Linda B. Buck

Linda Brown Buck is an American biologist well known for her work on the olfactory system. She is the recipient of the Nobel Prize in Physiology or Medicine 2004, together with her colleague Richard Axel. Linda Buck has worked on how odors are perceived and identified. She showed that certain chemical compounds such as pheromones and predator odors are not consciously smelled but more basically stimulate hormonal changes or instinctive behaviors. In 1991, Linda Buck cloned olfactory receptors proving them to be Gprotein-coupled receptors. She also gave a detailed outline of the organization of odor receptor neurons in the nose.

Linda Buck received the Takasago Award 1992, Lewis S. Rosenstiel Award 1997 and the Gairdner Foundation International Award 2003.

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2009  Member, European Academy of Sciences

2008  Member, American Academy of Arts & Sciences

2007  The Medal of Merit, State of Washington

2006  The International Hall of Fame, The International Women’s Forum

2006  Alumna Summa Laude Dignata, University of Washington

2006  Member, Institute of Medicine of the National Academies

2005  The Golden Plate Award, The Academy of Achievement

2005  Distinguished Alumnus Award, University of Washington

2005  Brava Award, Women’s University Club

2004  The Nobel Prize in Physiology or Medicine

2003  Member, National Academy of Sciences

2003  Gairdner Foundation International Award

2003  The Perl/UNC Neuroscience Prize

2002  Fellow, American Association for the Advancement of Science

2000  Senior Scholar Award in Aging, The Ellison Medical Foundation

1997  Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research, Brandeis University

1996  The Unilever Science Award, Unilever

1996  The R.H. Wright Award in Olfactory Research, Simon Fraser University

1995  Distinguished Alumnus, University of Texas Southwestern Medical Center at Dallas

1993  John Merck Scholar in the Biology of Developmental Disabilities, The John Merck Fund

1992  The Sense of Smell Award, The Fragrance Foundation

1992  The Takasago Award for Research in Olfaction, Takasago

1992  Science for Art Prize, LVMH Moet Hennessy Louis Vuitton

1992  McKnight Scholar Award, The McKnight Endowment Fund for Neuroscience

1992  Sloan Research Fellowship Award, Alfred P. Sloan Foundation

Petrascheck, M; Ye, X; Buck, LB A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans. Annals of the New York Academy of Sciences 2009;1170():698-701.

Liberles, SD; Horowitz, LF; Kuang, D; Contos, JJ; Wilson, KL; Siltberg-Liberles, J; Liberles, DA; Buck, LB Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ. Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9842-7.

Zou, Z; Horowitz, LF; Montmayeur, JP; Snapper, S; Buck, LB Genetic tracing reveals a stereotyped sensory map in the olfactory cortex. Nature 2008;452(7183):120.

Petrascheck, M; Ye, X; Buck, LB An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 2007;450(7169):553-6.

Liberles, SD; Buck, LB A second class of chemosensory receptors in the olfactory epithelium. Nature 2006;442(7103):645-50.

Zou, Z; Buck, LB Combinatorial effects of odorant mixes in olfactory cortex. Science (New York, N.Y.) 2006;311(5766):1477-81.

Boehm, U; Zou, Z; Buck, LB Feedback loops link odor and pheromone signaling with reproduction. Cell 2005;123(4):683-95.

Buck, LB Unraveling the sense of smell (Nobel lecture). Angewandte Chemie (International ed. in English) 2005;44(38):6128-40.

Zou, Z; Li, F; Buck, LB Odor maps in the olfactory cortex. Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7724-9.

Buck, LB Unraveling smell. Harvey lectures 2005;101():117-34.

Buck, LB Olfactory receptors and odor coding in mammals. Nutrition reviews 2004;62(11 Pt 2):S184-8; discussion S224-41.

Malnic, B; Godfrey, PA; Buck, LB The human olfactory receptor gene family. Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2584-9.

Godfrey, PA; Malnic, B; Buck, LB The mouse olfactory receptor gene family. Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2156-61.

Buck, LB The search for odorant receptors. Cell 2004;116(2 Suppl):S117-9, 1 p following S119.

Ranganathan, R; Buck, LB Olfactory axon pathfinding: who is the pied piper? Neuron 2002;35(4):599-600.

Zou, Z; Horowitz, LF; Montmayeur, JP; Snapper, S; Buck, LB Genetic tracing reveals a stereotyped sensory map in the olfactory cortex. Nature 2001;414(6860):173-9.

Sam, M; Vora, S; Malnic, B; Ma, W; Novotny, MV; Buck, LB Neuropharmacology. Odorants may arouse instinctive behaviours. Nature 2001;412(6843):142.

Montmayeur, JP; Liberles, SD; Matsunami, H; Buck, LB A candidate taste receptor gene near a sweet taste locus. Nature neuroscience 2001;4(5):492-8.

Matsunami, H; Montmayeur, JP; Buck, LB A family of candidate taste receptors in human and mouse. Nature 2000;404(6778):601-4.

Buck, LB The molecular architecture of odor and pheromone sensing in mammals. Cell 2000;100(6):611-8.

Horowitz, LF; Montmayeur, JP; Echelard, Y; Buck, LB A genetic approach to trace neural circuits. Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3194-9.

Malnic, B; Hirono, J; Sato, T; Buck, LB Combinatorial receptor codes for odors. Cell 1999;96(5):713-23.

Matsunami, H; Buck, LB A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 1997;90(4):775-84.

Berghard, A; Buck, LB; Liman, ER Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2365-9.

Berghard, A; Buck, LB Sensory transduction in vomeronasal neurons: evidence for G alpha o, G alpha i2, and adenylyl cyclase II as major components of a pheromone signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):909-18.

Sullivan, SL; Adamson, MC; Ressler, KJ; Kozak, CA; Buck, LB The chromosomal distribution of mouse odorant receptor genes. Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):884-8.

Buck, LB Information coding in the mammalian olfactory system. Cold Spring Harbor symposia on quantitative biology 1996;61():147-55.

Buck, LB Information coding in the vertebrate olfactory system. Annual review of neuroscience 1996;19():517-44.

Buck, LB Unraveling chemosensory diversity. Cell 1995;83(3):349-52.

Sullivan, SL; Bohm, S; Ressler, KJ; Horowitz, LF; Buck, LB Target-independent pattern specification in the olfactory epithelium. Neuron 1995;15(4):779-89.

Sullivan, SL; Ressler, KJ; Buck, LB Spatial patterning and information coding in the olfactory system. Current opinion in genetics & development 1995;5(4):516-23.

Ressler, KJ; Sullivan, SL; Buck, LB Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 1994;79(7):1245-55.

Liman, ER; Buck, LB A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron 1994;13(3):611-21.

Ressler, KJ; Sullivan, SL; Buck, LB A molecular dissection of spatial patterning in the olfactory system. Current opinion in neurobiology 1994;4(4):588-96.

Sullivan, SL; Ressler, KJ; Buck, LB Odorant receptor diversity and patterned gene expression in the mammalian olfactory epithelium. Progress in clinical and biological research 1994;390():75-84.

Ressler, KJ; Sullivan, SL; Buck, LB A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 1993;73(3):597-609.

Ngai, J; Dowling, MM; Buck, L; Axel, R; Chess, A The family of genes encoding odorant receptors in the channel catfish. Cell 1993;72(5):657-66.

Buck, LB Receptor diversity and spatial patterning in the mammalian olfactory system. Ciba Foundation symposium 1993;179():51-64; discussion 64-7, 88-96.

Buck, LB The olfactory multigene family. Current opinion in neurobiology 1992;2(3):282-8.

Buck, LB The olfactory multigene family. Current opinion in genetics & development 1992;2(3):467-73.

Buck, LB A novel multigene family may encode odorant receptors. Society of General Physiologists series 1992;47():39-51.

Chess, A; Buck, L; Dowling, MM; Axel, R; Ngai, J Molecular biology of smell: expression of the multigene family encoding putative odorant receptors. Cold Spring Harbor symposia on quantitative biology 1992;57():505-16.

Buck, L; Axel, R A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991;65(1):175-87.

Hynes, MA; Gitt, M; Barondes, SH; Jessell, TM; Buck, LB Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(3):1004-13.

Hynes, MA; Buck, LB; Gitt, M; Barondes, S; Dodd, J; Jessell, TM Carbohydrate recognition in neuronal development: structure and expression of surface oligosaccharides and beta-galactoside-binding lectins. Ciba Foundation symposium 1989;145():189-210; discussion 210-8.

Buck, LB; Bigelow, JM; Axel, R Alternative splicing in individual Aplysia neurons generates neuropeptide diversity. Cell 1987;51(1):127-33.

Roberts, JM; Buck, LB; Axel, R A structure for amplified DNA. Cell 1983;33(1):53-63.

Vitetta, E; Puré, E; Isakson, P; Buck, L; Uhr, J The activation of murine B cells: the role of surface immunoglobulins. Immunological reviews 1980;52():211-31.

Buck, LB; Yuan, D; Vitetta, ES A dichotomy between the expression of IgD on B cells and its requirement for triggering such cells with two T-independent antigens. The Journal of experimental medicine 1979;149(4):987-92.

Storb, U; Hager, L; Putnam, D; Buck, L; Farin, F; Clagett, J Sequences related to immunoglobulin kappa chain messenger RNA in T cells. Proceedings of the National Academy of Sciences of the United States of America 1976;73(7):2467-71.



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    Affiliate Professor
    Physiology and Biophysics
    University of Washington