cu-Catalyzed Three-Component Reactions of Sulfonyl Azides, 1-Alkynes and Amines, Alcohols, or Water: Dichotomy via a Common Pathway, J. Org. Chem., 73(14), 5520 (2008).
10. Z. Radic, R. Manetsch, D. Fournier, K. B. Sharpless and P. Taylor, Probing Gorge Dimensions of Cholinesterases by Freeze-Frame Click Chemistry, Chem.-Biol. Interact., 175(1-3), 161 (2008).
11. S. W. Kwok, J. E. Hein, V. V. Fokin and K. B. Sharpless, Regioselective Synthesis of either 1H- or 2H-1,2,3-Triazoles via Michael Addition to Alpha, Beta-Unsaturated Ketones, Heterocycles, 76(2), 1141 (2008).
12. J. Kalisiak, K. B. Sharpless and V. V. Fokin, Efficient Synthesis of 2-Substituted-1,2,3-triazoles, Org. Lett., 10(15), 3171 (2008).
13. E. Van der Eycken and K. B. Sharpless, Click Chemistry, QSAR Comb. Sci., 26(11-12), 1115 (2007).
14. A. Sugawara, T. Sunazuka, T. Hirose, K. Nagai, Y. Yamaguchi, H. Hanaki, K. B. Sharpless and S. Omura, Design and Synthesis via Click Chemistry of 8,9-Anhydroerythromycin A 6,9-Hemiketal Analogues with anti-MRSA and -VRE Activity, Bioorg. Med. Chem. Lett., 17(22), 6340 (2007).
15. M. G. Finn, H. C. Kolb, V. V. Fokin and K. B. Sharpless, Concept and Applications of Click Chemistry. From the Standpoint of Advocates, Kagaku to Kogyo (Tokyo, Jpn.), 60(10), 976 (2007).
16. R. Vestberg, M. Malkock, M. Kade, P. Wu, V. V. Fokin, K. B. Sharpless, E. Drokenmuller and C. J. Hawker, Role of Architecture and Molecular Weight in the Formation of Tailor-made Ultrathin Multilayers Using Dendritic Macromolecules and Click Chemistry, J. Polymer Sci., Part A., 45(14), 2835 (2007).
17. Y. Liu, D. D. Diaz, A. A. Accurso, K. B. Sharpless, V. V. Fokin and M. G. Finn, Metal-Adhesive Polymers from Cu(I)-Catalyzed Azide-Alkyne Cycloaddition, J. Polymer Sci., Part A., 45, 5182 (2007).
18. C. J. Hawker, V. V. Fokin, M. G. Finn and K. B. Sharpless, Bringing Efficiency to Materials Synthesis: The Philosophy of Click Chemistry, Aust. J. Chem., 60(6), 381 (2007).
19. E. J. Yoo, M. Ahlquist, S. H. Kim, I. Bae, V. V. Fokin, K. B. Sharpless and S. Chang, Synthesis of N-Sulfonyl-1,2,3-triazoles: Controlling Selectivity, Angew. Chem. Int. Ed., 46(10), 1730 (2007).
20. S. Narayan, V. V. Fokin and K. B. Sharpless Organic Synthesis in Aqueous Suspension: Chemistry ’On Water’ in ”Organic Synthesis in Water”, U. Lindstrom, ed., Blackwell Scientific (2007).
21. T. Hirose, T. Sunazuka, Y. Noguchi, Y. Yamaguchi, H. Hanaki, K. B. Sharpless and S. Omura, Rapid ’SAR’ via Click Chemistry: An Alkyne-Bearing Spiramycin is Fused with Diverse Azides to Yield New Triazole-Antibacterial Candidates, Heterocycles, 69, 55 (2006).
22. K. B. Sharpless and R. Manetsch, In Situ Click Chemistry: A Powerful Means for Lead Discovery, Expert Opinion in Drug Discovery, 1(6), 525 (2006).
23. M. Whiting, J. Tripp, Y.-C. Lin, W. Lindstrom, A. J. Olson, J. H. Elder, K. B. Sharpless and V. V. Fokin, Rapid Discovery and Structure-Activity Profiling of Novel Inhibitors of HIV-1 Protease Enabled by the Copper(I)-Catalyzed Synthesis of 1,2,3-Triazoles and Their Further Functionalization, J. Med. Chem., 49, 7697 (2006).
24. D. D. Diaz, A. Converso, K. B. Sharpless and M. G. Finn, 2,6-Dichloro-9-thiabiycyclo[3.3.1]nonane: Multigram Display of Azide and Cyanide Components on a Versatile Scaffold, Molecules, 11(4), 212 (2006).
25. M. Whiting, J. Muldoon, Y.-C. Lin, S. M. Silverman, W. Lindstrom, A. Olson, H. C. Kolb, M. G. Finn, K. B. Sharpless, J. H. Elder and V. V. Fokin, Inhibitors of HIV-1 Protease By Using In Situ Click Chemistry, Angew. Chem. Int. Ed., 45(9), 1435 (2006).
26. Z. Radic, R. Manetsch, A. Krasinski, J. Raushel, J. Yamauchi, C. Garcia, H. Kolb, K. B. Sharpless and P. Taylor, Molecular Basis of Interactions of Cholinesterases with Tight Binding Inhibitors, Chem.-Biol. Interact., 157-158, 133 (2005).
27. Y. Bourne, Z. Radic, H. C. Kolb, K. B. Sharpless, P. Taylor and P. Marchot, Structural Insights into Conformational Flexibility at the Peripheral Site and Within the Active Center Gorge of AChE, Chem.-Biol. Interact., 157-158, 159 (2005).
28. P. Wu, M. Malkoch, J. Hunt, R. Vestburg, E. Kaltgrad, M. G. Finn, V. V. Fokin, K. B. Sharpless and C. J. Hawker, Multivalent, Bifunctional Dendrimers Prepared by Click Chemistry, Chem. Commun., 46, 5775 (2005).
29. L. Zhang, X. Chen, P. Xue, H. H. Y. Sun, I. D. Williams, K. B. Sharpless, V. V. Fokin and G. Jia, Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides, J. Am. Chem. Soc., 127 (46), 15998 (2005).
30. J. C. Loren, A. Krasinski, V. V. Fokin and K. B. Sharpless, NH-1,2,3-Triazoles from Azidomethyl Pivalate and Carbamates: Tunable Base Labile Protecting Groups, Synlett, 18, 2847 (2005).
31. S. M. Johnson, H.M. Petrassi, S. K. Palaninathan, N. N. Mohamedmohaideen, H. E. Purkey, C. Nichols, K. P. Chiang, T. Walkup, J. C. Sacchettini, K. B. Sharpless and J. W. Kelly, Bisaryloxime Ethers as Potent Inhibitors of Transthyretin Amyloid Fibril Formation, J. Med. Chem., 48, 1576 (2005).
32. J. C. Loren and K. B. Sharpless, The Banert Cascade: A Synthetic Sequence to Polyfunctional NH-1,2,3-Triazoles, Synthesis, 9, 1514 (2005).
33. A. K. Feldman, B. Colasson, K. B. Sharpless and V. V. Fokin, The Allylic Azide Rearrangement: Achieving Selectivity, J. Am. Chem. Soc, 127, 13444 (2005).
34. K. B. Sharpless, M. Andersson, R. Epple and V. V. Fokin, Second Cycle Asymmetric Dihydroxylation Reaction, U.S. Patent Number 6,852,874 B2, issued February 8, 2005.
35. A. Krasinski, Z. Radik, R. Manetsch, J. Raushel, P. Taylor, K. B. Sharpless and H. C. Kolb, In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors, J. Am. Chem. Soc., 127, 6686 (2005).
36. S. Narayan, M. G. Finn, V. V. Fokin, H. C. Kolb and K. B. Sharpless, ”On Water”: Unique Reactivity Effects of Organic Compounds in Aqueous Suspensions, Angew. Chem. Int. Ed., 44, 3275 (2005).
37. V. P. Mocharla, B. Colasson, L. V. Lee, S. Roeper, K. B. Sharpless, C.-H. Wong and H. C. Kolb, In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II, Angew. Chem. Int. Ed., 44, 116 (2005).
38. F. Himo, T. Lovell, R. Hilgraf, V. V. Rostovtsev, L. Noodleman, K. B. Sharpless and V. V. Fokin, Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates, J. Am. Chem. Soc., 127, 210 (2005).
39. T. R. Chan, R. Hilgraf, K. B. Sharpless and V. V. Fokin, Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis, Org. Lett., 6, 2853 (2004).
40. R. Manetsch, A. Krasinski, Z. Radic, J. Raushel, P. Taylor, K. B. Sharpless and H. C. Kolb, In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications, J. Am. Chem. Soc., 126, 12809 (2004).
41. A. Converso, P.-L. Saaidi, M. G. Finn and K. B. Sharpless, Nucleophilic Substitution by Grignard Reagents on Sulfur Mustards, J. Org. Chem., 69, 7336 (2004).
42. D. D. Diaz, S. Punna, P. Holzer, A. K. McPherson, K. B. Sharpless, V. V. Fokin, and M. G. Finn, Click Chemistry in Materials Synthesis. 1. Adhesive Polymers from Copper-Catalyzed Azide-Alkyne Cycloaddition, J. Polym. Sci. Part A: Polym. Chem., 42, 4392 (2004).
43. P. Wu, A. K. Feldman, A. K. Nugent, C. J. Hawker, A. Scheel, B. Voit, J. Pyun, J. M. J. Fréchet, K. B. Sharpless and V. V. Fokin, Efficiency and Fidelity in a Click Chemistry Route to Triazole Dendrimers via the Cu(I)-Catalyzed Ligation of Azides and Alkynes, Angew. Chem. Int. Ed., 43, 3928 (2004).
44. A. Krasinski, V. V. Fokin and K. B. Sharpless, The Direct Synthesis of 1,5-Disubstituted-4-magnesio-1,2,3-triazoles, Revisited, Org. Lett., 6(8), 1237 (2004).
45. Y. Bourne, H. C. Kolb, Z. Radic, K. B. Sharpless, P. Taylor and P. Marchot, Freeze-frame Inhibitor Captures Acetylcholinesterase in a Unique Conformation, Proc. Nat. Acad. Sci., 101(6), 1449 (2004).
46. Kitayama, T. Yokoi, Y. Kawai, R. K. Hill, M. Morita, T. Okamoto, Y. Yamamoto, V. V. Fokin, K. B. Sharpless and S. Sawada, The Chemistry of Zerumbone. Part 5: Structural Transformation of the Dimethylamine Derivatives, Tetrahedron, 59, 4857 (2003).
47. H. C. Kolb and K. B. Sharpless, The Growing Impact of Click Chemistry on Drug Discovery, Drug Discovery Today, 8, 1128 (2003).
48. A. Brik, J. Muldoon, Y.-C. Lin, J. Elder, D. Goodsell, A. Olson, V. V. Fokin, K. B. Sharpless and C.-H. Wong, Rapid Diversity-Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors, ChemBioChem, 4, 1246 (2003).
49. L. V. Lee, M. L. Mitchell, S.-J. Huang, V. V. Fokin, K. B. Sharpless and C.-H. Wong, A Potent and Highly Sensitive Inhibitor of Human a–1,3–Fucosyltransferase Via Click Chemistry, J. Am. Chem. Soc., 125, 9588 (2003).
50. A. E. Rubin and K. B. Sharpless, Synthesis of a,ß–Substituted Amino Amides, Esters, and Acids, U.S. Patent Number 6,573,387, issued June 3, 2003.
51. F. Himo, Z. P. Demko, L. Noodleman and K. B. Sharpless, Why is Tetrazole Formation by Addition of Azide to Organic Nitriles Catalyzed by Zinc (II) Salts?, J. Am. Chem. Soc., 125, 9983 (2003).
52. A. S. Ripka, D. D. Diaz, K. B. Sharpless and M. G. Finn, The First Practical Synthesis of Formamidine Ureas and Derivatives, Org. Lett., 5, 1531 (2003).
53. G. Li and K. B. Sharpless, Two Step Synthesis of D–and L–a–Amino Acids and D– and L–a–Amino Aldehydes, U.S. Patent Number 6,509,506, issued January 21, 2003.
54. Q. Wang, T. R. Chan, R. Hilgraf, V. V. Fokin, K. B. Sharpless and M. G. Finn, Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3+2] Cycloaddition, J. Am. Chem. Soc., 125, 3192 (2003).
55. F. Himo, Z. P. Demko, L. Noodleman and K. B. Sharpless, Mechanisms of Tetrazole Formation by Addition of Azide to Nitriles, J. Am. Chem. Soc., 124, 12210 (2002).
56. V. V. Rostovtsev, L. G. Green, V. V. Fokin and K. B. Sharpless, A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective ”Ligation” of Azides and Terminal Alkynes, Angew. Chem. Int. Ed., 41, 2596 (2002).
57. Z. P. Demko and K. B. Sharpless, An Expedient Route to the Tetrazole Analogs of a–Amino Acids, Org. Lett., 4, 2525 (2002).
58. K. B. Sharpless, Searching for New Reactivity, Angew. Chem. Int. Ed., 41, 2024 (2002).
59. V. Fokin and K. B. Sharpless, Aminohydroxylation of Olefins, U.S. Patent Number 6,350,905, issued February 26, 2002.
60. Z. Demko and K. B. Sharpless, A Click Chemistry Approach to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis of 5-Acyltetrazoles from Azides and Acyl Cyanides, Angew. Chem. Int. Ed., 41, 2113 (2002).
61. Z. Demko and K. B. Sharpless, A Click Chemistry Approach to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis of 5-Sulfonyl Tetrazoles from Azides and Sulfonyl Cyanides, Angew. Chem. Int. Ed., 41, 2110 (2002).
62. W. G. Lewis, L. G. Green, F. Grynszpan, Z. Radic, P. R. Carlier, P. Taylor, M. G. Finn and K. B. Sharpless, Click Chemistry in Situ: Aceytlcholinesterase as a Molecular-Scale Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks, Angew. Chem. Int. Ed., 41, 1053 (2002).
63. P. Dupau, R. Epple, A. A. Thomas, V. V. Fokin and K. B. Sharpless, Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks, Adv. Synth. Catal., 344, 421 (2002).
64. M. A. Andersson, R. Epple, V. V. Fokin and K. B. Sharpless, A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins, Angew. Chem. Int. Ed., 41, 472 (2002).
65. Z. P. Demko and K. B. Sharpless, An Intramolecular [2+3] Cycloaddition Route to Fused 5-Heterosubstituted Tetrazoles, Org. Lett., 3, 4091 (2001).
66. Z. P. Demko and K. B. Sharpless, Preparation of 5-Substituted- 1H-Tetrazoles from Nitriles in Water, J. Org. Chem., 66, 7945 (2001).
67. A. K. Yudin and K. B. Sharpless, Epoxidation of Olefins, U.S. Patent number 6,271,400, issued August 7, 2001.
68. A. Converso, K. Burow, A. Marzinzik, K. B. Sharpless and M.G. Finn, 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: a Privileged, Bivalent Scaffold for the Display of Nucelophilic Components, J. Org. Chem., 66, 4386 (2001).
69. V. V. Fokin and K. B. Sharpless, A Practical and Highly Efficient Aminohydroxylation of Unsaturated Carboxylic Acids, Angew. Chem. Int. Ed., 40, 3455 (2001).
70. H. Becker and K. B. Sharpless, Asymmetric Dihydroxylation, in ”Asymmetric Oxidation Reactions: A Practical Approach in Chemistry”, T. Katsuki, ed., Oxford University Press (2001).
71. H. M. Petrassi, K. B. Sharpless and J. W. Kelly, The Copper Mediated Cross-Coupling of Phenylboronic Acids and N-Hydroxyphthalimide at Room Temperature: Synthesis of Aryloxyamines, Org. Lett., 3, 139 (2001).
72. H. C. Kolb, M. G. Finn and K. B. Sharpless, Click Chemistry: Diverse Chemical Function From a Few Good Reactions, Angew. Chem., 40, 2004 (2001).
73. T.-H. Chuang and K. B. Sharpless, Applications of Aziridinium Ions. Selective Syntheses of a,ß-Diamino Esters, a-Sulfanyl-ß-amino Esters, ?-Lactams and 1,5-Benzodiazepin-2-one, Org. Lett., 2, 3555 (2000).
74. A. L. Marzinzik and K. B. Sharpless, A Simple Method for the Preparation of N-Sulfonylsulfilimines from Sulfides, J. Org. Chem., 66, 594 (2001).
75. T.-H. Chuang and K. B. Sharpless, Applications of Aziridinium Ions: Selective Syntheses of Pyrazolidin-3-ones and Pyrazolo[1,2-a]pyrazoles, Helv. Chim. Acta, 83, 1734 (2000).
76. B. Tao, G. Schlingloff and K. B. Sharpless, Synthesis of Aryl Serines, U.S. Patent number 6,057,473, issued May 2, 2000.
77. Z. Demko, M. Bartsch and K. B. Sharpless, Primary Amides. A General Nitrogen Source for Catalytic Asymmetric Aminohydroxylation of Olefins, Org. Lett., 2, 2221 (2000).
78. A. Gontcharov, H. Liu and K. B. Sharpless, Aminohydroxylation of Olefins with Tert-Alkyl Sulfonamides, U. S. Patent number 6,008,376, issued December 28, 1999.
79. G. Li and K. B. Sharpless, Two Step Synthesis of D- and L- a-Amino Acids and D- and L- a-Amino-Aldehydes, U.S. Patent number 5,994,583, issued November 30, 1999.
80. J. Rudolph and K. B. Sharpless, Accelerated Catalysis of Olefinic Epoxidations, U.S. Patent number 5,939,568, issued August 17, 1999.
81. J. U. Jeong and K. B. Sharpless, Aziridination of Olefins, U.S. Patent number 5,929,252, issued July 27, 1999.
82. T.-H. Chuang and K. B. Sharpless, Applications of Aziridinium Ions. Selective Syntheses of ß-Aryl-a,ß-diamino Esters, Org. Lett., 1, 1435 (1999).
83. G. Li, H.-T. Chang and K. B. Sharpless, Catalytic Asymmetric Aminohydroxylation of Olefins with Sulfonamides, U.S. Patent number 5,859,281, issued January 12, 1999.
84. A. A. Thomas and K. B. Sharpless, The Catalytic Asymmetric Aminohydroxylation (AA) of Unsaturated Phosphonates, J. Org. Chem., 64, 8379 (1999).
85. A. V. Gontcharov, H. Liu and K. B. Sharpless, tert-Butylsulfonamide. A New Nitrogen Source for Catalytic Aminohydroxylation and Aziridination of Olefins, Org. Lett., 1, 783 (1999).
86. W. Pringle and K. B. Sharpless, The Osmium-Catalyzed Aminohydroxylation of Baylis-Hillman Olefins, Tetrahedron Lett., 40, 5151 (1999).
87. H. Adolfsson, A. Converso and K. B. Sharpless, Comparison of Amine Additives Most Effective in the New Methyltrioxorhenium-Catalyzed Epoxidation Process, Tetrahedron Lett., 40, 3991 (1999).
88. L. J. Goossen, H. Liu, K. R. Dress and K. B. Sharpless, Catalytic Asymmetric Aminohydroxylation with Amino-Substituted Heterocycles as Nitrogen Sources, Angew. Chem., 38, 1089 (1999).
89. G. Li and K. B. Sharpless, Catalytic Asymmetric Aminohydroxylation of Olefins with Carbamates, U.S. Patent number 5,767,304, issued June 16, 1998.
90. A. Gypser, D. Michel, D. S. Nirschl and K. B. Sharpless, Dihydroxylation of Polyenes using Narasaka’s Modification of the Upjohn Procedure, J. Org. Chem., 63, 7322 (1998).
91. K. R. Dress, L. J. Goossen, H. Liu, D. M. Jerina and K. B. Sharpless, Catalytic Aminohydroxylation Using Adenine-Derivatives as the Nitrogen Source, Tetrahedron Lett., 39, 7669 (1998).
92. J. U. Jeong, B. Tao, I. Sagasser, H. Henniges and K. B. Sharpless, Bromine-Catalyzed Aziridination of Olefins. A Rare Example of Atom-Transfer Redox Catalysis by a Main Group Element, J. Am. Chem. Soc., 120, 6844 (1998).
93. K. L. Reddy, K. R. Dress and K. B. Sharpless, N-Chloro-N-Sodio-2-Trimethylsilyl Ethyl Carbamate: A New Nitrogen Source for the Catalytic Asymmetric Aminohydroxylation, Tetrahedron Lett., 39, 3667 (1998).
94. Tao, G. Schlingloff and K. B. Sharpless, Reversal of Regioselection in the Asymmetric Aminohydroxylation of Cinnamates, Tetrahedron Lett., 39, 2507 (1998).
95. Copéret, H. Adolfsson, T.-A. V. Khuong, A. K. Yudin and K. B. Sharpless, A Simple and Efficient Method for the Preparation of Pyridine-N-oxides, J. Org. Chem., 63, 1740 (1998).
96. H. C. Kolb and K. B. Sharpless, Asymmetric Dihydroxylation, in ”Transition Metals for Organic Synthesis: Building Blocks and Fine Chemicals”, M. Beller and C. Bolm, eds., Wiley-VCH (1998).
97. H. C. Kolb and K. B. Sharpless, Asymmetric Aminohydroxylation, in ”Transition Metals for Organic Synthesis: Building Blocks and Fine Chemicals”, M. Beller and C. Bolm, eds., Wiley-VCH (1998).
98. G. Schlingloff and K. B. Sharpless, Asymmetric Aminohydroxylation, in ”Asymmetric Oxidation Reactions: A Practical Approach in Chemistry”, T. Katsuki, ed., Oxford University Press (2001).
99. D. Copéret, H. Adolfsson, J. P. Chiang, A. K. Yudin and K. B. Sharpless, A Simple and Efficient Method for the Preparation of Pyridine-N-oxides II, Tetrahedron Lett., 39, 761 (1998).
100. K. L. Reddy and K. B. Sharpless, From Styrenes to Enantiopure a-Arylglycines in Two Steps, J. Am. Chem. Soc., 120, 1207 (1998).
101. A. J. DelMonte, J. Haller, K. N. Houk, K. B. Sharpless, D. A. Singleton, T. Strassner and A. A. Thomas, Experimental and Theoretical Kinetic Isotope Effects for Asymmetric Dihyroxylation. Evidence Supporting a Rate-Limiting ”(3 + 2)” Cycloaddition, J. Am. Chem. Soc., 119, 9907 (1997).
102. K. Yudin and K. B. Sharpless, Bis(trimethylsilyl) Peroxide Extends the Range of Oxorhenium Catalysts for Olefin Expoxidation, J. Am. Chem. Soc., 119, 11536 (1997).
103. A. Erik Rubin and K. B. Sharpless, A Highly Efficient Aminohydroxylation Process, Angew. Chem., 36, 2637 (1997).
104. Copéret, H. Adolfsson and K. B. Sharpless, A Simple and Efficient Method for Epoxidation of Terminal Alkenes, Chem. Comm., 16, 1565 (1997).
105. J. Rudolph, K.L. Reddy, J. P. Chiang and K. B. Sharpless, Highly Efficient Epoxidation of Olefins using Aqueous H2O2 and Catalytic Methyltrioxorhenium/Pyridine: Pyridine-mediated Ligand Acceleration, J. Am. Chem. Soc., 119, 6189 (1997).
106. M. Bruncko, G. Schlingloff and K. B. Sharpless, N-Bromoacetamide – A New Nitrogen Source for the Catalytic Asymmetric Aminohydroxylation, Angew. Chem., 36, 1483 (1997).
107. D.W. Nelson, A. Gypser, P.T. Ho, H.C. Kolb, T. Kondo, H.-L. Kwong, D.V. McGrath, A.E. Rubin, P.-O. Norrby, K.P. Gable and K.B. Sharpless, Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation. 4. Electronic Effects in Amine-Accelerated Osmylations, J. Am. Chem. Soc., 119, 1840 (1997).
108. K.P.M. Vanhessche and K.B. Sharpless, Catalytic Asymmetric Synthesis of New Halogenated Chiral Synthons, Chemistry – A European Journal, 3, 517 (1997).
109. G. Li, H.H. Angert and K.B. Sharpless, N-Halocarbamate Salts Provide a More Useful Catalytic-Asymmetric-Aminohydroxylation Process, Angew. Chem., 35, 2813 (1996).
110. J. Rudolph, P.C. Sennhenn, C.P. Vlaar and K.B. Sharpless, Smaller Substituents on Nitrogen Facilitate the Osmium Catalyzed Asymmetric Aminohydroxylation Process, Angew. Chem., 35, 2810 (1996).
111. K.P.M. Vanhessche and K.B. Sharpless, Ligand-Dependent Reversal of Facial Selectivity in the Asymmetric Dihydroxylation, J. Org. Chem., 61, 7978 (1996).
112. H.-T. Chang and K.B. Sharpless, Molar Scale Synthesis of Enantiopure Stilbene Oxide, J. Org. Chem., 61, 6456 (1996).
113. M. Beller and K.B. Sharpless, Syntheses of Diols by Catalytic Dihydroxylation Reactions, ”Applied Homogeneous Catalysis by Organometallic Complexes”, Boy Cornils and Wolfgang A. Herrmann. Eds.; VCH Publishers, 1996.
114. K.B.Sharpless, M. Beller, B. Blackburn, Y. Kawanami, H.-L. Kwong, Y. Ogino, T. Shibata, T. Ukita and L. Wang, Method For Catalytic Asymmetric Dihydroxylation of Olefins Using Heterocyclic Chiral Ligands, U.S. Patent 5,516,929, 1996 assigned to Massachusetts Institute of Technology.
115. I.E. Marko and K. B. Sharpless, Ligand-Accelerated Catalytic Asymmetric Dihydroxylation, European Patent 0395729, 1996, assigned to Massachusetts Institute of Technology.
116. H.-T. Chang and K.B. Sharpless, A Practical Route to Enantiopure 1,2-Aminoalcohols, Tetrahedron Lett., 37, 3219 (1996).
117. G. Li and K.B. Sharpless, Catalytic Asymmetric Aminohydroxylation Provides a Short Taxol Side-chain Synthesis, Acta Chem. Scand., 50, 649 (1996).
118. M. Bruncko, T.-A.V. Khuong. and K.B. Sharpless, Allylic Amination and 1,2-Diamination via a Modified Diimido Selenium Reagent, Angew. Chem., 35, 454 (1996).
119. G. Li, H.-T. Chang, and K.B. Sharpless, Catalytic Asymmetric Aminohydroxylation of Olefins, Angew. Chem., 35, 451 (1996).
120. H. Becker and K.B. Sharpless, A New Ligand Class for the Asymmetric Dihydroyxlation of Olefins, Angew. Chem., 35, 448 (1996).
121. P.F. Richardson, L.T.J. Nelson, and K.B. Sharpless, Synthesis of Vicinal Diamines from Cyclic Sulfates, Tetrahedron Lett., 36, 9241 (1995).
122. P.-O. Norrby, H. Becker, and K.B. Sharpless, Towards an Understanding of the High Enantioselectivity in the Osmium Catalyzed Asymmetric Dihydroyxlation (AD). Part 3. New Insights into Isomeric Forms of the Putative Osmaoxetane Intermediate, J. Am. Chem. Soc, 118, 35 (1996).
123. H.-T. Chang, C.-T. Chen, T. Kondo, G. Siuzdak, and K.B. Sharpless, Asymmetric Dihydroxylation Enables Rapid Construction of Chiral Dendrimers, Angew. Chem., 35, 182 (1996).
124. U. Hugger and K.B. Sharpless, Asymmetric Dihyroxylation Affords Enantiomerically Pure C12 Building Blocks from trans, trans, cis-1,5,9-Cyclododecatriene, Tetrahedron Lett., 36, 6603 (1995).
125. H. Becker, S.B. King, M. Taniguchi, K.P.M. Vanhessche, and K.B. Sharpless, New Ligands and Improved Enantioselectivities for the Asymmetric Dihydroxylation of Olefins, J. Org. Chem., 60, 3940 (1995).
126. K.B. Sharpless and J.M. Klunder, Optically Active Derivatives of Glycidol, U.S. Patent 5,344,947, 1994 assigned to Massachusetts Institute of Technology.
127. D.J. Berrisford, C. Bolm, and K.B. Sharpless, Ligand Accelerated Catalysis, Angew. Chem., Int. Ed. Engl., 34, 1059 (1995).
128. H. Becker, M.A. Soler, and K.B. Sharpless, Selective Asymmetric Dihydroxylation of Polyenes, Tetrahedron, 51, 1345 (1995).
129. Z.-M. Wang and K.B. Sharpless, A Solid-to-Solid Asymmetric Dihydroxylation Procedure for Kilo-Scale Preparation of Enantiopure Hydrobenzoin, J. Org. Chem., 59, 8302 (1994).
130. Z.-M. Wang, K. Kakiuchi, and K.B. Sharpless, Osmium-Catalyzed Asymmetric Dihydroxylation of Cyclic cis-Disubstituted Olefins, J. Org. Chem., 59, 6895 (1994).
131. H.C. Kolb, M.S. VanNieuwenhze, and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation, Chem. Rev., 94, 2483 (1994).
132. H. Becker, P.T. Ho, H.C. Kolb, S. Loren, P.-O. Norrby, and K.B. Sharpless, Comparing Two Models for the Selectivity in the Asymmetric Dihydroxylation Reaction (AD), Tetrahedron Lett., 35, 7315 (1994).
133. P.-O. Norrby, H.C. Kolb, and K.B. Sharpless, Towards an Understanding of the High Enantioselectivity in the Osmium Catalyzed Asymmetric Dihydroxylation (AD). Part 2. A Qualitative Molecular Mechanics Approach., J. Am. Chem. Soc., 116, 8470 (1994).
134. Y.L. Bennani, K.P.M. Vanhessche, and K.B. Sharpless, A Short Route to a Mosher’s Acid Precursor Via Catalytic Asymmetric Dihydroxylation (AD), Tetrahedron: Asymmetry, 5, 1473 (1994).
135. K.B. Sharpless and Y. Gao, Ruthenium-Catalyzed Production of Cyclic Sulfates, U.S. Patent 5,321,143, 1994 assigned to Massachusetts Institute of Technology.
136. S.B. King and K.B. Sharpless, An Efficient Synthesis of Enantiomerically Pure trans-2-Phenylcyclohexanol, Tetrahedron Lett., 35, 5611 (1994).
137. Z.-M. Wang, H.C. Kolb, and K.B. Sharpless, A Large-Scale and Highly Enantioselective Synthesis of the Taxol C-13 Side Chain Through Asymmetric Dihydroxylation (AD), J. Org. Chem., 59, 5104 (1994).
138. P.J. Walsh, P.T. Ho, S.B. King, and K.B. Sharpless, Asymmetric Dihydroxylation of Olefins Containing Sulfur: Chemoselective Oxidation of C-C Double Bonds in the Presence of Sulfides, 1,3-Dithianes, and Disulfides, Tetrahedron Lett., 35, 5129 (1994).
139. C. Xu and K.B. Sharpless, Synthesis and Stereochemical Assignments for Goniobutenolides A and B, Tetrahedron Lett., 35, 4685 (1994).
140. K. P. M. Vanhessche, Z.-M. Wang, and K. B. Sharpless, Asymmetric Dihydroxylation of Primary Alloylic Halides and a Concise Synthesis of (-)-Diepoxybutane, Tetrahedron Lett., 35, 3469 (1994)
141. D. Xu, C.Y. Park, and K.B. Sharpless, Study of the Regio- and Enantioselectivity of the Reactions of Osmium Tetroxide with Allylic Alcohols and Allylic Sulfonamides, Tetrahedron Lett., 35, 2495 (1994).
142. K.B. Sharpless, Coelacanths and Catalysis, Tetrahedron, 50, 4235 (1994).
143. H.C. Kolb, P.G. Andersson, and K.B. Sharpless, Towards an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). Part 1: Kinetics, J. Am. Chem. Soc., 116, 1278 (1994).
144. M.S. VanNieuwenhze and K.B. Sharpless, The Asymmetric Dihydroxylation of cis-Allylic and Homoallylic Alcohols, Tetrahedron Lett., 35, 843 (1994).
145. I. Henderson, K.B. Sharpless, and C.-H. Wong, Synthesis of Carbohydrates via Tandem Use of the Osmium-Catalyzed Asymmetric Dihydroxylation and Enzyme-Catalyzed Aldol Addition Reactions, J. Am. Chem. Soc., 116, 558 (1994).
146. H.C. Kolb, P.G. Andersson, Y.L. Bennani, G.A. Crispino, K.-S. Jeong, H.-L. Kwong, and K.B. Sharpless, On ”The Origin of High Enantioselectivity in the Dihydroxylation of Olefins Using Osmium Tetroxide and Cinchona Alkaloid Catalysts,” J. Am. Chem. Soc., 115, 12226 (1993).
147. G. Crispino, A. Makita, Z.-M. Wang, and K.B. Sharpless, A Comparison of Ligands Proposed for the Asymmetric Dihydroxylation, Tetrahedron Lett., 35, 543 (1994).
148. P.-O. Norrby, H. Kolb, and K.B. Sharpless, Calculations on the Reaction of Ruthenium Tetroxide with Olefins Using Density Functional Theory (DFT). Implications for the Possibility of Intermediates in the Osmium-catalyzed Asymmetric Dihydroxylation (AD), Organometallics, 13, 344 (1994).
149. Z.-M. Wang and K.B. Sharpless, Asymmetric Dihydroxylation of Tertiary Allylic Alcohols, Tetrahedron Lett., 34, 8225 (1993).
150. R. Oi and K.B. Sharpless, 3-(1S,2-Dihydroxyethyl)-1,5-Dihydro-3H-2,4-Benzodioxepine, Org. Synth., 73, 1 (1995).
151. M. Arrington, Y.L. Bennani, T. Göbel, P. Walsh, S.-H. Zhao, and K.B. Sharpless, Modified Cinchona Alkaloid Ligands: Improved Selectivities in the Osmium Tetroxide Catalyzed Asymmetric Dihydroxylation (AD) of Terminal Olefins, Tetrahedron Lett., 34, 7375 (
152. K. Morikawa and K.B. Sharpless, Double Diastereoselection in Asymmetric Dihydroxylation, Tetrahedron Lett., 34, 5575 (1993).
153. K. Morikawa, J. Park, P.G. Andersson, T. Hashiyama, and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation of Tetrasubstituted Olefins, J. Am. Chem. Soc., 115, 8463 (1993).
154. P.J. Walsh, Y.L. Bennani, and K.B. Sharpless, Asymmetric Dihydroxylation (AD)/Cyclization of N-DiBoc Allylic and Homoallylic Amines: Selective Differentiation of the Hydroxyl Groups, Tetrahedron Lett., 34, 5545 (1993).
155. D.V. McGrath, G.D. Brabson, K.B. Sharpless, and L. Andrews, Reinvestigation of the Infrared Spectra of Oxoosmium (VI) Esters by Isotopic Labeling, Inorg. Chem., 32, 4164 (1993).
156. G.A. Crispino and K.B. Sharpless, Enantioselective Synthesis of Juvenile Hormone III in Three Steps from Methyl Farnesoate, Synthesis, 8, 777 (1993).
157. P.J. Walsh and K.B. Sharpless, Asymmetric Dihydroxylation (AD) of a,b-Unsaturated Ketones, Synlett, 8, 605 (1993).
158. Z.-M. Wang and K.B. Sharpless, Asymmetric Dihydroxylation of a-Substituted Styrene Derivatives, Synlett, 8, 603 (1993).
159. M.S. VanNieuwenhze and K.B. Sharpless, Kinetic Resolution of Racemic Olefins via Asymmetric Dihydroxylation, J. Am. Chem. Soc., 115, 7864 (1993).
160. P.G. Andersson and K.B. Sharpless, A Dramatic Ligand Effect on the Relative Reactivities of Substituted Alkenes with Osmium Tetroxide, J. Am. Chem. Soc., 115, 7047 (1993).
161. T. Göbel and K.B. Sharpless, Temperature Effects in Asymmetric Dihydroxylation: Evidence for a Stepwise Mechanism, Angew. Chem., Int. Ed. Engl., 32, 1329 (1993).
162. G. Crispino, K.-S. Jeong, H. Kolb, Z.-M. Wang, D. Xu, and K.B. Sharpless, Improved Enantioselectivity in Asymmetric Dihydroxylations of Terminal Olefins Using Pyrimidine Ligands, J. Org. Chem., 58, 3785 (1993).
163. S. Okamoto, K. Tani, F. Sato, K.B. Sharpless, and D. Zargarian, Synthesis of Optically Active Secondary Allylic Alcohols from Allylsilanes via Successive Asymmetric Dihydroxylation (AD) and Peterson Olefination Reactions, Tetrahedron Lett., 34, 2509 (1993
164. Z.-M. Wang, X.L. Zhang, and K.B. Sharpless, Asymmetric Dihydroxylation of Aryl Allyl Ethers, Tetrahedron Lett., 34, 2267 (1993).
165. Y.L. Bennani and K.B. Sharpless, Asymmetric Synthesis of g-Hydroxy a,b-Unsaturated Amides via an AD-Elimination Process; Synthesis of (+)-Coriolic Acid, Tetrahedron Lett., 34, 2083 (1993).
166. Y.L. Bennani and K.B. Sharpless, Asymmetric Dihydroxylation (AD) of N,N-Dialkyl and N-Methoxy-N-methyl a,ß-and ß, ?-unsaturated amides, Tetrahedron Lett., 34, 2079 (1993).
167. E. Xu and K.B. Sharpless, A Simple Route to Enantiomerically Enriched Oxazolidin-2-ones, Tetrahedron Lett., 34, 951 (1993).
168. H.C. Kolb, Y.L. Bennani, and K.B. Sharpless, Short and Practical Syntheses of (R)-(–)-Carnitine and (R)-(–)-g-Amino-b-hydroxybutyric Acid (GABOB), Tetrahedron: Asymmetry, 4, 133 (1993).
169. G.A. Crispino and K.B. Sharpless, Enantioselective Synthesis of Both Enantiomers of 7,7-Dimethyl-6,8-dioxabicyclo-[3.2.1]octane via Regioselective Asymmetric Dihydroxylation, Synlett, 1, 47 (1993) .
170. G.A. Crispino, P.T. Ho, and K.B. Sharpless, Selective Perhydroxylation of Squalene: Taming the Arithmetic Demon, Science, 259, 64 (1993).
171. H.C. Kolb and K.B. Sharpless, A Simplified Procedure for the Stereospecific Transformation of 1,2-Diols into Epoxides, Tetrahedron, 48, 10515 (1992).
172. F. Keinan, S.C. Sinha, A. Sinha-Bagchi, Z.-M. Wang, X.L. Zhang, and K.B. Sharpless, Synthesis of All Four Isomers of Disparlure Using Osmium-Catalyzed Asymmetric Dihydroxylation, Tetrahedron Lett., 33, 6411 (1992).
173. Z.-M. Wang, X.L. Zhang, K.B. Sharpless, S.C. Sinha, A. Sinha-Bagchi, and E. Keinan, A General Approach to g-Lactones via Osmium-Catalyzed Asymmetric Dihydroxylation. Synthesis of (–)- and (+)-Muricatacin, Tetrahedron Lett., 33, 6407 (1992).
174. R.A. Johnson and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation, ”Catalytic Asymmetric Synthesis,” Iwao Ojima, Ed.; VCH Publishers (1993).
175. R.A. Johnson and K.B. Sharpless, Catalytic Asymmetric Epoxidation of Allylic Alcohols, ”Catalytic Asymmetric Synthesis,” Iwao Ojima, Ed.; VCH Publishers (1993).
176. W. Amberg, Y.L. Bennani, R.J. Chadha, G.A. Crispino, W.D. Davis, J. Hartung, K.-S. Jeong, Y. Ogino, T. Shibata, and K.B. Sharpless, Syntheses and Crystal Structures of the Cinchona Alkaloid Derivatives used as Ligands in the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins, J. Org. Chem., 58, 844 (1993).
177. T. Hashiyama, K. Morikawa, and K.B. Sharpless, a-Hydroxy Ketones in High Enantiomeric Purity from Asymmetric Dihydroxylation of Enol Ethers, J. Org. Chem., 57, 5067 (1992).
178. E. Xu, G. A. Crispino, and K.B. Sharpless, Selective Asymmetric Dihydroxylation (AD) of Dienes, J. Am. Chem. Soc., 114, 7570 (1992).
179. L. Wang and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation of Cis-Disubstituted Olefins, J. Am. Chem. Soc., 114, 7568 (1992).
180. T. Kalantar and K.B. Sharpless, Transformations of Hydroxy Cyclic Sulfates: Stereospecific Conversion to 2,3,5-Trisubstituted Tetrahydrofurans, Acta Chemica Scandinavica, 47, 307 (1993).
181. F. Crispino and K.B. Sharpless, Asymmetric Dihydroxylation of Squalene, Tetrahedron Lett., 33, 4273 (1992).
182. K.-S. Jeong, P. Sjö, and K.B. Sharpless, Asymmetric Dihydroxylation of Enynes, Tetrahedron Lett., 33, 3833 (1992).
183. K.B. Sharpless, W. Amberg, Y. Bennani, G. Crispino, J. Hartung, K. Jeong, H. Kwong, K. Morikawa, Z.M. Wang, D. Xu, and X.L. Zhang, The Osmium-Catalyzed Asymmetric Dihydroxylation (AD): A New Ligand Class and a Process Improvement, J. Org. Chem., 57, 2768
184. R. Oi and K.B. Sharpless, Asymmetric Dihydroxylation of Acrolein Acetals: Synthesis of Stable Equivalents of Enantiopure Glyceraldehyde and Glycidaldehyde, Tetrahedron Lett., 33, 2095 (1992).
185. B. McKee, T. Kalantar, and K.B. Sharpless, Subtle Effects in the Asymmetric Epoxidation: Dependence of Kinetic Resolution Efficiency on the Monodentate Alkoxide Ligands of the Bystander Titanium Center, J. Org. Chem., 56, 6966 (1991).
186. Y. Ogino, H. Chen, E. Manoury, T. Shibata, M. Beller, D. Lübben, and K.B. Sharpless, A Ligand Structure-Enantioselectivity Relationship for the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins, Tetrahedron Lett., 32, 5761, (1991).
187. R. Oi and K.B. Sharpless, Facile Synthesis of Enantiopure trans-2,3-Diphenyl-1,4-Diazabicyclo[2.2.2.]Octane, Tetrahedron Lett., 32, 4853, (1991).
188. K. B. Sharpless, W. Amberg, M. Beller, H. Chen, J. Hartung, Y. Kawanami, D. Lübben, E. Manoury, Y. Ogino, T. Shibata, and T. Ukita, New Ligands Double the Scope of the Catalytic Asymmetric Dihydroxylation of Olefins., J. Org. Chem., 56, 4585, (1991).
189. Y. Ogino, H. Chen, H.L. Kwong, and K.B. Sharpless, On the Timing of Hydrolysis/Reoxidation in the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins Using Potassium Ferricyanide as the Reoxidant., Tetrahedron Lett., 32, 3965, (1991).
190. K.B. Sharpless, J.M. Klunder, and T.H. Onami, Optically Active Derivatives of Glycidol, U. S. Patent 4,946,974, 1990 assigned to Massachusetts Institute of Technology.
191. K.B. Sharpless and I.E. Markó, Ligand-Accelerated Catalytic Asymmetric Dihydroxylation, U.S. Patent 4,965,364, 1990 assigned to Massachusetts Institute of Technology.
192. McKee, D. Gilheany, and K.B. Sharpless, R,R-1,2-Diphenyl-1,2-ethanediol (stilbene diol)., Org. Synth., 70, 47, (1991).
193. Park, B.M. Kim, and K.B. Sharpless, Catalytic Osmylation of Conjugated Dienes: A One-Pot Stereoselective Synthesis of Polyols., Tetrahedron Lett., 32, 1003, (1991).
194. R. Oi and K.B. Sharpless, Stereospecific Conversion of Chiral 1,2-Cyclic Sulfates to Chiral Imidazolines., Tetrahedron Lett., 32, 999, (1991).
195. P.R. Fleming and K.B. Sharpless, Selective Transformation of threo-2,3-Dihydroxy Esters., J. Org. Chem., 56, 2869, (1991).
196. M.G. Finn and K.B. Sharpless, Mechanism of Asymmetric Epoxidation. 2. Catalyst Structure, J. Am. Chem. Soc., 113, 113, (1991).
197. S.S. Woodard, M.G. Finn, and K. Barry Sharpless, The Mechanism of Asymmetric Epoxidation. 1. Kinetics, J. Am. Chem. Soc., 113, 106, (1991).
198. R.A. Johnson and K.B. Sharpless, Addition Reactions with Formation of Carbon-Oxygen Bonds: (ii) Asymmetric Methods of Epoxidation, ”Comprehensive Organic Synthesis,” Vol. 7, Barry M. Trost, Ed.; Pergamon Press, (1991), pp. 389-436.
199. B.M. Kim and K.B. Sharpless, A Short Route to ß-Lactams: Use of Cyclic Sulfites From Syn-2,3-Dihydroxy Esters, Tetrahedron Lett., 31, 4317, (1990).
200. T. Shibata, D.G. Gilheany, B.K. Blackburn, and K.B. Sharpless, Ligand-Based Improvement of Enantioselectivity in the Catalytic Asymmetric Dihydroxylation of Dialkyl Substituted Olefins, Tetrahedron Lett., 31, 3817, (1990).
201. K.B. Sharpless, R. Hanson, and S.Y. Ko, Catalytic Asymmetric Epoxidation, U.S. Patent 4,900,847, 1990 assigned to the Massachusetts Institute of Technology.
202. B.M. Kim and K.B. Sharpless, Heterogeneous Catalytic Asymmetric Dihydroxylation: Use of a Polymer-Bound Alkaloid, Tetrahedron Lett., 31, 3003, (1990).
203. G. Kwong, C. Sorato, Y. Ogino, H. Chen, and K.B. Sharpless, Preclusion of the ”Second Cycle” in the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins Leads to a Superior Process, Tetrahedron Lett., 31, 2999, (1990).
204. R.M. Pearlstein, B.K. Blackburn, W.M. Davis, and K.B. Sharpless, Structural Characterization of the Pseudoenantiomeric Cis-Dioxo Osmium(VI) Esters of Chiral Diols with Cinchona Alkaloid Ligands, Angew. Chem., Int. Ed. Engl., 29, 639, (1990).
205. M. Hayashi, F. Okamura. T. Toba, N. Oguni, and K.B. Sharpless, Kinetic Resolution of Racemic ß-Hydroxy Amines by Enantioselective N-Oxide Formation, Chem. Lett., 547 (1990).
206. K.B. Sharpless and I.E. Markó, Ligand-Accelerated Catalytic Asymmetric Dihydroxylation using Dihydroquinidine and Dihydroquinidine Esters as Ligands, U.S Patent 4,871,855, 1989 assigned to the Massachusetts Institute of Technology.
207. G.D.H. Dijkstra, R.M. Kellogg, and H. Wynberg; J.S. Svendsen, I. Markó, and K.B. Sharpless, Conformational Study of Cinchona Alkaloids. A Combined NMR, Molecular Mechanics and X-Ray Approach, J. Am. Chem. Soc., 111, 8069 (1989).
208. P.R. Carlier and K.B. Sharpless, Studies on the Mechanism of the Asymmetric Epoxidation: A Ligand Variation Approach, J. Org. Chem., 54, 4016 (1989).
209. C.J. Burns, C.A. Martin, and K.B. Sharpless, Tartrate-Like Ligands in the Asymmetric Epoxidation, J. Org. Chem., 54, 2826 (1989).
210. B.M. Kim and K.B. Sharpless, Cyclic Sulfates Containing Acid-Sensitive Groups and Chemoselective Hydrolysis of Sulfate Esters, Tetrahedron Lett., 30, 655, (l989).
211. B.B. Lohray, T.H. Kalantar, B.M. Kim, C.Y. Park, T. Shibita, J.S.M. Wai, and K.B. Sharpless, Documenting the Scope of the Catalytic Asymmetric Dihydroxylation, Tetrahedron Lett., 30, 2041 (1989).
212. J.S. Svendsen, I. Markó, E.N. Jacobsen, Ch.P. Rao, S. Bott, and K.B. Sharpless, On the Structure of Osmium Tetroxide-Cinchona Alkaloid Complexes, J. Org. Chem., 54, 2263 (1989).
213. B.B. Lohray, Y. Gao, and K.B. Sharpless, One Pot Synthesis of Homochiral Aziridines and Aminoalcohols from Homochiral 1,2-Cyclic Sulfates, Tetrahedron Lett., 30, 2623 (1989).
214. W. Bartmann and K.B. Sharpless, eds., ”Stereochemistry of Organic and Bioorganic Transformations,” VCH Verlagsgesellschaft, Weinheim, 1987.
215. S.Y. Ko, A.W.M. Lee, S.A. Masamune, L.A. Reed, III, K.B. Sharpless, and F.J. Walker, Total Synthesis of the L-Hexoses, Tetrahedron, 46, 245 (1990).
216. J.S.M. Wai, I. Markó, J.S. Svendsen, M.G. Finn, E.N. Jacobsen, and K.B. Sharpless, A Mechanistic Insight Leads to a Greatly Improved Osmium-Catalyzed Asymmetric Dihydroxylation Process, J. Am. Chem. Soc., 111, 1123 (1989).
217. E.N. Jacobsen, I. Markó, M.B. France, J.S. Svendsen, and K.B. Sharpless, Kinetic Role of the Alkaloid Ligands in Asymmetric Catalytic Dihydroxylation, J. Am. Chem. Soc., 111, 737 (1989).
218. J.M. Klunder, T. Onami, and K.B. Sharpless, Arenesulfonate Derivatives of Homochiral Glycidol: Versatile Chiral Building Blocks for Organic Synthesis, J. Org. Chem., 54, 1295 (1989).
219. Y. Gao and K.B. Sharpless, Vicinal Diol Cyclic Sulfates: Like Epoxides Only More Reactive, J. Am. Chem. Soc., 110, 7538 (1988).
220. C. Bolm and K.B. Sharpless, Synthesis of a C3-Symmetric Phospha[2.2.2] Cyclophane, Tetrahedron Lett., 29, 5101 (1988).
221. M. Caron, P.R. Carlier, and K.B. Sharpless, Regioselective Azide Opening of 2,3-Epoxy Alcohols by [Ti(Oi-Pr)2(N3)2]: Synthesis of a-Amino Acids, J. Org. Chem., 53, 5185 (1988).
222. Y. Gao and K.B. Sharpless, Asymmetric Synthesis of Both Enantiomers of Tomoxetine and Fluoxetine. Selective Reduction of 2,3-Epoxycinnamyl Alcohol with Red-Al, J. Org. Chem., 53, 4081 (1988).
223. Y. Gao and K.B. Sharpless, Ti(O-i-Pr)4-Mediated Formation of 2,3-Epithio Alcohols from 2,3-Epoxy Alcohols, J. Org. Chem., 53, 4114 (1988).
224. A. Bolm, W.M. Davis, R.L. Halterman, and K.B. Sharpless, Synthesis and Crystal Structure of a Chiral C3-Symmetric Monophosphine, Angew. Chem., Int. Ed. Engl., 27, 835 (1988).
225. P. Carlier, W.S. Mungall, G. Schröder, and K.B. Sharpless, Enhanced Kinetic Resolution and Enzyme-Like Shape Selectivity, J. Am. Chem. Soc., 110, 2978 (1988).
226. K.B. Sharpless, Catalytic Asymmetric Epoxidation, Janssen Chimica Acta, 6, 3 (1988).
227. E.N. Jacobsen, I. Markó, W.S. Mungall, G. Schröder, and K.B. Sharpless, Asymmetric Dihydroxylation via Ligand-Accelerated Catalysis, J. Am. Chem. Soc., 110, 1968 (1988).
228. J.M. Hawkins and K.B. Sharpless, Asymmetric Epoxidation Models: An Alkyl Hydroperoxide Dependent Change in Mechanism, Tetrahedron Lett., 28, 2825 (1987).
229. J.M. Klunder and K.B. Sharpless, A Convenient Synthesis of Sulfinate Esters from Sulfonyl Chlorides, J. Org. Chem., 52, 2598 (1987).
230. S.F. Pedersen, J.C. Dewan, R.R. Eckman, and K.B. Sharpless, Unexpected Diversity in the Coordination Chemistry of Tartrate Esters with Titanium(IV), J. Am. Chem. Soc., 109, 1279 (1987).
231. A.D. Elbein, T. Szumilo, B.A. Sanford, K.B. Sharpless, and C.E. Adams, Effect of Isomers of Swainsonine on Glycosidase Activity and Glycoprotein Processing, Biochemistry, 26, 2502 (1987).
232. S.Y. Ko, H. Masamune, and K.B. Sharpless, p-Nitrobenzoate Esters of Epoxy Alcohols: Convenient Synthons for Water-Soluble Epoxy Alcohols, J. Org. Chem., 52 , 667 (1987).
233. K.B. Sharpless, Architecturally Interesting Metal Complexes with Thermodynamically Dictated Structures, Chemica Scripta (Sweden), 27, 521 (1987).
234. S.Y. Ko and K.B. Sharpless, In Situ Opening of Epoxy Alcohols: A Convenient Alternative to the Isolation of Unstable Epoxy Alcohols, J. Org. Chem., 51, 5413 (1986).
235. Y. Gao, R.M. Hanson, J.M. Klunder, S.Y. Ko, H. Masamune, and K.B. Sharpless, Catalytic Asymmetric Epoxidation and Kinetic Resolution: Modified Procedures Including In Situ Derivatization, J. Am. Chem. Soc., 109, 5765 (1987).
236. K.S. Kirshenbaum and K.B. Sharpless, Regioselective Nucleophilic Opening of erythro- and threo-2, 3 Epoxy Alcohols, Chem. Lett., 11 (1987).
237. J.M. Klunder, S.Y. Ko, and K.B. Sharpless, Asymmetric Epoxidation of Allyl Alcohol: Efficient Routes to Homochiral b-Adrenergic Blocking Agents, J. Org. Chem., 51, 3710 (1986).
238. K.B. Sharpless and R.A. Johnson, Metal-Mediated Halohydrin Formation, U. S. Patent 4,560,811, 1985, assigned to the Massachusetts Institute of Technology.
239. R.M. Hanson and K.B. Sharpless, Procedure for the Catalytic Asymmetric Epoxidation of Allylic Alcohols in the Presence of Molecular Sieves, J. Org. Chem., 51, 1922 (1986).
240. K.B. Sharpless, The Discovery of the Asymmetric Epoxidation, Chem. Brit., 22, 1 (1986).
241. J.M. Hawkins, J.C. Dewan, and K.B. Sharpless, Dioxomolybdenum(VI)-Substituted 2,6-Pyridinedimethanol Complexes: New Five-Coordinate Species, Inorg. Chem., 25, 1501 (1986).
242. K.B. Sharpless, The Discovery of Titanium-Catalyzed Asymmetric Epoxidation, CHEMTECH, 692 (1985).
243. T. Katsuki and K.B. Sharpless, Method for Asymmetric Epoxidation, U.S. Patent 4,471,130, 1984, assigned to Stanford University.
244. C.H. Behrens and K.B. Sharpless, Selective Transformations of 2,3-Epoxy Alcohols and Related Derivatives. Strategies for Nucleophilic Attack at Carbon-3 or Carbon-2, J. Org. Chem., 50, 5696 (1985).
245. C.H. Behrens, S.Y. Ko, F.J. Walker, and K.B. Sharpless, Selective Transformation of 2,3-Epoxy Alcohols and Related Derivatives. Strategies for Nucleophilic Attack at Carbon-1, J. Org. Chem., 50, 5687 (1985).
246. J.M. Chong and K.B. Sharpless, Regioselective Openings of 2,3-Epoxy Acids with Organocuprates, Tetrahedron Lett., 4683 (1985).
247. S. Miyano, L.D.-L. Lu, S.M. Viti and K.B. Sharpless, Kinetic Resolution of Racemic b-Hydroxyamines by Enantioselective N-Oxide Formation, J. Org. Chem., 50, 4350 (1985).
248. J.M. Chong and K.B. Sharpless, Nucleophilic Opening of 2,3-Epoxy Acids and Amides Mediated by Ti(OiPr)4 . Reliable C-3 Selectivity, J. Org. Chem., 50, 1560 (1985).
249. M. Caron and K.B. Sharpless, Ti(OiPr)4-Mediated Nucleophilic Openings of 2,3-Epoxy Alcohols. A Mild Procedure for Regioselective Ring-Opening, J. Org. Chem., 50, 1557 (1985).
250. M.J. Schweiter and K.B. Sharpless, The Asymmetric Epoxidation of tert-Butyl Substituted Allylic Alcohols, Tetrahedron Lett., 2543 (1985).
251. K.S. Kirshenbaum and K.B. Sharpless, Improved Procedure for the Tungstate-catalyzed Epoxidation of a,b-Unsaturated Acids, J. Org. Chem., 50, 1979 (1985).
252. J.M. Klunder, M. Caron, M. Uchiyama, and K.B. Sharpless, Chlorohydroxylation of Olefins with Peroxides and Titanium Tetrachloride, J. Org. Chem., 50, 912 (1985).
253. M.G. Finn and K.B. Sharpless, On the Mechanism of Asymmetric Epoxidation with Titanium-Tartrate Catalysts, ”Asymmetric Synthesis,” Vol. 5, James D. Morrison, Ed.; Academic Press, Inc., New York, (1985), Chapter 8, pp. 247-308.
254. K.B. Sharpless, A New Strategy For Full Control of Relative Stereochemistry Expands the Role of Asymmetric Synthesis, Chemica Scripta (Sweden), 25, 71 (1985).
255. C.E. Adams, F.J. Walker, and K.B. Sharpless, Enantioselective Synthesis of Swainsonine, A Trihydroxylated Indolizidine Alkaloid, J. Org. Chem., 50, 420 (1985).
256. J.G. Hill, K.B. Sharpless, C.M. Exon, and R. Regenye, Enantioselective Epoxidation of Allylic Alcohols: (2S,3S)-3-Propyloxiranemethanol, Org. Synth., 63, 66 (1984).
257. I.D. Williams, S.F. Pedersen, K.B. Sharpless, and S.J. Lippard, Crystal Structures of Two Titanium Tartrate Asymmetric Epoxidation Catalysts, J. Am. Chem. Soc., 106, 6430 (1984).
258. J.M. Hawkins and K.B. Sharpless, threo-N,N’-Bis (a-methylbenzyl) sulfamide: A Readily Available Chiral Ligand for Asymmetric Lithium Aluminum Hydride Reductions. J. Org. Chem., 49, 3861, (1984).
259. B.E. Rossiter and K.B. Sharpless, Asymmetric Epoxidation of Homoallylic Alcohols. Synthesis of (–)-g-Amino-b-(R)-Hydroxybutyric Acid (GABOB). J. Org. Chem., 49, 3707 (1984).
260. K.B. Sharpless, Discovery of the Titanium-Catalyzed Asymmetric Epoxidation—A Personal Account., Proceedings of the Robert A. Welch Foundation Conferences on Chemical Research XXVII Stereospecificity in Chemistry and Biochemistry, November 7–9, 1983, Houston, TX.
261. L.D.-L. Lu, R.A. Johnson, M.G. Finn, and K.B. Sharpless, Two New Asymmetric Epoxidation Catalysts. Unusual Stoichiometry and Inverse Enantiofacial Selection, J. Org. Chem., 49, 728 (1984).
262. C.H. Behrens and K.B. Sharpless, New Transformations of 2,3-Epoxy Alcohols and Related Derivatives. Easy Routes to Homochiral Substances, Aldrichimica Acta, 16, 4 (1983).
263. K.B. Sharpless, S.S. Woodard and M.G. Finn, On the Mechanism of Titanium-Tartrate Catalyzed Asymmetric Epoxidation, Pure and Appl. Chem., 55, 1823 (1983).
264. S. Miyano, L.D.-L. Lu, S.M. Viti, and K.B. Sharpless, Kinetic Resolution of Racemic b-Hydroxyamines by Enantioselective N-Oxide Formation., J. Org. Chem., 48, 3608 (1983).
265. J.G. Hill, B.E. Rossiter, and K.B. Sharpless, Anhydrous tert-Butyl Hydroperoxide in Toluene. The Preferred Reagent for Applications Requiring Dry TBHP., J. Org. Chem., 48, 3607 (1983).
266. S.Y. Ko, A.W.M. Lee, S. Masamune, L.A. Reed, K.B. Sharpless, and F.J. Walker, Total Synthesis of the L-Hexoses, Science, 220, 949 (1983).
267. L.A. Reed, Y. Ito, S. Masamune, and K.B. Sharpless, Synthesis of Saccharides and Related Polyhydroxylated Natural Products. 4. a-D-and b-D-C-Glycopyranosides (2,6-Dialkyl-Substituted Tetrahydropyrans), J. Am. Chem. Soc., 104, 6468 (1982).
268. K.B. Sharpless, C.H. Behrens, T. Katsuki, A.W.M. Lee, V.S. Martin, M. Takatani, S.M. Viti, F.J. Walker, and S.S. Woodard, Stereo- and Regioselective Openings of Chiral 2,3-Epoxy Alcohols. Versatile Routes to Optically Pure Natural Products and Drugs. Unususal Kinetic Resolutions, <=”” i=””>, 55, 589 (1983).
269. N.C. Gonnella, K. Nakanishi, V.S. Martin, and K.B. Sharpless, General Method for Determining Absolute Configurations of Acyclic Allylic Alcohols, J. Am. Chem. Soc., 104, 3775 (1982).
270. M.A. Warpehoski, B. Chabaud, and K.B. Sharpless, Selenium Dioxide Oxidation of Endocyclic Olefins. Evidence for a Dissociation-Recombination Pathway, J. Org. Chem., 47, 2897 (1982).
271. A.W.M. Lee, V.S. Martin, S. Masamune, K.B. Sharpless, and F.J. Walker, Synthesis of Saccharides and Related Polyhydroxylated Natural Products 3: Efficient Conversion of 2,3-erythro-Aldoses to 2,3-threo-Aldoses, J. Am. Chem. Soc., 104, 3515 (1982).
272. P. Ma, V.S. Martin, S. Masamune, K.B. Sharpless, and S.M. Viti, Synthesis of Saccharides and Related Polyhydroxylated Natural Products 2: Simple Deoxyalditols, J. Org. Chem., 47, 1378 (1982).
273. T. Katsuki, A.W.M. Lee, P. Ma, V.S. Martin, S. Masamune, K.B. Sharpless, D. Tuddenham, and F.J. Walker, Synthesis of Saccharides and Related Polyhydroxylated Natural Products 1: Simple Alditols, J. Org. Chem., 47, 1373 (1982).
274. V.S. Martin, S.S. Woodard, T. Katsuki, Y. Yamada, M. Ikeda, and K.B. Sharpless, Kinetic Resolution of Racemic Allylic Alcohols by Enantioselective Epoxidation. A Route to Substances of Absolute Enantiomeric Purity?, J. Am. Chem. Soc., 103, 6237 (1981).
275. P.H.J. Carlsen, T. Katsuki, V.S. Martin, and K.B. Sharpless, A Greatly Improved Procedure for Ruthenium Tetroxide-Catalyzed Oxidations of Organic Compounds, J. Org. Chem., 46, 3936 (1981).
276. E. Herranz and K.B. Sharpless, Osmium Catalyzed Vicinal Oxyamination of Olefins by N-Chloro-N-Argento-Carbamates: threo-N-(1-Hydroxy-1,2-Diphenyl-2-yl) Ethyl Carbamate, Org. Synth., 61, 93 (1981).
277. D.J. Morgans, K.B. Sharpless, and S.G. Traynor, Epoxy Alcohol Rearrangements: Hydroxyl Mediated Delivery of Lewis Acid Promoters, J. Am. Chem. Soc., 103, 462 (1981).
278. B.E. Rossiter, T. Katsuki, and K.B. Sharpless, Asymmetric Epoxidation Provides Shortest Routes to Four Chiral Epoxy Alcohols which are Key Intermediates in Syntheses of Methymycin, Erythromycin, Leukotriene C-1 and Disparlure, J. Am. Chem. Soc., 103, 464
279. E. Herranz and K.B. Sharpless, Osmium Catalyzed Vicinal Oxyamination of Olefins by Chloramine-T: cis-2-(p-Toluenesulfonamido)-cyclohexanol and 2-Methyl-3-(p-toluenesulfonamido)-2-pentanol, Org. Synth., 61, 85 (1983).
280. T. Katsuki and K.B. Sharpless, The First Practical Method for Asymmetric Epoxidation, J. Am. Chem. Soc., 102, 5974 (1980).
281. S.G. Hentges and K.B. Sharpless, Improved Procedure for the Oxyamination of Olefins with Trioxo(tert-butylimido)osmium(VIII), J. Org. Chem., 45, 2257 (1980).
282. S.G. Hentges and K.B. Sharpless, Asymmetric Induction in the Reaction of Osmium Tetroxide with Olefins, J. Am. Chem. Soc., 102, 4263 (1980).
283. E. Herranz and K.B. Sharpless, Osmium-Catalyzed Vicinal Oxyamination of Olefins by N-Chloro-N-Metallocarbamates, J. Org. Chem., 45, 2710 (1980).
284. M.A. Umbreit and K.B. Sharpless, Deoxygenation of Epoxides with Lower Valent Tungsten Halides: trans-Cyclododecene, Org. Synth., 60, 29 (1981).
285. K.B. Sharpless and T.R. Verhoeven, Metal-Catalyzed, Highly Selective Oxygenations of Olefins and Acetylenes with tert-Butyl Hydroperoxide. Practical Considerations and Mechanisms, Aldrichimica Acta, 12, 63 (1979).
286. B.E. Rossiter, T.R. Verhoeven, and K.B. Sharpless, Stereoselective Epoxidation of Acyclic Allylic Alcohols. A Correction of Our Previous Work, Tetrahedron Lett., 4733 (1979).
287. B. Chabaud and K.B. Sharpless, Oxidation of Acetylenes with tert-Butyl Hydroperoxide Catalyzed by Selenium Dioxide. a,a’-Dioxygenation of Internal Alkynes, J. Org. Chem., 44, 4202 (1979).
288. T. Hori and K.B. Sharpless, Selenium Catalyzed Non-Radical Chlorination of Olefins with N-Chlorosuccinimide, J. Org. Chem., 44, 4204 (1979).
289. T. Hori and K.B. Sharpless, Conversion of Allylic Phenylselenides to the Rearranged Allylic Chlorides by N-Chlorosuccinimide. Mechanism of Selenium Catalyzed Allylic Chlorination of &$946;-Pinene, J. Org. Chem., 44, 4208 (1979).
290. J.-E. Bäckvall, K. Oshima, R.E. Palermo, and K.B. Sharpless, Some Reactions of N-(2-hydroxyalkyl)-p-toluenesulfonamides and N-allyl-p-toluenesulfonamides, J. Org. Chem., 44, 1953 (1979).
291. S. Current and K.B. Sharpless, Carbonyl Participation in the Addition of p-Chlorophenylselenenyl Bromide to (E)-4-Hexenal: A New Route to 2,6-Dideoxyglycosides, Tetrahedron Lett., 5075 (1978).
292. L.S. Liebeskind, K.B. Sharpless, R.D. Wilson, and J.A. Ibers, The First d0 Metallooxaziridines. Amination of Olefins, J. Am. Chem. Soc., 100, 7061 (1978).63.
293. F. Herranz, S.A. Biller, and K.B. Sharpless, Osmium-Catalyzed Vicinal Oxyamination of Olefins by N-Chloro-N-Argentocarbamates, J. Am. Chem. Soc., 100, 3596 (1978).
294. E. Herranz and K.B. Sharpless, Improvements in the Osmium Catalyzed Oxyamination of Olefins by Chloramine-T, J. Org. Chem., 43, 2544 (1978).
295. T. Frejd and K.B. Sharpless, A New Rearrangement of N-Arylhydroxamic Acids Catalyzed by Seleninic Acids and Phenylselenenyl Chloride, Tetrahedron Lett., 2239 (1978).
296. D.W. Patrick, L.K. Truesdale, S.A. Biller, and K.B. Sharpless, Stereospecific Vicinal Oxyamination of Olefins by Alkyl Imido Osmium Compounds, J. Org. Chem., 43, 2628 (1978).
297. K. Akashi, R.E. Palermo, and K.B. Sharpless, A Major Improvement in the Osmium Catalyzed Vicinal Hydroxylation of Olefins by tert-Butyl Hydroperoxide, J. Org. Chem., 43, 2063 (1978).
298. T. Hori and K.B. Sharpless, Synthetic Applications of Arylselenenic and of Arylseleninic Acids. Conversion of Olefins to Allylic Alcohols and to Epoxides, J. Org. Chem., 43, 1689 (1978).
299. S.P. Singer and K.B. Sharpless, Synthesis of d,l-Gabaculine Utilizing Direct Allylic Amination as the Key Step, J. Org. Chem., 43, 1448 (1978).
300. T. Hori, S.P. Singer, and K.B. Sharpless, Allylic Deuteration and Tritiation of Olefins with N-Sulfinylsulfonamides, J. Org. Chem., 43, 1456 (1978).
301. J.-E. Bäckvall, M.W. Young, and K.B. Sharpless, Vicinal Acetoxychlorination of Olefins by Chromyl Chloride in Acetyl Chloride, Tetrahedron Lett., 3523 (1977).
302. M.A. Umbreit and K.B. Sharpless, Allylic Oxidation of Olefins by Catalytic and Stoichiometric Selenium Dioxide with tert-Butyl Hydroperoxide, J. Am. Chem. Soc., 99, 5526 (1977).
303. A.O. Chong, K. Oshima, and K.B. Sharpless, Synthesis of Dioxo(tert-alkylimido)Osmium(VIII) and Oxotris(tert-alkylimido)Osmium(VIII) Complexes. Stereospecific Vicinal Diamination of Olefins, J. Am. Chem. Soc., 99, 3420 (1977).
304. K.B. Sharpless, A.Y. Teranishi, and J.-E. Bäckvall, Chromyl Chloride Oxidations of Olefins. Possible Role of Organometallic Intermediates in the Oxidations of Olefins by Oxotransition Metal Species, J. Am. Chem. Soc., 99, 3120 (1977).
305. A.O. Chong and K.B. Sharpless, On the Mechanism of the Molybdenum and Vanadium Catalyzed Epoxidation of Olefins by Alkyl Hydroperoxides, J. Org. Chem., 42, 1587 (1977).
306. R.C. Michaelson, R.E. Palermo, and K.B. Sharpless, Chiral Hydroxamic Acids as Ligands in the Vanadium Catalyzed Asymmetric Epoxidation of Allylic Alcohols by tert-Butyl Hydroperoxide, J. Am. Chem. Soc., 99, 1990 (1977).
307. K.B. Sharpless and S.P. Singer, 1,2-Diamination of 1,3-Dienes by Imido Selenium Compounds, J. Org. Chem., 41, 2504 (1976).
308. K.B. Sharpless, K. Akashi, and K. Oshima, Ruthenium Catalyzed Oxidation of Alcohols to Aldehydes and Ketones by Amine-N-Oxides, Tetrahedron Lett., 22503 (1976).
309. K.B. Sharpless and K. Akashi, Osmium Catalyzed Vicinal Hydroxylation of Olefins by tert-Butyl Hydroperoxide Under Alkaline Conditions, J. Am. Chem. Soc., 98, 1986 (1976).
310. K.B. Sharpless, A.O. Chong, and K. Oshima, Osmium Catalyzed Oxyamination of Olefins by Chloramine-T, J. Org. Chem., 41, 177 (1976).
311. K.B. Sharpless and T. Hori, Allylic Amination of Olefins and Acetylenes by Imido Sulfur Compounds, J. Org. Chem., 41, 176 (1976).
312. K.B. Sharpless and K.M. Gordon, Selenium Dioxide Oxidation of Ketones and Aldehydes. Evidence for the Intermediacy of b-Ketoseleninic Acids, J. Am. Chem. Soc., 98, 300 (1976).
313. K.B. Sharpless, T. Hori, L.K. Truesdale, and C.O. Dietrich, Allylic Amination of Olefins and Acetylenes by Imido Selenium Compounds, J. Am. Chem. Soc., 98, 269 (1976).
314. K.B. Sharpless and K. Akashi, Oxidation of Alcohols to Aldehydes by Reagents Derived from Chromyl Chloride, J. Am. Chem. Soc., 97, 5927 (1975).
315. K.B. Sharpless, K.M. Gordon, R.F. Lauer, D.W. Patrick, S.P. Singer, and M.W. Young, The Utility of Selenium Reagents in Organic Synthesis, Chemica Scripta (Sweden), Vol. 8A, 9 (1975).
316. J.A. Nelson, S. Kahn, T.A. Spencer, K.B. Sharpless, and R.B. Clayton, Some Aspects of Substrate Specificity in Biological Demethylation at C4 of Steroids, Bioorgan. Chem., 4, 363 (1975).
317. K.B. Sharpless and D.R. Williams, The Reactions of Olefins with Permanganate, Ruthenium Tetroxide, and Osmium Tetroxide; Dependence of Rate on Degree of Substitution, Tetrahedron Lett., 3045 (1975).
318. K.B. Sharpless, A.O. Chong, and J.A. Scott, Rapid Separation of Organic Mixtures by Formation of Metal Complexes, J. Org. Chem., 40, 1252 (1975).
319. K.B. Sharpless, D.W. Patrick, L.K. Truesdale, and S.A. Biller, A New Reaction. Stereospecific Vicinal Oxyamination of Olefins by Alkyl Imido Osmium Compounds, J. Am. Chem. Soc., 97, 2305 (1975).
320. K.B. Sharpless and M.W. Young, Olefin Synthesis. Rate Enhancement of the Elimination of Alkyl Aryl Selenoxides by Electron-Withdrawing Substituents, J. Org. Chem., 40, 947 (1975).
321. H.P. Jensen and K.B. Sharpless, Selenium Dioxide Oxidation of d-Limonene—a Reinvestigation, J. Org. Chem., 40, 264 (1975).
322. H.P. Jensen and K.B. Sharpless, An Improved Procedure for the Direct Oxidation of Olefins to a-Diketones by Potassium Permanganate in Acetic Anhydride, J. Org. Chem., 39, 2314 (1974).
323. K.B. Sharpless and H.P. Jensen, Synthesis of a Novel Pentacoordinate Glyoxime Based Ligand and Preparation of its Chlorocobalt(III) Complex, Inorg. Chem., 13, 2617 (1974)
324. S. Tanaka, H. Yamamoto, H. Nozaki, K.B. Sharpless, R.C. Michaelson, and J.D. Cutting, Stereoselective Epoxidations of Acyclic Allylic Alcohols by Transition Metal-Hydroperoxide Reagents. Synthesis of d,l-C18 Cecropia Juvenile Hormone from Farnesol, J. Am. Chem. Soc., 96, 5254 (1974).
325. K.B. Sharpless and R.F. Lauer, Electrophilic Organoselenium Reagents. A New Route to Allylic Acetates and Ethers, J. Org. Chem., 39, 429 (1974).
326. D. Arigoni, A. Vasella, K.B. Sharpless, and H.P. Jensen, Selenium Dioxide Oxidations of Olefins. Trapping of the Allylic Seleninic Acid Intermediate as a Seleninolactone, J. Am. Chem. Soc., 95, 7917 (1973).
327. K.B. Sharpless, R.F. Lauer, and A.Y. Teranishi, Electrophilic and Nucleophilic Organoselenium Reagents. New Routes to a,b-Unsaturated Carbonyl Compounds, J. Am. Chem. Soc., 95, 6137 (1973).
328. K.B. Sharpless and R.C. Michaelson, High Stereo- and Regioselectivities in the Transition Metal Catalyzed Epoxidations of Olefinic Alcohols by t-Butyl Hydroperoxide, J. Am. Chem. Soc., 95, 6136 (1973).
329. K.B. Sharpless, M.W. Young, and R.F. Lauer, Reactions of Selenoxides. Thermal syn-Elimination and H218O Exchange, Tetrahedron Lett., 1979 (1973).
330. K.B. Sharpless and R.F. Lauer, A Mild Procedure for the Conversion of Epoxides to Allylic Alcohols. The First Organoselenium Reagent, J. Am. Chem. Soc., 95, 2697 (1973).
331. K.B. Sharpless and A.Y. Teranishi, Chromyl Chloride in Acetone. a-Chloro Ketones or Ketones Directly from Olefins, J. Org. Chem., 38, 185 (1973).
332. K.B. Sharpless and R.F. Lauer, Facile Thermal Rearrangements of Allyl Selenides and Diselenides. [1,3] and [2,3] Shifts, J. Org. Chem., 37, 3973 (1972).
333. K.B. Sharpless and R.F. Lauer, Selenium Dioxide Oxidation of Olefins, Evidence for the Intermediacy of Allyl Seleninic Acids, J. Am. Chem. Soc., 94, 7154 (1972).
334. J.M. Townsend and K.B. Sharpless, Mechanism of Decomposition of Sulfonium Betaines to Epoxides, Tetrahedron Lett., 3313 (1972).
335. K.B. Sharpless, M.A. Umbreit, M.T. Nieh, and T.C. Flood, Lower Valent Tungsten Halides. A New Class of Reagents for Deoxygenation of Organic Molecules, J. Am. Chem. Soc., 94, 6538 (1972).
336. K.B. Sharpless and T.C. Flood, Direct Deoxygenation of Vicinal Diols with Tungsten (IV). A New Olefin Synthesis, J. Chem. Soc., Chem. Commun., 370, (1972).
337. K.B. Sharpless, J.M. Townsend, and D.R. Williams, On the Mechanism of Epoxidation of Olefins by Covalent Peroxides of Molybdenum(VI), J. Am. Chem. Soc., 94, 295 (1972).
338. K.B. Sharpless and R.F. Lauer, O. Repic, A.Y. Teranishi, and D.R. Williams, Permanganate in Acetic Anhydride. a-Diketones Directly from Olefins, J. Am. Chem. Soc., 93, 3303 (1971).
339. K.B. Sharpless and T.C. Flood, Oxotransition Metal Oxidants as Mimics for the Action of Mixed-Function Oxygenases. ”NIH Shift” with Chromyl Reagents, J. Am. Chem. Soc., 93, 2316 (1971).
340. K.B. Sharpless, d,l-Malabaricane Diol. The First Cyclic Natural Product Derived from Squalene in a Nonenzymic Process, J. Am. Chem. Soc., 92, 6999 (1970).
341. K.B. Sharpless, Synthesis of erythro-18,19-Dihydroxysqualene 2,3-Oxide and Other Internally Oxidized Squalene Derivatives, J. Chem. Soc., Chem. Commun., 1450 (1970).
342. R. Rahman, K.B. Sharpless, T.A. Spencer, and R.B. Clayton, Removal of the 4,4-Dimethyl Carbons in the Enzymic Conversion of Lanosterol to Cholesterol: Initial Loss of the 4a-Methyl Group, J. Biol. Chem., 245, 2667 (1970).
343. K.B. Sharpless, T.E. Snyder, T.A. Spencer, K.K. Maheshwari, J.A. Nelson, and R.B. Clayton, Biological Demethylation of 4,4-Dimethyl Sterols. Evidence for Enzymic Epimerization of the 4b-Methyl Group Prior to Its Oxidative Removal, J. Am. Chem. Soc., 91, 3
344. R. J. Anderson, R.P. Hanzlik, K.B. Sharpless, and E.E. van Tamelen, Enzymic Transformation of an Acyclic Sesterterpene Terminal Epoxide to a Lanosterol Analog, J. Chem. Soc., Chem. Commun., 53 (1969).
345. E.E. van Tamelen, B. Åkermark, and K.B. Sharpless, Mechanism of the Titanium-Promoted Deoxygenative Coupling of Allyl and Benzyl Alcohols to Hydrocarbons, J. Am. Chem. Soc., 91, 1552 (1969).
346. K.B. Sharpless and E.E. van Tamelen, Terpene Terminal Epoxides. Skeletal Rearrangement Accompanying Bicyclization of Squalene 2,3-Oxide, J. Am. Chem. Soc., 91, 1848 (1969).
347. K.B. Sharpless, T.E. Snyder, T.A. Spencer, K.K. Maheshwari, G. Guhn, and R.B. Clayton, Biological Demethylation of 4,4-Dimethyl Sterols. Initial Removal of the 4a-Methyl Group, J. Am. Chem. Soc., 90, 6874 (1968).
348. K.B. Sharpless, Studies of the Mechanism of Action of 2,3-Oxidosqualene-Lanosterol Cyclase: Featuring Enzymic Cyclization of Modified Squalene Oxides, Ph.D. Dissertation, Stanford University (1968).
349. E.E. van Tamelen, R.P. Hanzlik, K.B. Sharpless, R.B. Clayton, W.J. Richter, and A.L. Burlingame, Enzymic Cyclization of 15-Norsqualene 2,3-Oxide, J. Am. Chem. Soc., 90, 3284 (1968)
350. E.E. van Tamelen, K.B. Sharpless, R.P. Hanzlik, R.B. Clayton, A.L. Burlingame, and, P.C. Wszolek, Enzymic Cyclization of trans, trans, trans-18,19-Dihydrosqualene 2,3-Oxide, J. Am. Chem. Soc., 89, 7150 (1967).
351. K.B. Sharpless, R.P. Hanzlik, and E.E. van Tamelen, A One-Step Synthesis of 1,5-Dienes Involving Reductive Coupling of Allyl Alcohols, J. Am. Chem. Soc., 90, 209 (1968).
352. E.E. van Tamelen, K.B. Sharpless, J.D. Willett, R.B. Clayton, and A.L. Burlingame, Biological Activities of Some Terminally Modified Squalene and Squalene 2,3-Oxide Analogs, J. Am. Chem. Soc., 89, 3920 (1967).
353. J.D. Willett, K.B. Sharpless, K.E. Lord, E.E. van Tamelen, and R.B. Clayton, Squalene-2,3-Oxide, an Intermediate in the Enzymatic Conversion of Squalene to Lanosterol and Cholesterol, J. Biol. Chem., 242, 4182 (1967).
354. E.E. van Tamelen and K.B. Sharpless, Positional Selectivity During Controlled Oxidation of Polyolefins, Tetrahedron Lett., 28, 2655 (1967).
355. T.A. Spencer, M.A. Schwartz, and K.B. Sharpless, Synthesis of Resin Acid Intermediates. 8a,10b-Dimethyl-8-carbomethoxy-D19-octalone-2, J. Org. Chem., 29, 782 (1964).
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