1975 – 1980 U.S.P.H.S. CAREER DEVELOPMENT AWARD
1973 Pharmaceutical Manufacturers Association Foundation Research Award
1975 – 1977 Arthritis Foundation Research Award
1975 First recipient of the George Clark Memorial Arthritis Fund
1976 First recipient of the James Woodrow Waggoner Arthritis Fund
1983 Tulane Medical School – Outstanding Teacher Award
1986 UCLA School of Medicine – Outstanding Teacher Award
1987 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1988 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1989 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1990 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1990 Alpha Omega Alpha – Honorary Member
1991 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1993 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1993 UCLA School of Medicine Award for Excellence in Education
1994 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1995 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1995 Wellcome Visiting Professor – Marshall University School of Medicine
1996 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1997 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1999 AMSA Golden Apple Award (for teaching) – UCLA School of Medicine
1994 ROUSSEL UCLAF PRIZE
1995 CIBA Award for Hypertension Research
1998 Basic Research Prize of the American Heart Association
1998 NOBEL PRIZE in Physiology or Medicine
1999 NATIONAL ACADEMY OF SCIENCES
1999 AMERICAN ACADEMY OF ARTS AND SCIENCES
2001 INSTITUTE OF MEDICINE
2007 AMERICAN PHILOSOPHICAL SOCIETY
2008 CANADIAN MEDAL OF MERIT
Kyoung Ja Kwon; Kyu Suk Cho; Sung Hoon Lee; Jung Nam Kim; So Hyun Joo; Jong Hoon Ryu; Louis J Ignarro; Seol-Heui Han; Chan Young Shin Regulation of tissue plasminogen activator/plasminogen activator inhibitor-1 by hydrocortisone in rat primary astrocytes. Journal of neuroscience research 2011;89(7):1059-69.
Hisako Matsui-Hirai; Toshio Hayashi; Seiji Yamamoto; Koichiro Ina; Morihiko Maeda; Hitoshi Kotani; Akihisa Iguchi; Louis J Ignarro; Yuichi Hattori Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide. The Journal of pharmacology and experimental therapeutics 2011;337(3):591-9.
Claudio Napoli; Antonio Giordano; Amelia Casamassimi; Francesca Pentimalli; Louis J Ignarro; Filomena De Nigris Directed in vivo angiogenesis assay and the study of systemic neoangiogenesis in cancer. International journal of cancer. Journal international du cancer 2011;128(7):1505-8.
Claudio Napoli; Toshio Hayashi; Francesco Cacciatore; Amelia Casamassimi; Costanza Casini; Mohammed Al-Omran; Louis J Ignarro Endothelial progenitor cells as therapeutic agents in the microcirculation: an update. Atherosclerosis 2011;215(1):9-22.
Kyoung Ja Kwon; Jung Nam Kim; Min Kyeong Kim; Jongmin Lee; Louis J Ignarro; Hee-Jin Kim; Chan Young Shin; Seol-Heui Han Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. Journal of pineal research 2011;50(2):110-23.
Ji Woon Kim; Sung Hoon Lee; Hyun Myung Ko; Kyoung Ja Kwon; Kyu Suk Cho; Chang Soon Choi; Jin-Hee Park; Hahn Young Kim; Jongmin Lee; Seol-Heui Han; et al. Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: Essential role of astrocyte-derived plasminogen activator inhibitor-1. Neurochemistry international 2011;58(3):423-33.
David R Meldrum; Joseph C Gambone; Marge A Morris; Louis J Ignarro A multifaceted approach to maximize erectile function and vascular health. Fertility and sterility 2010;94(7):2514-20.
Filomena de Nigris; Valeria Crudele; Alfonso Giovane; Amelia Casamassimi; Antonio Giordano; Hermes J Garban; Francesco Cacciatore; Francesca Pentimalli; Diana C Marquez-Garban; Antonella Petrillo; et al. CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14484-9.
Claudio Napoli; Louis J Ignarro Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. Archives of pharmacal research 2009;32(8):1103-8.
Louis J Ignarro Preface to this special journal issue on nitric oxide chemistry and biology. Archives of pharmacal research 2009;32(8):1099-101.
Ettore Crimi; Louis J Ignarro; Francesco Cacciatore; Claudio Napoli Mechanisms by which exercise training benefits patients with heart failure. Nature reviews. Cardiology 2009;6(4):292-300.
Roberta d’Emmanuele di Villa Bianca; Raffaella Sorrentino; Pasquale Maffia; Vincenzo Mirone; Ciro Imbimbo; Ferdinando Fusco; Raffaele De Palma; Louis J Ignarro; Giuseppe Cirino Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4513-8.
Berish Strauch; Charles Herman; Richard Dabb; Louis J Ignarro; Arthur A Pilla Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery 2009;29(2):135-43.
Claudio Napoli; Giuseppe Bruzzese; Louis J Ignarro; Ettore Crimi; Filomena de Nigris; Sharon Williams-Ignarro; Sabina Libardi; Linda Sommese; Carmela Fiorito; Francesco P Mancini; et al. Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension. American heart journal 2008;156(6):1154.e1-8.
Claudio Napoli; Sharon William-Ignarro; Russell Byrns; Maria Luisa Balestrieri; Ettore Crimi; Bartolomeo Farzati; Francesco P Mancini; Filomena de Nigris; Angelo Matarazzo; Maurizio D’Amora; et al. Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia. Nature clinical practice. Cardiovascular medicine 2008;5(9):571-9.
Louis Ignarro; David Heber; Y Steven Henig; Ezra Bejar Herbalife nutritional products and liver injury revisited. Journal of hepatology 2008;49(2):291-3; author reply 293-4.
Filomena de Nigris; Francesco Paolo Mancini; Maria Luisa Balestrieri; Russell Byrns; Carmela Fiorito; Sharon Williams-Ignarro; Antonio Palagiano; Ettore Crimi; Louis J Ignarro; Claudio Napoli Therapeutic dose of nebivolol, a nitric oxide-releasing beta-blocker, reduces atherosclerosis in cholesterol-fed rabbits. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;19(1):57-63.
Paola Salvatore; Amelia Casamassimi; Linda Sommese; Carmela Fiorito; Alfredo Ciccodicola; Raffaele Rossiello; Bice Avallone; Vincenzo Grimaldi; Valerio Costa; Monica Rienzo; et al. Detrimental effects of Bartonella henselae are counteracted by L-arginine and nitric oxide in human endothelial progenitor cells. Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9427-32.
Liu Hua Wei; Yang Yang; Guoyao Wu; Louis J Ignarro IL-4 and IL-13 upregulate ornithine decarboxylase expression by PI3K and MAP kinase pathways in vascular smooth muscle cells. American journal of physiology. Cell physiology 2008;294(5):C1198-205.
Filomena de Nigris; Raffaele Rossiello; Concetta Schiano; Claudio Arra; Sharon Williams-Ignarro; Antonio Barbieri; Alessandro Lanza; Antonio Balestrieri; Maria Teresa Giuliano; Louis J Ignarro; et al. Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. Cancer research 2008;68(6):1797-808.
Antonio Liguori; Carmela Fiorito; Maria Luisa Balestrieri; Ettore Crimi; Giuseppe Bruzzese; Sharon Williams-Ignarro; Maurizio D’Amora; Linda Sommese; Vincenzo Grimaldi; Pellegrino Biagio Minucci; et al. Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease. European journal of haematology 2008;80(3):258-64.
Louis J Ignarro Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol. Cardiovascular therapeutics 2008;26(2):115-34.
Anna Bratasz; Karuppaiyah Selvendiran; Tomasz Wasowicz; Andrey Bobko; Valery V Khramtsov; Louis J Ignarro; Periannan Kuppusamy NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols. Journal of translational medicine 2008;6():9.
Karuppaiyah Selvendiran; Anna Bratasz; Liyue Tong; Louis J Ignarro; Periannan Kuppusamy NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell cycle (Georgetown, Tex.) 2008;7(1):81-8.
E Crimi; L J Ignarro; C Napoli Microcirculation and oxidative stress. Free radical research 2007;41(12):1364-75.
A Liguori; F P D’Armiento; A Palagiano; M L Balestrieri; S Williams-Ignarro; F de Nigris; L O Lerman; M D’Amora; M Rienzo; C Fiorito; et al. Effect of gestational hypercholesterolaemia on omental vasoreactivity, placental enzyme activity and transplacental passage of normal and oxidised fatty acids. BJOG : an international journal of obstetrics and gynaecology 2007;114(12):1547-56.
Narasimham L Parinandi; Ashish Sharma; Timothy D Eubank; Bruce F Kaufman; Vijay Kumar Kutala; Clay B Marsh; Louis J Ignarro; Periannan Kuppusamy Nitroaspirin (NCX-4016), an NO donor, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells. Antioxidants & redox signaling 2007;9(11):1837-49.
Filomena de Nigris; Maria Luisa Balestrieri; Sharon Williams-Ignarro; Francesco P D’Armiento; Lilach O Lerman; Russell Byrns; Ettore Crimi; Antonio Palagiano; Gennaro Fatigati; Louis J Ignarro; et al. Therapeutic effects of autologous bone marrow cells and metabolic intervention in the ischemic hindlimb of spontaneously hypertensive rats involve reduced cell senescence and CXCR4/Akt/eNOS pathways. Journal of cardiovascular pharmacology 2007;50(4):424-33.
Louis J Ignarro Heart mtNOS, a key mediator of oxidative injury in ischemia/reperfusion. Journal of molecular and cellular cardiology 2007;43(4):409-10.
Filomena de Nigris; Maria Luisa Balestrieri; Sharon Williams-Ignarro; Francesco P D’Armiento; Carmela Fiorito; Louis J Ignarro; Claudio Napoli The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;17(1):50-4.
Claudio Napoli; Ciro Maione; Concetta Schiano; Carmela Fiorito; Louis J Ignarro Bone marrow cell-mediated cardiovascular repair: potential of combined therapies. Trends in molecular medicine 2007;13(7):278-86.
Stefanie M Bode-Böger; Fortunato Scalera; Louis J Ignarro The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio. Pharmacology & therapeutics 2007;114(3):295-306.
Filomena de Nigris; Sharon Williams-Ignarro; Vincenzo Sica; Francesco P D’Armiento; Lilach O Lerman; Russell E Byrns; Giacomo Sica; Carmela Fiorito; Louis J Ignarro; Claudio Napoli Therapeutic effects of concurrent autologous bone marrow cell infusion and metabolic intervention in ischemia-induced angiogenesis in the hypercholesterolemic mouse hindlimb. International journal of cardiology 2007;117(2):238-43.
Claudio Napoli; Louis J Ignarro Polymorphisms in endothelial nitric oxide synthase and carotid artery atherosclerosis. Journal of clinical pathology 2007;60(4):341-4.
Toshio Hayashi; Packiasamy A R Juliet; Asaka Miyazaki; Louis J Ignarro; Akihisa Iguchi High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis. Biochimica et biophysica acta 2007;1772(3):364-72.
Andrew H Baker; Vincenzo Sica; Lorraine M Work; Sharon Williams-Ignarro; Filomena de Nigris; Lilach O Lerman; Amelia Casamassimi; Alessandro Lanza; Concetta Schiano; Monica Rienzo; et al. Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3597-602.
Masako Osawa; Toshio Hayashi; Hideki Nomura; Jun Funami; Asaka Miyazaki; Louis J Ignarro; Akihisa Iguchi Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;16(1):157-63.
Fumio Ohta; Tomo Takagi; Hiroyuki Sato; Louis J Ignarro Low-dose L-arginine administration increases microperfusion of hindlimb muscle without affecting blood pressure in rats. Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1407-11.
Claudio Napoli; William C Stanley; Louis J Ignarro Nutrition and cardiovascular disease: putting a pathogenic framework into focus. Cardiovascular research 2007;73(2):253-6.
Filomena de Nigris; Sharon Williams-Ignarro; Vincenzo Sica; Lilach O Lerman; Francesco P D’Armiento; Russell E Byrns; Amelia Casamassimi; Daniela Carpentiero; Concetta Schiano; Daigo Sumi; et al. Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovascular research 2007;73(2):414-23.
Louis J Ignarro; Maria Luisa Balestrieri; Claudio Napoli Nutrition, physical activity, and cardiovascular disease: an update. Cardiovascular research 2007;73(2):326-40.
Claudio Napoli; Antonio Balestrieri; Louis J Ignarro Therapeutic approaches in vascular repair induced by adult bone marrow cells and circulating progenitor endothelial cells. Current pharmaceutical design 2007;13(31):3245-51.
Vincenzo Sica; Sharon Williams-Ignarro; Filomena de Nigris; Francesco P D’Armiento; Lilach O Lerman; Maria Luisa Balestrieri; Ciro Maione; Antonio Palagiano; Luigi Rossiello; Louis J Ignarro; et al. Autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the diabetic mouse hindlimb. Cell cycle (Georgetown, Tex.) 2006;5(24):2903-8.
Claudio Napoli; Filomena de Nigris; Sharon Williams-Ignarro; Orlando Pignalosa; Vincenzo Sica; Louis J Ignarro Nitric oxide and atherosclerosis: an update. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;15(4):265-79.
Toshio Hayashi; Hisako Matsui-Hirai; Asaka Miyazaki-Akita; Akiko Fukatsu; Jun Funami; Qun-Fang Ding; Sumitra Kamalanathan; Yuichi Hattori; Louis J Ignarro; Akihisa Iguchi Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes. Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):17018-23.
Filomena de Nigris; Sharon Williams-Ignarro; Chiara Botti; Vincenzo Sica; Louis J Ignarro; Claudio Napoli Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;15(3):259-63.
Georgette M Buga; Joy S Frank; Giuliano A Mottino; Michael Hendizadeh; Ashkan Hakhamian; Jan H Tillisch; Srinivasa T Reddy; Mohamad Navab; G M Anantharamaiah; Louis J Ignarro; et al. D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet. Journal of lipid research 2006;47(10):2148-60.
William A Pryor; Kendall N Houk; Christopher S Foote; Jon M Fukuto; Louis J Ignarro; Giuseppe L Squadrito; Kelvin J A Davies Free radical biology and medicine: it’s a gas, man! American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(3):R491-511.
Louis J Ignarro; Russell E Byrns; Daigo Sumi; Filomena de Nigris; Claudio Napoli Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;15(2):93-102.
Larissa V Rodríguez; Zeni Alfonso; Rong Zhang; Joanne Leung; Benjamin Wu; Louis J Ignarro Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12167-72.
M Matteo; E Cicinelli; D Baldini; Y S Cho; L J Ignarro; A Vitarelli; D Boffoli; P Greco Influence of human menopausal gonadotrophin treatment on testicular blood flow and on seminal plasma nitric oxide levels in infertile males. International journal of andrology 2006;29(4):441-5.
Claudio Napoli; Sharon Williams-Ignarro; Filomena de Nigris; Lilach O Lerman; Francesco P D’Armiento; Ettore Crimi; Russell E Byrns; Amelia Casamassimi; Alessandro Lanza; Fernando Gombos; et al. Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice. Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10479-84.
Ettore Crimi; Vincenzo Sica; Arthur S Slutsky; Haibo Zhang; Sharon Williams-Ignarro; Louis J Ignarro; Claudio Napoli Role of oxidative stress in experimental sepsis and multisystem organ dysfunction. Free radical research 2006;40(7):665-72.
Allan J Pantuck; John T Leppert; Nazy Zomorodian; William Aronson; Jenny Hong; R James Barnard; Navindra Seeram; Harley Liker; Hejing Wang; Robert Elashoff; et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(13):4018-26.
Anna Bratasz; Nathan M Weir; Narasimham L Parinandi; Jay L Zweier; Rajagopalan Sridhar; Louis J Ignarro; Periannan Kuppusamy Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin. Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3914-9.
Ettore Crimi; Vincenzo Sica; Sharon Williams-Ignarro; Haibo Zhang; Arthur S Slutsky; Louis J Ignarro; Claudio Napoli The role of oxidative stress in adult critical care. Free radical biology & medicine 2006;40(3):398-406.
Claudio Napoli; Sharon Williams-Ignarro; Filomena de Nigris; Gaetano de Rosa; Lilach O Lerman; Bartolomeo Farzati; Angelo Matarazzo; Giacomo Sica; Chiara Botti; Andrea Fiore; et al. Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb. Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17202-6.
Toshio Hayashi; Packiasamy A R Juliet; Hisako Matsui-Hirai; Asaka Miyazaki; Akiko Fukatsu; Jun Funami; Akihisa Iguchi; Louis J Ignarro l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits. Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13681-6.
Filomena de Nigris; Sharon Williams-Ignarro; Lilach O Lerman; Ettore Crimi; Chiara Botti; Gelsomina Mansueto; Francesco P D’Armiento; Gaetano De Rosa; Vincenzo Sica; Louis J Ignarro; et al. Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress. Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4896-901.
Daigo Sumi; Louis J Ignarro Sp1 transcription factor expression is regulated by estrogen-related receptor alpha1. Biochemical and biophysical research communications 2005;328(1):165-72.
Hermes J Garbán; Diana C Márquez-Garbán; Richard J Pietras; Louis J Ignarro Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: regulation of estrogen-dependent gene transcription. Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2632-6.
Louis J Ignarro; Claudio Napoli Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis. Current diabetes reports 2005;5(1):17-23.
Mariarosaria Bucci; Fiorentina Roviezzo; Inmaculada Posadas; Jun Yu; Luca Parente; William C Sessa; Louis J Ignarro; Giuseppe Cirino Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):904-8.
Louis J Ignarro Nitric oxide. Current topics in medicinal chemistry 2005;5(7):595.
Louis J Ignarro Experimental evidences of nitric oxide-dependent vasodilatory activity of nebivolol, a third-generation beta-blocker. Blood pressure. Supplement 2004;1():2-16.
Angelica P Olcott; Georges Tocco; Jide Tian; Dan Zekzer; Jon Fukuto; Louis Ignarro; Daniel L Kaufman A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection. Diabetes 2004;53(10):2574-80.
Toshio Hayashi; Juliet Arockia Rani P; Akiko Fukatsu; Hisako Matsui-Hirai; Masako Osawa; Asaka Miyazaki; Taku Tsunekawa; Hatsuyo Kano-Hayashi; Akihisa Iguchi; Daigo Sumi; et al. A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits. Atherosclerosis 2004;176(2):255-63.
Packiasamy A R Juliet; Toshio Hayashi; Sumi Daigo; Hisako Matsui-Hirai; Asaka Miyazaki; Akiko Fukatsu; Jun Funami; Akihisa Iguchi; Louis J Ignarro Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells. Biochimica et biophysica acta 2004;1693(3):185-91.
Daigo Sumi; Louis J Ignarro Regulation of inducible nitric oxide synthase expression in advanced glycation end product-stimulated raw 264.7 cells: the role of heme oxygenase-1 and endogenous nitric oxide. Diabetes 2004;53(7):1841-50.
C Napoli; V Sica; F de Nigris; O Pignalosa; M Condorelli; L J Ignarro; A Liguori Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. American heart journal 2004;148(1):e5.
Louis J Ignarro; Claudio Napoli Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis. Current atherosclerosis reports 2004;6(4):281-7.
Claudio Napoli; Sharon Williams-Ignarro; Filomena De Nigris; Lilach O Lerman; Loredana Rossi; Carmen Guarino; Gelsomina Mansueto; Francesco Di Tuoro; Orlando Pignalosa; Gaetano De Rosa; et al. Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8797-802.
Ennio Ongini; Francesco Impagnatiello; Albino Bonazzi; Massimiliano Guzzetta; Mirco Govoni; Angela Monopoli; Piero Del Soldato; Louis J Ignarro Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties. Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8497-502.
Hermes J Garbán; Georgette M Buga; Louis J Ignarro Estrogen receptor-mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation. Journal of cardiovascular pharmacology 2004;43(5):638-44.
Kazuhiko Takeuchi; Hiroshi Watanabe; Quang-Kim Tran; Mariko Ozeki; Daigo Sumi; Toshio Hayashi; Akihisa Iguchi; Louis J Ignarro; Kyoichi Ohashi; Hideharu Hayashi Nitric oxide: inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression. Cardiovascular research 2004;62(1):194-201.
Toshio Hayashi; Daigo Sumi; Packiasamy A R Juliet; Hisako Matsui-Hirai; Yukako Asai-Tanaka; Hatsuyo Kano; Akiko Fukatsu; Taku Tsunekawa; Asaka Miyazaki; Akihisa Iguchi; et al. Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits. Cardiovascular research 2004;61(2):339-51.
Daigo Sumi; Louis J Ignarro Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression. Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14451-6.
Manuel Castellá; Gerald D Buckberg; Saleh Saleh; Zhongtuo Tan; Louis J Ignarro A new role for cardioplegic buffering: should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts? The Journal of thoracic and cardiovascular surgery 2003;126(5):1442-8.
Packiasamy A R Juliet; Toshio Hayashi; Akihisa Iguchi; Louis J Ignarro Concomitant production of nitric oxide and superoxide in human macrophages. Biochemical and biophysical research communications 2003;310(2):367-70.
Filomena de Nigris; Amir Lerman; Louis J Ignarro; Sharon Williams-Ignarro; Vincenzo Sica; Andrew H Baker; Lilach O Lerman; Yong J Geng; Claudio Napoli Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends in molecular medicine 2003;9(8):351-9.
Aaron T Jacobs; Louis J Ignarro Cell density-enhanced expression of inducible nitric oxide synthase in murine macrophages mediated by interferon-beta. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;8(4):222-30.
Daigo Sumi; Toshio Hayashi; Hisako Matsui-Hirai; Aaron T Jacobs; Louis J Ignarro; Akihisa Iguchi 17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells. Biochimica et biophysica acta 2003;1640(2-3):113-8.
Giuseppe Cirino; Raffaella Sorrentino; Roberta d’Emmanuele di Villa Bianca; Ada Popolo; Alessandro Palmieri; Ciro Imbimbo; Ferdinando Fusco; Nicola Longo; Gianfranco Tajana; Louis J Ignarro; et al. Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5531-6.
Aaron T Jacobs; Louis J Ignarro Nuclear factor-kappa B and mitogen-activated protein kinases mediate nitric oxide-enhanced transcriptional expression of interferon-beta. The Journal of biological chemistry 2003;278(10):8018-27.
Bradley S Allen; Jeffrey S Veluz; Gerald D Buckberg; Ernesto Aeberhard; Louis J Ignarro Deep hypothermic circulatory arrest and global reperfusion injury: avoidance by making a pump prime reperfusate–a new concept. The Journal of thoracic and cardiovascular surgery 2003;125(3):625-32.
Scott Chiang; Babak Azizzadeh; Georgette Buga; Lou Ignarro; Thomas Calcaterra; Keith Blackwell Local administration of nitric oxide donor significantly impacts microvascular thrombosis. The Laryngoscope 2003;113(3):406-9.
Filomena de Nigris; Lilach O Lerman; Sharon Williams Ignarro; Giacomo Sica; Amir Lerman; Wulf Palinski; Louis J Ignarro; Claudio Napoli Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress. Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1420-5.
Michael R Davis; Delio P Ortegon; Jeffrey D Kerby; Louis J Ignarro; Vikram S Kashyap Endothelial dysfunction after arterial thrombosis is ameliorated by L-arginine in combination with thrombolysis. Journal of vascular and interventional radiology : JVIR 2003;14(2 Pt 1):233-9.
Claudio Napoli; Louis J Ignarro Nitric oxide-releasing drugs. Annual review of pharmacology and toxicology 2003;43():97-123.
Babak Azizzadeh; Georgette M Buga; Gerald S Berke; Babak Larian; Louis J Ignarro; Keith E Blackwell Inhibitors of nitric oxide promote microvascular thrombosis. Archives of facial plastic surgery : official publication for the American Academy of Facial Plastic and Reconstructive Surgery, Inc. and the International Federation of Facial Plastic Surgery Societies 2003;5(1):31-5.
L J Ignarro Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2002;53(4 Pt 1):503-14.
Manuel Castellá; Gerald D Buckberg; Zhongtuo Tan; Louis J Ignarro Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na/H exchange. The Journal of thoracic and cardiovascular surgery 2002;124(6):1113-21.
Stefano Fiorucci; Elisabetta Antonelli; Eleonora Distrutti; Piero Del Soldato; Roderick J Flower; Mark J Paul Clark; Antonio Morelli; Mauro Perretti; Louis J Ignarro NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15770-5.
Antoni Ribas; Saral N Amarnani; Georgette M Buga; Lisa H Butterfield; Vivian B Dissette; William H McBride; John A Glaspy; Louis J Ignarro; James S Economou Immunosuppressive effects of interleukin-12 coexpression in melanoma antigen gene-modified dendritic cell vaccines. Cancer gene therapy 2002;9(11):875-83.
Claudio Napoli; Lilach O Lerman; Filomena de Nigris; Joseph Loscalzo; Louis J Ignarro Glycoxidized low-density lipoprotein downregulates endothelial nitricoxide synthase in human coronary cells. Journal of the American College of Cardiology 2002;40(8):1515-22.
Louis J Ignarro; Manisha Sisodia; Kim Trinh; Sahar Bedrood; Guoyao Wu; Liu Hua Wei; Georgette M Buga Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;7(2):83-90.
Louis J Ignarro; Russell E Byrns; Kim Trinh; Manisha Sisodia; Georgette M Buga Nebivolol: a selective beta(1)-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;7(2):75-82.
Ettore Cicinelli; Louis J Ignarro; Pietro Galantino; Vincenzo Pinto; Bruno Barba; Sergio Schonauer Effects of tibolone on plasma levels of nitric oxide in postmenopausal women. Fertility and sterility 2002;78(3):464-8.
Louis J Ignarro Wei Lun Visiting Professorial Lecture: Nitric oxide in the regulation of vascular function: an historical overview. Journal of cardiac surgery 2002;17(4):301-6.
Louis J Ignarro After 130 years, the molecular mechanism of action of nitroglycerin is revealed. Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):7816-7.
John L Wallace; Louis J Ignarro; Stefano Fiorucci Potential cardioprotective actions of no-releasing aspirin. Nature reviews. Drug discovery 2002;1(5):375-82.
Claudio Napoli; Giancarlo Aldini; John L Wallace; Filomena de Nigris; Roberto Maffei; Pasquale Abete; Domenico Bonaduce; Gianluigi Condorelli; Franco Rengo; Vincenzo Sica; et al. Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis. Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1689-94.
Louis J Ignarro; Claudio Napoli; Joseph Loscalzo Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview. Circulation research 2002;90(1):21-8.
A T Jacobs; L J Ignarro Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. The Journal of biological chemistry 2001;276(51):47950-7.
B Azizzadeh; H T Yip; K E Blackwell; S Horvath; T C Calcaterra; G M Buga; L J Ignarro; M B Wang Nitric oxide improves cisplatin cytotoxicity in head and neck squamous cell carcinoma. The Laryngoscope 2001;111(11 Pt 1):1896-900.
P M Bauer; G M Buga; L J Ignarro Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide. Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12802-7.
P M Bauer; G M Buga; J M Fukuto; A E Pegg; L J Ignarro Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. The Journal of biological chemistry 2001;276(37):34458-64.
V S Kashyap; T D Reil; W S Moore; T X Hoang; H A Gelabert; R E Byrns; L J Ignarro; J A Freischlag Acute arterial thrombosis causes endothelial dysfunction: a new paradigm for thrombolytic therapy. Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2001;34(2):323-9.
L H Wei; G Wu; S M Morris; L J Ignarro Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9260-4.
L Ma; S N Elliott; G Cirino; A Buret; L J Ignarro; J L Wallace Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6470-5.
C Napoli; L J Ignarro Nitric oxide and atherosclerosis. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2001;5(2):88-97.
L J Ignarro; G M Buga; L H Wei; P M Bauer; G Wu; P del Soldato Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4202-8.
C Napoli; G Cirino; P Del Soldato; R Sorrentino; V Sica; M Condorelli; A Pinto; L J Ignarro Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2860-4.
S Fiorucci; A Mencarelli; B Palazzetti; P Del Soldato; A Morelli; L J Ignarro An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity. Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2652-7.
M Jayachandran; T Hayashi; D Sumi; N K Thakur; H Kano; L J Ignarro; A Iguchi Up-regulation of endothelial nitric oxide synthase through beta(2)-adrenergic receptor–the role of a beta-blocker with NO-releasing action. Biochemical and biophysical research communications 2001;280(3):589-94.
S Shah; A Hobbs; R Singh; J Cuevas; L J Ignarro; G Chaudhuri Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves. American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1478-85.
L J Ignarro The unique role of nitric oxide as a signaling molecule in the cardiovascular system. Italian heart journal : official journal of the Italian Federation of Cardiology 2000;1 Suppl 3():S28-9.
T J Bivalacqua; H C Champion; Y S Mehta; A B Abdel-Mageed; S C Sikka; L J Ignarro; P J Kadowitz; W J Hellstrom Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat. International journal of impotence research 2000;12 Suppl 3():S8-17.
L H Wei; A T Jacobs; S M Morris; L J Ignarro IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells. American journal of physiology. Cell physiology 2000;279(1):C248-56.
C Napoli; C Cicala; J L Wallace; F de Nigris; V Santagada; G Caliendo; F Franconi; L J Ignarro; G Cirino Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3678-83.
L H Wei; S M Morris; S D Cederbaum; M Mori; L J Ignarro Induction of arginase II in human Caco-2 tumor cells by cyclic AMP. Archives of biochemistry and biophysics 2000;374(2):255-60.
J Honold; N L Pusser; L Nathan; G Chaudhuri; L J Ignarro; M P Sherman Production and excretion of nitrate by human newborn infants: neonates are not little adults. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2000;4(1):35-46.
L J Ignarro; G Cirino; A Casini; C Napoli Nitric oxide as a signaling molecule in the vascular system: an overview. Journal of cardiovascular pharmacology 1999;34(6):879-86.
H C Champion; T J Bivalacqua; A L Hyman; L J Ignarro; W J Hellstrom; P J Kadowitz Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11648-52.
E Cicinelli; L J Ignarro; L M Schonauer; M G Matteo; P Galantino; N Falco Different plasma levels of nitric oxide in arterial and venous blood. Clinical physiology (Oxford, England) 1999;19(5):440-2.
P M Bauer; J M Fukuto; G M Buga; A E Pegg; L J Ignarro Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation. Biochemical and biophysical research communications 1999;262(2):355-8.
L J Ignarro Nitric oxide: a unique endogenous signaling molecule in vascular biology. Bioscience reports 1999;19(2):51-71.
E Cicinelli; L J Ignarro; M G Matteo; P Galantino; L M Schonauer; N Falco Effects of estrogen replacement therapy on plasma levels of nitric oxide in postmenopausal women. American journal of obstetrics and gynecology 1999;180(2 Pt 1):334-9.
S X Ma; L J Ignarro; R Byrns; X Y Li Increased nitric oxide concentrations in posterior hypothalamus and central sympathetic function on nitrate tolerance following subcutaneous nitroglycerin. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1999;3(2):153-61.
B Gaston; E Fry; S Sears; W M Heroman; L Ignarro; J S Stamler Umbilical arterial S-nitrosothiols in stressed newborns: role in perinatal circulatory transition. Biochemical and biophysical research communications 1998;253(3):899-901.
G M Buga; L H Wei; P M Bauer; J M Fukuto; L J Ignarro NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. The American journal of physiology 1998;275(4 Pt 2):R1256-64.
M Ding; M Zhang; J L Wong; N E Rogers; L J Ignarro; R R Voskuhl Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2560-4.
L H Wei; N Arabolos; L J Ignarro Certain S-substituted isothioureas not only inhibit NO synthase catalytic activity but also decrease translation and stability of inducible NO synthase protein. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1998;2(3):155-64.
E Cicinelli; L J Ignarro; L M Schönauer; M G Matteo; P Galantino; G Balzano Effects of short-term transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women. Fertility and sterility 1998;69(1):58-61.
S Nene; H Gelabert; W Moore; W Quinones-Baldrich; A Santibanez-Gallerani; L Ignarro Cigarette smoking increases endothelial-derived vasorelaxation in the rat carotid artery in a dose-dependent manner. The Journal of surgical research 1997;71(2):101-6.
M Ding; J L Wong; N E Rogers; L J Ignarro; R R Voskuhl Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis. Journal of neuroimmunology 1997;77(1):99-106.
J E Merrill; S P Murphy; B Mitrovic; A Mackenzie-Graham; J C Dopp; M Ding; J Griscavage; L J Ignarro; C J Lowenstein Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes. Journal of neuroscience research 1997;48(4):372-84.
M Ding; B A St Pierre; J F Parkinson; P Medberry; J L Wong; N E Rogers; L J Ignarro; J E Merrill Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis. The Journal of biological chemistry 1997;272(17):11327-35.
R Singh; S Pervin; N E Rogers; L J Ignarro; G Chaudhuri Evidence for the presence of an unusual nitric oxide- and citrulline-producing enzyme in rat kidney. Biochemical and biophysical research communications 1997;232(3):672-7.
K Ihnken; K Morita; G D Buckberg; B Winkelmann; M Schmitt; L J Ignarro; M P Sherman Nitric-oxide-induced reoxygenation injury in the cyanotic immature heart is prevented by controlling oxygen content during initial reoxygenation. Angiology 1997;48(3):189-202.
A Mizuno; R Baretti; G D Buckberg; H H Young; J Vinten-Johansen; X L Ma; L J Ignarro Endothelial stunning and myocyte recovery after reperfusion of jeopardized muscle: a role of L-arginine blood cardioplegia. The Journal of thoracic and cardiovascular surgery 1997;113(2):379-89.
R E Glasgow; G M Buga; L J Ignarro; G Chaudhuri; M A Heymann Endothelium-derived relaxing factor as a mediator of bradykinin-induced perinatal pulmonary vasodilatation in fetal sheep. Reproduction, fertility, and development 1997;9(2):213-6.
E Cicinelli; L J Ignarro; M Lograno; G Matteo; N Falco; L M Schonauer Acute effects of transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women. Fertility and sterility 1997;67(1):63-6.
E Cicinelli; L J Ignarro; M Lograno; P Galantino; G Balzano; L M Schonauer Circulating levels of nitric oxide in fertile women in relation to the menstrual cycle. Fertility and sterility 1996;66(6):1036-8.
G M Buga; R Singh; S Pervin; N E Rogers; D A Schmitz; C P Jenkinson; S D Cederbaum; L J Ignarro Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. The American journal of physiology 1996;271(5 Pt 2):H1988-98.
A Atiya; G Cohen; L Ignarro; F C Brunicardi Nitric oxide regulates insulin secretion in the isolated perfused human pancreas via a cholinergic mechanism. Surgery 1996;120(2):322-7.
G A Cohen; A J Hobbs; R M Fitch; M J Zinner; G Chaudhuri; L J Ignarro Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo. The American journal of physiology 1996;271(1 Pt 2):H133-9.
J Lee; D C Drinkwater; H Laks; A Chong; A Blitz; M A Chen; L J Ignarro; P Chang Preservation of endothelium-dependent vasodilation with low-potassium University of Wisconsin solution. The Journal of thoracic and cardiovascular surgery 1996;112(1):103-10.
K Morita; K Ihnken; G D Buckberg; L J Ignarro Oxidative insult associated with hyperoxic cardiopulmonary bypass in the infantile heart and lung. Japanese circulation journal 1996;60(6):355-63.
L J Ignarro Physiology and pathophysiology of nitric oxide. Kidney international. Supplement 1996;55():S2-5.
K Morita; K Ihnken; G D Buckberg; M P Sherman; L J Ignarro Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass. The Annals of thoracic surgery 1996;61(6):1775-80.
J M Griscavage; S Wilk; L J Ignarro Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B. Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3308-12.
H Sheng; L J Ignarro Biochemical and immunohistochemical characterization of nitric oxide synthase in the rat retina. Pharmacological research : the official journal of the Italian Pharmacological Society 1996;33(1):29-34.
A J Hobbs; L J Ignarro Nitric oxide-cyclic GMP signal transduction system. Methods in enzymology 1996;269():134-48.
J Hunt; R E Byrns; L J Ignarro; B Gaston Condensed expirate nitrite as a home marker for acute asthma. Lancet 1995;346(8984):1235-6.
T Hayashi; J M Fukuto; L J Ignarro; G Chaudhuri Gender differences in atherosclerosis: possible role of nitric oxide. Journal of cardiovascular pharmacology 1995;26(5):792-802.
J M Griscavage; S Wilk; L J Ignarro Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene. Biochemical and biophysical research communications 1995;215(2):721-9.
W Radziszewski; M Chopra; A Zembowicz; R Gryglewski; L J Ignarro; G Chaudhuri Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. International journal of cardiology 1995;51(3):211-20.
K Ihnken; K Morita; G D Buckberg; M P Sherman; L J Ignarro; H H Young Studies of hypoxemic/reoxygenation injury: with aortic clamping. XIII. Interaction between oxygen tension and cardioplegic composition in limiting nitric oxide production and oxidant damage. The Journal of thoracic and cardiovascular surgery 1995;110(4 Pt 2):1274-86.
K Morita; M P Sherman; G D Buckberg; K Ihnken; G Matheis; H H Young; L J Ignarro Studies of hypoxemic/reoxygenation injury: without aortic clamping. V. Role of the L-arginine-nitric oxide pathway: the nitric oxide paradox. The Journal of thoracic and cardiovascular surgery 1995;110(4 Pt 2):1200-11.
H M Abu-Soud; J Wang; D L Rousseau; J M Fukuto; L J Ignarro; D J Stuehr Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis. The Journal of biological chemistry 1995;270(39):22997-3006.
W W Wang; C P Jenkinson; J M Griscavage; R M Kern; N S Arabolos; R E Byrns; S D Cederbaum; L J Ignarro Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide. Biochemical and biophysical research communications 1995;210(3):1009-16.
A G Patel; M T Toyama; T N Nguyen; G A Cohen; L J Ignarro; H A Reber; S W Ashley Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats. Gastroenterology 1995;108(4):1215-20.
E E Aeberhard; S A Henderson; N S Arabolos; J M Griscavage; F E Castro; C T Barrett; L J Ignarro Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene. Biochemical and biophysical research communications 1995;208(3):1053-9.
B Mitrovic; L J Ignarro; H V Vinters; M A Akers; I Schmid; C Uittenbogaart; J E Merrill Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes. Neuroscience 1995;65(2):531-9.
J Hyun; Y Komori; G Chaudhuri; L J Ignarro; J M Fukuto The protective effect of tetrahydrobiopterin on the nitric oxide-mediated inhibition of purified nitric oxide synthase. Biochemical and biophysical research communications 1995;206(1):380-6.
J M Griscavage; A J Hobbs; L J Ignarro Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds. Advances in pharmacology (San Diego, Calif.) 1995;34():215-34.
K Ihnken; K Morita; G D Buckberg; L J Ignarro; F Beyersdorf Reduction of reoxygenation injury and nitric oxide production in the cyanotic immature heart by controlling pO2. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1995;9(8):410-8.
A J Hobbs; J M Fukuto; L J Ignarro Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10992-6.
G J Chang; P Woo; H M Honda; L J Ignarro; L Young; J A Berliner; L L Demer Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen. Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(11):1808-14.
S A Henderson; P H Lee; E E Aeberhard; J W Adams; L J Ignarro; W J Murphy; M P Sherman Nitric oxide reduces early growth response-1 gene expression in rat lung macrophages treated with interferon-gamma and lipopolysaccharide. The Journal of biological chemistry 1994;269(41):25239-42.
J M Griscavage; J M Fukuto; Y Komori; L J Ignarro Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide. The Journal of biological chemistry 1994;269(34):21644-9.
B Mitrovic; L J Ignarro; S Montestruque; A Smoll; J E Merrill Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro. Neuroscience 1994;61(3):575-85.
B S Slusher; A E Zacco; J A Maslanski; T E Norris; M W McLane; W C Moore; N E Rogers; L J Ignarro The cloned neurotensin receptor mediates cyclic GMP formation when coexpressed with nitric oxide synthase cDNA. Molecular pharmacology 1994;46(1):115-21.
K Morita; K Ihnken; G D Buckberg; M P Sherman; H H Young; L J Ignarro Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts. The Journal of clinical investigation 1994;93(6):2658-66.
J M Pearl; H Laks; D C Drinkwater; T J Sorensen; P Chang; A S Aharon; R E Byrns; L J Ignarro Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution. The Journal of thoracic and cardiovascular surgery 1994;107(1):257-64.
L J Ignarro Regulation of cytosolic guanylyl cyclase by porphyrins and metalloporphyrins. Advances in pharmacology (San Diego, Calif.) 1994;26():35-65.
B Mitrovic; F C Martin; A C Charles; L J Ignarro; P A Anton; F Shanahan; J E Merrill Neurotransmitters and cytokines in CNS pathology. Progress in brain research 1994;103():319-30.
G Chaudhuri; J Cuevas; G M Buga; L J Ignarro NO is more important than PGI2 in maintaining low vascular tone in feto-placental vessels. The American journal of physiology 1993;265(6 Pt 2):H2036-43.
J M Griscavage; N E Rogers; M P Sherman; L J Ignarro Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6329-37.
E Z Moriel; N Gonzalez-Cadavid; L J Ignarro; R Byrns; J Rajfer Levels of nitric oxide metabolites do not increase during penile erection. Urology 1993;42(5):551-3.
G M Buga; J M Griscavage; N E Rogers; L J Ignarro Negative feedback regulation of endothelial cell function by nitric oxide. Circulation research 1993;73(5):808-12.
J M Fukuto; A J Hobbs; L J Ignarro Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO. Biochemical and biophysical research communications 1993;196(2):707-13.
L J Ignarro; J M Fukuto; J M Griscavage; N E Rogers; R E Byrns Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8103-7.
J E Merrill; L J Ignarro; M P Sherman; J Melinek; T E Lane Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):2132-41.
M B Gilliam; M P Sherman; J M Griscavage; L J Ignarro A spectrophotometric assay for nitrate using NADPH oxidation by Aspergillus nitrate reductase. Analytical biochemistry 1993;212(2):359-65.
L J Ignarro Nitric oxide-mediated vasorelaxation. Thrombosis and haemostasis 1993;70(1):148-51.
D B McNamara; B Bedi; H Aurora; L Tena; L J Ignarro; P J Kadowitz; D L Akers L-arginine inhibits balloon catheter-induced intimal hyperplasia. Biochemical and biophysical research communications 1993;193(1):291-6.
T J McMahon; L J Ignarro; P J Kadowitz Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed. Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(4):1704-11.
M P Sherman; E E Aeberhard; V Z Wong; J M Griscavage; L J Ignarro Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochemical and biophysical research communications 1993;191(3):1301-8.
F Trigo-Rocha; W J Aronson; M Hohenfellner; L J Ignarro; J Rajfer; T F Lue Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. The American journal of physiology 1993;264(2 Pt 2):H419-22.
R W Day; T S Klitzner; L J Ignarro Endothelium-dependent relaxation and the acute pulmonary vascular response to alveolar hyperoxia in neonatal pigs. Biology of the neonate 1993;63(6):389-96.
A F Varela; A Runge; L J Ignarro; G Chaudhuri Nitric oxide and prostacyclin inhibit fetal platelet aggregation: a response similar to that observed in adults. American journal of obstetrics and gynecology 1992;167(6):1599-604.
T Hayashi; J M Fukuto; L J Ignarro; G Chaudhuri Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11259-63.
N E Rogers; L J Ignarro Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. Biochemical and biophysical research communications 1992;189(1):242-9.
M P Sherman; J M Griscavage; L J Ignarro Nitric oxide-mediated neuronal injury in multiple sclerosis. Medical hypotheses 1992;39(2):143-6.
P A Bush; N E Gonzalez; L J Ignarro Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochemical and biophysical research communications 1992;186(1):308-14.
P A Bush; N E Gonzalez; J M Griscavage; L J Ignarro Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. Biochemical and biophysical research communications 1992;185(3):960-6.
P A Bush; W J Aronson; G M Buga; J Rajfer; L J Ignarro Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. The Journal of urology 1992;147(6):1650-5.
L J Ignarro Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism. Biochemical Society transactions 1992;20(2):465-9.
G M Buga; L J Ignarro Electrical field stimulation causes endothelium-dependent and nitric oxide-mediated relaxation of pulmonary artery. The American journal of physiology 1992;262(4 Pt 2):H973-9.
G Matheis; M P Sherman; G D Buckberg; D M Haybron; H H Young; L J Ignarro Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. The American journal of physiology 1992;262(2 Pt 2):H616-20.
J Rajfer; W J Aronson; P A Bush; F J Dorey; L J Ignarro Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. The New England journal of medicine 1992;326(2):90-4.
L J Ignarro Mechanism of action of nitric oxide: heme-dependent activation of guanylate cyclase represents a unifying signal transduction mechanism. Japanese journal of pharmacology 1992;58 Suppl 2():207P-212P.
R W Day; W W Lai; T S Klitzner; L J Ignarro Oxygen-mediated regulation of neonatal and adult rabbit aortic tension. Developmental pharmacology and therapeutics 1992;19(2-3):90-8.
H M Vargas; J M Cuevas; L J Ignarro; G Chaudhuri Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release. The Journal of pharmacology and experimental therapeutics 1991;257(3):1208-15.
G Ross; G Chaudhuri; L J Ignarro; K Y Chyu Acetylcholine vasodilation of resistance vessels in vivo may not entirely depend on newly synthesized nitric oxide. European journal of pharmacology 1991;195(2):291-3.
L J Ignarro Signal transduction mechanisms involving nitric oxide. Biochemical pharmacology 1991;41(4):485-90.
G Chaudhuri; M A Heymann; L J Ignarro; L D Longo; D McNellis; M D Mitchell; P M Vanhoutte Research recommendations and conclusions from the National Institutes of Child Health and Human Development Conference on Endothelium-Derived Vasoactive Substances in Perinatal Research. Seminars in perinatology 1991;15(1):2-3.
G M Buga; M E Gold; J M Fukuto; L J Ignarro Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension 1991;17(2):187-93.
G Chaudhuri; G M Buga; M E Gold; K S Wood; L J Ignarro Characterization and actions of human umbilical endothelium derived relaxing factor. British journal of pharmacology 1991;102(2):331-6.
L J Ignarro Physiological significance of endogenous nitric oxide. Seminars in perinatology 1991;15(1):20-6.
L J Ignarro; G Ross; J Tillisch Pharmacology of endothelium-derived nitric oxide and nitrovasodilators. The Western journal of medicine 1991;154(1):51-62.
L J Ignarro Heme-dependent activation of guanylate cyclase by nitric oxide: a novel signal transduction mechanism. Blood vessels 1991;28(1-3):67-73.
M E Gold; K S Wood; R E Byrns; G M Buga; L J Ignarro L-arginine-dependent vascular smooth muscle relaxation and cGMP formation. The American journal of physiology 1990;259(6 Pt 2):H1813-21.
H M Vargas; L J Ignarro; G Chaudhuri Physiological release of nitric oxide is dependent on the level of vascular tone. European journal of pharmacology 1990;190(3):393-7.
L J Ignarro Nitric oxide. A novel signal transduction mechanism for transcellular communication. Hypertension 1990;16(5):477-83.
L J Ignarro; P A Bush; G M Buga; J Rajfer Neurotransmitter identity doubt. Nature 1990;347(6289):131-2.
W J Pearce; A M Reynier-Rebuffel; J Lee; P Aubineau; L Ignarro; J Seylaz Effects of methylene blue on hypoxic cerebral vasodilatation in the rabbit. The Journal of pharmacology and experimental therapeutics 1990;254(2):616-25.
L J Ignarro; P A Bush; G M Buga; K S Wood; J M Fukuto; J Rajfer Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochemical and biophysical research communications 1990;170(2):843-50.
K S Wood; G M Buga; R E Byrns; L J Ignarro Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide. Biochemical and biophysical research communications 1990;170(1):80-8.
L J Ignarro Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: a unique transduction mechanism for transcellular signaling. Pharmacology & toxicology 1990;67(1):1-7.
M E Gold; K S Wood; R E Byrns; J Fukuto; L J Ignarro NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein. Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4430-4.
J M Fukuto; K S Wood; R E Byrns; L J Ignarro NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation. Biochemical and biophysical research communications 1990;168(2):458-65.
M E Gold; G M Buga; K S Wood; R E Byrns; G Chaudhuri; L J Ignarro Antagonistic modulatory roles of magnesium and calcium on release of endothelium-derived relaxing factor and smooth muscle tone. Circulation research 1990;66(2):355-66.
L J Ignarro Biosynthesis and metabolism of endothelium-derived nitric oxide. Annual review of pharmacology and toxicology 1990;30():535-60.
M E Gold; P A Bush; L J Ignarro Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. Biochemical and biophysical research communications 1989;164(2):714-21.
L J Ignarro Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters. Pharmaceutical research 1989;6(8):651-9.
L J Ignarro Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circulation research 1989;65(1):1-21.
M E Gold; K S Wood; G M Buga; R E Byrns; L J Ignarro L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation. Biochemical and biophysical research communications 1989;161(2):536-43.
G M Buga; M E Gold; K S Wood; G Chaudhuri; L J Ignarro Endothelium-derived nitric oxide relaxes nonvascular smooth muscle. European journal of pharmacology 1989;161(1):61-72.
L J Ignarro; M E Gold; G M Buga; R E Byrns; K S Wood; G Chaudhuri; G Frank Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein. Circulation research 1989;64(2):315-29.
L J Ignarro Endothelium-derived nitric oxide: actions and properties. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(1):31-6.
L J Ignarro Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins. Seminars in hematology 1989;26(1):63-76.
L J Ignarro; G M Buga; R E Byrns; K S Wood; G Chaudhuri Endothelium-derived relaxing factor and nitric oxide possess identical pharmacologic properties as relaxants of bovine arterial and venous smooth muscle. The Journal of pharmacology and experimental therapeutics 1988;246(1):218-26.
L J Ignarro; G M Buga; G Chaudhuri EDRF generation and release from perfused bovine pulmonary artery and vein. European journal of pharmacology 1988;149(1-2):79-88.
S Ashwal; W J Pearce; L J Ignarro Hypoxia increases cGMP and decreases calcium uptake in rabbit cranial arteries. Proceedings of the Western Pharmacology Society 1988;31():125-8.
L J Ignarro; R E Byrns; G M Buga; K S Wood; G Chaudhuri Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation. The Journal of pharmacology and experimental therapeutics 1988;244(1):181-9.
L J Ignarro Contributions to a quest. Nature 1987;330(6148):526.
L J Ignarro; R E Byrns; G M Buga; K S Wood Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circulation research 1987;61(6):866-79.
L J Ignarro; G M Buga; K S Wood; R E Byrns; G Chaudhuri Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9265-9.
L J Ignarro; R E Byrns; G M Buga; K S Wood Mechanisms of endothelium-dependent vascular smooth muscle relaxation elicited by bradykinin and VIP. The American journal of physiology 1987;253(5 Pt 2):H1074-82.
L J Ignarro; K S Wood Activation of purified soluble guanylate cyclase by arachidonic acid requires absence of enzyme-bound heme. Biochimica et biophysica acta 1987;928(2):160-70.
K S Wood; L J Ignarro Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase. The Journal of biological chemistry 1987;262(11):5020-7.
L J Ignarro; R E Byrns; K S Wood Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein. Circulation research 1987;60(1):82-92.
L J Ignarro; R G Harbison; K S Wood; P J Kadowitz Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. The Journal of pharmacology and experimental therapeutics 1986;237(3):893-900.
D G Guinee; D B McNamara; L J Ignarro; A L Hyman; P J Kadowitz Arachidonic acid and acetylcholine induced relaxation of bovine coronary artery: effect of indomethacin and methylene blue. The Canadian journal of cardiology 1986;2(3):170-5.
L J Ignarro; J B Adams; P M Horwitz; K S Wood Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms. The Journal of biological chemistry 1986;261(11):4997-5002.
L J Ignarro; K S Wood; R G Harbison; P J Kadowitz Atriopeptin II relaxes and elevates cGMP in bovine pulmonary artery but not vein. Journal of applied physiology (Bethesda, Md. : 1985) 1986;60(4):1128-33.
L J Ignarro; R G Harbison; K S Wood; P J Kadowitz Dissimilarities between methylene blue and cyanide on relaxation and cyclic GMP formation in endothelium-intact intrapulmonary artery caused by nitrogen oxide-containing vasodilators and acetylcholine. The Journal of pharmacology and experimental therapeutics 1986;236(1):30-6.
H A Pretus; L J Ignarro; H E Ensley; L P Feigen Inhibition of soybean lipoxygenase by SKF 525-A and metyrapone. Prostaglandins 1985;30(4):591-8.
L J Ignarro; R G Harbison; K S Wood; M S Wolin; D B McNamara; A L Hyman; P J Kadowitz Differences in responsiveness of intrapulmonary artery and vein to arachidonic acid: mechanism of arterial relaxation involves cyclic guanosine 3’:5’-monophosphate and cyclic adenosine 3’:5’-monophosphate. The Journal of pharmacology and experimental therapeutics 1985;233(3):560-9.
H L Lippton; P M Horwitz; D B McNamara; L J Ignarro; A Z Landry; A L Hyman; P J Kadowitz The effects of amrinone on human platelet aggregation: evidence that amrinone does not act through a cyclic nucleotide mechanism in platelet rich plasma. Prostaglandins, leukotrienes, and medicine 1985;18(2):193-204.
L J Ignarro; P J Kadowitz The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annual review of pharmacology and toxicology 1985;25():171-91.
L J Ignarro; B Ballot; K S Wood Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. The Journal of biological chemistry 1984;259(10):6201-7.
L J Ignarro; K S Wood; B Ballot; M S Wolin Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes. The Journal of biological chemistry 1984;259(9):5923-31.
L J Ignarro; T M Burke; K S Wood; M S Wolin; P J Kadowitz Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery. The Journal of pharmacology and experimental therapeutics 1984;228(3):682-90.
J C Edwards; L J Ignarro; A L Hyman; P J Kadowitz Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP. The Journal of pharmacology and experimental therapeutics 1984;228(1):33-42.
L J Ignarro; K S Wood; M S Wolin Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept. Advances in cyclic nucleotide and protein phosphorylation research 1984;17():267-74.
B T Mellion; L J Ignarro; C B Myers; E H Ohlstein; B A Ballot; A L Hyman; P J Kadowitz Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation. Molecular pharmacology 1983;23(3):653-64.
M S Wolin; K S Wood; L J Ignarro Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. The Journal of biological chemistry 1982;257(22):13312-20.
E H Ohlstein; K S Wood; L J Ignarro Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX. Archives of biochemistry and biophysics 1982;218(1):187-98.
L J Ignarro; J N Degnan; W H Baricos; P J Kadowitz; M S Wolin Activation of purified guanylate cyclase by nitric oxide requires heme. Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung. Biochimica et biophysica acta 1982;718(1):49-59.
L J Ignarro; K S Wood; M S Wolin Activation of purified soluble guanylate cyclase by protoporphyrin IX. Proceedings of the National Academy of Sciences of the United States of America 1982;79(9):2870-3.
H L Lippton; C A Gruetter; L J Ignarro; R L Meyer; P J Kadowitz Vasodilator actions of several N-nitroso compounds. Canadian journal of physiology and pharmacology 1982;60(1):68-75.
C A Gruetter; D Y Gruetter; J E Lyon; P J Kadowitz; L J Ignarro Relationship between cyclic guanosine 3’:5’-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin. The Journal of pharmacology and experimental therapeutics 1981;219(1):181-6.
J C Edwards; B K Barry; D Y Gruetter; E H Ohlstein; W H Baricos; L J Ignarro Activation of hepatic guanylate cyclase by nitrosyl-heme complexes. Comparison of unpurified and partially purified enzyme. Biochemical pharmacology 1981;30(18):2531-8.
L J Ignarro; H Lippton; J C Edwards; W H Baricos; A L Hyman; P J Kadowitz; C A Gruetter Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. The Journal of pharmacology and experimental therapeutics 1981;218(3):739-49.
B T Mellion; L J Ignarro; E H Ohlstein; E G Pontecorvo; A L Hyman; P J Kadowitz Evidence for the inhibitory role of guanosine 3’, 5’-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood 1981;57(5):946-55.
L J Ignarro; P J Kadowitz; W H Baricos Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site -SH groups and both substrate and activator. Archives of biochemistry and biophysics 1981;208(1):75-86.
L J Ignarro; B K Barry; D Y Gruetter; E H Ohlstein; C A Gruetter; P J Kadowitz; W H Baricos Selective alterations in responsiveness of guanylate cyclase to activation by nitroso compounds during enzyme purification. Biochimica et biophysica acta 1981;673(4):394-407.
P J Kadowitz; P Nandiwada; C A Gruetter; L J Ignarro; A L Hyman Pulmonary vasodilator responses to nitroprusside and nitroglycerin in the dog. The Journal of clinical investigation 1981;67(3):893-902.
C A Gruetter; L J Ignarro; A L Hyman; P J Kadowitz Contractile effects of 5-hydroxytryptamine in isolated intrapulmonary arteries and veins. Canadian journal of physiology and pharmacology 1981;59(2):157-62.
C A Gruetter; P J Kadowitz; L J Ignarro Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite. Canadian journal of physiology and pharmacology 1981;59(2):150-6.
D B McNamara; P J Kadowitz; A L Hyman; L J Ignarro Adenosine 3’,5’-monophosphate formation by preparations of rat liver soluble guanylate cyclase activated with nitric oxide, nitrosyl ferroheme, S-nitrosothiols, and other nitroso compounds. Canadian journal of physiology and pharmacology 1980;58(12):1446-56.
D Y Gruetter; C A Gruetter; B K Barry; W H Baricos; A L Hyman; P J Kadowitz; L J Ignarro Activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside, and nitrosoguanidine–inhibition by calcium, lanthanum, and other cations, enhancement by thiols. Biochemical pharmacology 1980;29(21):2943-50.
L J Ignarro; C A Gruetter Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols. Biochimica et biophysica acta 1980;631(2):221-31.
C A Gruetter; B K Barry; D B McNamara; P J Kadowitz; L J Ignarro Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N’-nitrosonornicotine and nitric oxide. The Journal of pharmacology and experimental therapeutics 1980;214(1):9-15.
L J Ignarro; B K Barry; D Y Gruetter; J C Edwards; E H Ohlstein; C A Gruetter; W H Baricos Guanylate cyclase activation of nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediates. Biochemical and biophysical research communications 1980;94(1):93-100.
S A Napoli; C A Gruetter; L J Ignarro; P J Kadowitz Relaxation of bovine coronary arterial smooth muscle by cyclic GMP, cyclic AMP and analogs. The Journal of pharmacology and experimental therapeutics 1980;212(3):469-73.
L J Ignarro; J C Edwards; D Y Gruetter; B K Barry; C A Gruetter Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds. FEBS letters 1980;110(2):275-8.
D Y Gruetter; L J Ignarro Arachidonic acid activation of guinea pig lung guanylate cyclase by two independent mechanisms. Prostaglandins 1979;18(4):541-56.
E H Ohlstein; B K Barry; D Y Gruetter; L J Ignarro Methemoglobin blockade of coronary arterial soluble guanylate cyclase activation by nitroso compounds and its reversal with dithiothreitol. FEBS letters 1979;102(2):316-20.
C A Gruetter; B K Barry; D B McNamara; D Y Gruetter; P J Kadowitz; L Ignarro Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. Journal of cyclic nucleotide research 1979;5(3):211-24.
L J Ignarro; R A Gross Stimulation of mammalian adenylate cyclase activity with guanosine 5’-tetraphosphate and other guanine nucleotides. Biochimica et biophysica acta 1978;541(2):170-80.
S Y Cech; L J Ignarro Cytidine 3’,5’-monophosphate (cyclic CMP) formation by homogenates of mouse liver. Biochemical and biophysical research communications 1978;80(1):119-25.
L J Ignarro Interference with stimulus-secretion coupling by glucocorticosteroids. Advances in cyclic nucleotide research 1978;9():677-89.
S Y Cech; L J Ignarro Cytidine 3’,5’-monophosphate (cyclic CMP) formation in mammalian tissues. Science (New York, N.Y.) 1977;198(4321):1063-5.
L J Ignarro Glucocorticosteroid inhibition of nonphagocytic discharge of lysosomal enzymes from human neutrophils. Arthritis and rheumatism 1977;20(1):73-83.
L J Ignarro; R A Gross; D M Gross Inhibition of mammalian soluble guanylate cyclase activity by adenosine 5’-tetraphosphate, guanosine 5’-tetraphosphate and other nucleotides. Journal of cyclic nucleotide research 1976;2(5):337-46.
L J Ignarro; S Y Cech Bidirectional regulation of lysosomal enzyme secretion and phagocytosis in human neutrophils by guanosine 3’,5’-monophosphate and adenosine 3’,5’-monophosphate. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1976;151(3):448-52.
W J George; L J Ignarro; R J Paddock; L White; P J Kadowitz Oppositional effects of acetylcholine and isoproterenol on isometric tension and cyclic nucleotide concentrations in rabbit atria. Journal of cyclic nucleotide research 1975;1(5):339-47.
W J George; R W Busuttil; R J Paddock; L A White; L J Ignarro Opposing regulatory influences of cyclic guanosine monophosphate and cyclic adenosine monophosphate in the control of cardiac muscle contraction. Recent advances in studies on cardiac structure and metabolism 1975;8():243-50.
R J Smith; L J Ignarro Bioregulation of lysosomal enzyme secretion from human neutrophils: roles of guanosine 3’:5’-monophosphate and calcium in stimulus-secretion coupling. Proceedings of the National Academy of Sciences of the United States of America 1975;72(1):108-12.
L J Ignarro Regulation of lysosomal enzyme release by prostaglandins, autonomic neurohormones and cyclic nucleotides. Frontiers of biology 1975;43(4):481-523.
W J George; L J Ignarro; L E White Muscarinic stimulation of cardiac guanylate cyclase. Recent advances in studies on cardiac structure and metabolism 1975;7():381-90.
L J Ignarro; S Y Cech Lysosomal enzyme secretion from human neutrophils mediated by cyclic CMP: inhibition of cyclic GMP accumulation and neutrophil function by glucocorticosteroids. Journal of cyclic nucleotide research 1975;1(6):283-92.
R J Smith; L J Ignarro; P M Heidger; J W Fisher Lysosomal enzyme release in vivo: an evaluation of the mechanism of cobalt polycythemia. The Journal of pharmacology and experimental therapeutics 1974;191(3):564-74.
L J Ignarro Regulation of lysosomal enzyme secretion: role in inflammation. Agents and actions 1974;4(4):241-58.
R J Smith; L J Ignarro; J W Fisher Lysosomal enzyme release: a possible mechanism of action of cobalt as an erythropoietic stimulant. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1974;146(3):781-5.
L J Ignarro Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants. Journal of immunology (Baltimore, Md. : 1950) 1974;113(1):298-308.
L J Ignarro; W J George Mediation of immunologic discharge of lysosomal enzymes from human neutrophils by guanosine 3’,5’-monophosphate. Requirement of calcium, and inhibition by adenosine 3’,5’-monophosphate. The Journal of experimental medicine 1974;140(1):225-38.
L J Ignarro; T F Lint; W J George Hormonal control of lysosomal enzyme release from human neutrophils. Effects of autonomic agents on enzyme release, phagocytosis, and cylic nucleotide levels. The Journal of experimental medicine 1974;139(6):1395-414.
L J Ignarro; W J George Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones. Proceedings of the National Academy of Sciences of the United States of America 1974;71(5):2027-31.
L J Ignarro; R J Paddock; W J George Hormonal control of neutrophil lysosomal enzyme release: effect of epinephrine on adenosine 3’,5’-monophosphate. Science (New York, N.Y.) 1974;183(127):855-7.
L J Ignarro Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3’,5’-guanosine monophosphate. Journal of immunology (Baltimore, Md. : 1950) 1974;112(1):210-4.
L J Ignarro Nonphagocytic release of neutral protease and beta-glucuronidase from human neutrophils. Regulation by autonomic neurohormones and cyclic nucleotides. Arthritis and rheumatism 1974;17(1):25-36.
L J Ignarro; A L Oronsky; R J Perper Breakdown of noncollagenous chondromucoprotein matrix by leukocyte lysosome granule lysates from guinea pig, rabbit, and human. Clinical immunology and immunopathology 1973;2(1):36-51.
L J Ignarro Neutral protease release from human leukocytes regulated by neurohormones and cyclic nucleotides. Nature: New biology 1973;245(144):151-4.
A Oronsky; L Ignarro; R Perper Release of cartilage mucopolysaccharide-degrading neutral protease from human leukocytes. The Journal of experimental medicine 1973;138(2):461-72.
L J Ignarro; N Krassikoff; J Slywka Release of enzymes from a rat liver lysosome fraction: inhibition by catecholamines and cyclic3’, 5’-adenosine monophosphate, stimulation by cholinergic agents and cyclic 3’, 5’-guanosine monophosphate. The Journal of pharmacology and experimental therapeutics 1973;186(1):86-99.
L J Ignarro; C Colombo Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides. Science (New York, N.Y.) 1973;180(91):1181-3.
L J Ignarro Preservation of structural integrity of liver lysosomes and membrane-stabilizing action of anti-inflammatory drugs, catecholamines and cyclic adenosine monophosphate in isotonic salt media. Biochemical pharmacology 1973;22(11):1269-82.
L J Ignarro; C Colombo Enzyme release from guinea-pig polymorphonuclear leucocyte lysosomes inhibited in vitro by anti-inflammatory drugs. Nature: New biology 1972;239(92):155-7.
L J Ignarro Lysosome membrane stabilization in vivo: effects of steroidal and nonsteroidal anti-inflammatory drugs on the integrity of rat liver lysosomes. The Journal of pharmacology and experimental therapeutics 1972;182(1):179-88.
L J Ignarro; N Krassikoff; J Slywka Inhibition of lysosomal enzyme release by adenosine 5’ triphosphate and N 6 ,O 2 -dibutyryl cyclic 3’,5’-adenosine monophosphate. Life sciences. Pt. 1: Physiology and pharmacology 1972;11(7):317-22.
L J Ignarro; J Slywka Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis. Biochemical pharmacology 1972;21(6):875-86.
L J Ignarro; J Slywka; N Krassikoff Inhibition of lysosomal enzyme release by catecholamines: possible mediation by cyclic 3’,5’-adenosine monophosphate. Life sciences. Pt. 1: Physiology and pharmacology 1971;10(22):1309-15.
L J Ignarro Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver. Biochemical pharmacology 1971;20(10):2861-70.
L J Ignarro Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro. Biochemical pharmacology 1971;20(10):2847-60.
L J Ignarro; E Titus The presence of antagonistically acting alpha and beta adrenergic receptors in the mouse spleen. The Journal of pharmacology and experimental therapeutics 1968;160(1):72-80.
L J Ignarro; F E Shideman Norepinephrine and epinephrine in the embryo and embryonic heart of the chick: uptake and subcellular distribution. The Journal of pharmacology and experimental therapeutics 1968;159(1):49-58.
L J Ignarro; F E Shideman The requriement of sympathetic innervation for the active transport of norepinephrine by the heart. The Journal of pharmacology and experimental therapeutics 1968;159(1):59-65.
L J Ignarro; F E Shideman Appearance and concentrations of catecholamines and their biosynthesis in the embryonic and developing chick. The Journal of pharmacology and experimental therapeutics 1968;159(1):38-48.
L J Ignarro; F E Shideman Catechol-O-methyl transferase and monoamine oxidase activities in the heart and liver of the embryonic and developing chick. The Journal of pharmacology and experimental therapeutics 1968;159(1):29-37.
F E Shideman; L J Ignarro New species may create new problems: norepinephrine in the heart of the avian embryo. Federation proceedings 1967;26(4):1137-8.
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