1986 Biophysics Prize of the American Physical Society (together with J. Deisenhofer)
1986 Leibniz Prize of the ”Deutsche Forschungsgemeinschaft”
1986 Otto-Klung-Prize of Chemistry
1986 Lecturer Stipend of the ”Fonds der Chemischen Industrie”
1988 Otto-Bayer-Prize (together with J. Deisenhofer)
1986 Nobel Prize of Chemistry (together with J. Deisenhofer and R. Huber)
1991 Medal of the European Society for Photobiology
1995 Doctor honoris causa by the university of Würzburg
1995 Johnson-Foundation Prize (Philadelphia, USA) for adventurous and innovative research in structural biology
1995 Roentgen medal of the City of Würzburg
1996 Medal of the university of Helsinki
2004 Peter Mitchell Medal of the European Bioenergetics Conference
1. von der Hocht Iris; van Wonderen Jessica H; Hilbers Florian; Angerer Heike; MacMillan Fraser; Michel Hartmut. Interconversions of P and F intermediates of cytochrome c oxidase from Paracoccus denitrificans. Proceedings of the National Academy of Sciences of the United States of America 2011;108(10):3964-9.
2. Marcia Marco; Langer Julian D; Parcej David; Vogel Vitali; Peng Guohong; Michel Hartmut. Characterizing a monotopic membrane enzyme. Biochemical, enzymatic and crystallization studies on Aquifex aeolicus sulfide:quinone oxidoreductase. Biochimica et biophysica acta 2010;1798(11):2114-23.
3. Buschmann Sabine; Warkentin Eberhard; Xie Hao; Langer Julian D; Ermler Ulrich; Michel Hartmut. The structure of cbb3 cytochrome oxidase provides insights into proton pumping. Science (New York, N.Y.) 2010;329(5989):327-30.
4. Rajendran Chitra; Ermler Ulrich; Ludwig Bernd; Michel Hartmut. Structure at 1.5 A resolution of cytochrome c(552) with its flexible linker segment, a membrane-anchored protein from Paracoccus denitrificans. Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 7):850-4.
5. Marcia Marco; Ermler Ulrich; Peng Guohong; Michel Hartmut. A new structure-based classification of sulfide:quinone oxidoreductases. Proteins 2010;78(5):1073-83.
6. Baier J; Gabrielsen M; Oellerich S; Michel H; van Heel M; Cogdell R J; Köhler J Spectral diffusion and electron-phonon coupling of the B800 BChl a molecules in LH2 complexes from three different species of purple bacteria. Biophysical journal 2009;97(9):2604-12.
7. Olkhova Elena; Kozachkov Lena; Padan Etana; Michel Hartmut. Combined computational and biochemical study reveals the importance of electrostatic interactions between the ”pH sensor” and the cation binding site of the sodium/proton antiporter NhaA of Escherichia coli. Proteins 2009;76(3):548-59.
8. Marcia Marco; Ermler Ulrich; Peng Guohong; Michel Hartmut. The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respiration. Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9625-30.
9. Koepke Juergen; Olkhova Elena; Angerer Heike; Müller Hannelore; Peng Guohong; Michel Hartmut. High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: new insights into the active site and the proton transfer pathways. Biochimica et biophysica acta 2009;1787(6):635-45.
10. Dürr Katharina L; Koepke Juergen; Hellwig Petra; Müller Hannelore; Angerer Heike; Peng Guohong; Olkhova Elena; Richter Oliver-Matthias H; Ludwig Bernd; Michel Hartmut. A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate. Journal of molecular biology 2008;384(4):865-77.
11. Xia Hongyan; Liu Lihong; Reinhart Christoph; Michel Hartmut. Heterologous expression of human Neuromedin U receptor 1 and its subsequent solubilization and purification. Biochimica et biophysica acta 2008;1778(10):2203-9.
12. Rimon Abraham; Hunte Carola; Michel Hartmut.; Padan Etana Epitope mapping of conformational monoclonal antibodies specific to NhaA Na+/H+ antiporter: structural and functional implications. Journal of molecular biology 2008;379(3):471-81.
13. Roy Ankita; Shukla Arun Kumar; Haase Winfried; Michel Hartmut. Employing Rhodobacter sphaeroides to functionally express and purify human G protein-coupled receptors. Biological chemistry 2008;389(1):69-78.
14. Lopez Jakob J; Shukla Arun K; Reinhart Christoph; Schwalbe Harald; Michel Hartmut.; Glaubitz Clemens The structure of the neuropeptide bradykinin bound to the human G-protein coupled receptor bradykinin B2 as determined by solid-state NMR spectroscopy. Angewandte Chemie (International ed. in English) 2008;47(9):1668-71.
15. Chillakuri Chandramouli Reddy; Reinhart Christoph; Michel Hartmut. C-terminal truncated cannabinoid receptor 1 coexpressed with G protein trimer in Sf9 cells exists in a precoupled state and shows constitutive activity. The FEBS journal 2007;274(23):6106-15.
16. Wedemeyer Ulrike; Peng Guohong; Michel Hartmut.; Hartung Klaus Protein AQ_1862 from the hyperthermophilic bacterium Aquifex aeolicus is a porin and contains two conductance pathways of different selectivity. Biophysical journal 2007;93(8):2667-77.
17. Srinivasan Vasundara; Netz Daili J A; Webert Holger; Mascarenhas Judita; Pierik Antonio J; Michel Hartmut.; Lill Roland Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Structure (London, England : 1993) 2007;15(10):1246-57.
18. Shukla Arun Kumar; Haase Winfried; Reinhart Christoph; Michel Hartmut. Heterologous expression and characterization of the recombinant bradykinin B2 receptor using the methylotrophic yeast Pichia pastoris. Protein expression and purification 2007;55(1):1-8.
19. Klammt Christian; Srivastava Ankita; Eifler Nora; Junge Friederike; Beyermann Michael; Schwarz Daniel; Michel Hartmut.; Doetsch Volker; Bernhard Frank Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation. The FEBS journal 2007;274(13):3257-69.
20. Olkhova Elena; Padan Etana; Michel Hartmut. The influence of protonation states on the dynamics of the NhaA antiporter from Escherichia coli. Biophysical journal 2007;92(11):3784-91.
21. Shukla Arun Kumar; Haase Winfried; Reinhart Christoph; Michel Hartmut. Heterologous expression and comparative characterization of the human neuromedin U subtype II receptor using the methylotrophic yeast Pichia pastoris and mammalian cells. The international journal of biochemistry & cell biology 2007;39(5):931-42.
22. Peng Guohong; Bostina Mihnea; Radermacher Michael; Rais Isam; Karas Michael; Michel Hartmut. Biochemical and electron microscopic characterization of the F1F0 ATP synthase from the hyperthermophilic eubacterium Aquifex aeolicus. FEBS letters 2006;580(25):5934-40.
23. Shukla Arun Kumar; Haase Winfried; Reinhart Christoph; Michel Hartmut. Functional overexpression and characterization of human bradykinin subtype 2 receptor in insect cells using the baculovirus system. Journal of cellular biochemistry 2006;99(3):868-77.
24. Shukla Arun Kumar; Reinhart Christoph; Michel Hartmut. Comparative analysis of the human angiotensin II type 1a receptor heterologously produced in insect cells and mammalian cells. Biochemical and biophysical research communications 2006;349(1):6-14.
25. Screpanti Emanuela; Padan Etana; Rimon Abraham; Michel Hartmut.; Hunte Carola Crucial steps in the structure determination of the Na+/H+ antiporter NhaA in its native conformation. Journal of molecular biology 2006;362(2):192-202.
26. Surade Sachin; Klein Markus; Stolt-Bergner Peggy C; Muenke Cornelia; Roy Ankita; Michel Hartmut. Comparative analysis and ”expression space” coverage of the production of prokaryotic membrane proteins for structural genomics. Protein science : a publication of the Protein Society 2006;15(9):2178-89.
27. Shukla Arun Kumar; Reinhart Christoph; Michel Hartmut. Dimethylsulphoxide as a tool to increase functional expression of heterologously produced GPCRs in mammalian cells. FEBS letters 2006;580(17):4261-5.
28. Lundstrom Kenneth; Wagner Renaud; Reinhart Christoph; Desmyter Aline; Cherouati Nadia; Magnin Thierry; Zeder-Lutz Gabrielle; Courtot Melanie; Prual Cécile; André Nicolas; Hassaine Gherici; Michel Hartmut.; Cambillau Christian; Pattus Franc Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems. Journal of structural and functional genomics 2006;7(2):77-91.
29. Shukla Arun Kumar; Haase Winfred; Reinhart Christoph; Michel Hartmut. Biochemical and pharmacological characterization of the human bradykinin subtype 2 receptor produced in mammalian cells using the Semliki Forest virus system. Biological chemistry 2006;387(5):569-76.
30. André Nicolas; Cherouati Nadia; Prual Cécile; Steffan Tania; Zeder-Lutz Gabrielle; Magnin Thierry; Pattus Franc; Michel Hartmut.; Wagner Renaud; Reinhart Christoph Enhancing functional production of G protein-coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen. Protein science : a publication of the Protein Society 2006;15(5):1115-26.
31. Farver Ole; Grell Ernst; Ludwig Bernd; Michel Hartmut.; Pecht Israel Rates and Equilibrium of CuA to heme a electron transfer in Paracoccus denitrificans cytochrome c oxidase. Biophysical journal 2006;90(6):2131-7.
32. Olkhova Elena; Hunte Carola; Screpanti Emanuela; Padan Etana; Michel Hartmut. Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications. Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2629-34.
33. MacMillan Fraser; Budiman Kerstin; Angerer Heike; Michel Hartmut. The role of tryptophan 272 in the Paracoccus denitrificans cytochrome c oxidase. FEBS letters 2006;580(5):1345-9.
34. Olkhova Elena; Helms Volkhard; Michel Hartmut. Titration behavior of residues at the entrance of the D-pathway of cytochrome c oxidase from paracoccus denitrificans investigated by continuum electrostatic calculations. Biophysical journal 2005;89(4):2324-31.
35. Hunte Carola; Screpanti Emanuela; Venturi Miro; Rimon Abraham; Padan Etana; Michel Hartmut. Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature 2005;435(7046):1197-202.
36. Ma Xueyan; Koepke Juergen; Bayer Anja; Fritzsch Günter; Michel Hartmut.; Stöckigt Joachim Crystallization and preliminary X-ray analysis of native and selenomethionyl vinorine synthase from Rauvolfia serpentina. Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 6):694-6.
37. Koepke Juergen; Ma Xueyan; Fritzsch Günter; Michel Hartmut.; Stöckigt Joachim Crystallization and preliminary X-ray analysis of strictosidine synthase and its complex with the substrate tryptamine. Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 6):690-3.
38. Hofmann Clemens; Michel Hartmut.; van Heel Marin; Köhler Jürgen Multivariate analysis of single-molecule spectra: surpassing spectral diffusion. Physical review letters 2005;94(19):195501.
39. Barleben Leif; Ma Xueyan; Koepke Juergen; Peng Guohong; Michel Hartmut.; Stöckigt Joachim Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons. Biochimica et biophysica acta 2005;1747(1):89-92.
40. Srinivasan Vasundara; Rajendran Chitra; Sousa Filipa L; Melo Ana M P; Saraiva Lígia M; Pereira Manuela M; Santana Margarida; Teixeira Miguel; Michel Hartmut. Structure at 1.3 A resolution of Rhodothermus marinus caa(3) cytochrome c domain. Journal of molecular biology 2005;345(5):1047-57.
41. Michel H; Wilske B; Hettche G; Göttner G; Heimerl C; Reischl U; Schulte-Spechtel U; Fingerle V An ospA-polymerase chain reaction/restriction fragment length polymorphism-based method for sensitive detection and reliable differentiation of all European Borrelia burgdorferi sensu lato species and OspA types. Medical microbiology and immunology 2004;193(4):219-26.
42. Ma Xueyan; Koepke Juergen; Fritzsch Günter; Diem Ralf; Kutchan Toni M; Michel Hartmut.; Stöckigt Joachim Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family. Biochimica et biophysica acta 2004;1702(1):121-4.
43. Budiman Kerstin; Kannt Aimo; Lyubenova Sevdalina; Richter Oliver-Matthias H; Ludwig Bernd; Michel Hartmut.; MacMillan Fraser Tyrosine 167: the origin of the radical species observed in the reaction of cytochrome c oxidase with hydrogen peroxide in Paracoccus denitrificans. Biochemistry 2004;43(37):11709-16.
44. Ma Xueyan; Koepke Juergen; Bayer Anja; Linhard Verena; Fritzsch Günter; Zhang Bin; Michel Hartmut.; Stöckigt Joachim Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily. Biochimica et biophysica acta 2004;1701(1-2):129-32.
45. Deisenhofer Johann; Michel Harmut. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis. Bioscience reports 2004;24(4-5):323-61.
46. Cismasiu Valeriu B; Denes Stefan A; Reiländer Helmut; Michel Hartmut.; Szedlacsek Stefan E The MAM (meprin/A5-protein/PTPmu) domain is a homophilic binding site promoting the lateral dimerization of receptor-like protein-tyrosine phosphatase mu. The Journal of biological chemistry 2004;279(26):26922-31.
47. Maeda Yoshitake; Kuroki Ryota; Haase Winfried; Michel Hartmut.; Reiländer Helmut Comparative analysis of high-affinity ligand binding and G protein coupling of the human CXCR1 chemokine receptor and of a CXCR1-Galpha fusion protein after heterologous production in baculovirus-infected insect cells. European journal of biochemistry / FEBS 2004;271(9):1677-89.
48. Fingerle V; Michel H; Hettche G; Hizo-Teufel C; Wilske B Borrelia burgdorferi s.l. OspA-types are widespread in Bavaria but show distinct local patterns. International journal of medical microbiology : IJMM 2004;293 Suppl 37():165-6.
49. Olkhova Elena; Hutter Michael C; Lill Markus A; Helms Volkhard; Michel Hartmut. Dynamic water networks in cytochrome C oxidase from Paracoccus denitrificans investigated by molecular dynamics simulations. Biophysical journal 2004;86(4):1873-89.
50. Grünewald Sylvia; Haase Winfried; Molsberger Eva; Michel Hartmut.; Reiländer Helmut Production of the human D2S receptor in the methylotrophic yeast P. pastoris. Receptors & channels 2004;10(1):37-50.
51. Hofmann Clemens; Aartsma Thijs J; Michel Hartmut.; Köhler Jürgen Direct observation of tiers in the energy landscape of a chromoprotein: a single-molecule study. Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15534-8.
52. Grimaldi S; Ostermann T; Weiden N; Mogi T; Miyoshi H; Ludwig B; Michel H; Prisner T F; MacMillan F Asymmetric binding of the high-affinity Q(H)(*)(-) ubisemiquinone in quinol oxidase (bo3) from Escherichia coli studied by multifrequency electron paramagnetic resonance spectroscopy. Biochemistry 2003;42(19):5632-9.
53. Essen Lars-Oliver; Harrenga Axel; Ostermeier Christian; Michel Hartmut. 1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization. Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 4):677-87.
54. Peng Guohong; Fritzsch Günter; Zickermann Volker; Schägger Hermann; Mentele Reinhardt; Lottspeich Friedrich; Bostina Mihnea; Radermacher Michael; Huber Robert; Stetter Karl Otto; Michel Hartmut. Isolation, characterization and electron microscopic single particle analysis of the NADH:ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus. Biochemistry 2003;42(10):3032-9.
55. Hofmann Clemens; Ketelaars Martijn; Matsushita Michio; Michel Hartmut.; Aartsma Thijs J; Köhler Jürgen Single-molecule study of the electronic couplings in a circular array of molecules: light-harvesting-2 complex from Rhodospirillum molischianum. Physical review letters 2003;90(1):013004.
56. Wendling Markus; Mourik Frank van; van Stokkum Ivo H M; Salverda Jante M; Michel Hartmut.; Grondelle Rienk van Low-intensity pump-probe measurements on the B800 band of Rhodospirillum molischianum. Biophysical journal 2003;84(1):440-9.
57. Hunte Carola; Michel Hartmut. Crystallisation of membrane proteins mediated by antibody fragments. Current opinion in structural biology 2002;12(4):503-8.
58. Hellwig Petra; Pfitzner Ute; Behr Julia; Rost Borries; Pesavento Russell P; Donk Wilfred V; Gennis Robert B; Michel Hartmut.; Ludwig Bernd; Mäntele Werner Vibrational modes of tyrosines in cytochrome c oxidase from Paracoccus denitrificans: FTIR and electrochemical studies on Tyr-D4-labeled and on Tyr280His and Tyr35Phe mutant enzymes. Biochemistry 2002;41(29):9116-25.
59. Ruitenberg Maarten; Kannt Aimo; Bamberg Ernst; Fendler Klaus; Michel Hartmut. Reduction of cytochrome c oxidase by a second electron leads to proton translocation. Nature 2002;417(6884):99-102.
60. Ungar D; Barth A; Haase W; Kaunzinger A; Lewitzki E; Ruiz T; Reiländer H; Michel H Analysis of a putative voltage-gated prokaryotic potassium channel. European journal of biochemistry / FEBS 2001;268(20):5386-96.
61. Kuglstatter A; Ermler U; Michel H; Baciou L; Fritzsch G X-ray structure analyses of photosynthetic reaction center variants from Rhodobacter sphaeroides: structural changes induced by point mutations at position L209 modulate electron and proton transfer. Biochemistry 2001;40(14):4253-60.
62. Grimaldi S; MacMillan F; Ostermann T; Ludwig B; Michel H; Prisner T QH*- ubisemiquinone radical in the bo3-type ubiquinol oxidase studied by pulsed electron paramagnetic resonance and hyperfine sublevel correlation spectroscopy. Biochemistry 2001;40(4):1037-43.
63. Schiller H; Molsberger E; Janssen P; Michel H; Reiländer H Solubilization and purification of the human ETB endothelin receptor produced by high-level fermentation in Pichia pastoris. Receptors & channels 2001;7(6):453-69.
64. Lancaster C R; Bibikova M V; Sabatino P; Oesterhelt D; Michel H Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described at 2.00-A resolution. The Journal of biological chemistry 2000;275(50):39364-8.
65. Hunte C; Koepke J; Lange C; Rossmanith T; Michel H Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure (London, England : 1993) 2000;8(6):669-84.
66. Pfitzner U; Hoffmeier K; Harrenga A; Kannt A; Michel H; Bamberg E; Richter O M; Ludwig B Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificans. Biochemistry 2000;39(23):6756-62.
67. Rengers J U; Touchard G; Decourt C; Deret S; Michel H; Cogné M Heavy and light chain primary structures control IgG3 nephritogenicity in an experimental model for cryocrystalglobulinemia. Blood 2000;95(11):3467-72.
68. Ruitenberg M; Kannt A; Bamberg E; Ludwig B; Michel H; Fendler K Single-electron reduction of the oxidized state is coupled to proton uptake via the K pathway in Paracoccus denitrificans cytochrome c oxidase. Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4632-6.
69. Chen I P; Mathis P; Koepke J; Michel H Uphill electron transfer in the tetraheme cytochrome subunit of the Rhodopseudomonas viridis photosynthetic reaction center: evidence from site-directed mutagenesis. Biochemistry 2000;39(13):3592-602.
70. Charnock J M; Dreusch A; Körner H; Neese F; Nelson J; Kannt A; Michel H; Garner C D; Kroneck P M; Zumft W G Structural investigations of the CuA centre of nitrous oxide reductase from Pseudomonas stutzeri by site-directed mutagenesis and X-ray absorption spectroscopy. European journal of biochemistry / FEBS 2000;267(5):1368-81.
71. Venturi M; Rimon A; Gerchman Y; Hunte C; Padan E; Michel H The monoclonal antibody 1F6 identifies a pH-dependent conformational change in the hydrophilic NH(2) terminus of NhaA Na(+)/H(+) antiporter of Escherichia coli. The Journal of biological chemistry 2000;275(7):4734-42.
72. Hampe W; Voss R H; Haase W; Boege F; Michel H; Reiländer H Engineering of a proteolytically stable human beta 2-adrenergic receptor/maltose-binding protein fusion and production of the chimeric protein in Escherichia coli and baculovirus-infected insect cells. Journal of biotechnology 2000;77(2-3):219-34.
73. Behr J; Michel H; Mäntele W; Hellwig P Functional properties of the heme propionates in cytochrome c oxidase from Paracoccus denitrificans. Evidence from FTIR difference spectroscopy and site-directed mutagenesis. Biochemistry 2000;39(6):1356-63.
74. Harrenga A; Reincke B; Rüterjans H; Ludwig B; Michel H Structure of the soluble domain of cytochrome c(552) from Paracoccus denitrificans in the oxidized and reduced states. Journal of molecular biology 2000;295(3):667-78.
75. Schiller H; Haase W; Molsberger E; Janssen P; Michel H; Reiländer H The human ET(B) endothelin receptor heterologously produced in the methylotrophic yeast Pichia pastoris shows high-affinity binding and induction of stacked membranes. Receptors & channels 2000;7(2):93-107.
76. Kannt A; Pfitzner U; Ruitenberg M; Hellwig P; Ludwig B; Mäntele W; Fendler K; Michel H Mutation of Arg-54 strongly influences heme composition and rate and directionality of electron transfer in Paracoccus denitrificans cytochrome c oxidase. The Journal of biological chemistry 1999;274(53):37974-81.
77. Kuglstatter A; Hellwig P; Fritzsch G; Wachtveitl J; Oesterhelt D; Mäntele W; Michel H Identification of a hydrogen bond in the phe M197–>Tyr mutant reaction center of the photosynthetic purple bacterium Rhodobacter sphaeroides by X-ray crystallography and FTIR spectroscopy. FEBS letters 1999;463(1-2):169-74.
78. Michel H Proton pumping by cytochrome c oxidase. Nature 1999;402(6762):602-3.
79. Lancaster C R; Kröger A; Auer M; Michel H Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution. Nature 1999;402(6760):377-85.
80. Harrenga A; Michel H The cytochrome c oxidase from Paracoccus denitrificans does not change the metal center ligation upon reduction. The Journal of biological chemistry 1999;274(47):33296-9.
81. Michel H Cytochrome c oxidase: catalytic cycle and mechanisms of proton pumping–a discussion. Biochemistry 1999;38(46):15129-40.
82. Tandori J; Sebban P; Michel H; Baciou L In Rhodobacter sphaeroides reaction centers, mutation of proline L209 to aromatic residues in the vicinity of a water channel alters the dynamic coupling between electron and proton transfer processes. Biochemistry 1999;38(40):13179-87.
83. Pfitzner U; Kirichenko A; Konstantinov A A; Mertens M; Wittershagen A; Kolbesen B O; Steffens G C; Harrenga A; Michel H; Ludwig B Mutations in the Ca2+ binding site of the Paracoccus denitrificans cytochrome c oxidase. FEBS letters 1999;456(3):365-9.
84. MacMillan F; Kannt A; Behr J; Prisner T; Michel H Direct evidence for a tyrosine radical in the reaction of cytochrome c oxidase with hydrogen peroxide. Biochemistry 1999;38(29):9179-84.
85. Rost B; Behr J; Hellwig P; Richter O M; Ludwig B; Michel H; Mäntele W Time-resolved FT-IR studies on the CO adduct of Paracoccus denitrificans cytochrome c oxidase: comparison of the fully reduced and the mixed valence form. Biochemistry 1999;38(23):7565-71.
86. Lancaster C R; Michel H Refined crystal structures of reaction centres from Rhodopseudomonas viridis in complexes with the herbicide atrazine and two chiral atrazine derivatives also lead to a new model of the bound carotenoid. Journal of molecular biology 1999;286(3):883-98.
87. Hellwig P; Grzybek S; Behr J; Ludwig B; Michel H; Mäntele W Electrochemical and ultraviolet/visible/infrared spectroscopic analysis of heme a and a3 redox reactions in the cytochrome c oxidase from Paracoccus denitrificans: separation of heme a and a3 contributions and assignment of vibrational modes. Biochemistry 1999;38(6):1685-94.
88. Padan E; Venturi M; Michel H; Hunte C Production and characterization of monoclonal antibodies directed against native epitopes of NhaA, the Na+/H+ antiporter of Escherichia coli. FEBS letters 1998;441(1):53-8.
89. Hellwig P; Ostermeier C; Michel H; Ludwig B; Mäntele W Electrochemically induced FT-IR difference spectra of the two- and four-subunit cytochrome c oxidase from P. denitrificans reveal identical conformational changes upon redox transitions. Biochimica et biophysica acta 1998;1409(2):107-12.
90. Michel H The mechanism of proton pumping by cytochrome c oxidasex127e comments]. Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12819-24.
91. Marheineke K; Lenhard T; Haase W; Beckers T; Michel H; Reiländer H Characterization of the human gonadotropin-releasing hormone receptor heterologously produced using the baculovirus/insect cell and the Semliki Forest virus systems. Cellular and molecular neurobiology 1998;18(5):509-24.
92. Kannt A; Soulimane T; Buse G; Becker A; Bamberg E; Michel H Electrical current generation and proton pumping catalyzed by the ba3-type cytochrome c oxidase from Thermus thermophilus. FEBS letters 1998;434(1-2):17-22.
93. Albert I; Rutherford A W; Grav H; Kellermann J; Michel H The 18 kDa cytochrome c553 from Heliobacterium gestii: gene sequence and characterization of the mature protein. Biochemistry 1998;37(25):9001-8.
94. Chen I P; Michel H Cloning, sequencing, and characterization of the recA gene from Rhodopseudomonas viridis and construction of a recA strain. Journal of bacteriology 1998;180(12):3227-32.
95. Lenhard T; Marheineke K; Lingen B; Haase W; Hammermann R; Michel H; Reiländer H Characterization of the human dopamine transporter heterologously expressed in BHK-21 cells. Cellular and molecular neurobiology 1998;18(3):347-60.
96. Behr J; Hellwig P; Mäntele W; Michel H Redox dependent changes at the heme propionates in cytochrome c oxidase from Paracoccus denitrificans: direct evidence from FTIR difference spectroscopy in combination with heme propionate 13C labeling. Biochemistry 1998;37(20):7400-6.
97. Hellwig P; Behr J; Ostermeier C; Richter O M; Pfitzner U; Odenwald A; Ludwig B; Michel H; Mäntele W Involvement of glutamic acid 278 in the redox reaction of the cytochrome c oxidase from Paracoccus denitrificans investigated by FTIR spectroscopy. Biochemistry 1998;37(20):7390-9.
98. Weiss H M; Haase W; Michel H; Reiländer H Comparative biochemical and pharmacological characterization of the mouse 5HT5A 5-hydroxytryptamine receptor and the human beta2-adrenergic receptor produced in the methylotrophic yeast Pichia pastoris. The Biochemical journal 1998;330 ( Pt 3)():1137-47.
99. Kannt A; Lancaster C R; Michel H The role of electrostatic interactions for cytochrome c oxidase function. Journal of bioenergetics and biomembranes 1998;30(1):81-7.
100. Kannt A; Lancaster C R; Michel H The coupling of electron transfer and proton translocation: electrostatic calculations on Paracoccus denitrificans cytochrome c oxidase. Biophysical journal 1998;74(2 Pt 1):708-21.
101. Michel H; Behr J; Harrenga A; Kannt A Cytochrome c oxidase: structure and spectroscopy. Annual review of biophysics and biomolecular structure 1998;27():329-56.
102. Lancaster C R; Michel H The coupling of light-induced electron transfer and proton uptake as derived from crystal structures of reaction centres from Rhodopseudomonas viridis modified at the binding site of the secondary quinone, QB. Structure (London, England : 1993) 1997;5(10):1339-59.
103. Ostermeier C; Michel H Crystallization of membrane proteins. Current opinion in structural biology 1997;7(5):697-701.
104. Ostermeier C; Harrenga A; Ermler U; Michel H Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment. Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10547-53.
105. Grünewald S; Reiländer H; Michel H In vivo reconstitution of dopamine D2S receptor-mediated G protein activation in baculovirus-infected insect cells: preferred coupling to Gi1 versus Gi2. Biochemistry 1996;35(48):15162-73.
106. Grünewald S; Haase W; Reiländer H; Michel H Glycosylation, palmitoylation, and localization of the human D2S receptor in baculovirus-infected insect cells. Biochemistry 1996;35(48):15149-61.
107. Shima S; Thauer R K; Michel H; Ermler U Crystallization and preliminary X-ray diffraction studies of formylmethanofuran: tetrahydromethanopterin formyltransferase from Methanopyrus kandleri. Proteins 1996;26(1):118-20.
108. Ostermeier C; Iwata S; Michel H Cytochrome c oxidase. Current opinion in structural biology 1996;6(4):460-6.
109. Germeroth L; Reiländer H; Michel H Molecular cloning, DNA sequence and transcriptional analysis of the Rhodospirillum molischianum B800/850 light-harvesting genes. Biochimica et biophysica acta 1996;1275(3):145-50.
110. Lancaster C R; Michel H; Honig B; Gunner M R Calculated coupling of electron and proton transfer in the photosynthetic reaction center of Rhodopseudomonas viridis. Biophysical journal 1996;70(6):2469-92.
111. Sauer P R; Lottspeich F; Unger E; Mentele R; Michel H Deletion of a B800-850 light-harvesting complex in Rhodospirillum molischianum DSM119 leads to ”revertants” expressing a B800-820 complex: insights into pigment binding. Biochemistry 1996;35(20):6500-7.
112. Koepke J; Hu X; Muenke C; Schulten K; Michel H The crystal structure of the light-harvesting complex II (B800-850) from Rhodospirillum molischianum. Structure (London, England : 1993) 1996;4(5):581-97.
113. Iwata S; Saynovits M; Link T A; Michel H Structure of a water soluble fragment of the ’Rieske’ iron-sulfur protein of the bovine heart mitochondrial cytochrome bc1 complex determined by MAD phasing at 1.5 A resolution. Structure (London, England : 1993) 1996;4(5):567-79.
114. Ostermeier C; Michel H Improved cloning of antibody variable regions from hybridomas by an antisense-directed RNase H digestion of the P3-X63-Ag8.653 derived pseudogene mRNA. Nucleic acids research 1996;24(10):1979-80.
115. Hellwig P; Rost B; Kaiser U; Ostermeier C; Michel H; Mäntele W Carboxyl group protonation upon reduction of the Paracoccus denitrificans cytochrome c oxidase: direct evidence by FTIR spectroscopy. FEBS letters 1996;385(1-2):53-7.
116. Seidler A; Rutherford A W; Michel H On the role of the N-terminus of the extrinsic 33 kDa protein of Photosystem II. Plant molecular biology 1996;31(1):183-8.
117. Ribrioux S; Kleymann G; Haase W; Heitmann K; Ostermeier C; Michel H Use of nanogold- and fluorescent-labeled antibody Fv fragments in immunocytochemistry. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1996;44(3):207-13.
118. Weiss H M; Haase W; Michel H; Reiländer H Expression of functional mouse 5-HT5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization. FEBS letters 1995;377(3):451-6.
119. Ostermeier C; Iwata S; Ludwig B; Michel H Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase. Nature structural biology 1995;2(10):842-6.
120. Dohse B; Mathis P; Wachtveitl J; Laussermair E; Iwata S; Michel H; Oesterhelt D Electron transfer from the tetraheme cytochrome to the special pair in the Rhodopseudomonas viridis reaction center: effect of mutations of tyrosine L162. Biochemistry 1995;34(36):11335-43.
121. Hu X; Xu D; Hamer K; Schulten K; Koepke J; Michel H Predicting the structure of the light-harvesting complex II of Rhodospirillum molischianum. Protein science : a publication of the Protein Society 1995;4(9):1670-82.
122. Iwata S; Ostermeier C; Ludwig B; Michel H Structure at 2.8 A resolution of cytochrome c oxidase from Paracoccus denitrificans. Nature 1995;376(6542):660-9.
123. Tsiotis G; Haase W; Engel A; Michel H Isolation and structural characterization of trimeric cyanobacterial photosystem I complex with the help of recombinant antibody fragments. European journal of biochemistry / FEBS 1995;231(3):823-30.
124. Visschers R W; Germeroth L; Michel H; Monshouwer R; van Grondelle R Spectroscopic properties of the light-harvesting complexes from Rhodospirillum molischianum. Biochimica et biophysica acta 1995;1230(3):147-54.
125. Baciou L; Michel H Interruption of the water chain in the reaction center from Rhodobacter sphaeroides reduces the rates of the proton uptake and of the second electron transfer to QB. Biochemistry 1995;34(25):7967-72.
126. Kleymann G; Ostermeier C; Heitmann K; Haase W; Michel H Use of antibody fragments (Fv) in immunocytochemistry. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(6):607-14.
127. Kleymann G; Iwata S; Wiesmüller K H; Ludwig B; Haase W; Michel H Immunoelectron microscopy and epitope mapping with monoclonal antibodies suggest the existence of an additional N-terminal transmembrane helix in the cytochrome b subunit of bacterial ubiquinol:cytochrome-c oxidoreductases. European journal of biochemistry / FEBS 1995;230(1):359-63.
128. Deisenhofer J; Epp O; Sinning I; Michel H Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis. Journal of molecular biology 1995;246(3):429-57.
129. Kleymann G; Ostermeier C; Ludwig B; Skerra A; Michel H Engineered Fv fragments as a tool for the one-step purification of integral multisubunit membrane protein complexes. Bio/technology (Nature Publishing Company) 1995;13(2):155-60.
130. Ostermeier C; Essen L O; Michel H Crystals of an antibody Fv fragment against an integral membrane protein diffracting to 1.28 A resolution. Proteins 1995;21(1):74-7.
131. Sander P; Grünewald S; Bach M; Haase W; Reiländer H; Michel H Heterologous expression of the human D2S dopamine receptor in protease-deficient Saccharomyces cerevisiae strains. European journal of biochemistry / FEBS 1994;226(2):697-705.
132. Ermler U; Fritzsch G; Buchanan S K; Michel H Structure of the photosynthetic reaction centre from Rhodobacter sphaeroides at 2.65 A resolution: cofactors and protein-cofactor interactions. Structure (London, England : 1993) 1994;2(10):925-36.
133. Albert I; Leibl W; Ewald G; Michel H; Rutherford A W Structural and functional consequences of a Glu L212–>Lys mutation in the QB binding site of the photosynthetic reaction center of Rhodopseudomonas viridis. Biochemistry 1994;33(37):11355-63.
134. Sander P; Grünewald S; Maul G; Reiländer H; Michel H Constitutive expression of the human D2S-dopamine receptor in the unicellular yeast Saccharomyces cerevisiae. Biochimica et biophysica acta 1994;1193(2):255-62.
135. Sander P; Grünewald S; Reiländer H; Michel H Expression of the human D2S dopamine receptor in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe: a comparative study. FEBS letters 1994;344(1):41-6.
136. Ermler U; Michel H; Schiffer M Structure and function of the photosynthetic reaction center from Rhodobacter sphaeroides. Journal of bioenergetics and biomembranes 1994;26(1):5-15.
137. Schertler G F; Bartunik H D; Michel H; Oesterhelt D Orthorhombic crystal form of bacteriorhodopsin nucleated on benzamidine diffracting to 3.6 A resolution. Journal of molecular biology 1993;234(1):156-64.
138. Gerhus E; Grisshammer R; Michel H; Ludwig B; Turba A Synthesis of the Rhodopseudomonas viridis holo-cytochrome c2 in Paracoccus denitrificans. FEMS microbiology letters 1993;113(1):29-34.
139. Bach M; Reiländer H; Gärtner P; Lottspeich F; Michel H Nucleotide sequence of a putative succinate dehydrogenase operon in Thermoplasma acidophilum. Biochimica et biophysica acta 1993;1174(1):103-7.
140. Germeroth L; Lottspeich F; Robert B; Michel H Unexpected similarities of the B800-850 light-harvesting complex from Rhodospirillum molischianum to the B870 light-harvesting complexes from other purple photosynthetic bacteria. Biochemistry 1993;32(21):5615-21.
141. Buchanan S K; Fritzsch G; Ermler U; Michel H New crystal form of the photosynthetic reaction centre from Rhodobacter sphaeroides of improved diffraction quality. Journal of molecular biology 1993;230(4):1311-4.
142. Leibl W; Sinning I; Ewald G; Michel H; Breton J Evidence that serine L223 is involved in the proton transfer pathway to QB in the photosynthetic reaction center of Rhodopseudomonas viridis. Biochemistry 1993;32(8):1958-64.
143. Feiler U; Nitschke W; Michel H Characterization of an improved reaction center preparation from the photosynthetic green sulfur bacterium Chlorobium containing the FeS centers FA and FB and a bound cytochrome subunit. Biochemistry 1992;31(9):2608-14.
144. Buchanan S; Michel H; Gerwert K Light-induced charge separation in Rhodopseudomonas viridis reaction centers monitored by Fourier-transform infrared difference spectroscopy: the quinone vibrations. Biochemistry 1992;31(5):1314-22.
145. Treutlein H; Schulten K; Brünger A T; Karplus M; Deisenhofer J; Michel H Chromophore-protein interactions and the function of the photosynthetic reaction center: a molecular dynamics study. Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):75-9.
146. Schertler G F; Lozier R; Michel H; Oesterhelt D Chromophore motion during the bacteriorhodopsin photocycle: polarized absorption spectroscopy of bacteriorhodopsin and its M-state in bacteriorhodopsin crystals. The EMBO journal 1991;10(9):2353-61.
147. Vasudevan S; Reiländer H; Maul G; Michel H Expression and cell membrane localization of rat M3 muscarinic acetylcholine receptor produced in Sf9 insect cells using the baculovirus system. FEBS letters 1991;283(1):52-6.
148. Reiländer H; Boege F; Vasudevan S; Maul G; Hekman M; Dees C; Hampe W; Helmreich E J; Michel H Purification and functional characterization of the human beta 2-adrenergic receptor produced in baculovirus-infected insect cells. FEBS letters 1991;282(2):441-4.
149. Söhlemann P; Oeckl C; Michel H Expression in Escherichia coli of the genes coding for reaction center subunits from Rhodobacter sphaeroides: wild-type proteins and fusion proteins containing one or four truncated domains from Staphylococcus aureus protein A at the carboxy-terminus. Biochimica et biophysica acta 1991;1089(1):103-12.
150. Grisshammer R; Oeckl C; Michel H Expression in Escherichia coli of c-type cytochrome genes from Rhodopseudomonas viridis. Biochimica et biophysica acta 1991;1088(2):183-90.
151. Deisenhofer J; Michel H High-resolution structures of photosynthetic reaction centers. Annual review of biophysics and biophysical chemistry 1991;20():247-66.
152. Deisenhofer J; Michel H Structures of bacterial photosynthetic reaction centers. Annual review of cell biology 1991;7():1-23.
153. Grisshammer R; Wiessner C; Michel H Sequence analysis and transcriptional organization of the Rhodopseudomonas viridis cytochrome c2 gene. Journal of bacteriology 1990;172(9):5071-8.
154. Seidler A; Michel H Expression in Escherichia coli of the psbO gene encoding the 33 kd protein of the oxygen-evolving complex from spinach. The EMBO journal 1990;9(6):1743-8.
155. Wiessner C; Dunger I; Michel H Structure and transcription of the genes encoding the B1015 light-harvesting complex beta and alpha subunits and the photosynthetic reaction center L, M, and cytochrome c subunits from Rhodopseudomonas viridis. Journal of bacteriology 1990;172(6):2877-87.
156. Ewald G; Wiessner C; Michel H Sequence analysis of four atrazine-resistant mutants from Rhodopseudomonas viridis. Zeitschrift für Naturforschung. C, Journal of biosciences 1990;45(5):459-62.
157. Sinning I; Koepke J; Schiller B; Michel H First glance on the three-dimensional structure of the photosynthetic reaction center from a herbicide-resistant Rhodopseudomonas viridis mutant. Zeitschrift für Naturforschung. C, Journal of biosciences 1990;45(5):455-8.
158. Deisenhofer J; Michel H The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis. Bioscience reports 1989;9(4):383-419.
159. Deisenhofer J; Michel H Nobel lecture. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis. The EMBO journal 1989;8(8):2149-70.
160. Sinning I; Michel H; Mathis P; Rutherford A W Characterization of four herbicide-resistant mutants of Rhodopseudomonas viridis by genetic analysis, electron paramagnetic resonance, and optical spectroscopy. Biochemistry 1989;28(13):5544-53.
161. Becker S; Atherton E; Michel H; Gordon R D Synthesis and characterization of conotoxin IIIa. Journal of protein chemistry 1989;8(3):393-4.
162. Miki K; Deisenhofer J; Michel H [Three-dimensional structure of photosynthetic reaction center from purple bacteria]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1989;34(6):726-40.
163. Weyer K A; Lottspeich F; Gruenberg H; Lang F; Oesterhelt D; Michel H Amino acid sequence of the cytochrome subunit of the photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis. The EMBO journal 1987;6(8):2197-202.
164. Allen J P; Feher G; Yeates T O; Rees D C; Deisenhofer J; Michel H; Huber R Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction. Proceedings of the National Academy of Sciences of the United States of America 1986;83(22):8589-93.
165. Michel H; Weyer K A; Gruenberg H; Dunger I; Oesterhelt D; Lottspeich F The ’light’ and ’medium’ subunits of the photosynthetic reaction centre from Rhodopseudomonas viridis: isolation of the genes, nucleotide and amino acid sequence. The EMBO journal 1986;5(6):1149-58.
166. Michel H; Weyer K A; Gruenberg H; Lottspeich F The ;heavy’ subunit of the photosynthetic reaction centre from Rhodopseudomonas viridis: isolation of the gene, nucleotide and amino acid sequence. The EMBO journal 1985;4(7):1667-72.
167. Deisenhofer J; Epp O; Miki K; Huber R; Michel H X-ray structure analysis of a membrane protein complex. Electron density map at 3 A resolution and a model of the chromophores of the photosynthetic reaction center from Rhodopseudomonas viridis. Journal of molecular biology 1984;180(2):385-98.
168. Michel H Characterization and crystal packing of three-dimensional bacteriorhodopsin crystals. The EMBO journal 1982;1(10):1267-71.
169. Schnabel H; Zillig W; Pfäffle M; Schnabel R; Michel H; Delius H Halobacterium halobium phage øH. The EMBO journal 1982;1(1):87-92.
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